ST002391 Evaluation of Two Simultaneous Metabolomic and Proteomic Extraction Protocols Assessed by Ultra-High-Performance Liq-uid Chromatography Tandem Mass Spectrometry
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
ABH2 mediated Reversal of Alkylation Damage (1) REACT_526
ABH3 mediated Reversal of Alkylation Damage (1) REACT_1662
Abnormal metabolism in phenylketonuria (3) REACT_121117
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Aflatoxin activation and detoxification (1) REACT_228214
Amino acid synthesis and interconversion (transamination) (3) REACT_238
Amino acid transport across the plasma membrane (8) REACT_13796
Androgen biosynthesis (1) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (9) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (9) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (1) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (1) REACT_13639
Beta-oxidation of pristanoyl-CoA (1) REACT_17017
Beta-oxidation of very long chain fatty acids (1) REACT_17062
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (3) REACT_197
Catecholamine biosynthesis (1) REACT_15551
Circadian Clock (1) REACT_24941
Class C/3 (Metabotropic glutamate/pheromone receptors) (2) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (1) REACT_163862
Conjugation of phenylacetate with glutamine (1) REACT_6800
Creatine metabolism (1) REACT_813
Cross-presentation of soluble exogenous antigens (endosomes) (9) REACT_111056
CYP2E1 reactions (2) REACT_13797
Cytosolic sulfonation of small molecules (2) REACT_6913
Cytosolic tRNA aminoacylation (9) REACT_15306
Digestion of dietary lipid (1) REACT_9518
Endosomal/Vacuolar pathway (9) REACT_111168
ER-Phagosome pathway (9) REACT_111178
Ethanol oxidation (2) REACT_34
FMO oxidises nucleophiles (1) REACT_13653
Free fatty acid receptors (1) REACT_21268
G alpha (i) signalling events (1) REACT_19231
G alpha (q) signalling events (2) REACT_18283
Gluconeogenesis (1) REACT_1520
Glucuronidation (1) REACT_6784
Glutamate Neurotransmitter Release Cycle (1) REACT_12591
Glutathione synthesis and recycling (10) REACT_6960
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG biosynthesis (1) REACT_121248
HS-GAG degradation (1) REACT_120752
Hydrolysis of LPE (1) REACT_120785
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Linoleic acid (LA) metabolism (1) REACT_121100
Lysine catabolism (2) REACT_1298
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (1) REACT_15532
Methionine salvage pathway (2) REACT_75881
Methylation (2) REACT_6946
Mitochondrial tRNA aminoacylation (9) REACT_15302
Molybdenum cofactor biosynthesis (1) REACT_25073
Na+/Cl- dependent neurotransmitter transporters (8) REACT_20506
Nicotinate metabolism (1) REACT_11088
NoRC negatively regulates rRNA expression (1) REACT_200856
Organic anion transport (1) REACT_22310
Organic anion transporters (1) REACT_19372
Orphan transporters (1) REACT_267716
Passive transport by Aquaporins (1) REACT_23826
Phenylalanine and tyrosine catabolism (2) REACT_1786
PPARA activates gene expression (1) REACT_116145
Proline catabolism (1) REACT_1002
Proton-coupled neutral amino acid transporters (1) REACT_19348
Proton/oligonucleotide cotransporters (9) REACT_19328
Purine catabolism (1) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (2) REACT_1776
Pyrimidine biosynthesis (2) REACT_21376
Pyrimidine catabolism (2) REACT_1023
Pyrimidine salvage reactions (2) REACT_655
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Retinoid metabolism and transport (1) REACT_24968
REV-ERBA represses gene expression (1) REACT_118789
RORA activates circadian gene expression (1) REACT_118659
Serotonin and melatonin biosynthesis (1) REACT_15439
Sphingolipid de novo biosynthesis (1) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfur amino acid metabolism (1) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (1) REACT_21330
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of PE (1) REACT_120919
Synthesis of PG (1) REACT_121280
Synthesis of PS (1) REACT_120823
Synthesis of UDP-N-acetyl-glucosamine (1) REACT_22394
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The canonical retinoid cycle in rods (twilight vision) (1) REACT_160156
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (1) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (2) REACT_1206
Triglyceride Biosynthesis (1) REACT_1190
Tryptophan catabolism (4) REACT_916
Urea cycle (1) REACT_847
Xenobiotics (1) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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