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ST002173 Unveiling the mechanism of action of nature-inspired anti-cancer compounds using a multi-Omics approachList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
5-Phosphoribose 1-diphosphate biosynthesis (1)
REACT_850
Abacavir metabolism (2)
REACT_121388
Abnormal metabolism in phenylketonuria (2)
REACT_121117
Activation of AMPA receptors (1)
REACT_18338
Activation of Ca-permeable Kainate Receptor (1)
REACT_21346
Activation of Na-permeable Kainate Receptors (1)
REACT_21343
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (1)
REACT_200686
Acyl chain remodeling of DAG and TAG (1)
REACT_121122
Adenylate cyclase activating pathway (1)
REACT_15312
Adrenaline,noradrenaline inhibits insulin secretion (1)
REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1)
REACT_19180
Adrenoceptors (1)
REACT_16927
Aflatoxin activation and detoxification (2)
REACT_228214
alpha-linolenic acid (ALA) metabolism (2)
REACT_121147
Alpha-oxidation of phytanate (1)
REACT_17003
Amino acid synthesis and interconversion (transamination) (2)
REACT_238
Amino acid transport across the plasma membrane (5)
REACT_13796
AMPK inhibits chREBP transcriptional activation activity (1)
REACT_1988
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (4)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (5)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1)
REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (1)
REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1)
REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1)
REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1)
REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1)
REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1)
REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1)
REACT_2025
Beta-oxidation of pristanoyl-CoA (1)
REACT_17017
Beta-oxidation of very long chain fatty acids (1)
REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2)
REACT_416
Biotin transport and metabolism (1)
REACT_11153
Branched-chain amino acid catabolism (2)
REACT_197
Cam-PDE 1 activation (2)
REACT_15408
Carnitine synthesis (1)
REACT_2125
Catecholamine biosynthesis (1)
REACT_15551
Cell redox homeostasis (1)
REACT_121394
Cholesterol biosynthesis (2)
REACT_9405
Citric acid cycle (TCA cycle) (2)
REACT_1785
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (2)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cobalamin (Cbl, vitamin B12) transport and metabolism (1)
REACT_163862
Coenzyme A biosynthesis (1)
REACT_11218
Conjugation of benzoate with glycine (2)
REACT_6933
Conjugation of phenylacetate with glutamine (1)
REACT_6800
Conjugation of salicylate with glycine (2)
REACT_6812
Creatine metabolism (2)
REACT_813
CREB phosphorylation through the activation of Adenylate Cyclase (1)
REACT_20625
CREB phosphorylation through the activation of CaMKII (2)
REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (4)
REACT_111056
CYP2E1 reactions (2)
REACT_13797
Cytosolic iron-sulfur cluster assembly (1)
REACT_160176
Cytosolic sulfonation of small molecules (2)
REACT_6913
Cytosolic tRNA aminoacylation (5)
REACT_15306
DARPP-32 events (2)
REACT_15334
Deadenylation of mRNA (1)
REACT_20514
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (1)
REACT_169149
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (1)
REACT_169439
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (1)
REACT_115654
Degradation of GABA (1)
REACT_23964
Detoxification of Reactive Oxygen Species (1)
REACT_172715
Digestion of dietary lipid (1)
REACT_9518
DNA replication initiation (1)
REACT_2244
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Electron transport from NADPH to Ferredoxin (1)
REACT_150128
Endosomal/Vacuolar pathway (4)
REACT_111168
eNOS activation (1)
REACT_12477
Enzymatic degradation of dopamine by COMT (1)
REACT_15548
Enzymatic degradation of Dopamine by monoamine oxidase (1)
REACT_15511
EPHB-mediated forward signaling (2)
REACT_228085
ER-Phagosome pathway (4)
REACT_111178
Ethanol oxidation (1)
REACT_34
Factors involved in megakaryocyte development and platelet production (1)
REACT_24970
Fatty acid, triacylglycerol, and ketone body metabolism (1)
REACT_22279
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
FCERI mediated NF-kB activation (1)
REACT_163994
FMO oxidises nucleophiles (1)
REACT_13653
Free fatty acid receptors (1)
REACT_21268
GABA synthesis (1)
REACT_24020
G alpha (12/13) signalling events (1)
REACT_18407
G alpha (i) signalling events (5)
REACT_19231
G alpha (q) signalling events (3)
REACT_18283
G alpha (s) signalling events (3)
REACT_19327
G alpha (z) signalling events (2)
REACT_19333
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (1)
REACT_18274
Gluconeogenesis (3)
REACT_1520
Glucuronidation (1)
REACT_6784
Glutamate Neurotransmitter Release Cycle (1)
REACT_12591
Glutathione synthesis and recycling (5)
REACT_6960
Glycogen breakdown (glycogenolysis) (1)
REACT_1008
Glycolysis (2)
REACT_1383
Glyoxylate metabolism (2)
REACT_16925
HCN channels (1)
REACT_75862
Hedgehog 'off' state (1)
REACT_267634
Heme biosynthesis (2)
REACT_9465
Histidine catabolism (2)
REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1)
REACT_494
Hydrolysis of LPE (1)
