Clustering data with hclust algorithm for (Study ST004468)
(Analysis AN007491)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IMP | ME1253972 | 0.38 | 0.27 | 5.06 | 0.52 | 4.93 | 0.20 | 0.15 | 0.19 | 0.07 | 0.86 | 0.51 | 0.74 | 0.08 | 0.04 |
| saccharopine | ME1253999 | 0.15 | 0.12 | 3.68 | 4.01 | 3.81 | 0.22 | 0.20 | 0.30 | 0.25 | 0.24 | 0.22 | 0.16 | 0.35 | 0.29 |
| citrate | ME1253944 | NA | NA | NA | NA | NA | NA | NA | 1.34 | 1.33 | 0.35 | 0.31 | 0.30 | 1.76 | 1.61 |
| Fructose.1.6.bisphosphate | ME1253953 | NA | NA | NA | NA | NA | NA | NA | 0.74 | 0.83 | 1.17 | 1.65 | 1.13 | 0.71 | 0.76 |
| NADH | ME1253984 | NA | NA | NA | NA | NA | NA | NA | 0.65 | 0.91 | 1.39 | 1.38 | 1.23 | 0.72 | 0.72 |
| palmitate | ME1253989 | NA | NA | NA | NA | NA | NA | NA | 1.44 | 0.80 | 0.67 | 0.57 | 0.97 | 0.73 | 1.81 |
| Acetyl.CoA | ME1253925 | NA | NA | NA | NA | NA | NA | NA | 0.81 | 1.58 | 0.84 | 0.48 | 0.94 | 1.30 | 1.05 |
| acetylserine | ME1253928 | NA | NA | NA | NA | NA | NA | NA | 0.88 | 1.55 | 0.95 | 0.52 | 1.04 | 0.86 | 1.20 |
| proline | ME1253994 | NA | NA | NA | NA | NA | NA | NA | 0.79 | 1.54 | 0.89 | 0.70 | 1.11 | 0.98 | 0.99 |
| glutamate | ME1253958 | NA | NA | NA | NA | NA | NA | NA | 1.12 | 1.21 | 0.77 | 0.81 | 0.78 | 1.20 | 1.11 |
| phosphocholine | ME1253991 | NA | NA | NA | NA | NA | NA | NA | 1.07 | 1.21 | 0.80 | 0.63 | 0.76 | 1.30 | 1.23 |
| Glycerophosphocholine | ME1253961 | NA | NA | NA | NA | NA | NA | NA | 0.90 | 1.32 | 0.74 | 0.71 | 0.90 | 1.32 | 1.12 |
| NADP | ME1253985 | NA | NA | NA | NA | NA | NA | NA | 0.96 | 1.32 | 0.89 | 0.77 | 0.86 | 1.13 | 1.08 |
| argininosuccinate | ME1253935 | NA | NA | NA | NA | NA | NA | NA | 0.78 | 1.14 | 1.11 | 0.72 | 0.93 | 1.16 | 1.16 |
| fumarate | ME1253954 | NA | NA | NA | NA | NA | NA | NA | 0.83 | 1.25 | 1.14 | 0.62 | 0.98 | 1.08 | 1.11 |
| adenine | ME1253929 | NA | NA | NA | NA | NA | NA | NA | 1.12 | 1.10 | 1.02 | 0.60 | 0.85 | 0.99 | 1.31 |
| guanine | ME1253967 | NA | NA | NA | NA | NA | NA | NA | 0.90 | 1.24 | 1.08 | 0.60 | 0.92 | 0.90 | 1.37 |
| acetylcarnitine | ME1253926 | NA | NA | NA | NA | NA | NA | NA | 1.22 | 0.82 | 0.87 | 0.73 | 1.16 | 0.99 | 1.21 |
| methylthioadenosine | ME1253980 | NA | NA | NA | NA | NA | NA | NA | 1.06 | 1.18 | 1.00 | 0.39 | 1.23 | 0.93 | 1.20 |
| niacinamide | ME1253987 | NA | NA | NA | NA | NA | NA | NA | 1.21 | 1.26 | 0.99 | 0.65 | 1.24 | 0.75 | 0.89 |
