| Analysis | Metabolite Name | Measured Value | Units | Genotype | Treatment | Metabolite | Tissue |
|---|---|---|---|---|---|---|---|
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.068 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.087 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.090 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.093 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.094 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.096 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.105 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.111 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.114 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.123 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.129 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.136 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.144 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.184 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.221 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.231 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.235 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.238 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.242 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.246 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.250 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.250 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.250 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.265 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.273 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.274 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.281 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.291 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.299 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.311 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.314 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.333 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.333 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.349 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.349 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.374 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.379 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.393 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.403 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.409 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.410 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.423 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.471 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.501 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.541 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.592 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.620 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.632 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.634 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.693 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.707 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.718 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.719 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.749 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.760 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.764 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.772 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.777 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.816 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.829 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.842 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.846 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.867 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.882 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.886 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.908 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.937 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.946 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.957 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.980 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.986 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 0.999 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.053 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.059 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.079 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.088 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.090 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.093 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.096 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.104 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.112 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.126 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.133 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.139 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.146 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.173 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.198 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.203 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.209 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.210 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.214 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.230 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.238 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.241 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.267 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.284 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.304 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.380 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.413 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.454 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.597 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.651 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.753 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 1.811 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 2.096 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 2.106 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 2.213 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 2.504 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Arachidonic acid | 2.842 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
- UCSD Metabolomics Workbench, a resource sponsored by the Common Fund of the National Institutes of Health
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