Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST004424)

(Analysis AN007401)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8
dihydroorotate	ME1233543	6.03	0.23	0.06	0.11	0.09	0.10	0.18	1.15
N-carbamoyl-L-aspartate	ME1233593	4.81	0.42	0.14	0.20	0.18	0.21	0.41	1.47
PVNF	ME1233614	1.57	1.12	0.01	1.05	0.11	0.06	3.13	0.96
PE	ME1233606	1.37	3.08	0.12	0.48	0.20	0.16	1.56	1.02
PEE	ME1233607	1.13	3.16	0.17	0.55	0.20	0.28	1.48	1.01
DLH	ME1233546	1.32	2.79	0.04	0.78	0.19	0.21	1.63	1.03
N-acetyl-L-ornithine	ME1233592	1.24	2.55	0.11	0.79	0.24	0.25	1.82	1.00
SID	ME1233627	1.42	2.44	0.11	0.88	0.16	0.16	1.84	1.00
DLS	ME1233547	1.42	2.45	0.11	0.88	0.16	0.16	1.83	1.00
SDL	ME1233624	1.42	2.45	0.11	0.88	0.16	0.16	1.83	1.00
lysine	ME1233583	2.12	1.15	0.39	0.61	0.34	0.93	1.45	1.01
5-phosphoribosyl-1-pyrophosphate	ME1233510	1.70	1.06	0.77	0.83	0.43	0.46	1.73	1.01
DL-Pipecolic Acid	ME1233545	1.95	0.92	0.50	0.62	0.33	0.60	2.06	1.01
PD	ME1233605	2.39	1.23	0.15	0.65	0.14	0.13	2.26	1.03
SD	ME1233623	1.46	1.93	0.39	0.83	0.42	0.38	1.55	1.03
VD	ME1233644	1.58	1.80	0.38	0.74	0.41	0.36	1.71	1.02
PEEK	ME1233608	1.66	1.68	0.13	0.69	0.13	0.32	2.32	1.05
Acetyllysine	ME1233515	1.89	1.76	0.12	0.70	0.18	0.23	2.09	1.02
PTT	ME1233613	2.01	1.89	0.15	0.66	0.12	0.16	2.01	1.00
4-phosphopantetheine	ME1233506	1.17	0.94	2.34	0.90	0.33	0.60	0.78	0.94
dTMP	ME1233549	0.24	0.60	3.16	1.26	0.67	0.45	0.59	1.02
dTTP	ME1233550	0.55	0.83	2.39	0.85	0.74	0.65	0.98	1.02
Hexose	ME1233568	0.63	0.68	2.87	0.73	0.73	0.71	0.53	1.09
xanthosine-5-phosphate	ME1233646	0.72	0.61	3.05	0.63	0.67	0.62	0.67	1.02
IDS	ME1233574	0.33	2.05	1.55	0.88	0.86	0.68	0.61	1.03
CMP	ME1233525	0.55	1.12	1.13	1.39	0.96	0.78	1.05	1.02
dAMP	ME1233534	0.58	0.95	1.32	1.85	0.86	0.52	0.90	1.01
dTDP	ME1233548	0.41	0.91	1.51	1.59	0.90	0.62	1.05	1.00
UMP	ME1233641	0.50	1.20	0.69	1.57	0.94	0.71	1.38	1.01
dGMP/AMP	ME1233541	0.69	1.10	0.44	1.78	1.14	0.81	1.02	1.02
UDP	ME1233637	0.46	0.99	0.41	1.88	1.18	0.88	1.22	0.99
CDP	ME1233522	0.62	1.04	0.54	1.46	1.24	1.07	1.07	0.98
dCDP	ME1233536	0.83	0.94	0.77	1.55	1.01	0.86	1.09	0.97
succinyl-CoA/methylmalonyl-CoA	ME1233630	0.97	1.31	0.55	1.38	0.70	0.76	1.27	1.04
guanine	ME1233567	1.30	1.14	0.24	1.57	1.06	0.87	0.81	1.00
GMP	ME1233565	1.08	1.18	0.25	1.52	0.94	0.74	1.29	1.01
dGDP/ADP	ME1233540	0.90	1.07	0.32	1.51	1.13	1.02	1.05	1.00
GDP	ME1233556	1.02	0.98	0.24	1.64	1.11	0.90	1.10	1.01
dCMP	ME1233537	0.74	1.04	1.67	0.97	0.86	0.79	0.91	1.02
succinate/Methylmalonic acid	ME1233629	0.94	1.15	1.62	0.86	0.55	0.78	1.05	1.04