| gamma.aminobutyric_acid | ME1253955 | NA | NA | NA | NA | NA | NA | NA | 0.86 | 0.91 | 1.03 | 0.95 | 0.98 | 1.23 | 1.04 |
| GSSG | ME1253965 | NA | NA | NA | NA | NA | NA | NA | 1.01 | 0.98 | 1.12 | 0.95 | 1.12 | 1.01 | 0.81 |
| AMP | ME1253933 | NA | NA | NA | NA | NA | NA | NA | 0.77 | 0.96 | 1.39 | 1.01 | 1.10 | 0.94 | 0.83 |
| carnitine | ME1253942 | NA | NA | NA | NA | NA | NA | NA | 0.79 | 0.96 | 1.21 | 1.02 | 1.15 | 1.01 | 0.87 |
| cystathionine | ME1253948 | NA | NA | NA | NA | NA | NA | NA | 1.26 | 0.69 | 0.90 | 0.92 | 0.67 | 1.29 | 1.27 |
| alanine | ME1253932 | NA | NA | NA | NA | NA | NA | NA | 1.17 | 0.85 | 0.87 | 1.26 | 1.04 | 0.93 | 0.88 |
| histidine | ME1253968 | NA | NA | NA | NA | NA | NA | NA | 1.05 | 1.05 | 0.89 | 1.16 | 0.83 | 1.02 | 1.00 |
| beta.alanine | ME1253940 | NA | NA | NA | NA | NA | NA | NA | 1.11 | 0.89 | 0.90 | 1.13 | 0.89 | 0.96 | 1.10 |
| UDP | ME1254010 | NA | NA | NA | NA | NA | NA | NA | 1.08 | 0.92 | 0.91 | 1.03 | 0.87 | 1.09 | 1.10 |
| 2.hydroxyglutarate | ME1253921 | NA | NA | NA | NA | NA | NA | NA | 1.10 | 1.07 | 0.82 | 1.15 | 0.53 | 1.09 | 1.23 |
| UDP.hexose | ME1254009 | NA | NA | NA | NA | NA | NA | NA | 1.36 | 1.06 | 0.71 | 0.92 | 0.66 | 1.16 | 1.13 |
| acetylglutamate | ME1253927 | NA | NA | NA | NA | NA | NA | NA | 1.21 | 1.09 | 0.74 | 1.06 | 0.81 | 1.11 | 0.97 |
| quinolinic_acid | ME1253996 | NA | NA | NA | NA | NA | NA | NA | 1.32 | 0.99 | 0.73 | 1.00 | 0.85 | 1.10 | 1.01 |
| 2.oxobutyric_acid | ME1253922 | NA | NA | NA | NA | NA | NA | NA | 1.18 | 0.99 | 0.78 | 0.87 | 0.92 | 1.00 | 1.25 |
| ornithine | ME1253988 | NA | NA | NA | NA | NA | NA | NA | 1.06 | 1.07 | 0.75 | 0.93 | 0.71 | 1.09 | 1.38 |
| Butyrylcarnitine | ME1253941 | 1.41 | 1.43 | 0.31 | 0.13 | 0.28 | 1.59 | 1.72 | 0.94 | 1.15 | 1.10 | 0.54 | 1.14 | 1.06 | 1.19 |
| UMP | ME1254011 | 1.12 | 0.61 | 0.34 | 1.20 | 0.35 | 0.92 | 0.78 | 0.83 | 0.94 | 1.59 | 2.09 | 1.47 | 0.75 | 1.03 |
| CDP | ME1253943 | 1.40 | 0.79 | 0.30 | 0.51 | 0.31 | 1.46 | 0.76 | 1.24 | 1.21 | 1.09 | 1.02 | 1.00 | 1.45 | 1.46 |
| UDP.GlcNAc | ME1254008 | 1.18 | 0.89 | 0.13 | 0.30 | 0.13 | 1.10 | 1.08 | 1.68 | 1.42 | 0.78 | 1.03 | 0.68 | 1.85 | 1.76 |
| CTP | ME1253947 | 1.17 | 0.46 | 0.10 | 0.30 | 0.11 | 1.07 | 0.55 | 1.93 | 1.52 | 1.02 | 1.41 | 1.02 | 1.74 | 1.61 |
| UTP | ME1254013 | 1.43 | 0.51 | 0.08 | 0.35 | 0.09 | 1.02 | 0.64 | 2.05 | 1.42 | 0.93 | 1.53 | 0.94 | 1.59 | 1.42 |
