Data for ST004205
| Metabolite structure | All data | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| (3-O-sulfo)GalCer(d18:1/16:0) | 0.10 | - | - | 0.11 | - | 0.07 | 0.10 | - | 0.11 | - | |
| (3-O-sulfo)GalCer(d18:1/18:0) | 5.09 | - | - | 5.07 | - | 3.98 | 4.49 | - | 5.11 | - | |
| (3-O-sulfo)GalCer(d18:1/18:0(2OH) | 1.03 | - | - | 1.03 | - | 0.77 | 1.04 | - | 1.09 | - | |
| (3-O-sulfo)GalCer(d18:1/18:0(d3)) | - | - | - | - | - | - | - | - | - | - | |
| (3-O-sulfo)GalCer(d18:1/24:0) | 25.19 | 0.02 | 0.01 | 27.22 | 0.01 | 20.73 | 25.80 | 0.01 | 23.79 | 0.01 | |
| (3-O-sulfo)GalCer(d18:1/24:0(2OH)) | 10.92 | - | - | 12.19 | - | 9.54 | 12.46 | - | 10.95 | - | |
| (3-O-sulfo)GalCer(d18:1/24:1) | 45.98 | 0.04 | 0.04 | 51.34 | 0.05 | 50.02 | 46.42 | 0.03 | 44.85 | 0.03 | |
| (3-O-sulfo)GalCer(d18:1/24:1(2OH)) | 9.68 | - | - | 10.84 | - | 9.37 | 9.78 | - | 10.03 | - | |
| Arachidonic acid | - | - | - | - | - | - | - | - | - | - | |
| Arachidonic acid-d8 | - | - | - | - | - | - | - | - | - | - | |
| Arachidonic acid-d8_MRM | - | - | - | - | - | - | - | - | - | - | |
| Arachidonic acid_MRM | 0.22 | 0.35 | 0.24 | 0.16 | 0.15 | 0.17 | 0.18 | 0.18 | 0.12 | 0.10 | |
| BMP(14:0/14:0) | - | - | - | - | - | - | - | - | - | - | |
| BMP(16:0_18:1) | 0.24 | 0.26 | 0.12 | 0.23 | 0.14 | 0.19 | 0.37 | 0.15 | 0.19 | 0.08 | |
| BMP(16:0_20:4) | 0.04 | 0.06 | 0.04 | 0.04 | 0.04 | 0.04 | 0.06 | 0.06 | 0.02 | 0.01 | |
| BMP(16:0_22:6) | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | |
| BMP(16:1/16:1) | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | |
| BMP(18:0_18:1) | 0.36 | 0.39 | 0.15 | 0.28 | 0.17 | 0.28 | 0.41 | 0.20 | 0.26 | 0.10 | |
| BMP(18:0_20:4) | 0.03 | 0.05 | 0.02 | 0.03 | 0.03 | 0.03 | 0.04 | 0.05 | 0.01 | 0.01 | |
| BMP(18:0_22:6) | - | - | - | - | - | - | - | - | - | - | |
| BMP(18:1/18:1) | 3.95 | 3.83 | 1.94 | 3.40 | 1.93 | 2.72 | 4.42 | 1.95 | 2.99 | 1.66 | |
| BMP(20:4/20:4) | 0.10 | 0.18 | 0.14 | 0.12 | 0.16 | 0.15 | 0.14 | 0.30 | 0.04 | 0.04 | |
| BMP(22:6/22:6) | 0.40 | 0.24 | 0.13 | 0.25 | 0.10 | 0.16 | 0.28 | 0.08 | 0.18 | 0.05 | |
| Cholesterol sulfate | 0.41 | 1.73 | 1.54 | 0.43 | 1.40 | 0.73 | 0.38 | 1.20 | 0.37 | 1.79 | |
| CL(14:0/14:0/14:0/14:0) | - | - | - | - | - | - | - | - | - | - | |
| CL(72:6/18:2) | 2.07 | 3.41 | 1.76 | 1.75 | 1.88 | 1.86 | 1.74 | 1.99 | 2.11 | 2.23 | |
| CL(72:7/18:2) | 3.52 | 5.28 | 3.09 | 2.72 | 3.13 | 3.24 | 2.70 | 2.88 | 2.86 | 3.50 | |
| CL(72:8/18:2) | 2.68 | 4.88 | 2.71 | 1.95 | 2.24 | 2.19 | 1.77 | 1.82 | 1.95 | 2.62 | |
| CL(72:8-2(OOH)/18:2) | 0.58 | 0.65 | 0.27 | 0.39 | 0.15 | 0.37 | 0.31 | 0.13 | 0.50 | 0.28 | |
