Clustering data with hclust algorithm for Isocitrate dehydrogenase-1/Glioma Fluxomics Study (Study ST000302)
GCMS(FAMES) Positive mode (Analysis AN000481)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FA_16:1_Me_13C_1 | ME108546 | 0.16 | 0.22 | 0.78 | 3.75 | 1.12 | 1.18 | 0.25 | 1.89 | 0.74 | 0.78 | 1.19 | 1.89 |
| FA_18:1_Me_13C_1 | ME108568 | 0.47 | 0.98 | 0.46 | 0.41 | 1.02 | 1.06 | 0.96 | 1.12 | 1.06 | 1.35 | 1.09 | 2.14 |
| FA_14:0_Me | ME108523 | 0.95 | 1.68 | 0.47 | 0.73 | 0.99 | 0.84 | 1.17 | 1.31 | 0.67 | 1.26 | 0.67 | 1.34 |
| FA_16:1_Me | ME108545 | 0.67 | 1.32 | 0.66 | 0.50 | 1.00 | 0.71 | 1.19 | 1.32 | 1.17 | 1.65 | 0.73 | 1.28 |
| FA_18:1_Me | ME108567 | 0.77 | 1.13 | 0.72 | 0.71 | 0.93 | 0.76 | 1.19 | 1.29 | 1.09 | 1.43 | 0.86 | 1.25 |
| FA_16:0_Me | ME108534 | 0.82 | 1.46 | 0.55 | 0.71 | 0.87 | 0.71 | 1.24 | 1.36 | 0.90 | 1.52 | 0.76 | 1.26 |
| FA_18:0_Me | ME108556 | 0.83 | 1.32 | 0.63 | 0.74 | 0.85 | 0.69 | 1.28 | 1.38 | 0.95 | 1.50 | 0.77 | 1.23 |
| FA_16:1_Me_13C_10 | ME108555 | NA | NA | 0.49 | NA | 0.49 | 1.12 | NA | NA | 0.17 | NA | 0.74 | 3.00 |
| FA_18:0_Me_13C_5 | ME108561 | NA | NA | 0.89 | 0.04 | 1.55 | 1.34 | NA | NA | 1.12 | 0.06 | 1.28 | 1.39 |
| FA_14:0_Me_13C_3 | ME108526 | NA | NA | 0.92 | 0.11 | 2.02 | 1.18 | NA | NA | 1.23 | 0.09 | 0.88 | 0.97 |
| FA_16:1_Me_13C_3 | ME108548 | NA | NA | 0.50 | NA | 1.55 | 1.33 | NA | NA | 1.13 | NA | 1.01 | 0.82 |
| FA_18:1_Me_13C_9 | ME108576 | NA | NA | 0.83 | NA | 1.05 | 1.15 | NA | NA | 0.76 | NA | 1.34 | 0.88 |
| FA_18:1_Me_13C_5 | ME108572 | NA | NA | 0.64 | NA | 1.35 | 1.43 | NA | NA | 0.66 | NA | 1.23 | 0.70 |
| FA_18:1_Me_13C_6 | ME108573 | NA | NA | 0.70 | NA | 1.18 | 1.35 | NA | NA | 0.62 | NA | 1.18 | 0.97 |
| FA_18:1_Me_13C_4 | ME108571 | NA | NA | 0.51 | NA | 1.11 | 1.44 | NA | NA | 0.56 | NA | 1.15 | 1.23 |
| FA_18:1_Me_13C_7 | ME108574 | NA | NA | 0.68 | NA | 1.05 | 1.23 | NA | NA | 0.51 | NA | 1.14 | 1.39 |
| FA_16:1_Me_13C_4 | ME108549 | NA | NA | 0.65 | NA | 1.37 | 1.18 | NA | NA | 0.73 | NA | 1.00 | 1.08 |
| FA_16:1_Me_13C_6 | ME108551 | NA | NA | 0.72 | NA | 1.29 | 1.09 | NA | NA | 0.81 | NA | 0.95 | 1.15 |
| FA_16:1_Me_13C_5 | ME108550 | NA | NA | 0.73 | NA | 1.10 | 1.09 | NA | NA | 0.82 | NA | 1.06 | 1.20 |