| ADP | ME1253930 | 0.45 | 0.63 | 0.63 | 0.14 | 0.61 | 1.04 | 0.83 | 1.04 | 1.58 | 1.51 | 0.84 | 1.44 | 1.63 | 1.62 |
| ATP | ME1253939 | 0.45 | 0.70 | 0.60 | 0.16 | 0.57 | 0.85 | 0.94 | 1.28 | 1.72 | 1.27 | 0.79 | 1.25 | 1.76 | 1.65 |
| asparagine | ME1253936 | 0.46 | 0.53 | 0.38 | 0.50 | 0.42 | 0.46 | 0.50 | 1.73 | 1.63 | 1.21 | 1.38 | 1.15 | 1.81 | 1.84 |
| GDP | ME1253956 | 0.28 | 0.30 | 0.55 | 0.44 | 0.54 | 0.54 | 0.27 | 1.34 | 1.64 | 1.78 | 1.24 | 1.68 | 1.70 | 1.68 |
| GTP | ME1253966 | 0.40 | 0.40 | 0.55 | 0.29 | 0.57 | 0.84 | 0.43 | 1.43 | 1.62 | 1.50 | 1.29 | 1.54 | 1.60 | 1.53 |
| Pyridoxine | ME1253995 | 1.02 | 1.42 | 0.88 | 0.98 | 0.79 | 1.02 | 1.30 | 1.08 | 1.08 | 0.82 | 0.65 | 1.06 | 0.83 | 1.08 |
| tyrosine | ME1254007 | 0.78 | 1.37 | 0.86 | 0.94 | 0.95 | 0.69 | 1.11 | 0.94 | 1.37 | 1.09 | 0.81 | 0.97 | 1.02 | 1.11 |
| Methionine.sulfoxide | ME1253978 | 0.71 | 1.05 | 0.67 | 0.78 | 0.78 | 0.62 | 1.08 | 1.12 | 1.47 | 1.08 | 1.08 | 1.01 | 1.29 | 1.26 |
| NAD | ME1253983 | 0.76 | 1.26 | 0.53 | 0.70 | 0.55 | 0.82 | 1.00 | 1.41 | 1.45 | 0.97 | 1.03 | 0.88 | 1.39 | 1.25 |
| arginine | ME1253934 | 0.87 | 0.60 | 0.51 | 0.69 | 0.64 | 0.70 | 0.90 | 1.50 | 1.40 | 1.06 | 1.22 | 0.99 | 1.43 | 1.49 |
| glutamine | ME1253959 | 0.64 | 0.86 | 0.59 | 0.79 | 0.64 | 0.71 | 0.83 | 1.48 | 1.37 | 1.04 | 1.21 | 0.95 | 1.48 | 1.41 |
| serine | ME1254002 | 0.67 | 0.76 | 0.61 | 0.75 | 0.65 | 0.66 | 0.78 | 1.50 | 1.35 | 0.95 | 1.31 | 0.95 | 1.45 | 1.61 |
| NADPH | ME1253986 | 0.58 | 0.84 | 0.46 | 0.45 | 0.54 | 0.76 | 0.79 | 1.58 | 1.45 | 1.24 | 1.27 | 0.92 | 1.59 | 1.53 |
| S.Adenosyl.L.methionine | ME1253998 | 0.69 | 0.82 | 0.47 | 0.26 | 0.49 | 0.77 | 0.85 | 1.42 | 1.60 | 1.15 | 1.08 | 1.06 | 1.69 | 1.67 |
| isoleucine | ME1253973 | 0.75 | 0.90 | 0.88 | 0.96 | 0.78 | 0.56 | 0.91 | 1.51 | 1.42 | 0.93 | 1.04 | 1.23 | 0.87 | 1.24 |
| lysine | ME1253976 | 0.97 | 0.70 | 0.96 | 1.02 | 0.94 | 0.74 | 0.71 | 1.36 | 1.19 | 0.92 | 1.12 | 0.84 | 1.21 | 1.32 |
| GSH_Ellmans | ME1253964 | 0.80 | 0.97 | 0.91 | 0.91 | 0.89 | 0.98 | 0.92 | 1.16 | 1.19 | 1.08 | 1.02 | 1.07 | 1.08 | 1.03 |
| myo.inositol | ME1253981 | 0.68 | 0.60 | 0.88 | 1.00 | 0.80 | 1.02 | 0.98 | 1.14 | 1.01 | 1.23 | 1.26 | 1.20 | 1.14 | 1.08 |
| dihydroxyacetone_phosphate | ME1253951 | NA | NA | NA | NA | NA | NA | NA | 0.55 | 0.43 | 1.50 | 2.95 | 1.21 | 0.21 | 0.14 |
| phosphoethanolamine | ME1253993 | NA | NA | NA | NA | NA | NA | NA | 1.23 | 0.60 | 0.83 | 3.06 | 0.63 | 0.33 | 0.31 |
