Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST002205)

(Analysis AN003608)

Metabolite	Structure	F1	F2	F3	F4
cystathionine	ME535336	0.07	0.18	0.38	3.36
N-acetylaspartate	ME535402	0.07	0.06	3.74	0.13
carnitine C3	ME535319	0.20	0.25	2.45	1.10
ophthalmate	ME535416	0.17	0.32	2.82	0.68
carnitine C18	ME535317	1.84	0.31	1.18	0.67
1-methylnicotinamide	ME535283	1.71	1.28	0.73	0.27
Glycerylphosphorylethanolamine	ME535368	0.84	1.07	1.63	0.46
citicoline	ME535326	1.35	0.96	1.34	0.35
glyceraldehyde 3-phosphate	ME535366	1.23	1.05	1.41	0.30
oxidized glutathione	ME535420	0.51	0.84	0.50	2.15
phosphoenolpyruvate	ME535427	0.39	0.75	0.58	2.28
dATP	ME535340	0.08	0.45	0.89	2.58
3-phosphoserine	ME535286	0.29	0.54	1.00	2.18
aspartate	ME535307	0.30	0.43	1.21	2.06
dCTP	ME535341	0.10	0.40	1.35	2.14
AICAR	ME535300	NA	NA	0.82	1.18
5-formamidoimidazole-4-carboxamide ribotide	ME535290	0.40	0.34	1.94	1.32
N-acetylglutamine	ME535406	0.25	0.29	1.88	1.59
malate	ME535392	0.32	0.33	1.81	1.54
N-acetylglutamate	ME535405	0.32	0.38	1.81	1.49
glutamate	ME535363	0.40	0.39	1.64	1.57
hypoxanthine	ME535382	0.36	0.46	1.68	1.49
N-acetylaspartylglutamate	ME535403	0.36	0.46	1.65	1.52
aconitate	ME535294	0.27	0.30	1.65	1.77
proline	ME535428	0.33	0.38	1.63	1.66
carnitine C5	ME535321	0.40	0.80	1.89	0.90
pentose 1,5-bisphosphate	ME535422	0.38	1.07	1.79	0.76
CMP-acetylneuraminate	ME535330	0.82	0.50	1.69	0.99
gluconate	ME535359	0.54	0.65	1.60	1.21
uridine	ME535454	0.46	0.65	1.60	1.30
orotidine	ME535419	0.48	0.62	1.76	1.14
2-oxoglutarate	ME535285	0.59	0.60	1.69	1.12
beta-citrylglutamate	ME535310	0.65	0.63	1.69	1.03
gamma-glutamylcysteine	ME535352	1.01	0.83	0.50	1.65
S-lactoylglutathione	ME535440	1.07	0.94	0.29	1.70
carnitine C14:1	ME535314	0.69	1.23	0.89	1.18
glutathione reduced	ME535365	1.00	1.07	0.69	1.24
cysteinylglycine	ME535338	1.02	0.99	0.66	1.33
N-acetylarginine	ME535400	0.99	1.04	0.62	1.34
acetyl-CoA	ME535293	0.78	0.88	1.42	0.92
sedoheptulose 7-phosphate	ME535438	0.79	0.79	1.43	0.99
deoxycarnitine	ME535292	0.74	1.02	1.35	0.89
guanidinoacetate	ME535374	0.81	1.04	1.27	0.88
glucose 6-phosphate	ME535361	0.93	1.15	1.23	0.69
betaine	ME535311	0.76	1.17	1.37	0.70
flavin adenine dinucleotide	ME535347	0.88	1.03	1.35	0.74
glycerylphosphorylcholine	ME535369	0.82	1.11	1.30	0.77
fructose 6-phosphate	ME535348	0.98	1.02	1.20	0.80
cyclic ADP-ribose	ME535334	0.97	1.01	1.15	0.87
NAD	ME535411	0.99	1.04	1.13	0.83
GDP-glucose	ME535358	1.05	1.10	1.11	0.75
lactate	ME535389	1.13	1.03	1.17	0.67
ADP-ribose	ME535299	0.92	1.19	1.02	0.87
glucuronate	ME535362	0.94	1.16	1.07	0.83
cyclic AMP	ME535335	1.00	1.09	1.00	0.92
sarcosine	ME535437	0.98	1.00	1.02	1.00
