Clustering data with hclust algorithm for Disruption of Zinc homeostasis can impair maternal glucocorticoid metabolism: consequences on the developing fetus (Study ST000120)
UPLC-MS/MS (Analysis AN000202)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 | F19 | F20 | F21 | F22 | F23 | F24 | F25 | F26 | F27 | F28 | F29 | F30 | F31 | F32 | F33 | F34 | F35 | F36 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estrone | ME681477 | 0.89 | 4.53 | 7.44 | 0.67 | NA | NA | NA | NA | 0.41 | 1.09 | 0.11 | 0.70 | 0.07 | 0.11 | 0.12 | 0.10 | 1.35 | 3.16 | 1.22 | 11.62 | 0.18 | 0.07 | 0.10 | 0.10 | 0.08 | 0.08 | 0.11 | 0.09 | 0.02 | 0.02 | 0.02 | 0.01 | 0.04 | 0.06 | 0.09 | 0.03 |
| Cortexolone | ME681469 | NA | NA | NA | NA | NA | NA | NA | NA | 0.16 | 0.04 | 0.02 | 0.01 | 0.25 | 0.25 | 0.16 | 0.51 | 0.38 | 0.13 | 0.17 | 0.19 | 0.71 | 0.16 | 0.31 | 0.60 | 0.06 | 0.04 | 0.02 | 0.04 | 0.85 | 1.07 | 0.90 | 0.87 | 4.59 | 2.74 | 3.75 | 3.60 |
| 17-hydroxyprogesterone | ME681468 | NA | NA | NA | NA | NA | NA | NA | NA | 1.07 | 1.27 | 1.65 | 0.95 | 0.30 | 0.38 | 0.52 | 0.46 | 1.55 | 1.06 | 1.19 | 1.86 | 0.66 | 0.30 | 0.64 | 0.47 | 0.42 | 0.63 | 0.33 | 0.42 | 2.42 | 1.29 | 2.37 | 1.31 | 0.35 | 3.03 | 0.20 | 0.28 |
| Estradiol | ME681478 | 1.95 | 2.49 | 4.28 | 0.63 | NA | NA | NA | NA | 0.26 | 0.54 | 0.26 | 0.22 | 0.32 | 0.30 | 0.56 | 1.23 | 0.41 | 0.89 | 0.36 | 1.40 | 0.26 | 0.18 | 1.34 | 0.43 | 1.89 | 0.93 | 5.21 | 0.48 | 0.50 | 0.20 | 0.22 | 0.18 | 0.83 | 1.06 | 2.18 | 0.67 |
| 17-hydroxypregnenolone | ME681465 | 4.00 | 1.99 | 4.98 | 3.77 | NA | NA | NA | NA | 0.07 | 0.08 | 0.06 | 0.08 | 0.16 | 0.15 | 0.13 | 0.35 | 0.21 | 0.41 | 0.24 | 0.25 | 0.39 | 0.26 | 0.16 | 0.23 | 0.94 | 0.28 | 0.42 | 0.39 | 3.09 | 1.00 | 3.40 | 0.84 | 0.20 | 0.15 | 0.14 | 0.12 |
| Allodihydrotestosterone | ME681476 | 1.88 | 2.17 | 2.45 | 1.31 | NA | NA | NA | NA | 1.15 | 2.20 | 0.91 | 1.05 | NA | NA | NA | NA | 1.23 | 1.10 | 0.72 | 1.06 | NA | NA | NA | NA | 0.25 | 0.20 | 0.27 | 0.32 | 0.26 | 0.18 | 0.30 | 0.23 | NA | NA | NA | NA |
| Androstenedione | ME681474 | 3.28 | 3.97 | 3.69 | 2.90 | NA | NA | NA | NA | NA | NA | NA | NA | 0.59 | 0.36 | 0.55 | 0.31 | NA | NA | NA | NA | 0.57 | 0.29 | 0.82 | 0.25 | 0.18 | 0.19 | 0.23 | 0.08 | 0.60 | 0.37 | 0.58 | 0.37 | 0.93 | 1.26 | 0.82 | 0.85 |
| Androstenolone (DHEA) | ME681466 | 2.07 | 2.13 | 2.35 | 1.75 | NA | NA | NA | NA | 0.44 | 0.58 | 0.28 | 0.75 | 0.90 | 1.00 | 1.67 | 1.07 | 0.57 | 2.20 | 0.48 | 0.74 | 1.27 | 0.70 | 0.76 | 0.62 | 0.36 | 0.16 | 0.30 | 0.52 | 1.03 | 1.55 | 0.60 | 1.08 | 1.29 | 1.06 | 0.83 | 0.97 |
