Data for ST001236   

(Analysis AN002054): Average values per metabolite and experimental factor (Units:Log10(Peak Area))

Metabolite structureAll dataF1F2F3F4F5F6F7F8F9F10F11F12F13F14F15F16F17F18
1,7-dimethyluric acid
4.90 4.21 4.73 4.64 4.89 4.24 4.63 4.43 4.38 4.13 4.74 3.90 4.88 4.80 4.35 4.36 4.71 4.43
1-methyladenosine
5.07 5.01 5.06 5.06 5.07 5.06 5.04 5.04 5.08 5.09 5.09 5.05 5.04 5.03 5.05 5.03 5.06 5.01
1-methylguanosine
5.05 4.99 4.99 4.98 5.03 4.98 5.04 5.03 5.05 5.06 5.10 4.98 5.04 5.03 5.01 4.99 5.07 5.07
1-methylnicotinamide
4.87 4.86 5.00 4.92 4.92 4.66 4.96 5.01 5.14 5.00 4.95 5.00 4.96 5.05 5.09 5.00 4.97 4.86
2-aminooctanoate
3.30 3.19 3.50 3.08 3.21 3.17 3.21 3.18 3.37 3.19 3.12 3.15 3.33 3.30 3.57 3.21 3.24 3.18
3-methylhistidine
5.88 6.05 6.04 5.93 6.06 5.84 5.96 6.03 6.10 6.02 6.08 5.94 5.98 6.09 5.99 5.92 6.10 6.08
3-methylxanthine
4.96 4.80 5.03 4.90 5.10 4.69 5.07 4.72 4.87 4.70 4.98 4.75 4.98 4.86 5.12 4.79 4.95 4.88
3-(N-acetyl-L-cystein-S-yl) acetaminophen
4.31 3.86 4.55 4.96 5.83 4.66 4.68 4.77 5.35 5.17 5.46 2.80 4.77 3.91 4.91 4.96 5.11 4.62
4-acetamidobutanoate
5.04 4.96 5.05 5.07 5.09 4.95 4.96 4.99 5.06 5.11 5.10 4.92 5.05 5.04 5.02 5.11 5.08 5.04
4-hydroxy-3-methylacetophenone
5.27 5.12 5.39 4.95 5.09 5.24 5.21 5.17 5.33 5.00 5.17 5.12 5.40 5.30 5.45 5.23 5.24 5.22
4-hydroxyhippurate
5.07 4.83 4.84 4.84 5.11 4.75 4.97 4.80 4.86 4.66 4.93 4.78 5.19 4.95 4.86 5.08 4.95 5.04
4-pyridoxate
4.91 4.58 4.87 4.73 4.72 4.59 4.70 4.61 4.87 4.73 4.71 4.58 4.79 4.64 4.64 4.86 4.54 4.73
5-hydroxytryptophan
4.39 3.94 4.18 4.29 4.35 4.15 4.39 3.91 4.26 4.42 4.39 4.33 4.50 4.06 4.25 4.28 4.24 4.56
5-hydroxytryptophol
4.01 3.73 3.75 3.67 3.70 3.23 3.93 3.84 3.86 3.91 3.68 3.86 3.80 3.77 3.71 3.89 3.89 3.86
7-methylguanine
5.12 5.08 5.12 5.08 5.12 5.07 5.08 5.09 5.15 5.16 5.14 5.07 5.12 5.15 5.14 5.19 5.14 5.16
8-hydroxy-deoxyguanosine
5.24 5.06 5.11 4.87 5.00 5.04 5.21 5.27 5.40 5.06 5.38 5.29 5.39 5.14 5.29 4.80 4.99 4.75
acetaminophen
4.38 4.10 4.58 4.38 5.16 4.99 4.69 4.15 4.92 4.68 4.88 3.63 4.62 4.45 4.80 4.68 4.84 4.04
acetaminophen glucuronide
5.54 4.60 5.44 5.54 6.36 5.33 5.26 5.41 5.84 5.50 5.80 3.97 5.65 5.11 5.72 5.47 5.45 4.79
acetyl-galactosamine
4.99 4.88 4.92 4.90 4.87 4.95 4.91 4.89 4.97 4.92 4.93 4.88 4.95 4.90 4.94 4.93 4.89 4.99
adenosine
6.50 6.30 6.51 6.24 6.33 6.43 6.27 6.31 6.64 6.25 6.40 6.29 6.66 6.43 6.47 6.15 6.38 6.08
alanine
5.61 5.52 5.56 5.48 5.53 5.49 5.55 5.53 5.59 5.47 5.50 5.51 5.67 5.58 5.56 5.44 5.53 5.60
allantoin
3.77 3.62 3.69 3.65 3.68 3.58 3.73 3.73 3.78 3.72 3.84 3.64 3.87 3.84 3.76 3.72 3.93 3.78
allopurinol riboside
2.57 2.00 2.09 1.40 2.58 2.75 2.27 1.88 2.33 1.60 3.21 3.42 3.07 2.41 1.96 1.79 2.53 5.86
alpha-glycerophosphocholine
5.52 5.47 5.50 5.55 5.57 5.47 5.49 5.45 5.52 5.54 5.59 5.40 5.52 5.55 5.57 5.50 5.67 5.69
anthranilic acid