| FA_16:1_Me_13C_8 | ME108553 | NA | NA | 0.81 | NA | 1.20 | 0.96 | NA | NA | 0.83 | NA | 1.02 | 1.17 |
| FA_18:1_Me_13C_10 | ME108577 | NA | NA | 0.82 | NA | 1.04 | 1.09 | NA | NA | 0.73 | NA | 1.19 | 1.13 |
| FA_18:1_Me_13C_8 | ME108575 | NA | NA | 0.77 | NA | 1.09 | 1.22 | NA | NA | 0.62 | NA | 1.09 | 1.20 |
| FA_14:0_Me_13C_9 | ME108532 | NA | NA | 1.08 | NA | 1.05 | 1.01 | NA | NA | 1.22 | NA | 0.78 | 0.85 |
| FA_16:1_Me_13C_7 | ME108552 | NA | NA | 0.87 | NA | 1.16 | 0.78 | NA | NA | 1.06 | NA | 0.89 | 1.24 |
| FA_16:1_Me_13C_9 | ME108554 | NA | NA | 0.72 | NA | 0.98 | 0.83 | NA | NA | 1.06 | NA | 0.90 | 1.50 |
| FA_16:0_Me_13C_10 | ME108544 | NA | 0.11 | 1.68 | 0.23 | 1.62 | 1.02 | NA | 0.15 | 1.65 | 0.70 | 1.32 | 1.43 |
| FA_16:0_Me_13C_9 | ME108543 | NA | 0.09 | 1.67 | 0.21 | 1.64 | 1.03 | NA | 0.12 | 1.70 | 0.59 | 1.34 | 1.47 |
| FA_16:0_Me_13C_4 | ME108538 | NA | 0.01 | 1.34 | 0.05 | 2.19 | 1.55 | NA | 0.01 | 1.63 | 0.07 | 1.44 | 1.41 |
| FA_18:0_Me_13C_10 | ME108566 | NA | 0.05 | 1.56 | 0.16 | 1.66 | 1.31 | NA | 0.06 | 1.44 | 0.35 | 1.55 | 1.63 |
| FA_18:0_Me_13C_9 | ME108565 | NA | 0.04 | 1.50 | 0.15 | 1.73 | 1.34 | NA | 0.06 | 1.44 | 0.34 | 1.57 | 1.62 |
| FA_18:0_Me_13C_6 | ME108562 | NA | 0.01 | 1.38 | 0.07 | 1.89 | 1.67 | NA | 0.01 | 1.38 | 0.09 | 1.56 | 1.64 |
| FA_18:0_Me_13C_7 | ME108563 | NA | 0.02 | 1.49 | 0.10 | 1.81 | 1.54 | NA | 0.02 | 1.44 | 0.18 | 1.58 | 1.55 |
| FA_18:0_Me_13C_8 | ME108564 | NA | 0.03 | 1.55 | 0.12 | 1.77 | 1.47 | NA | 0.03 | 1.41 | 0.19 | 1.54 | 1.62 |
| FA_16:0_Me_13C_7 | ME108541 | NA | 0.05 | 1.74 | 0.14 | 1.83 | 1.21 | NA | 0.06 | 1.68 | 0.34 | 1.36 | 1.37 |
| FA_16:0_Me_13C_8 | ME108542 | NA | 0.06 | 1.77 | 0.17 | 1.77 | 1.17 | NA | 0.07 | 1.65 | 0.40 | 1.37 | 1.37 |
| FA_16:0_Me_13C_5 | ME108539 | NA | 0.03 | 1.48 | 0.07 | 2.01 | 1.39 | NA | 0.02 | 1.66 | 0.14 | 1.48 | 1.43 |
| FA_16:0_Me_13C_6 | ME108540 | NA | 0.03 | 1.70 | 0.11 | 1.95 | 1.35 | NA | 0.03 | 1.65 | 0.20 | 1.39 | 1.33 |
| FA_14:0_Me_13C_4 | ME108527 | NA | NA | 1.38 | 0.11 | 2.09 | 1.04 | NA | NA | 1.38 | 0.15 | 0.85 | 0.72 |
| FA_14:0_Me_13C_5 | ME108528 | NA | NA | 1.51 | 0.16 | 1.78 | 0.95 | NA | NA | 1.42 | 0.40 | 0.93 | 0.66 |
| FA_14:0_Me_13C_6 | ME108529 | NA | NA | 1.69 | 0.27 | 1.80 | 0.83 | NA | NA | 1.41 | 0.42 | 0.75 | 0.63 |