| Testosterone | ME681475 | 2.90 | 2.76 | 2.19 | 1.79 | NA | NA | NA | NA | 0.96 | 0.72 | 0.34 | 0.26 | 2.28 | 0.23 | 0.09 | 0.21 | 1.64 | 1.38 | 1.20 | 1.11 | 0.38 | 0.23 | 0.37 | 0.33 | 0.46 | 0.35 | 0.25 | 0.18 | 0.70 | 0.51 | 0.66 | 0.50 | 1.97 | 1.44 | 1.50 | 0.95 |
| Cortisol | ME681470 | 2.19 | 1.44 | 2.30 | 13.53 | NA | NA | NA | NA | 0.83 | 0.44 | NA | 0.82 | 0.06 | 0.02 | 0.07 | 0.10 | 0.84 | 0.26 | 0.23 | 0.47 | 0.22 | 0.29 | 0.34 | 0.16 | 0.75 | 0.36 | 0.35 | 0.32 | 0.23 | 0.07 | 0.18 | 0.28 | 0.63 | 0.61 | 0.39 | 0.10 |
| Cortisone | ME681479 | 5.44 | 5.25 | 17.73 | 5.90 | NA | NA | NA | NA | 0.26 | 0.31 | 0.62 | 0.27 | 0.60 | 0.05 | 0.64 | 0.86 | 0.41 | 0.24 | 0.15 | 0.24 | 0.45 | 0.13 | 0.57 | 0.42 | 0.36 | 0.32 | 0.21 | 0.20 | 0.15 | 0.38 | 0.20 | 0.22 | 0.30 | 0.08 | 0.83 | 0.23 |
| Aldosterone | ME681473 | 6.39 | 8.34 | 6.08 | 9.31 | NA | NA | NA | NA | 0.02 | 0.01 | 0.01 | 0.01 | 0.05 | 0.02 | 0.03 | 0.04 | 0.03 | 0.02 | 0.02 | 0.02 | 0.05 | 0.02 | 0.04 | 0.04 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.02 | 0.03 | 0.01 | 0.02 | 0.03 |
| Cortexone | ME681471 | 8.69 | 3.82 | 11.38 | 6.82 | NA | NA | NA | NA | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.02 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.01 | 0.00 | 0.01 |
| Corticosterone, DOC | ME681472 | 8.84 | 5.99 | 7.82 | 7.88 | NA | NA | NA | NA | 0.01 | 0.00 | 0.01 | 0.01 | 0.04 | 0.04 | 0.04 | 0.05 | 0.01 | 0.01 | 0.01 | 0.01 | 0.06 | 0.03 | 0.04 | 0.05 | 0.00 | 0.00 | 0.00 | 0.00 | 0.04 | 0.03 | 0.04 | 0.04 | 0.02 | 0.02 | 0.02 | 0.02 |
| Progesterone | ME681467 | 8.89 | 6.20 | 8.57 | 7.49 | NA | NA | NA | NA | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.02 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 |
| 11-Dehydrocorticosterone | ME681480 | 9.04 | 4.59 | 7.45 | 6.55 | NA | NA | NA | NA | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.01 | 0.00 | 0.00 | 0.00 | 0.00 | 0.03 | 0.02 | 0.03 | 0.03 | 0.10 | 0.07 | 0.07 | 0.07 |
| Pregnenolone | ME681464 | 9.19 | 4.27 | 7.79 | 5.51 | NA | NA | NA | NA | 0.10 | 0.04 | 0.05 | 0.05 | 0.28 | 0.36 | 0.31 | 0.22 | 0.07 | 0.08 | 0.06 | 0.03 | 0.42 | 0.27 | 0.29 | 0.27 | 0.05 | 0.03 | 0.04 | 0.03 | 0.01 | 0.01 | 0.01 | 0.01 | 0.03 | 0.02 | 0.02 | 0.02 |
Factors:
| F1 | Tissue/Fluid:Adrenal gland | Treatment:Control |
