ST002447 Bioactive molecule(s) of gut bacteria of Crocodile (Crocodylus palustris) as potential pharmaceuticals
List of human metabolic pathways and metabolites (REACTOME)

Pathway name (# of metabolites detected in study)Reactome pathway
Abacavir metabolism (2) REACT_121388
ABH2 mediated Reversal of Alkylation Damage (2) REACT_526
ABH3 mediated Reversal of Alkylation Damage (2) REACT_1662
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (1) REACT_160183
Abnormal metabolism in phenylketonuria (4) REACT_121117
Acetylation (1) REACT_6732
Activation of AMPA receptors (1) REACT_18338
Activation of Ca-permeable Kainate Receptor (1) REACT_21346
Activation of gene expression by SREBF (SREBP) (1) REACT_147904
Activation of Na-permeable Kainate Receptors (1) REACT_21343
Acyl chain remodeling of DAG and TAG (1) REACT_121122
Adrenaline,noradrenaline inhibits insulin secretion (1) REACT_18339
Adrenaline signalling through Alpha-2 adrenergic receptor (1) REACT_19180
Adrenoceptors (1) REACT_16927
Aflatoxin activation and detoxification (4) REACT_228214
Agmatine biosynthesis (1) REACT_14800
alpha-linolenic acid (ALA) metabolism (1) REACT_121147
Alpha-oxidation of phytanate (3) REACT_17003
Amino acid synthesis and interconversion (transamination) (7) REACT_238
Amino acid transport across the plasma membrane (13) REACT_13796
Androgen biosynthesis (2) REACT_11059
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (11) REACT_75795
Antigen processing: Ubiquitination & Proteasome degradation (11) REACT_75842
Arachidonate production from DAG (1) REACT_19308
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 (2) REACT_13721
Astrocytic Glutamate-Glutamine Uptake And Metabolism (2) REACT_13639
Beta oxidation of butanoyl-CoA to acetyl-CoA (1) REACT_419
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA (1) REACT_1708
Beta oxidation of hexanoyl-CoA to butanoyl-CoA (1) REACT_1887
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA (1) REACT_735
Beta oxidation of myristoyl-CoA to lauroyl-CoA (1) REACT_2108
Beta oxidation of octanoyl-CoA to hexanoyl-CoA (1) REACT_1697
Beta oxidation of palmitoyl-CoA to myristoyl-CoA (1) REACT_2025
Beta-oxidation of pristanoyl-CoA (2) REACT_17017
Beta-oxidation of very long chain fatty acids (2) REACT_17062
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (2) REACT_416
Biotin transport and metabolism (1) REACT_11153
BMAL1:CLOCK,NPAS2 activates circadian gene expression (1) REACT_111118
Branched-chain amino acid catabolism (5) REACT_197
Carnitine synthesis (4) REACT_2125
Catecholamine biosynthesis (2) REACT_15551
Cell redox homeostasis (1) REACT_121394
Cholesterol biosynthesis (2) REACT_9405
Circadian Clock (1) REACT_24941
Citric acid cycle (TCA cycle) (7) REACT_1785
Class A/1 (Rhodopsin-like receptors) (3) REACT_14828
Class C/3 (Metabotropic glutamate/pheromone receptors) (7) REACT_18319
Class II GLUTs (1) REACT_19281
Cleavage of the damaged purine (1) REACT_1729
Cleavage of the damaged pyrimidine (1) REACT_2156
Cobalamin (Cbl, vitamin B12) transport and metabolism (2) REACT_163862
Collagen biosynthesis and modifying enzymes (2) REACT_121139
Condensation of Prophase Chromosomes (2) REACT_172744
Conjugation of benzoate with glycine (3) REACT_6933
Conjugation of phenylacetate with glutamine (2) REACT_6800
Conjugation of salicylate with glycine (1) REACT_6812
Creatine metabolism (4) REACT_813
CREB phosphorylation through the activation of CaMKII (2) REACT_20642
Cross-presentation of soluble exogenous antigens (endosomes) (11) REACT_111056
CYP2E1 reactions (3) REACT_13797
Cysteine formation from homocysteine (1) REACT_115589
Cytosolic sulfonation of small molecules (4) REACT_6913
Cytosolic tRNA aminoacylation (11) REACT_15306
degradation of AXIN (1) REACT_200766
Degradation of cysteine and homocysteine (2) REACT_115654
Degradation of GABA (5) REACT_23964
Detoxification of Reactive Oxygen Species (1) REACT_172715
Digestion of dietary carbohydrate (1) REACT_9472
Digestion of dietary lipid (2) REACT_9518
Downregulation of SMAD2/3:SMAD4 transcriptional activity (1) REACT_121111
