Analysis | Metabolite Name | Measured Value | Units | Genotype | Treatment | Metabolite | Tissue |
---|---|---|---|---|---|---|---|
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.073 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.079 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.084 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.090 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.091 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.099 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.100 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.100 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.109 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.115 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.116 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.119 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.122 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.124 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.124 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.125 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.126 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.128 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.130 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.145 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.150 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.152 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.153 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.158 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.161 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.162 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.164 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.172 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.177 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.178 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.183 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.184 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.188 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.190 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.196 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.202 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.202 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.203 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.206 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.212 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.218 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.224 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.225 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.226 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.228 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.228 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.229 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.237 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.241 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.243 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.244 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.247 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.249 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.256 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.259 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.264 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.265 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.269 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.272 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.276 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.279 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.289 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.289 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.292 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.299 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.302 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.303 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.308 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.313 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.315 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.318 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.321 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.324 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.329 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.330 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.341 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.342 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.359 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.366 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.386 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.387 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.387 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.387 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.393 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.400 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.400 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.417 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.427 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.432 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.449 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.449 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.455 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.484 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.492 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.503 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.504 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.515 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.523 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.544 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.556 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.597 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.614 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.709 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.774 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.781 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.895 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 0.977 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 1.746 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
None (Direct infusion) NEGATIVE ION MODE | Docosahexaenoic acid | 1.767 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |