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ST002283 The “ForensOMICS” approach to forensic post-mortem interval estimation: combining metabolomics, lipidomics and proteomics for the analysis human skeletal remainsList of human metabolic pathways and metabolites (REACTOME)
Pathway name (# of metabolites detected in study)
Reactome pathway
Abacavir metabolism (1)
REACT_121388
Abnormal metabolism in phenylketonuria (1)
REACT_121117
Acetylcholine Neurotransmitter Release Cycle (2)
REACT_15309
Acetylcholine regulates insulin secretion (1)
REACT_18405
Activation of gene expression by SREBF (SREBP) (3)
REACT_147904
Adenosine P1 receptors (1)
REACT_18288
Amino acid transport across the plasma membrane (3)
REACT_13796
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (1)
REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (1)
REACT_75842
Arachidonate production from DAG (1)
REACT_19308
Arachidonic acid metabolism (1)
REACT_147851
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1)
REACT_13721
BMAL1:CLOCK,NPAS2 activates circadian gene expression (3)
REACT_111118
Circadian Clock (3)
REACT_24941
Class A/1 (Rhodopsin-like receptors) (1)
REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (3)
REACT_18319
Class II GLUTs (1)
REACT_19281
Cleavage of the damaged purine (1)
REACT_1729
Cleavage of the damaged pyrimidine (1)
REACT_2156
Conjugation of salicylate with glycine (1)
REACT_6812
COX reactions (1)
REACT_1396
Creatine metabolism (2)
REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (1)
REACT_111056
Cytosolic tRNA aminoacylation (1)
REACT_15306
degradation of AXIN (1)
REACT_200766
Degradation of cysteine and homocysteine (1)
REACT_115654
Digestion of dietary carbohydrate (2)
REACT_9472
Digestion of dietary lipid (1)
REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1)
REACT_121111
Endosomal/Vacuolar pathway (1)
REACT_111168
eNOS activation (1)
REACT_12477
ER-Phagosome pathway (1)
REACT_111178
Fatty acids (2)
REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (2)
REACT_19193
Fatty Acyl-CoA Biosynthesis (1)
REACT_1319
Free fatty acid receptors (5)
REACT_21268
G alpha (i) signalling events (5)
REACT_19231
G alpha (q) signalling events (4)
REACT_18283
G alpha (s) signalling events (2)
REACT_19327
Glutathione synthesis and recycling (1)
REACT_6960
Highly calcium permeable nicotinic acetylcholine receptors (1)
REACT_22352
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (1)
REACT_22303
Highly sodium permeable acetylcholine nicotinic receptors (1)
REACT_22223
Histamine receptors (1)
REACT_16903
Histidine catabolism (2)
REACT_1249
Hydrolysis of LPC (1)
REACT_120977
Hydroxycarboxylic acid-binding receptors (1)
REACT_163785
Import of palmitoyl-CoA into the mitochondrial matrix (1)
REACT_11082
Linoleic acid (LA) metabolism (1)
REACT_121100
Methionine salvage pathway (1)
REACT_75881
Methylation (1)
REACT_6946
Miscellaneous substrates (1)
REACT_13425
Mitochondrial tRNA aminoacylation (1)
REACT_15302
Muscarinic acetylcholine receptors (1)
REACT_16943
Na+/Cl- dependent neurotransmitter transporters (4)
REACT_20506
Neurotransmitter Clearance In The Synaptic Cleft (2)
REACT_13583
NGF-independant TRKA activation (1)
REACT_11046
Nicotinamide salvaging (1)
REACT_11213
Organic anion transport (1)
REACT_22310
Organic cation transport (3)
REACT_22357
Orphan transporters (3)
REACT_267716
Phenylalanine and tyrosine catabolism (1)
REACT_1786
phospho-PLA2 pathway (1)
REACT_15466
Plasmalogen biosynthesis (1)
REACT_1407
PPARA activates gene expression (3)
REACT_116145
Proton/oligonucleotide cotransporters (1)
REACT_19328
Purine catabolism (5)
REACT_2086
Purine salvage (4)
REACT_1923
Pyrimidine biosynthesis (1)
REACT_21376
Pyrimidine catabolism (1)
REACT_1023
Pyrimidine salvage reactions (1)
REACT_655
Recycling of bile acids and salts (1)
REACT_11042
Regulation of HSF1-mediated heat shock response (1)
REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (3)
REACT_19241
Respiratory electron transport (1)
REACT_22393
Retinoid cycle disease events (1)
REACT_160130
Retinoid metabolism and transport (3)
REACT_24968
Reuptake of GABA (1)
REACT_23910
REV-ERBA represses gene expression (3)
REACT_118789
Role of phospholipids in phagocytosis (2)
REACT_160158
RORA activates circadian gene expression (3)
REACT_118659
SIRT1 negatively regulates rRNA Expression (1)
REACT_200827
Stimuli-sensing channels (1)
REACT_160189
Sulfide oxidation to sulfate (1)
REACT_116010
Sulfur amino acid metabolism (2)
REACT_115639
Synthesis of 12-eicosatetraenoic acid derivatives (1)
REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (1)
REACT_150422
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) (1)
REACT_150134
Synthesis of 5-eicosatetraenoic acids (1)
REACT_150209
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (1)
REACT_11041
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) (1)
REACT_150417
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (1)
REACT_150292
Synthesis of Leukotrienes (LT) and Eoxins (EX) (2)
REACT_150420
Synthesis of PA (1)
REACT_120906
Synthesis of PC (2)
REACT_121238
Synthesis of PG (1)
REACT_121280
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3)
REACT_150149
Synthesis of PS (1)
REACT_120823
Synthesis of very long-chain fatty acyl-CoAs (2)
REACT_380
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (6)
REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (2)
REACT_23824
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1)
REACT_111176
The canonical retinoid cycle in rods (twilight vision) (3)
REACT_160156
The retinoid cycle in cones (daylight vision) (1)
REACT_160083
Transcriptional activation of mitochondrial biogenesis (3)
REACT_200608
Transcriptional regulation of white adipocyte differentiation (3)
REACT_27161
Transport of fatty acids (4)
REACT_23892
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds (2)
REACT_19305
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (6)
REACT_1206
Tryptophan catabolism (2)
REACT_916
Xenobiotics (1)
REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (3)
REACT_118713
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