Endogenous sterols (2) REACT_13812
Endosomal/Vacuolar pathway (11) REACT_111168
eNOS activation (2) REACT_12477
EPHB-mediated forward signaling (2) REACT_228085
ER-Phagosome pathway (11) REACT_111178
Estrogen biosynthesis (2) REACT_11037
Ethanol oxidation (2) REACT_34
Fatty acids (1) REACT_13814
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (1) REACT_19193
Fatty Acyl-CoA Biosynthesis (3) REACT_1319
FMO oxidises nucleophiles (2) REACT_13653
Formation of the active cofactor, UDP-glucuronate (1) REACT_6737
Free fatty acid receptors (4) REACT_21268
GABA synthesis (2) REACT_24020
G alpha (12/13) signalling events (1) REACT_18407
G alpha (i) signalling events (9) REACT_19231
G alpha (q) signalling events (8) REACT_18283
G alpha (s) signalling events (2) REACT_19327
G alpha (z) signalling events (1) REACT_19333
Glucocorticoid biosynthesis (2) REACT_11036
Gluconeogenesis (7) REACT_1520
Glucuronidation (2) REACT_6784
Glutamate Neurotransmitter Release Cycle (2) REACT_12591
Glutathione conjugation (1) REACT_6926
Glutathione synthesis and recycling (13) REACT_6960
Glycolysis (2) REACT_1383
Glycosphingolipid metabolism (2) REACT_116105
Glyoxylate metabolism (1) REACT_16925
HDMs demethylate histones (2) REACT_228178
Heme biosynthesis (1) REACT_9465
Histidine catabolism (4) REACT_1249
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis (1) REACT_494
HS-GAG biosynthesis (1) REACT_121248
Hypusine synthesis from eIF5A-lysine (1) REACT_12469
Inactivation, recovery and regulation of the phototransduction cascade (1) REACT_163919
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate (1) REACT_25367
Keratan sulfate biosynthesis (1) REACT_121120
Ligand-gated ion channel transport (2) REACT_25387
Linoleic acid (LA) metabolism (2) REACT_121100
Lysine catabolism (5) REACT_1298
Metabolism of Angiotensinogen to Angiotensins (1) REACT_147707
Metabolism of folate and pterines (2) REACT_11167
Metabolism of polyamines (1) REACT_14820
Metabolism of serotonin (3) REACT_15532
Methionine salvage pathway (4) REACT_75881
Methylation (3) REACT_6946
Mineralocorticoid biosynthesis (1) REACT_11047
Miscellaneous substrates (1) REACT_13425
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids (1) REACT_160
Mitochondrial iron-sulfur cluster biogenesis (1) REACT_150353
Mitochondrial tRNA aminoacylation (11) REACT_15302
Molybdenum cofactor biosynthesis (2) REACT_25073
mRNA decay by 3' to 5' exoribonuclease (1) REACT_20619
mRNA decay by 5' to 3' exoribonuclease (1) REACT_20518
Na+/Cl- dependent neurotransmitter transporters (13) REACT_20506
NADPH regeneration (1) REACT_16904
Neurotransmitter Clearance In The Synaptic Cleft (1) REACT_13583
Nicotinamide salvaging (2) REACT_11213
Nicotinate metabolism (2) REACT_11088
Nitric oxide stimulates guanylate cyclase (2) REACT_23862
NoRC negatively regulates rRNA expression (1) REACT_200856
Norepinephrine Neurotransmitter Release Cycle (1) REACT_15418
Organic anion transport (3) REACT_22310
Organic anion transporters (4) REACT_19372
Organic cation transport (3) REACT_22357
Orphan transporters (2) REACT_267716
Oxidative Stress Induced Senescence (2) REACT_169436
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_121226
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (2) REACT_120916
Passive transport by Aquaporins (1) REACT_23826
Phagosomal maturation (early endosomal stage) (3) REACT_121256
Phenylalanine and tyrosine catabolism (6) REACT_1786
Platelet degranulation (1) REACT_318
PPARA activates gene expression (1) REACT_116145
Pre-NOTCH Processing in Golgi (1) REACT_118798
Presynaptic function of Kainate receptors (1) REACT_21254
Proline catabolism (3) REACT_1002
Proton-coupled neutral amino acid transporters (2) REACT_19348
Proton/oligonucleotide cotransporters (11) REACT_19328
Purine catabolism (8) REACT_2086
Purine ribonucleoside monophosphate biosynthesis (4) REACT_1776
Purine salvage (7) REACT_1923
Pyrimidine biosynthesis (3) REACT_21376
Pyrimidine catabolism (8) REACT_1023
Pyrimidine salvage reactions (7) REACT_655
Pyruvate metabolism (1) REACT_2071