2.25 2.25 2.16 2.10 2.43 2.21 2.20 2.22 2.31 2.26 2.45 2.83 2.40 2.35 2.25 2.40 2.45 2.25
arginine
6.64 6.55 6.59 6.58 6.54 6.58 6.57 6.56 6.62 6.56 6.50 6.60 6.65 6.59 6.60 6.44 6.46 6.59
asparagine
5.22 5.16 5.15 5.17 5.16 5.18 5.15 5.16 5.20 5.17 5.15 5.18 5.25 5.22 5.18 5.10 5.16 5.23
atenolol
5.14 2.51 2.09 - 3.54 1.71 6.40 2.04 - 1.72 3.87 1.58 4.70 1.82 1.78 1.70 4.85 -
betaine
7.34 7.30 7.30 7.36 7.28 7.32 7.28 7.30 7.32 7.39 7.26 7.30 7.33 7.32 7.32 7.33 7.26 7.31
bilirubin
7.14 6.99 7.05 7.14 6.94 7.03 7.09 7.10 7.12 7.15 7.07 7.10 7.10 7.09 7.06 6.87 6.83 6.96
biliverdin
6.08 6.00 6.01 6.04 5.92 5.98 6.06 6.10 6.09 6.07 6.01 6.00 6.06 6.07 6.02 5.90 5.99 5.85
butyrobetaine
5.90 5.83 5.79 5.82 5.86 5.83 5.88 5.89 5.82 5.86 5.87 5.81 5.91 5.90 5.80 5.78 5.92 5.88
C10 carnitine
5.44 5.40 5.40 5.40 5.50 5.39 5.66 5.67 5.53 5.67 5.70 5.46 5.43 5.43 5.33 5.24 5.62 5.46
C12:1 carnitine
5.19 5.14 5.18 5.16 5.24 5.15 5.37 5.41 5.31 5.44 5.43 5.20 5.16 5.19 5.13 5.02 5.37 5.22
C12 carnitine
5.01 4.96 4.97 5.00 5.04 4.97 5.19 5.21 5.08 5.22 5.23 4.97 5.03 5.01 4.93 4.85 5.17 4.98
C14:0 LPC
5.97 5.96 6.05 5.95 5.98 5.78 5.96 5.95 6.10 5.84 6.00 5.86 6.09 6.10 6.14 5.85 6.02 6.05
C14:0 SM
6.59 6.53 6.59 6.56 6.55 6.43 6.58 6.55 6.64 6.52 6.58 6.45 6.63 6.62 6.63 6.46 6.61 6.52
C14:1 carnitine
5.16 5.15 5.15 5.19 5.25 5.19 5.35 5.43 5.28 5.48 5.46 5.24 5.15 5.19 5.09 5.04 5.38 5.27
C14:2 carnitine
5.03 4.99 5.01 4.97 5.04 5.02 5.19 5.27 5.14 5.29 5.25 5.02 5.00 5.03 4.95 4.83 5.21 5.07
C14 carnitine
4.65 4.60 4.64 4.66 4.66 4.58 4.77 4.77 4.71 4.79 4.83 4.56 4.65 4.64 4.61 4.58 4.80 4.66
C16:0 ceramide (d18:1)
6.23 6.16 6.18 6.31 6.24 6.34 6.27 6.20 6.28 6.31 6.31 6.31 6.28 6.21 6.23 6.20 6.33 6.25
C16:0 LPC
7.87 7.89 7.93 7.88 7.86 7.85 7.87 7.90 8.00 7.85 7.88 7.86 7.95 8.00 8.01 7.78 7.91 7.99
C16:0 LPE
5.56 5.58 5.69 5.58 5.60 5.59 5.56 5.57 5.78 5.54 5.63 5.56 5.68 5.71 5.79 5.55 5.66 5.74
C16:0 SM
7.68 7.60 7.63 7.62 7.62 7.63 7.67 7.64 7.71 7.63 7.68 7.63 7.69 7.66 7.69 7.58 7.67 7.63
C16:1 LPC
6.24 6.29 6.38 6.30 6.32 6.24 6.26 6.31 6.45 6.24 6.38 6.36 6.37 6.41 6.47 6.25 6.36 6.46
C16:1 LPC plasmalogen
5.51 5.53 5.57 5.50 5.51 5.41 5.53 5.55 5.65 5.52 5.54 5.43 5.63 5.66 5.66 5.44 5.59 5.58
C16:1 SM
6.69 6.63 6.70 6.64 6.63 6.61 6.67 6.66 6.76 6.63 6.68 6.59 6.70 6.70 6.74 6.56 6.70 6.59
C16 carnitine
5.25 5.27 5.30 5.32 5.28 5.28 5.38 5.38 5.37 5.42 5.38 5.27 5.29 5.30 5.29 5.26 5.40 5.38
C18:0 LPC
7.33 7.34 7.41 7.31 7.32 7.23 7.33 7.34 7.46 7.30 7.34 7.28 7.41 7.47 7.50 7.20 7.37 7.45
C18:0 LPE
5.69 5.70 5.81 5.70 5.73 5.67 5.69 5.70 5.88 5.67 5.74 5.66 5.78 5.84 5.90 5.62 5.79 5.86
C18:0 SM
7.20 7.14 7.18 7.15 7.20 7.29 7.22 7.17 7.23 7.16 7.24 7.26 7.17 7.15 7.18 7.10 7.25 7.21
C18:1 carnitine
5.49 5.49 5.49 5.58 5.51 5.54 5.59 5.61 5.54 5.69 5.64 5.54 5.45 5.50 5.46 5.51 5.60 5.63