cytidine	ME1233529	0.95	0.81	1.27	0.88	1.12	1.15	0.78	1.03
NADH	ME1233595	0.85	1.10	1.61	0.61	0.76	1.33	0.75	0.99
NADPH	ME1233597	0.75	1.10	1.31	0.75	0.86	1.39	0.79	1.04
pyruvate	ME1233618	0.86	1.65	0.61	0.94	0.87	1.08	0.95	1.02
alanine/sarcosine	ME1233518	1.38	1.49	0.50	0.86	0.63	0.70	1.41	1.02
histidine	ME1233570	1.22	1.67	0.70	0.82	0.60	0.66	1.29	1.02
myo-inositol	ME1233587	1.19	1.37	0.68	0.88	0.67	1.03	1.13	1.03
proline	ME1233612	1.06	1.57	0.79	0.95	0.70	0.78	1.11	1.02
GTP	ME1233566	1.60	1.11	0.51	1.07	0.90	1.15	1.14	0.65
orotate	ME1233603	1.46	1.06	0.59	0.93	0.92	0.88	1.15	1.01
dGTP/ATP	ME1233542	1.22	1.08	0.57	1.03	0.95	1.14	1.06	0.96
Octulose Bisphosphate	ME1233602	1.26	1.09	0.50	0.98	0.84	1.10	1.22	1.01
arginine	ME1233519	1.73	0.84	0.94	0.82	0.66	0.72	1.26	1.03
L-arginino-succinate	ME1233579	1.38	0.92	1.16	0.78	0.68	0.83	1.26	0.99
malate	ME1233584	1.24	1.08	1.31	0.80	0.56	0.75	1.21	1.04
fumarate	ME1233555	1.25	1.07	1.32	0.80	0.57	0.75	1.20	1.03
maleic acid	ME1233585	1.24	1.07	1.32	0.80	0.57	0.75	1.21	1.03
dATP	ME1233535	1.43	0.96	0.97	1.09	0.80	0.75	1.08	0.95
glycodeoxycholic acid?	ME1233564	1.09	1.15	0.91	0.96	0.74	0.67	1.49	0.99
threonine/homoserine	ME1233634	1.27	1.11	0.87	0.91	0.74	0.79	1.31	1.01
N-acetyl-glutamine	ME1233590	1.30	0.97	0.82	0.90	0.72	0.76	1.48	1.03
xanthosine	ME1233645	1.33	0.99	0.80	0.99	0.72	0.77	1.35	1.04
CTP	ME1233528	0.76	1.09	0.75	1.03	1.13	1.18	1.07	0.99
UTP	ME1233642	0.63	1.06	0.83	1.08	1.06	1.08	1.28	0.99
adenine	ME1233516	1.00	1.02	0.61	1.21	1.06	1.08	0.93	1.06
FAD	ME1233551	0.96	1.00	0.74	1.01	1.19	1.15	0.85	1.08
aspartate	ME1233521	0.68	1.29	1.08	0.88	0.83	0.90	1.33	1.01
methionine	ME1233586	0.92	1.43	1.10	0.80	0.82	1.01	0.88	1.02
nicotinate	ME1233599	0.87	1.27	0.94	1.17	0.89	1.01	0.86	1.00
IDP	ME1233573	0.86	0.93	1.08	1.16	0.93	1.13	0.81	1.07
DAL	ME1233533	0.86	1.14	0.95	1.01	0.77	1.11	1.16	1.00
D-sedoheptulose-1/7-phosphate	ME1233532	1.08	0.94	1.12	0.92	0.92	1.00	0.97	1.03
fructose-1-6-bisphosphate	ME1233553	1.03	1.05	1.12	0.91	0.82	1.10	0.96	1.01
thiamine	ME1233632	1.06	0.98	1.03	0.93	0.90	1.11	0.99	1.00
deoxyuridine	ME1233539	0.97	1.06	1.07	1.00	1.05	1.03	0.96	0.90
taurine	ME1233631	0.96	1.02	0.94	1.09	0.93	1.01	1.04	1.01
UDP-N-acetyl-glucosamine	ME1233640	0.92	1.03	0.92	1.09	0.98	0.99	1.06	1.01
NAD+	ME1233594	1.02	1.03	0.92	1.01	0.95	1.02	1.00	1.03
Octulose 8/1P	ME1233601	0.99	1.02	0.98	1.03	0.91	1.02	1.02	1.03
ADP-D-glucose	ME1233517	1.07	1.03	1.00	1.05	0.88	0.96	0.97	1.02
IMP	ME1233575	1.05	1.10	1.08	1.04	0.83	0.96	0.92	1.02