Ras activation uopn Ca2+ infux through NMDA receptor (2) REACT_20546
Recycling of bile acids and salts (2) REACT_11042
Regulation of HSF1-mediated heat shock response (1) REACT_200780
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (1) REACT_19241
Regulation of ornithine decarboxylase (ODC) (1) REACT_13565
Regulation of pyruvate dehydrogenase (PDH) complex (1) REACT_12528
Removal of the Flap Intermediate (1) REACT_70
Removal of the Flap Intermediate from the C-strand (1) REACT_7999
Respiratory electron transport (1) REACT_22393
Retinoid metabolism and transport (1) REACT_24968
Reuptake of GABA (1) REACT_23910
REV-ERBA represses gene expression (1) REACT_118789
RORA activates circadian gene expression (1) REACT_118659
Serine biosynthesis (4) REACT_115789
Serotonin and melatonin biosynthesis (5) REACT_15439
Serotonin clearance from the synaptic cleft (1) REACT_15391
Serotonin Neurotransmitter Release Cycle (1) REACT_15425
Serotonin receptors (1) REACT_17064
Sialic acid metabolism (1) REACT_200874
SIRT1 negatively regulates rRNA Expression (1) REACT_200827
Sodium-coupled sulphate, di- and tri-carboxylate transporters (2) REACT_20646
Sphingolipid de novo biosynthesis (3) REACT_115810
Stimuli-sensing channels (1) REACT_160189
Sulfide oxidation to sulfate (2) REACT_116010
Sulfur amino acid metabolism (4) REACT_115639
Synthesis and interconversion of nucleotide di- and triphosphates (4) REACT_21330
Synthesis of 12-eicosatetraenoic acid derivatives (1) REACT_150201
Synthesis of 15-eicosatetraenoic acid derivatives (2) REACT_150422
Synthesis of 5-eicosatetraenoic acids (1) REACT_150209
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (1) REACT_11053
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (1) REACT_11048
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (3) REACT_11041
Synthesis of CL (1) REACT_120920
Synthesis of glycosylphosphatidylinositol (GPI) (1) REACT_952
Synthesis of Ketone Bodies (1) REACT_1464
Synthesis of Leukotrienes (LT) and Eoxins (EX) (3) REACT_150420
Synthesis of Lipoxins (LX) (1) REACT_150320
Synthesis of PA (1) REACT_120906
Synthesis of PC (1) REACT_121238
Synthesis of PE (1) REACT_120919
Synthesis of PG (2) REACT_121280
Synthesis of PI (1) REACT_121000
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (3) REACT_150149
Synthesis of UDP-N-acetyl-glucosamine (2) REACT_22394
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (2) REACT_24019
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (1) REACT_23824
Termination of O-glycan biosynthesis (1) REACT_115835
TET1,2,3 and TDG demethylate DNA (2) REACT_200682
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (1) REACT_111176
The activation of arylsulfatases (1) REACT_121036
The canonical retinoid cycle in rods (twilight vision) (2) REACT_160156
Tolerance by Mtb to nitric oxide produced by macrophages (1) REACT_120983
Transcriptional activation of mitochondrial biogenesis (1) REACT_200608
Transcriptional regulation of white adipocyte differentiation (1) REACT_27161
Transport of fatty acids (1) REACT_23892
Transport of glycerol from adipocytes to the liver by Aquaporins (1) REACT_23809
Transport of inorganic cations/anions and amino acids/oligopeptides (2) REACT_19397
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (11) REACT_1206
Transport of nucleotide sugars (1) REACT_22151
Transport of organic anions (1) REACT_23988
Triglyceride Biosynthesis (2) REACT_1190
Tryptophan catabolism (8) REACT_916
Unblocking of NMDA receptor, glutamate binding and activation (2) REACT_20594
Urea cycle (4) REACT_847
Utilization of Ketone Bodies (2) REACT_59
VEGFR2 mediated cell proliferation (1) REACT_228024
VEGFR2 mediated vascular permeability (2) REACT_228016
Vitamin B1 (thiamin) metabolism (1) REACT_11117
Vitamin B2 (riboflavin) metabolism (1) REACT_11070
Vitamin C (ascorbate) metabolism (2) REACT_11202
Vitamins B6 activation to pyridoxal phosphate (3) REACT_25012
Xenobiotics (3) REACT_13543
YAP1- and WWTR1 (TAZ)-stimulated gene expression (1) REACT_118713
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