C18:1 LPC
7.11 7.15 7.20 7.15 7.12 7.15 7.12 7.16 7.27 7.13 7.19 7.17 7.21 7.26 7.29 7.13 7.15 7.34
C18:1 LPC plasmalogen_A
5.51 5.52 5.54 5.55 5.52 5.43 5.55 5.57 5.62 5.60 5.59 5.47 5.59 5.61 5.66 5.46 5.61 5.65
C18:1 LPC plasmalogen_B
4.47 4.49 4.50 4.43 4.43 4.37 4.49 4.52 4.60 4.43 4.47 4.38 4.61 4.64 4.61 4.31 4.54 4.51
C18:1 LPE
5.68 5.69 5.79 5.68 5.64 5.69 5.61 5.59 5.81 5.61 5.66 5.58 5.84 5.83 5.87 5.69 5.65 5.93
C18:1 SM
6.57 6.53 6.60 6.53 6.55 6.60 6.58 6.55 6.66 6.52 6.58 6.56 6.55 6.55 6.61 6.47 6.60 6.53
C18:2 carnitine
5.23 5.21 5.21 5.26 5.20 5.21 5.29 5.32 5.23 5.38 5.33 5.13 5.19 5.20 5.16 5.14 5.36 5.35
C18:2 LPE
6.07 6.01 6.15 6.00 5.96 6.08 5.98 5.92 6.20 5.94 5.96 5.94 6.28 6.21 6.25 6.01 6.01 6.23
C18:2 SM
4.94 4.88 4.96 4.88 4.87 4.91 4.93 4.89 5.01 4.83 4.91 4.85 4.89 4.90 4.96 4.81 4.94 4.81
C18:3 LPC
7.10 7.11 7.14 7.10 7.10 7.09 7.09 7.12 7.20 7.07 7.11 7.09 7.16 7.20 7.20 7.00 7.13 7.16
C18 carnitine
4.70 4.66 4.63 4.71 4.69 4.70 4.85 4.77 4.77 4.76 4.71 4.72 4.82 4.75 4.77 4.63 4.77 4.80
C20:0 LPE
6.03 6.05 6.08 6.03 6.05 5.94 6.04 6.07 6.13 6.02 6.05 6.00 6.11 6.17 6.13 5.97 6.09 6.17
C20:0 SM
7.28 7.22 7.24 7.22 7.23 7.24 7.29 7.25 7.28 7.20 7.27 7.27 7.30 7.30 7.28 7.14 7.27 7.27
C20:4 carnitine
3.83 3.52 3.53 3.76 3.47 3.52 3.63 3.59 3.59 3.76 3.69 3.49 3.40 3.45 3.31 3.65 3.65 3.69
C20:4 LPC
6.83 6.90 6.93 6.87 6.84 6.87 6.83 6.91 6.98 6.85 6.90 6.88 6.93 6.96 7.00 6.84 6.89 7.00
C20:4 LPE
5.94 5.96 6.03 5.96 5.93 6.01 5.92 5.94 6.09 5.97 5.97 5.91 6.07 6.08 6.10 5.91 5.98 6.12
C20:5 LPC
6.64 6.65 6.69 6.60 6.59 6.64 6.59 6.62 6.75 6.55 6.60 6.58 6.79 6.76 6.76 6.61 6.60 6.75
C22:5 LPC
5.33 5.43 5.47 5.37 5.37 5.39 5.37 5.45 5.56 5.32 5.44 5.36 5.49 5.55 5.58 5.30 5.43 5.53
C22:6 LPC
6.01 6.10 6.09 6.06 6.06 6.10 6.01 6.11 6.17 6.06 6.12 6.10 6.09 6.19 6.20 5.97 6.08 6.24
C22:6 LPE
5.72 5.81 5.81 5.77 5.84 5.86 5.73 5.83 5.91 5.83 5.89 5.79 5.77 5.92 5.88 5.68 5.86 5.96
C24:1 ceramide (d18:1)
6.81 6.75 6.79 6.83 6.79 6.85 6.83 6.78 6.88 6.83 6.84 6.85 6.87 6.82 6.83 6.77 6.85 6.77
C26 carnitine
4.94 4.83 4.84 4.83 4.83 4.84 4.91 4.91 4.99 4.87 4.92 4.84 4.95 4.97 4.95 4.79 4.94 4.76
C2 carnitine
7.13 7.10 7.15 7.08 7.15 7.12 7.14 7.22 7.20 7.15 7.23 7.11 7.13 7.16 7.16 6.96 7.21 7.18
C30:0 PC
6.42 6.40 6.49 6.42 6.45 6.31 6.45 6.38 6.55 6.32 6.53 6.31 6.48 6.47 6.57 6.36 6.50 6.42
C32:2 PC
6.47 6.42 6.51 6.40 6.48 6.32 6.45 6.43 6.54 6.31 6.48 6.38 6.54 6.54 6.56 6.29 6.53 6.38
C34:0 PE
5.75 5.73 5.77 5.76 5.79 5.64 5.80 5.74 5.84 5.72 5.84 5.64 5.75 5.75 5.80 5.76 5.82 5.74
C34:1 DAG
5.90 5.87 5.91 5.95 5.91 5.86 5.88 5.83 6.00 5.88 5.86 5.82 5.92 5.92 5.95 5.76 5.90 5.98
C34:1 DAG*
4.81 4.84 4.85 4.70 4.85 4.70 4.74 4.89 4.89 4.69 4.78 4.60 4.79 5.00 4.82 4.51 4.87 4.85
C34:2 DAG
4.02 4.19 4.23 3.90 4.16 3.92 3.98 4.30 4.19 3.93 4.13 3.86 4.03 4.37 4.15 3.75 4.20 4.09