| CL(74:9/18:2) | 1.70 | 3.21 | 1.48 | 1.44 | 1.55 | 1.36 | 1.18 | 1.29 | 0.99 | 1.10 | |
| DHA | 0.02 | 0.03 | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | |
| EPA | 0.08 | 0.13 | 0.09 | 0.05 | 0.05 | 0.05 | 0.05 | 0.06 | 0.03 | 0.03 | |
| FAHFA(18:1/9-O-18:0) | - | - | - | - | - | - | - | - | - | - | |
| GD1a/b(d36:1) | - | - | - | - | - | - | - | - | - | - | |
| GD3(d34:1) | - | - | - | - | - | - | - | - | - | - | |
| GD3(d36:1) | - | - | - | - | - | - | - | - | - | - | |
| GM3(d18:1/18:0(d5)) | - | - | - | - | - | - | - | - | - | - | |
| GM3(d34:1) | 4.04 | 5.32 | 2.90 | 2.92 | 2.52 | 3.83 | 3.36 | 2.70 | 2.62 | 2.54 | |
| GM3(d36:1) | 1.77 | 2.16 | 1.30 | 1.53 | 1.17 | 1.41 | 1.40 | 1.03 | 0.88 | 0.81 | |
| GQ1b(d36:1) | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(14:0/14:0)_14:0 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(18:1/18:1)_16:0 | 0.02 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 | 0.02 | 0.00 | 0.01 | 0.00 | |
| Hemi-BMP(18:1/18:1)_18:0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | |
| Hemi-BMP(18:1/18:1)_18:1 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.01 | 0.00 | |
| Hemi-BMP(20:4/20:4)_16:0 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(20:4/20:4)_18:0 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(20:4/20:4)_18:1 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(20:4/20:4)_20:4 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(22:6/22:6)_16:0 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(22:6/22:6)_18:0 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(22:6/22:6)_18:1 | - | - | - | - | - | - | - | - | - | - | |
| Hemi-BMP(22:6/22:6)_22:6 | - | - | - | - | - | - | - | - | - | - | |
| Linoleic acid | - | - | - | - | - | - | - | - | - | - | |
| Linolenic acid | - | - | - | - | - | - | - | - | - | - | |
| LPE(16:0) | 0.15 | 0.08 | 0.08 | 0.15 | 0.06 | 0.10 | 0.14 | 0.05 | 0.20 | 0.04 | |
| LPE(18:0) | 3.54 | 1.38 | 1.03 | 2.65 | 0.85 | 1.86 | 3.22 | 0.86 | 5.87 | 0.54 | |
| LPE(18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| LPG(16:0) | - | - | - | - | - | - | - | - | - | - | |
| LPG(18:0) | - | - | - | - | - | - | - | - | - | - | |
| LPG(18:1) | 0.06 | 0.06 | 0.04 | 0.02 | 0.02 | 0.04 | 0.04 | 0.04 | 0.04 | 0.03 | |
| LPG(20:4) | - | - | - | - | - | - | - | - | - | - | |
| LPG(22:6) | - | - | - | - | - | - | - | - | - | - | |
| LPI(16:0) | - | - | - | - | - | - | - | - | - | - | |
| LPI(18:0) | 0.15 | 0.11 | 0.08 | 0.04 | 0.03 | 0.06 | 0.10 | 0.04 | 0.08 | 0.03 | |
| Oleic acid | 0.66 | 0.78 | 0.46 | 0.44 | 0.34 | 0.49 | 0.54 | 0.43 | 0.63 | 0.45 | |