| Fructose-6-phosphate/Glucose-1-phosphate/Glucose-6-phosphate | ME1253952 | 0.76 | 0.35 | 0.79 | 0.91 | 0.74 | 0.43 | 0.33 | 0.78 | 0.96 | 2.21 | 2.28 | 2.25 | 0.64 | 0.57 |
| Sedoheptulose.7.phosphate | ME1254001 | 0.04 | 0.11 | 0.97 | 0.42 | 0.86 | 0.10 | 0.09 | 0.64 | 0.99 | 2.96 | 2.90 | 2.80 | 0.56 | 0.55 |
| asymmetric.dimethylarginine (ADMA) | ME1253938 | 0.69 | 0.44 | 1.18 | 2.10 | 1.20 | 0.83 | 0.56 | NA | NA | NA | NA | NA | NA | NA |
| guanidinoacetate | ME1253969 | 0.75 | 0.63 | 1.09 | 1.93 | 1.16 | 0.55 | 0.90 | NA | NA | NA | NA | NA | NA | NA |
| phosphocreatine | ME1253990 | 0.71 | 0.76 | 1.32 | 1.01 | 1.31 | 0.93 | 0.95 | NA | NA | NA | NA | NA | NA | NA |
| threonine | ME1254005 | 0.92 | 1.41 | 0.88 | 1.01 | 0.81 | 0.66 | 1.32 | NA | NA | NA | NA | NA | NA | NA |
| methionine | ME1253979 | 0.82 | 1.31 | 0.97 | 1.09 | 0.91 | 0.71 | 1.19 | NA | NA | NA | NA | NA | NA | NA |
| tryptophan | ME1254006 | 0.86 | 1.24 | 0.97 | 1.11 | 0.92 | 0.74 | 1.18 | NA | NA | NA | NA | NA | NA | NA |
| taurine | ME1254004 | 0.86 | 1.07 | 0.99 | 1.30 | 0.90 | 1.05 | 0.83 | NA | NA | NA | NA | NA | NA | NA |
| hypotaurine | ME1253970 | 0.81 | 1.08 | 0.88 | 1.37 | 0.97 | 0.92 | 0.98 | NA | NA | NA | NA | NA | NA | NA |
| leucine | ME1253975 | 0.87 | 1.16 | 0.95 | 1.29 | 0.96 | 0.73 | 1.05 | NA | NA | NA | NA | NA | NA | NA |
| malate | ME1253977 | 0.90 | 1.42 | 0.59 | 0.35 | 0.69 | 1.47 | 1.58 | NA | NA | NA | NA | NA | NA | NA |
| sarcosine | ME1254000 | 1.23 | 1.11 | 0.65 | 0.84 | 0.68 | 1.46 | 1.52 | NA | NA | NA | NA | NA | NA | NA |
| S.Adenosyl.L.Homocysteine | ME1253997 | 1.00 | 2.03 | 0.47 | 0.47 | 0.61 | 0.87 | 1.55 | NA | NA | NA | NA | NA | NA | NA |
| hypoxanthine | ME1253971 | 0.73 | 1.99 | 0.69 | 0.98 | 0.62 | 0.78 | 1.21 | NA | NA | NA | NA | NA | NA | NA |
| Itaconic.Acid | ME1253974 | 0.89 | 1.76 | 0.75 | 0.74 | 0.93 | 1.03 | 0.90 | NA | NA | NA | NA | NA | NA | NA |
| creatine | ME1253946 | 1.83 | 1.67 | 1.76 | 2.57 | 1.86 | 1.33 | 2.10 | 0.10 | 0.13 | 0.13 | 0.16 | 0.14 | 0.12 | 0.10 |
| N.acetylglutamine | ME1253982 | 1.96 | 2.11 | 1.25 | 2.16 | 1.39 | 1.45 | 2.58 | 0.16 | 0.18 | 0.13 | 0.17 | 0.13 | 0.18 | 0.15 |
| succinate | ME1254003 | 0.80 | 1.56 | 2.13 | 1.19 | 2.28 | 1.05 | 0.82 | 0.61 | 0.60 | 0.55 | 0.67 | 0.45 | 0.64 | 0.64 |
| 3.ureidopropionate | ME1253924 | 1.55 | 1.77 | 1.27 | 1.70 | 1.40 | 1.54 | 1.69 | 0.52 | 0.44 | 0.34 | 0.39 | 0.39 | 0.44 | 0.54 |