C34:2 PE
6.46 6.32 6.47 6.37 6.41 6.46 6.39 6.29 6.54 6.31 6.38 6.38 6.47 6.40 6.50 6.37 6.47 6.43
C34:2 PE plasmalogen
5.65 5.62 5.67 5.67 5.62 5.59 5.67 5.65 5.74 5.64 5.67 5.61 5.77 5.75 5.75 5.65 5.65 5.75
C34:3 PC
7.07 7.09 7.15 7.04 7.09 7.05 7.06 7.10 7.17 6.98 7.14 7.08 7.11 7.18 7.16 6.98 7.12 7.06
C34:3 PC plasmalogen
6.81 6.76 6.80 6.78 6.78 6.74 6.83 6.80 6.87 6.82 6.79 6.70 6.89 6.85 6.86 6.82 6.83 6.72
C34:3 PE plasmalogen
5.95 5.88 5.94 5.91 5.87 5.82 5.97 5.88 6.02 5.90 5.87 5.84 6.11 6.04 6.04 5.88 5.90 5.97
C34:4 PC
5.66 5.65 5.72 5.56 5.68 5.37 5.65 5.65 5.72 5.42 5.70 5.54 5.71 5.76 5.76 5.43 5.71 5.61
C36:2 PC
8.37 8.32 8.38 8.33 8.33 8.32 8.36 8.31 8.41 8.32 8.35 8.32 8.39 8.39 8.43 8.30 8.35 8.37
C36:2 PE
6.81 6.69 6.82 6.70 6.75 6.74 6.73 6.63 6.84 6.62 6.69 6.70 6.84 6.82 6.87 6.70 6.77 6.79
C36:2 PS plasmalogen
5.94 5.93 5.91 5.87 5.94 5.94 5.95 5.97 5.97 5.92 5.98 5.90 5.92 5.95 5.96 5.81 5.97 5.89
C36:3 PE plasmalogen
6.30 6.22 6.29 6.26 6.21 6.19 6.32 6.22 6.37 6.23 6.22 6.20 6.43 6.36 6.37 6.24 6.23 6.30
C36:4 PE
6.57 6.50 6.61 6.54 6.57 6.59 6.52 6.52 6.65 6.52 6.56 6.54 6.55 6.54 6.61 6.54 6.61 6.60
C36:5 PC plasmalogen
7.03 7.00 7.01 7.04 7.02 6.96 7.05 7.06 7.07 7.07 7.05 6.95 7.09 7.07 7.08 7.02 7.09 6.99
C36:5 PE plasmalogen
6.60 6.58 6.62 6.61 6.55 6.50 6.60 6.60 6.66 6.63 6.56 6.51 6.72 6.69 6.68 6.57 6.58 6.68
C38:4 PE
6.83 6.77 6.88 6.78 6.84 6.80 6.81 6.79 6.90 6.76 6.81 6.82 6.81 6.80 6.87 6.74 6.85 6.83
C38:5 PE plasmalogen
6.80 6.76 6.82 6.80 6.75 6.71 6.80 6.78 6.87 6.80 6.75 6.68 6.91 6.86 6.87 6.78 6.78 6.83
C38:6 PC plasmalogen
6.75 6.74 6.75 6.75 6.77 6.70 6.74 6.78 6.82 6.77 6.80 6.69 6.79 6.81 6.82 6.70 6.81 6.75
C38:6 PE
6.58 6.55 6.62 6.56 6.69 6.62 6.56 6.58 6.68 6.57 6.66 6.65 6.49 6.56 6.62 6.52 6.66 6.63
C38:6 PE plasmalogen
6.63 6.63 6.67 6.65 6.62 6.56 6.63 6.66 6.72 6.64 6.62 6.56 6.73 6.74 6.74 6.59 6.63 6.73
C38:7 PC plasmalogen
6.17 6.16 6.15 6.17 6.22 6.12 6.16 6.21 6.23 6.23 6.24 6.12 6.20 6.26 6.23 6.13 6.22 6.21
C38:7 PE plasmalogen
6.37 6.38 6.38 6.37 6.38 6.34 6.36 6.41 6.44 6.39 6.40 6.36 6.39 6.46 6.45 6.29 6.38 6.46
C3 carnitine
5.98 5.92 5.98 5.99 5.99 5.89 5.95 5.93 5.95 5.89 6.00 5.93 6.05 6.00 5.94 5.86 6.05 6.09
C3-DC-CH3 carnitine
4.19 4.11 4.10 4.14 4.20 4.02 4.16 4.12 4.10 4.18 4.17 4.10 4.17 4.14 4.08 4.20 4.23 4.19
C40:6 PE
6.32 6.30 6.37 6.26 6.43 6.33 6.29 6.33 6.40 6.25 6.38 6.38 6.22 6.31 6.36 6.19 6.40 6.36
C40:7 PE plasmalogen
6.47 6.46 6.50 6.46 6.47 6.42 6.46 6.49 6.57 6.47 6.48 6.44 6.52 6.55 6.56 6.48 6.48 6.54
C4 carnitine
5.73 5.71 5.76 5.68 5.71 5.55 5.70 5.76 5.75 5.67 5.82 5.61 5.77 5.78 5.74 5.56 5.84 5.75
C4-OH carnitine
4.69 4.76 4.91 4.71 4.81 4.92 4.78 4.93 4.97 4.84 4.89 4.85 4.66 4.77 4.78 4.75 4.82 4.79
C5:1 carnitine
4.35 4.28 4.32 4.32 4.30 4.19 4.38 4.34 4.32 4.43 4.36 4.23 4.36 4.31 4.25 4.36 4.37 4.30