REACT_120785
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1)
REACT_25367
Interconversion of polyamines (2)
REACT_14805
ISG15 antiviral mechanism (1)
REACT_115831
Ligand-gated ion channel transport (1)
REACT_25387
Linoleic acid (LA) metabolism (1)
REACT_121100
Lysine catabolism (2)
REACT_1298
Metabolism of Angiotensinogen to Angiotensins (1)
REACT_147707
Metabolism of folate and pterines (2)
REACT_11167
Metabolism of polyamines (2)
REACT_14820
Metabolism of serotonin (1)
REACT_15532
Methionine salvage pathway (2)
REACT_75881
Methylation (2)
REACT_6946
Minus-strand DNA synthesis (1)
REACT_9055
Miscellaneous substrates (1)
REACT_13425
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (2)
REACT_228019
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (2)
REACT_228145
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1)
REACT_160
Mitochondrial tRNA aminoacylation (5)
REACT_15302
Molybdenum cofactor biosynthesis (1)
REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1)
REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1)
REACT_20518
Na+/Cl- dependent neurotransmitter transporters (5)
REACT_20506
Nicotinamide salvaging (1)
REACT_11213
Nicotinate metabolism (2)
REACT_11088
Norepinephrine Neurotransmitter Release Cycle (1)
REACT_15418
NOSIP mediated eNOS trafficking (1)
REACT_12510
NOSTRIN mediated eNOS trafficking (1)
REACT_12541
Organic anion transport (1)
REACT_22310
Organic anion transporters (3)
REACT_19372
Organic cation transport (2)
REACT_22357
PAOs oxidise polyamines to amines (2)
REACT_505
Passive transport by Aquaporins (1)
REACT_23826
PDE3B signalling (2)
REACT_1451
Phagosomal maturation (early endosomal stage) (1)
REACT_121256
Phenylalanine and tyrosine catabolism (3)
REACT_1786
Phosphate bond hydrolysis by NUDT proteins (1)
REACT_150237
PKA activation (1)
REACT_15530
PKA activation in glucagon signalling (1)
REACT_1946
Plasmalogen biosynthesis (1)
REACT_1407
Presynaptic function of Kainate receptors (1)
REACT_21254
Processive synthesis on the C-strand of the telomere (1)
REACT_8027
Proline catabolism (2)
REACT_1002
Proton-coupled neutral amino acid transporters (1)
REACT_19348
Proton/oligonucleotide cotransporters (4)
REACT_19328
Purine catabolism (8)
REACT_2086
Purine ribonucleoside monophosphate biosynthesis (3)
REACT_1776
Purine salvage (7)
REACT_1923
Pyrimidine biosynthesis (1)
REACT_21376
Pyrimidine catabolism (4)
REACT_1023
Pyrimidine salvage reactions (3)
REACT_655
Pyruvate metabolism (1)
REACT_2071
Rap1 signalling (1)
REACT_23898
Ras activation uopn Ca2+ infux through NMDA receptor (2)
REACT_20546
Recycling of bile acids and salts (2)
REACT_11042
Regulation of AMPK activity via LKB1 (1)
REACT_21285
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of insulin secretion (1)
REACT_18325
Regulation of pyruvate dehydrogenase (PDH) complex (1)
REACT_12528
Regulation of Rheb GTPase activity by AMPK (1)
REACT_21393
Removal of the Flap Intermediate (1)
REACT_70
Removal of the Flap Intermediate from the C-strand (1)
REACT_7999
Respiratory electron transport (2)
REACT_22393
Reuptake of GABA (1)
REACT_23910
Scavenging by Class A Receptors (1)
REACT_163699
Scavenging by Class B Receptors (1)
REACT_163679
Scavenging by Class F Receptors (1)
REACT_163813
Serine biosynthesis (1)
REACT_115789
Serotonin and melatonin biosynthesis (4)
REACT_15439
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Stimuli-sensing channels (2)
REACT_160189
Sulfide oxidation to sulfate (2)
REACT_116010
Sulfur amino acid metabolism (5)
REACT_115639
SUMO is conjugated to E1 (UBA2:SAE1) (1)
REACT_163812
Synthesis and interconversion of nucleotide di- and triphosphates (4)
REACT_21330
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1)
REACT_11053
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3)
REACT_11041
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PE (1)
REACT_120919
Synthesis of PG (1)
REACT_121280
Synthesis of PS (1)
REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1)
REACT_22394
Synthesis of very long-chain fatty acyl-CoAs (1)
REACT_380
Telomere C-strand synthesis initiation (1)
REACT_7993
Telomere Extension By Telomerase (1)
REACT_7974
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (2)
REACT_111176
Translocation of GLUT4 to the plasma membrane (1)
REACT_147867
Transport of glycerol from adipocytes to the liver by Aquaporins (1)
REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2)
REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (9)
REACT_1206
Triglyceride Biosynthesis (1)
REACT_1190
Tryptophan catabolism (4)
REACT_916
Ubiquinol biosynthesis (1)
REACT_160111
Unblocking of NMDA receptor, glutamate binding and activation (2)
REACT_20594
Uptake and function of anthrax toxins (1)
REACT_228255
Urea cycle (2)
REACT_847
Vasopressin regulates renal water homeostasis via Aquaporins (1)
REACT_24023
VEGFA-VEGFR2 Pathway (1)
REACT_228166
VEGFR2 mediated vascular permeability (1)
REACT_228016
Vitamin B1 (thiamin) metabolism (1)
REACT_11117
Vitamin B2 (riboflavin) metabolism (3)
REACT_11070
Vitamin C (ascorbate) metabolism (1)
REACT_11202
Vitamins B6 activation to pyridoxal phosphate (2)
REACT_25012
Xenobiotics (2)
REACT_13543
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