| PA(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PA(16:0_18:1) | 4.16 | 1.05 | 0.50 | 4.40 | 0.25 | 1.52 | 2.42 | 0.27 | 3.65 | 0.47 | |
| PA(18:0_18:1) | - | - | - | - | - | - | - | - | - | - | |
| PA(18:0_20:4) | - | - | - | - | - | - | - | - | - | - | |
| PA(18:0_22:6) | - | - | - | - | - | - | - | - | - | - | |
| PA(18:1/18:1) | - | - | - | - | - | - | - | - | - | - | |
| Palmitic acid | 3.51 | 3.84 | 2.71 | 3.02 | 3.00 | 3.24 | 3.21 | 3.11 | 2.88 | 2.99 | |
| Palmitoleic acid | 0.09 | 0.13 | 0.10 | 0.07 | 0.05 | 0.08 | 0.05 | 0.05 | 0.10 | 0.10 | |
| PE(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PE(O-16:0/20:4) | 3.62 | 5.10 | 3.04 | 2.63 | 2.40 | 2.79 | 2.21 | 1.88 | 2.73 | 2.28 | |
| PE(O-16:0/22:6) | 0.50 | 0.74 | 0.41 | 0.28 | 0.23 | 0.38 | 0.23 | 0.14 | 0.46 | 0.42 | |
| PE(O-18:0/20:4) | 4.77 | 3.55 | 1.86 | 3.39 | 1.38 | 2.37 | 3.27 | 1.29 | 3.79 | 1.23 | |
| PE(O-18:0/22:6) | 0.37 | 0.29 | 0.14 | 0.23 | 0.08 | 0.18 | 0.17 | 0.07 | 0.39 | 0.15 | |
| PE(P-16:0/20:4) | 44.71 | 59.85 | 38.28 | 33.05 | 31.25 | 35.08 | 28.43 | 28.46 | 29.76 | 26.39 | |
| PE(P-16:0/20:5) | 11.47 | 13.29 | 6.84 | 8.60 | 5.24 | 7.08 | 5.74 | 3.99 | 4.78 | 3.32 | |
| PE(P-16:0/22:4) | 34.14 | 29.41 | 16.20 | 24.61 | 10.47 | 19.88 | 22.10 | 10.20 | 27.42 | 14.49 | |
| PE(P-16:0/22:6) | 5.48 | 5.27 | 2.82 | 2.81 | 1.54 | 3.10 | 2.41 | 1.13 | 4.88 | 3.00 | |
| PE(P-18:0/18:1) | 159.32 | 6.20 | 3.16 | 171.38 | 2.35 | 51.49 | 135.07 | 2.64 | 158.66 | 2.95 | |
| PE(P-18:0/18:1(d9)) | - | - | - | - | - | - | - | - | - | - | |
| PE(P-18:0/18:2) | 3.27 | 1.12 | 0.61 | 2.89 | 0.37 | 1.33 | 2.43 | 0.35 | 3.59 | 0.70 | |
| PE(P-18:0/20:4) | 47.21 | 31.94 | 17.84 | 34.00 | 14.59 | 25.02 | 33.98 | 14.45 | 34.77 | 12.77 | |
| PE(P-18:0/20:5) | 6.00 | 4.61 | 2.06 | 4.02 | 1.78 | 2.78 | 3.18 | 1.49 | 3.13 | 1.12 | |
| PE(P-18:0/22:6) | 3.42 | 1.70 | 0.84 | 2.61 | 0.49 | 1.50 | 1.81 | 0.39 | 3.67 | 1.12 | |
| PE(P-18:1/20:4) | 60.89 | 50.64 | 32.34 | 42.66 | 23.72 | 37.97 | 41.82 | 20.90 | 46.65 | 27.72 | |
| PE(P-18:1/22:6) | 6.44 | 4.29 | 2.48 | 3.31 | 1.16 | 3.18 | 3.09 | 0.80 | 6.38 | 2.89 | |
| PEth(16:0_18:1) | 0.15 | 0.10 | 0.07 | 0.08 | 0.03 | 0.08 | 0.08 | 0.03 | 0.15 | 0.08 | |
| PEth(18:1/18:1) | - | - | - | - | - | - | - | - | - | - | |
| PG(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PG(16:0_18:1) | 0.51 | 0.51 | 0.35 | 0.36 | 0.27 | 0.34 | 0.32 | 0.25 | 0.32 | 0.22 | |
| PG(16:0_20:4) | 0.01 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | |
| PG(16:0_22:6) | - | - | - | - | - | - | - | - | - | - | |
| PG(18:0_18:1) | 0.13 | 0.12 | 0.10 | 0.10 | 0.08 | 0.11 | 0.11 | 0.08 | 0.17 | 0.11 | |
