Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Metabolomic analysis of normal and diabetic mouse bone marrow under PBS or metformin treatment (Study ST000164)

ESI positive ion mode (Analysis AN000256)

Metabolite	Structure	F1	F2	F3	F4
Metformin	ME696771	1.67	0.07	2.35	0.08
Cer(d18:0/17:0)	ME696887	1.42	0.63	0.59	1.46
L-Homocysteic acid	ME696780	1.63	0.46	0.67	1.41
Aminoadipic acid	ME696817	0.10	0.79	1.35	1.54
N1-Acetylspermidine	ME696843	0.30	0.75	1.67	1.10
DL-2-Aminoadipic acid	ME696833	0.95	1.28	0.57	1.19
Acetylcarnitine	ME696802	0.83	1.51	0.60	1.02
Ribose 5-phosphate	ME696914	0.88	1.42	0.66	1.06
Sucrose	ME696874	0.53	1.53	0.62	0.96
Glyceraldehyde 3-phosphate	ME696790	0.50	1.73	0.66	0.96
N-acetylaspartate	ME696801	0.38	1.77	0.77	0.93
Homovanillic acid	ME696795	0.76	1.81	0.33	0.92
CMP	ME696853	0.91	1.79	0.50	0.78
Pyridoxate	ME696868	0.79	1.72	0.64	0.85
Cysteineglutathione disulfide	ME696882	1.05	0.60	1.64	0.72
Agmatine	ME696818	1.35	0.61	1.09	1.03
Kynuramine	ME696784	1.50	0.82	0.99	0.82
Psychosine	ME696821	1.25	0.82	1.10	0.89
N-Acetylcadaverine	ME696778	1.29	0.85	1.18	0.75
PS(19:0/0:0)	ME696787	1.21	0.75	1.24	0.83
N2-Acetyl-L-ornithine	ME696960	1.06	1.14	0.84	0.98
Diethanolamine	ME696945	1.05	1.14	0.89	0.93
Glucosamine 1-phosphate	ME696910	1.02	1.16	0.91	0.92
Glycerol	ME696956	0.93	1.29	0.83	0.95
Ketoleucine	ME696922	0.98	1.19	0.81	1.01
Hexanoylcarnitine	ME696986	1.07	1.06	0.81	1.08
Selenocysteine	ME696916	0.95	1.13	0.84	1.07
Kynurenic acid	ME696917	0.95	1.07	0.89	1.08
Biotin	ME696913	0.90	1.11	0.90	1.06
DG(17:1(9Z)/17:1(9Z)/0:0)	ME696850	0.93	1.10	0.93	1.03
Hydroxy butyric acid	ME696837	0.82	1.34	0.89	0.91
Betaine aldehyde	ME696806	0.84	1.20	0.95	0.97
Cadaverine	ME696788	0.74	1.27	0.93	1.00
Formimino-L-glutamic acid	ME696838	0.80	1.25	0.86	1.05
ADMA	ME696886	0.76	1.03	1.06	1.09
Histamine	ME696847	0.79	1.04	1.02	1.10
Allantoate	ME696873	0.83	1.04	0.93	1.16
Creatine	ME696883	0.82	1.07	0.90	1.16
UMP	ME696901	0.76	1.12	0.93	1.13
Valine	ME696797	0.73	1.10	0.98	1.13
Anthranilic acid	ME696849	0.76	1.13	0.98	1.07
Phosphoric acid	ME696859	0.82	1.12	0.94	1.08
Glycerylphosphorylethanolamine	ME696826	0.80	1.12	0.93	1.10
H2O4S	ME696851	0.81	1.13	0.92	1.09
Imidazoleacetic acid	ME696830	0.77	1.31	0.75	1.11
Acetyl-L-serine	ME696799	0.70	1.25	0.86	1.11
Lauric acid	ME696779	0.73	1.24	0.82	1.13
Proline	ME696845	0.69	1.15	0.88	1.20
Biotin amide	ME696860	0.77	1.17	0.83	1.17
Choline	ME696804	0.74	1.18	0.90	1.12
4-Hydroxypyridine	ME696800	0.77	1.12	1.13	0.92
Gamma-Butyrolactone	ME696894	0.83	1.16	1.06	0.91