C5 carnitine
5.49 5.43 5.46 5.44 5.43 5.36 5.47 5.46 5.43 5.40 5.41 5.36 5.52 5.46 5.36 5.39 5.44 5.44
C5-DC carnitine
4.87 4.82 4.73 4.90 4.83 4.73 4.84 4.86 4.73 4.98 4.86 4.76 4.88 4.85 4.72 4.86 4.88 4.80
C6 carnitine
4.89 4.83 4.87 4.86 4.94 4.89 4.93 5.00 4.92 4.96 5.03 4.92 4.83 4.89 4.87 4.70 5.01 4.99
C8 carnitine
4.99 4.93 4.93 4.90 5.04 4.92 5.16 5.19 5.06 5.15 5.21 4.97 4.97 4.99 4.85 4.74 5.17 4.99
C9 carnitine
4.54 4.26 4.24 4.30 4.29 4.13 4.63 4.53 4.30 4.42 4.50 4.04 4.52 4.39 4.41 4.17 4.47 4.16
caffeine
6.26 5.41 5.57 5.63 5.95 5.42 5.71 5.13 5.39 5.27 5.58 4.92 6.17 5.71 5.60 5.55 5.81 5.80
carnitine
7.64 7.59 7.62 7.60 7.63 7.59 7.61 7.62 7.65 7.58 7.63 7.66 7.67 7.63 7.63 7.50 7.68 7.72
carvedilol
- 5.40 5.13 2.69 5.98 - - 5.25 3.20 1.88 5.91 - - 5.51 - - - -
choline
6.70 6.63 6.67 6.65 6.66 6.61 6.64 6.64 6.66 6.63 6.61 6.59 6.73 6.70 6.68 6.53 6.66 6.69
cinnamoylglycine
4.07 4.09 4.08 4.08 4.12 3.85 4.03 4.11 4.09 4.20 4.15 3.75 4.11 4.18 4.12 4.08 4.11 4.12
citrulline
5.59 5.46 5.51 5.48 5.50 5.34 5.53 5.47 5.57 5.52 5.51 5.45 5.62 5.57 5.53 5.49 5.44 5.49
cortisol
5.25 5.40 5.27 5.38 5.31 4.93 5.36 5.42 5.38 5.59 5.47 5.03 5.05 5.29 5.27 5.37 5.30 5.28
cortisone
3.81 3.93 3.75 3.92 3.70 3.62 3.82 3.97 3.82 4.01 3.81 3.83 3.43 3.82 3.70 3.77 3.66 3.59
cotinine
3.14 3.09 3.34 3.07 3.10 3.84 2.89 3.22 3.13 3.22 3.28 3.84 2.81 3.07 3.45 2.77 3.16 3.38
cotinine N-oxide
1.92 1.87 1.97 1.90 1.86 1.80 1.93 1.84 1.96 1.90 1.82 1.76 1.97 1.92 2.02 1.87 1.93 1.84
creatine
6.18 6.29 6.35 6.29 6.36 6.21 6.12 6.37 6.39 6.05 6.37 6.25 6.23 6.44 6.40 6.16 6.48 6.41
creatinine
7.38 7.34 7.36 7.35 7.34 7.30 7.36 7.37 7.39 7.40 7.36 7.29 7.38 7.39 7.36 7.32 7.35 7.34
cytosine
4.14 3.88 3.98 3.90 3.94 3.77 3.96 3.84 3.94 3.84 3.93 3.80 4.07 3.93 4.01 3.87 3.87 4.02
diacetylspermine
3.41 3.43 3.57 3.67 3.72 3.76 3.40 3.47 3.58 3.89 3.82 3.53 3.39 3.41 3.53 3.81 3.61 3.55
dimethylglycine
5.16 5.16 5.17 5.24 5.19 5.18 5.12 5.22 5.21 5.27 5.19 5.16 5.17 5.22 5.17 5.19 5.19 5.20
DMGV
5.27 4.98 5.22 5.24 5.26 5.00 5.18 4.90 5.27 5.22 5.28 4.86 5.24 4.90 5.25 5.20 5.27 5.24
ectoine
4.47 4.64 4.79 4.57 4.53 4.29 4.47 4.63 4.73 4.59 4.59 4.33 4.56 4.69 4.61 4.64 4.74 4.70
GABA
4.29 4.33 4.25 4.24 4.22 4.30 4.27 4.39 4.29 4.24 4.24 4.29 4.30 4.36 4.22 4.17 4.23 4.27
gabapentin
3.85 3.61 3.78 3.67 3.49 3.49 3.84 3.59 3.51 3.46 3.66 3.48 3.92 3.78 3.48 3.48 3.72 4.20
glutamate
5.04 5.02 5.00 5.11 5.10 5.04 4.99 5.04 4.99 4.96 5.02 4.97 4.83 5.06 4.95 4.85 5.12 5.15
glutamine
6.59 6.53 6.59 6.54 6.54 6.58 6.54 6.54 6.64 6.55 6.57 6.57 6.62 6.61 6.62 6.49 6.54 6.59
glycocholate
5.58 5.52 5.58 5.53 5.53 5.56 5.53 5.52 5.62 5.53 5.56 5.55 5.62 5.60 5.61 5.47 5.53 5.59
glycodeoxycholate/glycochenodeoxycholate
5.77 5.57 5.29 5.46 5.60 5.68 5.31 5.24 5.05 5.22 5.35 5.33 5.80 5.54 5.25 5.33 5.53 5.65