UMP	ME535452	0.95	0.99	1.08	0.98
AMP	ME535303	1.16	1.05	0.90	0.88
cysteate	ME535337	1.05	1.01	0.87	1.06
malonate	ME535393	1.10	1.00	0.92	0.97
adenosine	ME535296	1.03	1.16	0.80	1.02
N-carbamoylaspartate	ME535415	0.96	1.14	0.87	1.03
glycerol 3-phosphate	ME535367	0.88	1.31	0.82	0.99
gamma-glutamylalanine	ME535351	0.91	1.23	0.88	0.98
GDP-fucose	ME535357	0.90	1.21	0.95	0.94
N6,N6,N6-trimethyllysine	ME535399	1.22	1.22	0.71	0.85
choline	ME535325	1.16	1.29	0.87	0.68
beta-alanine	ME535309	0.95	1.32	1.07	0.66
hypotaurine	ME535381	1.02	1.31	0.96	0.71
CMP	ME535329	0.65	0.62	1.45	1.28
guanosine	ME535375	0.71	0.59	1.48	1.23
orotate	ME535418	0.49	0.77	1.40	1.34
cytosine	ME535339	0.54	0.74	1.49	1.24
gamma-glutamylglycine	ME535354	0.62	0.79	1.42	1.17
N-acetylasparagine	ME535401	0.58	0.79	1.40	1.23
carnitine C4	ME535320	0.54	0.96	1.14	1.35
NADPH	ME535414	0.55	0.89	1.20	1.37
methionine sulfoxide	ME535395	0.78	0.65	1.29	1.28
xanthosine	ME535458	0.64	0.77	1.28	1.31
pyruvate	ME535431	0.64	0.80	1.25	1.31
UDP	ME535449	0.61	0.80	1.25	1.33
glucose	ME535360	0.60	0.79	1.22	1.39
quinolinate	ME535432	0.64	0.79	1.21	1.35
tryptophan	ME535447	0.62	0.73	1.28	1.38
thiamine	ME535445	0.63	0.76	1.22	1.38
tyrosine	ME535448	0.64	0.75	1.22	1.39
kynurenine	ME535388	0.66	0.71	1.24	1.40
phenylalanine	ME535424	0.64	0.73	1.25	1.39
hippurate	ME535376	0.70	0.76	1.26	1.28
leucine+isoleucine	ME535390	0.71	0.79	1.24	1.27
valine	ME535456	0.71	0.79	1.21	1.29
creatinine	ME535332	0.69	0.79	1.15	1.37
pyridoxine	ME535429	0.69	0.83	1.17	1.31
6-phosphogluconate	ME535291	0.62	0.89	1.27	1.22
carnosine	ME535323	0.69	0.88	1.18	1.25
alanine	ME535301	0.72	0.74	1.32	1.22
S-adenosylhomocysteine	ME535434	0.67	0.77	1.33	1.23
UDP-glucose	ME535451	0.78	0.80	1.23	1.19
xanthine	ME535457	0.70	0.84	1.26	1.20
GDP	ME535356	0.61	1.08	0.93	1.39
NADH	ME535412	0.74	0.95	0.93	1.38
asparagine	ME535306	0.73	1.05	0.86	1.36
GMP	ME535372	0.74	1.06	0.93	1.27
phosphocholine	ME535425	0.77	1.01	0.93	1.29
threonine	ME535446	0.82	0.84	1.02	1.31
citrulline	ME535328	0.76	0.82	1.03	1.39
histidine	ME535377	0.76	0.79	1.06	1.39
gamma-glutamylproline	ME535355	0.80	0.82	0.93	1.46
N-acetylmethionine	ME535408	0.69	0.89	0.94	1.49
N-acetyltaurine	ME535410	0.76	1.15	1.09	1.00
4-hydroxyphenylpyruvate	ME535288	0.91	0.90	1.15	1.04
glycine	ME535370	0.94	0.89	1.16	1.01
taurine	ME535444	0.86	1.03	1.08	1.02
pentose phosphate	ME535423	0.84	0.97	1.12	1.06
dihydroxyacetone phosphate	ME535343	0.81	0.99	1.16	1.03
N-acetylhexosamine phosphate	ME535404	0.77	1.03	1.16	1.04
serine	ME535439	0.94	1.01	0.97	1.08
UDP-GlcNac	ME535450	0.88	1.00	1.00	1.12
epsilon-(gamma-glutamyl)lysine	ME535346	1.02	0.90	0.92	1.17