| FA_14:0_Me_13C_7 | ME108530 | NA | NA | 1.19 | 0.34 | 1.33 | 0.94 | NA | NA | 1.28 | 0.88 | 0.95 | 1.05 |
| FA_14:0_Me_13C_10 | ME108533 | NA | NA | 1.43 | 0.56 | 1.30 | 0.73 | NA | NA | 1.33 | 1.27 | 0.77 | 0.69 |
| FA_14:0_Me_13C_8 | ME108531 | NA | NA | 1.75 | 0.41 | 1.55 | 0.76 | NA | NA | 1.29 | 0.77 | 0.71 | 0.69 |
| FA_16:0_Me_13C_1 | ME108535 | 0.28 | 0.58 | 0.41 | 0.21 | 1.59 | 1.59 | 0.44 | 0.51 | 1.04 | 0.55 | 1.60 | 3.05 |
| FA_18:0_Me_13C_1 | ME108557 | 0.18 | 0.48 | 0.44 | 0.20 | 1.46 | 1.64 | 0.39 | 0.49 | 0.99 | 0.55 | 1.70 | 3.34 |
| FA_14:0_Me_13C_1 | ME108524 | 0.17 | 0.30 | 0.53 | 0.34 | 1.98 | 1.60 | 0.16 | 0.19 | 0.90 | 0.16 | 1.45 | 2.90 |
| FA_18:1_Me_13C_3 | ME108570 | 0.15 | 0.21 | 0.52 | 0.21 | 1.73 | 2.09 | 0.44 | 0.28 | 1.00 | 0.40 | 1.65 | 2.92 |
| FA_14:0_Me_13C_2 | ME108525 | 0.00 | 0.02 | 1.05 | 0.05 | 3.14 | 1.96 | 0.01 | 0.03 | 1.65 | 0.10 | 1.51 | 1.53 |
| FA_16:1_Me_13C_2 | ME108547 | 0.04 | 0.05 | 0.59 | 0.04 | 1.89 | 1.64 | 0.07 | 0.10 | 1.04 | NA | 1.39 | 1.97 |
| FA_18:1_Me_13C_2 | ME108569 | 0.13 | 0.13 | 0.76 | 0.15 | 1.99 | 2.18 | 0.34 | 0.44 | 1.26 | 0.57 | 2.06 | 1.84 |
| FA_18:0_Me_13C_2 | ME108558 | 0.01 | 0.04 | 0.78 | 0.09 | 2.21 | 2.11 | 0.00 | 0.05 | 1.37 | 0.17 | 1.87 | 2.36 |
| FA_18:0_Me_13C_3 | ME108559 | 0.01 | 0.03 | 0.77 | 0.03 | 2.09 | 2.04 | 0.01 | 0.02 | 1.35 | 0.03 | 1.95 | 2.36 |
| FA_16:0_Me_13C_2 | ME108536 | 0.00 | 0.01 | 0.79 | 0.02 | 2.46 | 1.98 | 0.00 | 0.01 | 1.51 | 0.04 | 1.79 | 2.07 |
| FA_16:0_Me_13C_3 | ME108537 | 0.02 | 0.02 | 1.11 | 0.05 | 2.59 | 1.99 | 0.01 | 0.01 | 1.76 | 0.06 | 1.94 | 2.13 |
| FA_18:0_Me_13C_4 | ME108560 | 0.00 | 0.01 | 1.15 | 0.04 | 2.31 | 2.11 | 0.00 | 0.01 | 1.54 | 0.05 | 1.83 | 1.98 |
Factors:
| F1 | Cell line:pLKO | Labelint time (hours):0 |
| F2 | Cell line:pLKO | Labelint time (hours):1 |
| F3 | Cell line:pLKO | Labelint time (hours):24 |
| F4 | Cell line:pLKO | Labelint time (hours):3 |
| F5 | Cell line:pLKO | Labelint time (hours):48 |
| F6 | Cell line:pLKO | Labelint time (hours):72 |
| F7 | Cell line:shIDH1 | Labelint time (hours):0 |
| F8 | Cell line:shIDH1 | Labelint time (hours):1 |
| F9 | Cell line:shIDH1 | Labelint time (hours):24 |
| F10 | Cell line:shIDH1 | Labelint time (hours):3 |
| F11 | Cell line:shIDH1 | Labelint time (hours):48 |
| F12 | Cell line:shIDH1 | Labelint time (hours):72 |