Docosanamide	ME696976	0.96	1.00	1.18	0.85
N-Methylurea	ME696981	1.00	0.98	1.14	0.88
Glycocholic Acid	ME696980	0.99	1.06	1.07	0.87
Methylglutarylcarnitine	ME696979	1.00	1.03	1.09	0.88
C-2 Ceramide	ME696959	1.01	1.07	1.13	0.79
Skatole	ME696970	0.99	1.05	1.14	0.82
Octanoylcarnitine	ME696912	1.22	1.05	1.03	0.75
Methyl-L-histidine	ME696852	1.17	0.95	1.09	0.83
Glyceric acid	ME696942	1.11	0.97	1.02	0.93
N-Acetyl-DL-methionine	ME696933	1.11	1.06	1.00	0.86
Citrulline	ME696903	1.04	0.77	1.20	1.00
Histidinal	ME696968	0.94	0.87	1.17	1.00
3-Methyl-2-oxovaleric acid	ME696950	1.02	0.92	1.11	0.96
Uric acid	ME696954	1.02	0.89	1.13	0.97
Pantoic acid	ME696939	0.89	0.97	1.10	1.01
Aspartic acid b-semialdehyde	ME696987	0.93	0.93	1.10	1.03
Sarcosine	ME696957	0.91	0.95	1.10	1.02
Betaine	ME696834	0.82	1.02	1.07	1.04
Carnosine	ME696902	0.90	0.99	1.04	1.04
Hydroxy-L-glutamic acid	ME696831	0.86	0.99	1.05	1.07
Thymine	ME696889	0.92	1.04	1.08	0.94
Coumaric acid	ME696915	0.90	1.02	1.10	0.96
Histidinol	ME696895	0.87	1.04	1.10	0.96
2-Methylbutyroylcarnitine	ME696863	0.89	1.11	1.02	0.95
Isovaleric acid	ME696890	0.92	1.06	1.02	0.97
Pyridoxal (Vitamin B6)	ME696931	0.89	1.07	0.99	1.02
Isobutyryl-L-carnitine	ME696904	0.94	1.04	0.95	1.05
Xylitol	ME696832	0.95	1.05	0.98	1.01
progesterone	ME696966	0.99	1.04	0.99	0.98
DG(17:2(9Z,12Z)/18:0/0:0)	ME696928	0.95	1.01	1.02	1.01
Phospho-L-serine	ME696935	0.96	1.02	1.02	0.99
Butyric acid	ME696948	0.99	1.03	1.05	0.93
Dopamine	ME696983	0.99	0.98	1.05	0.97
Pyridoxamine	ME696949	1.01	0.91	1.03	1.06
Quinic acid	ME696978	0.95	0.92	1.01	1.11
Cholic acid	ME696977	0.96	0.97	0.97	1.09
PC(16:0/5:1(4E))	ME696929	1.00	0.93	0.98	1.09
N-Acetyl-L-glutamic acid	ME696975	1.00	0.93	0.93	1.15
Tryptophol	ME696923	0.98	0.93	0.94	1.14
Phosphorylcholine	ME696965	1.02	0.99	0.90	1.10
Testosterone	ME696963	1.04	0.97	0.90	1.10
4-Guanidinobutanoic acid	ME696807	1.09	0.96	0.92	1.05
Retinoic acid	ME696947	1.04	0.99	0.98	1.01
4-Guanidinobutanamide	ME696861	1.09	0.98	0.94	1.01
Pantothenic Acid	ME696905	1.07	0.97	0.96	1.01
4-Aminobutyraldehyde	ME696941	1.01	1.09	0.95	0.96
Serotonin	ME696946	1.06	1.03	0.98	0.94
Arachidonic Acid	ME696958	1.07	0.94	0.75	1.26
Ribitol	ME696892	1.21	0.81	0.93	1.10
AMP	ME696899	1.16	0.81	0.88	1.18
Trigonelline	ME696785	1.18	0.86	0.86	1.14
GMP	ME696898	0.85	1.12	0.74	1.25
24,25-hydroxyvitamin D3	ME696927	0.92	0.83	0.88	1.35
NAD	ME696973	0.80	0.85	0.84	1.46
O-Phosphorylethanolamine	ME696937	0.76	0.88	0.96	1.34
Aminopropanol	ME696952	0.83	0.88	0.88	1.37
Guanidineacetic acid	ME696967	0.81	0.87	0.91	1.36