| F2 | Tissue/Fluid:Adrenal gland | Treatment:Control + DEHP |
| F3 | Tissue/Fluid:Adrenal gland | Treatment:Marginal Zinc deficient |
| F4 | Tissue/Fluid:Adrenal gland | Treatment:Marginal Zinc deficient + DEHP |
| F5 | Tissue/Fluid:Amniotic fluid | Treatment:Control |
| F6 | Tissue/Fluid:Amniotic fluid | Treatment:Control + DEHP |
| F7 | Tissue/Fluid:Amniotic fluid | Treatment:Marginal Zinc deficient |
| F8 | Tissue/Fluid:Amniotic fluid | Treatment:Marginal Zinc deficient + DEHP |
| F9 | Tissue/Fluid:Fetal Female brain | Treatment:Control |
| F10 | Tissue/Fluid:Fetal Female brain | Treatment:Control + DEHP |
| F11 | Tissue/Fluid:Fetal Female brain | Treatment:Marginal Zinc deficient |
| F12 | Tissue/Fluid:Fetal Female brain | Treatment:Marginal Zinc deficient + DEHP |
| F13 | Tissue/Fluid:Fetal Female Liver | Treatment:Control |
| F14 | Tissue/Fluid:Fetal Female Liver | Treatment:Control + DEHP |
| F15 | Tissue/Fluid:Fetal Female Liver | Treatment:Marginal Zinc deficient |
| F16 | Tissue/Fluid:Fetal Female Liver | Treatment:Marginal Zinc deficient + DEHP |
| F17 | Tissue/Fluid:Fetal Male brain | Treatment:Control |
| F18 | Tissue/Fluid:Fetal Male brain | Treatment:Control + DEHP |
| F19 | Tissue/Fluid:Fetal Male brain | Treatment:Marginal Zinc deficient |
| F20 | Tissue/Fluid:Fetal Male brain | Treatment:Marginal Zinc deficient + DEHP |
| F21 | Tissue/Fluid:Fetal Male Liver | Treatment:Control |
| F22 | Tissue/Fluid:Fetal Male Liver | Treatment:Control + DEHP |
| F23 | Tissue/Fluid:Fetal Male Liver | Treatment:Marginal Zinc deficient |
| F24 | Tissue/Fluid:Fetal Male Liver | Treatment:Marginal Zinc deficient + DEHP |
| F25 | Tissue/Fluid:Maternal Liver | Treatment:Control |
| F26 | Tissue/Fluid:Maternal Liver | Treatment:Control + DEHP |
| F27 | Tissue/Fluid:Maternal Liver | Treatment:Marginal Zinc deficient |
| F28 | Tissue/Fluid:Maternal Liver | Treatment:Marginal Zinc deficient + DEHP |
| F29 | Tissue/Fluid:Maternal plasma | Treatment:Control |
| F30 | Tissue/Fluid:Maternal plasma | Treatment:Control + DEHP |
| F31 | Tissue/Fluid:Maternal plasma | Treatment:Marginal Zinc deficient |
| F32 | Tissue/Fluid:Maternal plasma | Treatment:Marginal Zinc deficient + DEHP |
| F33 | Tissue/Fluid:Placenta | Treatment:Control |
| F34 | Tissue/Fluid:Placenta | Treatment:Control + DEHP |
| F35 | Tissue/Fluid:Placenta | Treatment:Marginal Zinc deficient |
| F36 | Tissue/Fluid:Placenta | Treatment:Marginal Zinc deficient + DEHP |