guanine
3.15 3.03 3.16 2.53 2.74 2.61 3.18 3.08 2.82 2.87 2.99 3.12 3.51 3.24 3.03 2.93 2.91 2.80
hippurate
5.61 5.62 5.62 5.57 5.62 5.65 5.62 5.66 5.70 5.75 5.73 5.69 5.57 5.68 5.65 5.69 5.62 5.78
histidine
6.27 6.24 6.27 6.21 6.22 6.21 6.23 6.27 6.32 6.20 6.24 6.28 6.34 6.36 6.34 6.14 6.22 6.31
hydroxycotinine
2.60 2.57 2.56 2.62 2.58 3.26 2.13 2.64 2.48 2.42 2.70 3.18 2.26 2.66 2.56 2.44 2.55 2.99
hydroxyproline
5.23 5.26 5.16 5.16 5.22 5.13 5.20 5.25 5.19 5.18 5.24 5.17 5.37 5.28 5.23 5.19 5.24 5.33
hypotaurine
3.52 3.40 3.34 3.54 3.55 3.45 3.50 3.39 3.40 3.62 3.58 3.32 3.52 3.41 3.38 3.37 3.63 3.69
hypoxanthine
7.00 6.94 6.95 6.92 7.00 6.88 6.99 6.95 6.98 6.95 6.99 6.87 6.96 6.97 6.95 6.82 6.97 6.97
imidazole propionate
3.44 3.36 3.36 3.55 3.53 3.56 3.42 3.35 3.40 3.62 3.57 3.43 3.56 3.42 3.44 3.57 3.52 3.42
inosine
7.82 7.67 7.72 7.42 7.65 7.64 7.73 7.84 7.94 7.67 7.87 7.88 7.89 7.78 7.78 7.24 7.50 7.17
Kyn/Trp
0.17 0.16 0.17 0.16 0.16 0.16 0.19 0.19 0.19 0.20 0.18 0.15 0.21 0.16 0.20 0.30 0.18 0.15
kynurenic acid
4.88 4.74 4.74 4.68 4.65 4.53 4.83 4.79 4.84 4.84 4.72 4.56 4.81 4.79 4.76 4.63 4.75 4.65
kynurenine
6.91 6.82 6.86 6.83 6.80 6.75 6.94 6.91 6.95 6.96 6.85 6.84 7.00 6.91 6.94 6.94 6.81 6.88
Kynurenine_μM
7.59 6.78 6.87 6.61 6.18 5.77 8.12 7.95 8.44 8.52 6.83 6.50 9.14 7.65 8.11 8.70 6.52 7.07
leucine
6.31 6.31 6.28 6.30 6.30 6.26 6.33 6.33 6.34 6.32 6.33 6.28 6.33 6.39 6.29 6.20 6.30 6.37
linoleoyl ethanolamide
2.94 3.17 3.11 3.18 3.21 3.03 3.23 3.16 3.42 3.20 3.25 2.83 2.82 3.16 3.23 2.82 3.37 2.91
lysine
6.12 6.06 6.07 6.06 6.07 6.08 6.05 6.07 6.10 6.02 6.03 6.10 6.15 6.15 6.05 5.95 6.03 6.14
metformin
3.03 3.39 3.31 3.05 3.05 3.49 3.05 3.35 3.28 3.06 3.06 3.58 3.06 3.36 3.16 3.07 3.08 3.77
methionine
5.36 5.30 5.34 5.31 5.30 5.35 5.33 5.34 5.40 5.31 5.32 5.33 5.39 5.38 5.34 5.24 5.32 5.38
metoprolol
0.71 1.23 1.93 1.85 2.51 1.03 0.68 1.23 1.71 1.42 2.25 0.58 0.29 1.17 1.90 1.39 2.21 0.97
metronidazole
1.88 1.59 1.85 2.31 1.77 1.86 1.75 1.85 1.86 2.30 1.86 1.69 1.84 1.97 1.74 2.36 1.51 1.86
myristoleate
4.67 4.61 4.67 4.56 4.58 4.64 4.64 4.63 4.68 4.58 4.64 4.65 4.69 4.65 4.70 4.54 4.63 4.65
N1-acetylspermidine
5.02 4.96 5.02 5.08 5.04 5.10 5.05 5.03 5.09 5.16 5.07 5.09 5.01 5.00 5.00 5.07 5.00 5.04
N1-methyl-2-pyridone-5-carboxamide
6.13 6.00 6.22 6.04 6.08 5.82 6.12 6.11 6.25 6.16 6.12 6.05 6.15 6.11 6.20 6.06 6.09 6.05
N4-acetylcytidine
5.01 4.97 5.00 5.00 5.03 5.00 4.98 5.00 5.04 5.12 5.08 4.96 4.96 4.98 4.97 5.02 5.08 5.01
N6-acetyllysine
4.38 4.38 4.39 4.38 4.36 4.36 4.33 4.39 4.46 4.42 4.38 4.37 4.37 4.43 4.39 4.38 4.37 4.47
N6,N6-dimethyllysine
5.05 4.99 5.09 5.03 5.11 5.04 5.03 5.01 5.13 5.02 5.12 5.04 5.06 5.02 5.05 4.98 5.11 5.15
N6,N6,N6-trimethyllysine
5.59 5.56 5.60 5.62 5.58 5.51 5.58 5.60 5.63 5.61 5.58 5.52 5.61 5.62 5.54 5.58 5.59 5.60
