Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for (Study ST004432)

(Analysis AN007413)

Metabolite	Structure	F1	F2	F3	F4	F5
"(13R,17R)-17-[(1R,2S)-1,2-dihydroxyheptyl]-1,5,10-triazabicyclo[11.4.0]heptadec-15-en-11-one"	ME1235579	1.04	0.92	0.82	0.97	1.25
"12-Butan-2-yl-19-hexyl-6-(1-hydroxyethyl)-9-(hydroxymethyl)-16,18-dimethyl-15-(2-methylpropyl)-1-oxa-4,7,10,13,16-pentazacyclononadecane-2,5,8,11,14,17-hexone"	ME1235649	0.60	1.49	1.23	1.31	0.32
"1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine"	ME1235967	1.24	0.68	0.86	1.07	1.23
1-Deoxyvaleric-acid	ME1235714	0.88	1.17	1.25	0.95	0.71
1-Hydroxy-2-naphthaldehyde	ME1235566	0.87	0.98	1.24	1.04	0.88
"1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine"	ME1235843	1.28	0.93	0.94	0.93	0.92
1-(11Z-eicosenoyl)-2-(9Z-tetradecenoyl)-glycero-3-phosphocholine	ME1235951	2.89	0.23	0.27	0.67	1.03
"1,2-Dimyristoleoyl-sn-glycero-3-phosphocholine"	ME1235892	1.06	1.23	0.82	1.00	0.84
"15-cis-4,4^-Diapophytoene"	ME1235980	0.56	0.83	1.58	0.36	1.58
"11-Hydroxy-9-(hydroxymethyl)-2,6a,6b,9,12a-pentamethyl-10-(3,4,5-trihydroxyoxan-2-yl)oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-2,4a-dicarboxylic acid"	ME1235640	1.32	0.96	0.89	0.95	0.87
11-Aminoundecanoic acid	ME1235423	1.28	0.85	1.04	0.94	0.91
"1,28-Dicaffeoyloctacosanediol"	ME1236061	0.80	0.95	1.51	1.05	0.72
1-Methylguanosine	ME1235568	1.07	0.81	0.90	0.79	1.42
"17alpha,21-Dihydroxypregnenolone"	ME1235541	1.06	1.07	1.15	0.91	0.78
"1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-dione"	ME1235448	1.09	0.94	0.85	1.25	0.93
"15,15-Difluoro-9alpha,11alpha-dihydroxy-16-phenoxy-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester"	ME1236092	1.09	1.16	1.03	1.03	0.67
13-Docosenamide	ME1235075	0.29	0.67	2.99	0.74	0.32
11a-Hydroxytetracycline	ME1236048	0.99	0.87	0.84	1.14	1.21
"1,2-di-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine"	ME1236006	1.17	0.95	0.97	0.97	0.93
15-Deoxoeucosterol	ME1236020	1.11	0.96	0.99	0.97	0.97
"1-(6-((3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione"	ME1235260	0.92	0.85	0.97	0.93	1.34
16alpha-Hydroxyestrone	ME1235306	1.04	1.00	1.00	0.93	1.02
"1,26-Dicaffeoylhexacosanediol"	ME1236054	1.13	0.99	0.89	0.93	1.05
1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine	ME1235793	1.71	0.65	0.39	0.51	1.71
"1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine"	ME1235245	2.13	0.38	0.61	0.39	1.49
1-Naphthyl glucuronide	ME1235415	0.90	0.73	0.86	1.13	1.45
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate	ME1235913	0.68	0.35	0.41	0.14	3.36
1-deoxy-D-xylulose 5-phosphate	ME1235399	0.81	1.03	1.47	0.91	0.75
"1,2-Dibenzoylbenzene"	ME1235401	1.18	0.92	0.96	0.99	0.95
1-Myristoyl-3-osbondoyl-sn-glycerol	ME1236279	0.94	0.93	0.97	1.19	1.01
1-Aminocyclobutanecarboxylic acid	ME1235051	1.01	0.94	1.07	0.92	1.05
1-Methylxanthine	ME1235154	0.78	0.98	1.14	1.17	0.96
1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone	ME1235342	0.89	1.05	1.10	1.02	0.92
"1,4-Dihydro-1-methyl-4-oxo-3-pyridinecarboxamide"	ME1235127	1.34	1.60	0.43	0.79	0.68
1-Heptanol	ME1235460	1.28	1.57	0.47	0.81	0.71