| PG(18:0_20:4) | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | 0.01 | 0.01 | 0.00 | 0.01 | 0.00 | |
| PG(18:0_22:6) | - | - | - | - | - | - | - | - | - | - | |
| PG(18:1/18:1) | 0.11 | 0.10 | 0.08 | 0.08 | 0.06 | 0.08 | 0.08 | 0.06 | 0.13 | 0.07 | |
| PI(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PI(16:0_18:1) | 0.88 | 0.32 | 0.22 | 0.77 | 0.15 | 0.45 | 0.93 | 0.17 | 1.11 | 0.29 | |
| PI(16:0_20:4) | 2.05 | 2.20 | 1.20 | 1.76 | 1.04 | 1.31 | 1.71 | 1.02 | 1.84 | 0.77 | |
| PI(16:0_22:6) | 0.21 | 0.09 | 0.05 | 0.23 | 0.04 | 0.10 | 0.19 | 0.03 | 0.23 | 0.04 | |
| PI(18:0_18:1) | 2.18 | 0.73 | 0.47 | 1.50 | 0.26 | 1.00 | 2.13 | 0.30 | 2.74 | 0.76 | |
| PI(18:0_20:4) | 35.48 | 39.09 | 24.34 | 26.78 | 18.79 | 23.22 | 23.30 | 17.49 | 26.88 | 18.94 | |
| PI(18:0_22:6) | 0.75 | 0.63 | 0.35 | 0.61 | 0.24 | 0.45 | 0.61 | 0.24 | 0.74 | 0.33 | |
| PI(18:1/18:1) | 2.62 | 2.03 | 1.38 | 1.68 | 0.77 | 1.83 | 1.82 | 0.70 | 4.27 | 2.69 | |
| PI(20:4/20:4) | 0.03 | 0.04 | 0.02 | 0.02 | 0.01 | 0.02 | 0.02 | 0.02 | 0.02 | 0.01 | |
| PS(15:0/18:1(d7)) | - | - | - | - | - | - | - | - | - | - | |
| PS(16:0_18:1) | 4.02 | 4.45 | 2.24 | 2.28 | 1.12 | 2.15 | 1.86 | 1.04 | 4.01 | 3.27 | |
| PS(16:0_20:4) | 0.34 | 0.43 | 0.26 | 0.25 | 0.19 | 0.24 | 0.19 | 0.15 | 0.20 | 0.18 | |
| PS(16:0_22:6) | 0.28 | 0.34 | 0.23 | 0.16 | 0.14 | 0.20 | 0.12 | 0.11 | 0.16 | 0.23 | |
| PS(18:0_18:1) | 201.37 | 165.57 | 87.29 | 174.11 | 58.63 | 108.66 | 157.52 | 51.37 | 180.06 | 79.44 | |
| PS(18:0_20:4) | 19.11 | 18.39 | 10.35 | 9.02 | 5.89 | 8.54 | 7.93 | 4.14 | 12.74 | 6.65 | |
| PS(18:0_22:6) | 12.56 | 17.24 | 9.79 | 7.95 | 5.97 | 7.93 | 4.89 | 4.26 | 10.91 | 12.09 | |
| PS(18:1/18:1) | 17.99 | 6.04 | 2.77 | 13.91 | 1.37 | 6.58 | 11.66 | 1.08 | 18.36 | 5.88 | |
| PS(22:6/22:6) | - | - | - | - | - | - | - | - | - | - | |
| Stearic acid | - | - | - | - | - | - | - | - | - | - |
Factors:
| F1 | Genotype:GPR34-KO | Treatment:Myelin | Sample source:iMicroglia |
| F2 | Genotype:GPR34 KO | Treatment:PBS | Sample source:iMicroglia |
| F3 | Genotype:GPR34-KO | Treatment:PBS | Sample source:iMicroglia |
| F4 | Genotype:GPR34/TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F5 | Genotype:GPR34/TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F6 | Genotype:NA | Treatment:NA | Sample source:iMicroglia |
| F7 | Genotype:TREM2-KO | Treatment:Myelin | Sample source:iMicroglia |
| F8 | Genotype:TREM2-KO | Treatment:PBS | Sample source:iMicroglia |
| F9 | Genotype:WT | Treatment:Myelin | Sample source:iMicroglia |
| F10 | Genotype:WT | Treatment:PBS | Sample source:iMicroglia |