glutamine	ME1233560	0.98	1.03	1.04	1.00	0.89	0.99	1.06	1.01
hydroxyproline/Aminolevulinate	ME1233571	1.01	1.09	1.03	1.00	0.86	0.97	1.01	1.02
glucono-lactone	ME1233557	0.94	1.07	1.03	1.06	0.83	1.05	1.01	1.01
Kynurenine	ME1233578	0.96	1.14	1.01	1.00	0.82	1.00	1.03	1.04
3-phospho-serine	ME1233503	1.06	1.01	0.99	1.02	0.86	0.93	1.10	1.02
glutathione	ME1233561	1.06	1.03	0.99	0.97	0.83	1.03	1.05	1.03
creatine	ME1233527	0.89	1.11	0.94	1.06	0.85	1.10	0.97	1.06
CDP-ethanolamine	ME1233524	0.84	0.98	1.00	1.02	0.97	1.13	1.02	1.03
2-Hydroxy-2-methylbutanedioic acid	ME1233502	0.85	1.05	1.03	1.07	0.95	1.11	0.90	1.04
4-Pyridoxic acid	ME1233508	0.88	1.08	1.10	1.03	0.98	1.06	0.85	1.02
hypoxanthine	ME1233572	0.99	1.10	0.99	1.01	0.95	1.05	0.89	1.02
6-phospho-D-gluconate	ME1233511	1.01	1.00	1.00	1.00	0.96	1.08	0.94	1.01
NADP+	ME1233596	0.91	1.03	1.01	1.09	0.98	1.06	0.89	1.02
UDP-D-glucuronate	ME1233639	0.95	1.03	1.03	1.06	0.94	1.07	0.90	1.02
UDP-D-glucose	ME1233638	0.94	1.01	1.04	1.01	0.98	1.03	0.95	1.02
D-glucosamine-1/6-phosphate	ME1233531	0.95	1.04	1.06	1.02	0.92	1.03	0.95	1.02
inosine	ME1233576	0.95	1.05	1.04	1.02	0.92	1.04	0.94	1.03
acetyl-aspartate	ME1233513	0.94	1.02	1.07	1.01	0.92	0.97	0.95	1.10
folate	ME1233552	0.93	1.04	1.13	1.00	0.89	1.04	0.94	1.02
S-adenosyl-L-homocysteine	ME1233622	1.03	0.98	0.83	1.04	0.90	1.03	1.21	0.99
Sedoheptulose bisphosphate	ME1233625	1.11	1.06	0.93	0.89	0.89	1.12	0.99	1.01
hexose-phosphate	ME1233569	1.10	1.07	0.85	0.94	0.89	1.17	0.95	1.02
fructose-6-phosphate	ME1233554	1.10	1.07	0.85	0.94	0.89	1.17	0.95	1.02
glucose-1-phosphate	ME1233558	1.10	1.07	0.85	0.94	0.89	1.17	0.95	1.02
Thiamine pyrophosphate	ME1233633	1.03	1.08	0.69	1.15	0.97	1.00	1.05	1.03
Pyrophosphate	ME1233617	1.09	1.06	0.83	1.07	0.86	1.11	1.05	0.96
1_3-Bisphosphoglyceric acid	ME1233499	1.06	1.07	0.80	1.09	0.91	1.08	1.00	0.99
2_3-Diphosphoglyceric acid	ME1233500	1.06	1.08	0.80	1.09	0.90	1.08	1.00	0.99
LD	ME1233581	1.05	1.36	0.70	1.00	0.93	0.90	1.03	1.02
N-Acetyl-L-alanine	ME1233591	0.93	1.35	0.93	0.95	0.85	0.80	1.18	1.01
4-phosphopantothenate	ME1233507	0.92	1.23	0.91	1.13	0.76	0.91	1.12	1.02
acetyl-CoA	ME1233514	0.88	1.22	0.73	1.17	0.89	0.92	1.20	1.00
leucine	ME1233582	1.11	1.47	1.05	0.78	0.68	0.82	1.06	1.03
phenylalanine	ME1233610	1.20	1.36	0.94	0.80	0.68	0.82	1.18	1.02
5-aminopentanoic acid	ME1233509	1.23	1.23	0.96	0.86	0.70	0.78	1.21	1.03
valine	ME1233643	1.22	1.22	0.96	0.85	0.69	0.77	1.25	1.02
D-gluconate	ME1233530	1.02	1.15	1.10	1.06	0.74	0.82	1.05	1.05
serine	ME1233626	1.10	1.10	0.98	0.94	0.80	0.87	1.18	1.02