"1-(9Z-octadecenoyl)-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol"	ME1236272	1.06	1.05	0.98	0.98	0.92
"1-(11Z,14Z-eicosadienoyl)-2-tetradecanoyl-glycero-3-phosphocholine"	ME1235961	0.85	1.17	1.33	1.12	0.52
1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride	ME1235314	1.01	1.12	1.05	0.91	0.87
"1,8-Diazacyclotetradecane-2,9-dione"	ME1235532	0.97	0.96	1.01	1.05	1.03
"13,14-dihydro-15-keto PGD2"	ME1235223	0.94	1.33	0.46	1.39	0.88
1-Oleoyl-2-acetyl-sn-glycerol	ME1235262	0.98	0.91	0.75	1.19	1.22
10-deoxyformamycin	ME1235141	1.16	1.02	1.14	0.93	0.73
1-[(9Z)-hexadecenoyl]-2-[(11Z)-octadecenoyl]-sn-glycero-3-phosphocholine	ME1235946	1.43	1.01	0.66	0.59	1.22
"1,2-Dioleoyl-sn-Glycero-3-Phosphocholine"	ME1235244	1.10	1.06	1.24	0.86	0.70
1-Octadecyl-2-acetyl-sn-glycero-3-phosphocholine	ME1235255	1.36	0.59	0.53	0.99	1.61
1-{4-[(3-Aminopropyl)amino]butyl}guanidine	ME1235588	1.01	0.99	1.01	0.99	1.00
1-Hydroxylamino-2-phenylethane	ME1235035	1.02	0.97	1.03	0.87	1.09
1-O-Hexadecyl-sn-glycero-3-phosphocholine	ME1235125	1.12	0.95	0.78	1.06	1.11
19-(4-Hydroxyphenyl)nonadecanoic acid	ME1236019	1.00	1.13	0.82	1.05	0.99
1-Heptadecanoyl-sn-glycero-3-phosphocholine	ME1235239	1.07	1.10	0.99	0.87	0.92
1-(4-Hydroxy-2-methylpyrimidin-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium bromide	ME1235989	1.03	1.13	1.04	1.08	0.71
13-Demethyl tacrolimus	ME1236008	1.18	1.00	0.96	0.88	0.97
"1-[(3aS,8bR)-8b-hydroxy-7-methoxy-1,2,3a,4-tetrahydropyrrolo[2,3-b]indol-3-yl]ethanone"	ME1236078	0.98	0.97	1.05	1.01	0.99
"11,14-Eicosadienoic acid"	ME1235421	1.15	1.04	0.97	0.96	0.86
"1,2-Distearoyl-sn-glycero-3-phosphocholine"	ME1235938	0.37	0.74	3.21	0.29	0.30
15(S)-HETE-d8	ME1235698	1.24	1.30	0.72	0.97	0.70
"16alpha,17-Dihydroxypregn-4-ene-3,20-dione cyclic acetal with 2-furyl methyl ketone"	ME1235710	1.03	1.10	1.03	0.91	0.90
"1,2-Dipentadecanoyl-sn-glycero-3-phosphocholine"	ME1235886	1.32	0.91	0.91	0.90	0.96
1-(2-Amino-4-methylpentanoyl)pyrrolidine-2-carboxylic acid	ME1236004	1.08	0.98	0.92	0.96	1.06
"1-[(2-Chloro-1,3-thiazol-5-yl)methyl]-2-methyl-3-nitroguanidine"	ME1235906	0.77	1.15	1.01	0.72	1.28
"(13E)-labda-7,13-dien-15-ol"	ME1236254	1.07	0.70	1.35	0.93	0.99
1-(2-Cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole	ME1235879	1.22	0.97	0.95	0.96	0.90
11-Oxo-beta-amyrin	ME1235594	1.13	0.97	0.99	0.94	0.96
1-beta-D-Galactosylsphingosine	ME1235919	1.23	0.93	0.95	0.93	0.96
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	ME1235580	0.98	1.01	1.01	1.01	0.98
11beta-PGE2	ME1235057	1.34	1.09	0.87	0.71	0.91
15(S)-HPETE	ME1235688	1.08	0.91	0.93	0.86	1.21
"15-Deoxy-delta-12,14-prostaglandin J2"	ME1235230	1.39	1.14	0.78	0.75	0.86
"1b,3a,7b-Trihydroxy-5b-cholanate"	ME1236026	1.44	0.80	1.11	1.01	0.68

Factors:

F1	Sample source:Brain cortex \| Treatment:cKO \| Genotype:Nexcre/+ NMNAT2f/f
F2	Sample source:Brain cortex \| Treatment:cKO S/+ \| Genotype:Nexcre/+ NMNAT2f/f Sarm1null/+
F3	Sample source:Brain cortex \| Treatment:cKO S/S \| Genotype:Nexcre/+ NMNAT2f/f Sarm1null/null
F4	Sample source:Brain cortex \| Treatment:Ctrl-2 \| Genotype:Nexcre/+ NMNAT2f/+ Sarm1null/+
F5	Sample source:Brain cortex \| Treatment:Ctrl \| Genotype:Nexcre/+ NMNAT2f/+

Data matrix