N-acetylalanine
4.39 4.32 4.34 4.34 4.32 4.32 4.36 4.35 4.41 4.37 4.37 4.30 4.39 4.36 4.36 4.32 4.38 4.39
N-acetylleucine
4.07 3.98 4.18 4.08 4.02 4.08 4.08 3.99 4.16 3.98 4.04 4.03 4.20 4.08 4.21 4.11 4.10 4.01
N-acetylmethionine
3.16 3.08 3.15 3.14 3.15 3.05 3.13 3.11 3.15 3.16 3.15 2.96 3.18 3.13 3.15 3.20 3.09 3.19
N-acetylornithine
4.61 4.55 4.57 4.43 4.61 4.39 4.56 4.53 4.67 4.59 4.63 4.54 4.66 4.60 4.64 4.44 4.62 4.65
N-acetylputrescine
4.20 4.11 4.19 4.29 4.29 4.25 4.16 4.15 4.22 4.32 4.29 4.28 4.20 4.17 4.15 4.32 4.20 4.27
N-acetyltryptophan
4.45 4.40 4.34 4.45 4.34 4.21 4.38 4.38 4.34 4.44 4.32 4.14 4.40 4.46 4.34 4.39 4.23 4.35
N-alpha-acetylarginine
4.48 4.39 4.48 4.43 4.34 4.16 4.42 4.41 4.49 4.51 4.32 4.20 4.55 4.55 4.46 4.50 4.30 4.37
N-carbamoyl-beta-alanine
4.24 4.26 4.20 4.33 4.36 4.35 4.20 4.29 4.28 4.47 4.44 4.31 4.26 4.30 4.22 4.43 4.36 4.21
niacinamide
4.82 4.85 4.93 4.81 4.85 4.74 4.90 4.89 4.75 4.74 4.74 4.67 4.72 4.93 4.76 4.89 4.93 5.02
N-methylproline
5.47 5.39 5.29 5.45 5.61 5.16 5.30 5.30 5.26 5.63 5.57 5.16 5.54 5.39 5.18 5.58 5.66 5.19
NMMA
4.92 4.92 4.91 4.89 4.84 4.82 4.84 4.93 4.94 4.87 4.78 4.87 4.99 4.99 4.90 4.79 4.82 4.96
oleoyl glycine
3.19 3.29 3.21 3.35 3.23 3.18 3.40 3.44 3.32 3.51 3.39 3.26 3.11 3.35 3.23 3.07 3.25 3.31
ornithine
5.49 5.40 5.41 5.44 5.41 5.33 5.40 5.36 5.40 5.36 5.34 5.32 5.51 5.48 5.41 5.34 5.34 5.47
pantothenate
5.85 5.70 5.83 5.67 5.72 5.69 5.84 5.77 5.87 5.70 5.75 5.65 5.84 5.79 5.82 5.62 5.71 5.78
pantothenol
4.00 3.97 3.89 4.21 4.08 4.17 4.08 4.05 4.09 3.82 4.25 4.13 4.02 4.05 4.12 3.96 4.23 3.52
phenylacetylglutamine
7.03 6.90 6.99 7.01 6.95 6.89 6.98 6.89 7.03 7.00 6.96 6.85 7.06 6.97 7.04 7.06 7.01 7.05
phenylalanine
6.27 6.23 6.24 6.26 6.26 6.22 6.27 6.24 6.28 6.28 6.28 6.23 6.26 6.25 6.26 6.23 6.28 6.28
piperine
5.59 5.78 5.97 5.56 5.71 5.44 5.89 5.71 6.08 5.43 5.71 5.18 6.01 5.97 6.12 6.02 5.58 5.38
proline
6.91 6.85 6.84 6.79 6.82 6.85 6.83 6.82 6.85 6.75 6.81 6.82 6.95 6.92 6.84 6.74 6.83 6.92
proline-betaine
6.66 6.64 6.84 6.76 6.92 6.51 6.66 6.69 6.86 7.08 7.00 6.40 6.68 6.61 6.73 7.03 7.01 6.50
pseudouridine
6.36 6.32 6.35 6.36 6.35 6.28 6.34 6.35 6.40 6.42 6.41 6.29 6.36 6.35 6.35 6.37 6.41 6.33
quinine
4.80 3.78 - 4.41 6.18 - 3.90 4.67 - 6.96 5.86 - - 3.22 3.38 - 3.24 -
ribothymidine
4.57 4.53 4.58 4.53 4.52 4.50 4.55 4.54 4.59 4.56 4.55 4.49 4.52 4.54 4.60 4.46 4.54 4.58
SDMA
5.90 5.87 5.88 5.87 5.86 5.83 5.87 5.91 5.93 5.89 5.89 5.85 5.92 5.93 5.88 5.82 5.87 5.85
serine
4.86 4.83 4.82 4.87 4.84 4.86 4.82 4.84 4.86 4.86 4.82 4.85 4.82 4.88 4.87 4.78 4.86 4.92
serotonin
4.48 4.03 4.30 4.35 4.31 4.28 4.46 4.06 4.38 4.49 4.48 4.45 4.56 4.11 4.35 4.34 4.32 4.62
sphinganine
3.63 3.49 3.62 3.65 3.60 3.53 3.67 3.52 3.64 3.68 3.67 3.52 3.65 3.55 3.65 3.60 3.77 3.82
taurine
6.27 6.19 6.24 6.24 6.27 6.11 6.25 6.16 6.29 6.29 6.31 6.07 6.23 6.20 6.28 6.15 6.29 6.35