CMP-N-acetylneuraminic acid	ME696920	0.80	0.96	0.82	1.37
UDP	ME696896	0.79	1.02	0.77	1.36
UDP-N-acetyl-D-galactosamine	ME696862	0.78	1.00	0.80	1.37
Arachidonoyl Ethanolamide	ME696926	0.93	1.00	0.84	1.20
IMP	ME696951	0.89	0.95	0.81	1.32
CDP-ethanolamine	ME696936	0.86	0.94	0.86	1.30
ADP-ribose	ME696940	0.88	0.99	0.84	1.25
UDP-D-galactose	ME696938	0.88	0.97	0.84	1.28
Caprylic acid	ME696879	1.05	0.68	1.13	1.16
LysoPE	ME696924	0.96	0.87	0.95	1.22
Inosine	ME696918	0.89	0.84	1.01	1.23
Selenium Sulfide	ME696985	0.86	0.86	1.01	1.23
Malonylcarnitine	ME696984	0.86	0.87	1.07	1.17
Sphinganine	ME696953	0.91	0.87	1.07	1.13
Distearyl phosphatidyl ethanolamine	ME696907	0.64	1.11	0.76	1.40
Cytosine	ME696786	0.63	1.24	0.84	1.20
Ergothioneine	ME696789	0.58	1.22	0.79	1.30
Na-Acetyl-L-glutamine	ME696794	0.55	1.18	0.83	1.33
Glutathione	ME696836	0.61	1.18	0.85	1.27
Glutathione, oxidized	ME696881	0.64	1.14	0.82	1.31
Glycine	ME696880	0.59	1.04	0.91	1.36
N-Acryloylglycine	ME696844	0.55	1.06	0.97	1.31
Propionyl-L-carnitine	ME696809	0.50	1.06	1.00	1.32
Phosphocholine	ME696792	0.64	1.15	0.95	1.17
Histidine	ME696829	0.58	1.17	0.96	1.19
N-Acetylserotonin	ME696825	0.56	1.13	0.99	1.21
Threonine	ME696869	0.64	1.09	0.98	1.21
Lysine	ME696841	0.61	1.04	1.04	1.22
Aspartate	ME696805	0.59	1.05	1.01	1.25
Glutamine	ME696866	0.61	1.06	1.01	1.23
Erythritol	ME696814	0.62	1.01	0.98	1.30
Asparagine	ME696877	0.67	0.99	0.98	1.27
Niacinamide	ME696824	0.69	1.01	0.99	1.23
Taurine	ME696812	0.69	1.02	0.99	1.23
Alanine	ME696842	0.69	1.10	0.94	1.18
Aminoethylphosphonic acid	ME696822	0.72	1.05	0.96	1.20
Glucose	ME696777	0.67	1.10	0.90	1.24
Hydroxyhydroquinone	ME696793	0.64	1.11	0.92	1.24
Acetylcholine	ME696810	0.62	1.10	0.91	1.28
Ne-Methyl-L-lysine	ME696773	0.60	1.06	0.94	1.29
Phenylalanine	ME696835	0.55	1.06	1.10	1.18
Serine	ME696846	0.57	1.02	1.10	1.20
Methionine	ME696848	0.56	1.12	1.08	1.13
Isoleucine	ME696855	0.63	1.09	1.10	1.09
N-Carbamoylputrescine	ME696854	0.61	1.08	1.09	1.11
Glucose 6-phosphate	ME696870	0.64	1.26	0.98	1.06
Tryptophan	ME696865	0.61	1.19	1.08	1.01
Methylhistamine	ME696781	0.53	1.21	1.06	1.09
Tyrosine	ME696839	0.59	1.19	1.00	1.11
Putrescine	ME696828	0.42	1.40	1.01	1.02
Cysteine	ME696813	0.39	1.31	0.82	1.25
Pyrrolidone-5-carboxylic acid	ME696803	0.55	1.43	0.75	1.16
Glutamate	ME696798	0.62	1.35	0.81	1.13
Cytidine	ME696876	0.65	1.35	0.85	1.07
Glycerophosphocholine	ME696816	0.60	1.38	0.84	1.08
Thiamine	ME696820	0.51	0.94	1.32	1.07
Tyramine	ME696856	0.71	1.00	1.31	0.91
Glutamic acid g-semialdehyde	ME696972	0.80	0.83	1.25	1.07
