| Analysis | Metabolite Name | Measured Value | Units | Genotype | Treatment | Metabolite | Tissue |
|---|---|---|---|---|---|---|---|
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 4.518 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 4.679 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 5.263 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 5.469 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 5.579 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 5.720 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 5.898 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.027 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.089 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.145 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.178 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.385 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.467 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.498 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.515 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.578 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.620 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.773 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.864 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 6.933 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.040 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.120 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.145 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.167 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.186 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.458 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.701 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.702 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.743 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.824 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.827 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.881 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.905 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.951 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 7.988 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.094 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.094 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.108 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.189 | mg/mL | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.229 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.321 | mg/mL | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.339 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.360 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.439 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.488 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.588 | mg/mL | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.818 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.853 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 8.921 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.010 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.032 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.103 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.217 | mg/mL | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.338 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.597 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 9.656 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 10.758 | mg/mL | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 10.888 | mg/mL | F344 Pirc | AIN-93G (control) | Fatty Acid | Plasma |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 12.012 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 12.999 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 13.370 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 13.609 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 13.897 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 14.892 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 15.301 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 15.466 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 16.210 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 18.919 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 19.838 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 19.930 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 20.431 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 20.789 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 21.827 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 25.585 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 26.062 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 26.193 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 26.459 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 26.477 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 27.164 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 29.026 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 29.572 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 30.562 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 33.884 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 36.042 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 38.689 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 40.035 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 40.417 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 43.563 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 43.769 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 44.326 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 44.515 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 45.875 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 49.940 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 54.680 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 55.521 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 55.893 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 59.251 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 62.070 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 68.425 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 71.728 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 72.552 | mg/g tissue | F344 Pirc | 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 75.924 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 76.376 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 94.300 | mg/g tissue | F344 Pirc | EPA-FFA (2% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 97.380 | mg/g tissue | F344 Pirc | EPA-FFA (2%) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 103.103 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 117.884 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 160.859 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) + 200 ppm Naproxen | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 167.981 | mg/g tissue | F344 Pirc | AIN-93G (control) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 221.790 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 332.320 | mg/g tissue | F344 Pirc | HD TP-252 (3% EPA) | Fatty Acid | Tumor-adjacent normal colon |
| None (Direct infusion) NEGATIVE ION MODE | Linoleic acid | 465.208 | mg/g tissue | F344 Pirc | LD TP-252 (1.5% EPA) | Fatty Acid | Tumor-adjacent normal colon |
- UCSD Metabolomics Workbench, a resource sponsored by the Common Fund of the National Institutes of Health
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