thiamine
4.11 3.97 4.25 3.91 4.00 3.92 4.11 3.96 4.22 3.81 3.96 3.90 4.25 4.11 4.15 3.86 3.96 4.02
threonine
5.32 5.27 5.30 5.22 5.24 5.27 5.26 5.28 5.32 5.26 5.26 5.30 5.33 5.33 5.29 5.16 5.29 5.37
threo-sphingosine
4.24 4.12 4.23 4.34 4.24 4.17 4.25 4.11 4.30 4.40 4.30 4.13 4.20 4.14 4.22 4.21 4.40 4.43
thyroxine
4.77 4.67 4.71 4.74 4.69 4.77 4.75 4.72 4.76 4.80 4.73 4.78 4.80 4.72 4.76 4.68 4.68 4.83
trigonelline
5.98 5.75 5.86 5.80 5.88 5.71 5.73 5.61 5.65 5.87 5.81 5.38 6.29 5.90 5.83 6.00 5.74 6.04
trimethylamine-N-oxide
5.46 5.32 5.49 5.43 5.63 5.31 5.35 5.34 5.51 5.52 5.51 5.40 5.54 5.43 5.42 5.53 5.57 5.47
tryptophan
8.13 8.09 8.09 8.08 8.07 8.02 8.11 8.11 8.14 8.10 8.08 8.10 8.13 8.15 8.12 8.00 8.06 8.15
Tryptophan_μM
49.59 44.92 45.11 44.34 43.38 37.73 47.56 46.92 50.84 44.87 47.94 45.19 47.53 50.55 47.80 40.05 45.20 49.32
tyrosine
5.82 5.76 5.76 5.74 5.77 5.74 5.75 5.74 5.77 5.74 5.76 5.73 5.78 5.80 5.72 5.67 5.76 5.83
urate
6.59 6.59 6.65 6.65 6.63 6.51 6.55 6.61 6.71 6.64 6.63 6.50 6.63 6.65 6.65 6.58 6.66 6.55
urobilinogen
4.87 4.19 4.22 4.86 4.53 4.90 4.34 4.30 4.85 4.29 4.32 4.15 4.58 4.11 4.26 4.89 4.07 5.12
urocanic acid
4.93 4.77 4.82 4.83 4.88 4.69 4.91 4.75 4.87 4.72 4.70 4.70 4.91 4.85 4.84 4.94 4.94 4.77
valsartan
3.98 4.22 3.10 3.35 5.72 4.24 3.85 4.38 1.12 2.31 5.35 4.22 5.26 4.49 2.25 4.38 4.94 3.97
warfarin
- - - - 6.12 3.37 - - - - 5.94 - - 7.21 - - 7.08 -
xanthine
5.12 5.05 5.04 5.05 5.12 5.09 5.19 5.08 4.97 5.08 5.11 5.06 5.08 5.07 4.99 4.95 5.12 5.32

Factors:

F1Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):0.3
F2Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):10
F3Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):2
F4Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):0.3
F5Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):10
F6Time point:baseline | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):2
F7Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):0.3
F8Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):10
F9Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):2
F10Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):0.3
F11Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):10
F12Time point:week 4 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):2
F13Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):0.3
F14Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):10
F15Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):1 | Nivolumab Dose (mg/kg):2
F16Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):0.3
F17Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):10
F18Time point:week 9 | OS_Censor (1 means the time is a censoring time and 0 means a failure time in OS):- | Nivolumab Dose (mg/kg):2
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