Cystathionine	ME696944	0.79	0.92	1.19	1.06
N-Acetyl-L-alanine	ME696925	0.78	0.97	1.22	0.98
Deoxycytosine	ME696906	0.76	0.86	1.15	1.16
Arginine	ME696872	0.61	0.98	1.18	1.13
2-Pyrrolidinone	ME696819	0.70	0.95	1.16	1.12
Homoserine	ME696885	0.70	0.95	1.15	1.12
Trigonellinamide	ME696772	0.53	0.96	0.93	1.47
1-Linoleoylglycerophosphocholine	ME696864	0.53	0.75	1.06	1.54
PC(16:0/0:0)	ME696867	0.49	0.76	1.09	1.53
Carnitine	ME696858	0.51	0.78	1.21	1.38
PC(20:4(5Z,8Z,11Z,14Z)/0:0)	ME696811	0.55	0.80	1.13	1.41
3-Hydroxy-L-proline	ME696888	0.66	0.89	1.04	1.32
CDPcholine	ME696871	0.65	0.90	1.01	1.36
Hypoxanthine	ME696932	0.67	0.82	1.09	1.34
PC(18:1(9Z)/0:0)[U] / PC(18:1(9Z)/0:0)[rac]	ME696897	0.62	0.79	1.13	1.36
Benzoic acid	ME696961	0.62	0.81	1.26	1.20
Hypotaurine	ME696791	0.55	0.92	1.16	1.27
Hydroxylysine	ME696955	0.90	1.05	1.30	0.72
Hydrogen selenide	ME696857	0.76	1.32	1.14	0.72
N-Acetylputrescine	ME696919	0.82	1.22	1.27	0.65
Succinate	ME696776	0.68	1.55	0.86	0.82
Urocanic acid	ME696815	0.70	1.45	1.01	0.77
Succinic acid semialdehyde	ME696884	0.93	1.25	0.96	0.85
N-Acetylneuraminic Acid	ME696930	1.07	1.37	0.91	0.67
Sulfite	ME696900	1.04	1.28	0.90	0.78
Dethiobiotin	ME696911	0.89	1.54	0.79	0.76
Methylcytidine	ME696908	0.93	1.46	0.97	0.62
Spermine	ME696827	1.22	1.50	0.84	0.49
Cyclic CMP	ME696971	1.35	1.29	0.61	0.83
N,N^-Dimethylurea	ME696921	1.26	1.09	0.88	0.84
Arabitol	ME696878	0.34	1.37	0.32	1.81
Butyryl-L-carnitine	ME696774	0.44	1.35	0.59	1.49
Ornithine	ME696782	0.51	1.18	0.60	1.59
7-ketocholesterol	ME696909	0.74	0.29	0.82	2.08
Stearoylcarnitine	ME696796	0.28	0.60	0.84	2.10
Cholecalciferol	ME696974	0.64	0.52	0.95	1.80
PC(24:0/0:0)	ME696808	0.70	0.45	0.96	1.73
Palmitoyl-L-carnitine	ME696775	0.47	0.77	0.86	1.77
delta-Tocopherol	ME696943	0.56	0.63	0.96	1.74
Mevalonic acid	ME696875	0.49	0.63	0.97	1.77
Cer(d18:0/13:0)	ME696969	0.80	0.70	0.57	1.88
N-Palmitoylsphingosine	ME696964	0.93	0.71	0.58	1.76
Linoleyl carnitine	ME696891	0.53	0.73	0.61	2.01
Dodecanoylcarnitine	ME696893	0.57	0.68	0.78	1.86
Elaidic carnitine	ME696962	0.67	0.73	0.70	1.81
Guanine	ME696988	1.02	1.01	0.46	1.51
PS(22:1(11Z)/0:0)	ME696823	0.99	0.55	0.83	1.63
PC(10:0/11:0)[U]	ME696840	1.02	0.60	0.89	1.50
PC(10:0/13:0)[U]	ME696783	1.01	0.59	0.98	1.39
Adenosine	ME696982	0.76	0.74	0.84	1.60
Cer(d18:0/16:0)	ME696934	0.99	0.78	0.70	1.51

Factors:

F1	Mice health condition:MKR \| Treatment:Metformin
F2	Mice health condition:MKR \| Treatment:PBS buffer
F3	Mice health condition:wild type \| Treatment:Metformin
F4	Mice health condition:wild type \| Treatment:PBS buffer

Data matrix