pantothenate	ME535421	0.95	1.00	0.87	1.19
4-hydroxyproline	ME535289	0.91	0.95	0.88	1.25
glutamine	ME535364	0.93	0.94	0.92	1.20
NADP	ME535413	0.78	0.90	1.12	1.19
pyroglutamate	ME535430	0.78	0.88	1.16	1.18
ADP	ME535298	0.78	0.92	1.03	1.27
2/3-phosphoglycerate	ME535284	0.83	0.93	1.02	1.22
fructose bisphosphate	ME535349	0.82	0.94	1.05	1.20
S-adenosylmethionine	ME535435	0.84	0.91	1.05	1.19
arginine	ME535304	0.87	0.81	1.16	1.17
homoarginine	ME535378	0.85	0.77	1.18	1.20
creatine	ME535331	0.83	0.71	1.17	1.29
lysine	ME535391	0.78	0.79	1.16	1.27
N-acetylneuranimic acid	ME535409	0.93	0.73	1.07	1.28
N,N-dimethylarginine	ME535397	0.91	0.84	1.05	1.20
GTP	ME535373	0.43	0.95	0.93	1.69
dihydroorotate	ME535342	0.66	1.02	0.70	1.62
N2-gamma-glutamylglutamine	ME535398	0.75	0.88	0.78	1.59
IMP	ME535383	0.78	0.66	0.86	1.70
gamma-glutamylglutamate	ME535353	0.57	0.83	0.88	1.71
uric acid	ME535453	0.65	0.81	0.77	1.77
4-hydroxyphenyllactate	ME535287	0.52	0.52	1.48	1.48
homocysteine	ME535380	0.59	0.50	1.42	1.49
citrate	ME535327	0.54	0.58	1.32	1.56
ketoleucine	ME535386	0.50	0.53	1.40	1.57
homocitrulline	ME535379	0.43	0.62	1.45	1.50
phosphocreatine	ME535426	0.50	0.65	1.35	1.50
adenine	ME535295	0.51	0.70	1.12	1.66
N-acetylhistidine	ME535407	0.56	0.73	1.19	1.52
ATP	ME535308	0.50	0.81	1.12	1.58
CDP	ME535324	0.45	0.75	1.22	1.58
methylthioadenosine	ME535396	0.65	0.68	0.98	1.69
inosine	ME535384	0.66	0.76	1.04	1.54
methionine	ME535394	0.68	0.68	1.08	1.56
ornithine	ME535417	0.63	0.48	1.27	1.62
glycylglycine	ME535371	0.60	0.54	1.14	1.72
ketovaline	ME535387	0.56	0.53	1.20	1.71
dTMP	ME535344	0.46	0.59	1.18	1.78
dTTP	ME535345	0.38	0.54	1.20	1.87
CTP	ME535333	0.34	0.66	1.19	1.81
UTP	ME535455	0.35	0.69	1.26	1.70
carnitine C16	ME535315	0.92	2.06	0.53	0.49
carnitine C14	ME535313	0.61	2.34	0.56	0.49
carnitine C16:1	ME535316	0.67	2.39	0.35	0.59
carnitine	ME535312	0.88	1.58	0.84	0.71
carnitine C6	ME535322	0.93	1.73	0.58	0.77
inositol	ME535385	0.90	1.68	0.65	0.76
carnitine C2	ME535318	1.12	1.59	0.84	0.45
succinate	ME535442	1.12	1.48	1.11	0.29
aminoimidazole ribonucleotide	ME535302	1.13	0.87	NA	NA
S-(2-succinyl)cysteine	ME535433	2.29	1.68	0.01	0.02
SAICAR	ME535436	1.78	2.15	0.03	0.04
S-Succinylglutathione	ME535441	1.91	1.99	0.04	0.06
argininosuccinate	ME535305	1.96	1.96	0.03	0.04
succinyladenosine	ME535443	1.96	1.98	0.02	0.05
adenylosuccinate	ME535297	1.56	1.76	0.01	0.01
fumarate	ME535350	1.68	1.86	0.25	0.22

Factors:

F1	Genotype:Fh1-/- CL19 \| Treatment:Cas9
F2	Genotype:Fh1-/- CL19 \| Treatment:sg1Hira
F3	Genotype:Fh1 fl/fl \| Treatment:Cas9
F4	Genotype:Fh1 fl/fl \| Treatment:sg1Hira

Data matrix