| glycine | ME1253962 | 1.47 | 1.59 | 1.39 | 1.44 | 1.19 | 1.31 | 1.37 | 0.71 | 0.59 | 0.47 | 0.69 | 0.49 | 0.64 | 0.64 |
| CMP | ME1253945 | 1.28 | 1.06 | 1.04 | 1.61 | 1.00 | 1.52 | 0.83 | 0.65 | 0.44 | 1.14 | 1.15 | 0.83 | 0.80 | 0.65 |
| Glucose.6.phosphate | ME1253957 | 1.72 | 0.74 | 1.87 | 2.06 | 1.52 | 0.85 | 0.75 | 0.56 | 0.63 | 0.76 | 0.78 | 0.70 | 0.60 | 0.50 |
| aspartate | ME1253937 | 2.33 | 1.27 | 0.16 | 0.14 | 0.14 | 3.37 | 2.89 | 0.68 | 0.55 | 0.16 | 0.21 | 0.15 | 1.04 | 0.92 |
| 3.phosphoglycerate | ME1253923 | 2.88 | 1.57 | 0.69 | 0.68 | 0.55 | 2.19 | 1.19 | 0.73 | 0.55 | 0.74 | 0.81 | 0.67 | 0.42 | 0.35 |
| phosphoenolpyruvate | ME1253992 | 4.11 | 2.01 | 0.30 | 0.41 | 0.28 | 2.62 | 1.83 | 0.56 | 0.28 | 0.34 | 0.46 | 0.29 | 0.27 | 0.24 |
| AICAR | ME1253931 | 1.37 | 0.27 | 1.55 | 0.12 | 2.91 | 2.04 | 0.37 | 0.32 | 0.15 | 0.52 | 0.26 | 2.53 | 1.46 | 0.13 |
| dihydroorotate | ME1253950 | 0.07 | 0.14 | 3.45 | 1.55 | 3.84 | 0.10 | 0.16 | 0.09 | 0.25 | 1.76 | 0.54 | 1.85 | 0.06 | 0.12 |
| Ureidosuccinic_acid | ME1254012 | 0.02 | 0.01 | 3.45 | 1.03 | 2.56 | 0.03 | 0.02 | 0.17 | 0.28 | 2.36 | 1.36 | 2.37 | 0.18 | 0.17 |
| Glycerol.3.Phosphate | ME1253960 | 0.04 | 0.16 | 2.13 | 2.32 | 2.14 | 0.07 | 0.07 | 0.39 | 0.60 | 1.78 | 2.13 | 1.70 | 0.23 | 0.22 |
| D.RIBOSE.5.PHOSPHATE | ME1253949 | 0.40 | 0.39 | 1.46 | 1.70 | 1.43 | 0.31 | 0.30 | 1.24 | 0.95 | 1.19 | 2.16 | 1.05 | 0.64 | 0.81 |
| GMP | ME1253963 | 0.19 | 0.35 | 1.81 | 2.48 | 1.54 | 0.36 | 0.33 | 0.84 | 0.79 | 1.34 | 1.17 | 1.17 | 0.83 | 0.82 |
Factors:
| F1 | Sample source:NALM6 leukemia cells | treatment:6MP |
| F2 | Sample source:NALM6 leukemia cells | treatment:ADDA5 |
| F3 | Sample source:NALM6 leukemia cells | treatment:BCS |
| F4 | Sample source:NALM6 leukemia cells | treatment:BCS+6MP |
| F5 | Sample source:NALM6 leukemia cells | treatment:BCS+MTX |
| F6 | Sample source:NALM6 leukemia cells | treatment:MTX |
| F7 | Sample source:NALM6 leukemia cells | treatment:Vehicle |
| F8 | Sample source:SEM leukemia cells | treatment:6MP |
| F9 | Sample source:SEM leukemia cells | treatment:ADDA5 |
| F10 | Sample source:SEM leukemia cells | treatment:BCS |
| F11 | Sample source:SEM leukemia cells | treatment:BCS+6MP |
| F12 | Sample source:SEM leukemia cells | treatment:BCS+MTX |
| F13 | Sample source:SEM leukemia cells | treatment:MTX |
| F14 | Sample source:SEM leukemia cells | treatment:Vehicle |