asparagine	ME1233520	1.00	1.15	0.95	0.97	0.86	0.89	1.16	1.01
tryptophan	ME1233635	1.07	1.17	0.99	0.89	0.88	0.86	1.10	1.03
Phenol Red	ME1233609	1.02	1.31	1.07	0.86	0.76	0.88	1.11	1.01
isoleucine	ME1233577	1.03	1.18	1.16	0.89	0.79	0.93	0.99	1.02
tyrosine	ME1233636	1.03	1.21	1.07	0.88	0.82	0.93	1.03	1.02
pyridoxine	ME1233615	1.10	1.36	1.05	0.86	0.72	0.97	0.94	1.01
ribulose-5-phosphate	ME1233621	1.09	1.34	0.94	0.94	0.71	0.99	0.97	1.01
CDP-choline	ME1233523	0.96	1.27	0.94	0.95	0.82	1.00	1.04	1.01
lactate	ME1233580	1.10	1.23	0.80	0.91	0.81	1.01	1.08	1.03
N-acetyl-glucosamine-1/6-phosphate	ME1233588	1.29	1.03	0.77	1.06	0.89	0.89	1.05	1.01
glycerate	ME1233563	1.10	1.15	0.94	1.04	0.75	0.95	1.05	1.02
Ribose-5-phosphate	ME1233619	1.24	1.06	0.92	0.99	0.69	0.95	1.12	1.03
ribose-phosphate	ME1233620	1.23	1.07	0.92	0.98	0.69	0.95	1.12	1.02
coenzyme A	ME1233526	1.08	1.27	1.19	1.12	0.63	0.88	0.99	0.89
sn-glycerol-3-phosphate	ME1233628	1.13	1.12	1.32	0.88	0.62	0.95	0.94	1.03
4-aminobutyrate	ME1233505	1.17	1.02	1.39	0.90	0.73	0.73	1.00	1.05
glutamate	ME1233559	1.13	1.00	1.33	0.90	0.78	0.85	0.97	1.03
O-acetyl-L-serine	ME1233600	1.15	1.00	1.34	0.89	0.78	0.85	0.96	1.03
a-ketoglutarate	ME1233512	0.95	0.97	1.25	1.16	0.74	0.84	1.07	1.02
dCTP	ME1233538	1.10	0.99	1.20	0.92	0.83	0.88	1.08	1.00
glutathione disulfide	ME1233562	1.01	0.94	1.08	1.02	0.90	0.90	1.13	1.02
dihydroxy-acetone-phosphate	ME1233544	0.94	1.08	1.44	0.77	0.75	1.10	0.88	1.03
3-phosphoglycerate	ME1233504	0.90	1.21	1.22	1.05	0.74	0.98	0.89	1.01
phosphoenolpyruvate	ME1233611	0.90	1.14	1.21	1.14	0.73	0.95	0.88	1.03
nicotinamide mononucleotide	ME1233598	0.90	1.04	1.41	0.89	0.83	0.92	0.99	1.02
N-acetyl-glutamate	ME1233589	0.91	1.02	1.24	0.89	0.97	1.08	0.85	1.03
Pyroglutamic acid	ME1233616	0.83	1.05	1.27	1.06	0.91	0.93	0.90	1.03
2-dehydro-D-gluconate	ME1233501	0.94	1.07	1.23	0.96	0.87	0.97	0.92	1.03
pantothenate	ME1233604	1.04	1.09	1.22	0.92	0.80	0.95	0.94	1.02

Factors:

F1	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:10nM Atovaquone
F2	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:Compound 16
F3	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:Compound 19
F4	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:Compound 33
F5	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:Compound 35
F6	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:Compound 4
F7	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:DMSO
F8	Sample source:Cultured Plasmodium falciparum 3D7 MR4 \| Treatment:Pooled Quality Control

Data matrix