Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Uniquely Tumor-Selective Englerin A Profoundly Alters Lipid Metabolism in Renal Cell Carcinoma inducing ER-Stress and an Acute Inflammatory Response (Study ST000465)

HILIC POSITIVE ION MODE (Analysis AN000727)

Metabolite	Structure	F1	F2	F3	F4
Ceramide(d18:1/25:0)	ME154530	0.15	2.65	0.50	0.70
GC(18:1/22:0)	ME154585	0.02	2.87	0.75	0.35
Cytidine	ME154551	0.40	2.44	0.99	0.17
GC(18:1/20:0)	ME154584	0.07	2.63	1.00	0.30
GC(18:1/24:1)	ME154587	0.06	2.53	1.08	0.34
Ceramide(d18:1/24:0 OH)	ME154525	0.19	2.11	0.95	0.74
Ceramide(d18:1/24:1)	ME154527	0.21	1.98	1.10	0.71
Ceramide(d18:1/18:0)	ME154508	0.36	1.93	0.63	1.08
Cholesterol	ME154537	0.37	1.51	0.71	1.41
Ceramide(d18:1/22:0)	ME154520	NA	NA	0.95	1.05
Pyridoxine	ME154702	NA	NA	1.08	0.92
Adenosine	ME154469	0.23	0.76	2.10	0.91
GC(18:1/16:0)	ME154583	0.26	1.52	1.94	0.28
Linoleylcarnitine	ME154616	0.53	1.06	2.12	0.29
9-Hexadecenoylcarnitine	ME154466	0.61	1.14	1.99	0.26
L-Palmitoylcarnitine	ME154621	0.60	1.10	2.01	0.29
Octadecanoylcarnitine	ME154645	0.35	1.01	2.47	0.16
Oleoylcarnitine	ME154647	0.39	1.22	2.20	0.19
3-Hydroxyhexadecenoylcarnitine	ME154452	0.48	1.04	2.23	0.25
3-Hydroxyoleoylcarnitine	ME154457	0.42	1.03	2.30	0.24
O-Phosphoethanolamine	ME154648	1.14	0.86	NA	NA
PG(32:1)	ME154687	1.20	0.80	NA	NA
3-Hydroxyanthranilic acid	ME154448	0.43	0.37	1.73	1.48
Adenosine monophosphate	ME154470	0.58	0.24	1.54	1.64
LysoPC(18:0)	ME154629	0.45	0.49	1.44	1.62
Guanosine monophosphate	ME154594	0.69	0.84	0.97	1.49
S-Adenosylhomocysteine	ME154706	0.65	1.02	0.91	1.42
Deoxyinosine monophosphate	ME154559	0.84	0.66	1.23	1.27
Uridine 5-monophosphate	ME154727	0.79	0.74	1.18	1.29
L-Kynurenine	ME154618	0.75	0.77	1.45	1.04
Norepinephrine	ME154642	0.95	0.59	1.42	1.04
Serotonin	ME154709	0.99	0.67	1.32	1.02
Thymidine	ME154719	0.78	1.47	1.23	0.52
Cytidine monophosphate	ME154552	0.99	1.18	1.06	0.77
Ergosterol	ME154573	0.93	1.08	1.14	0.84
THC 18:1/18:0	ME154715	0.99	1.46	0.72	0.84
Ceramide(d18:1/16:0)	ME154502	0.90	1.39	1.00	0.71
Ceramide(d18:1/16:1 OH)	ME154503	0.87	1.47	0.92	0.74
PC(20:4/P-16:0)	ME154661	1.08	0.49	2.09	0.34
PC(36:0)	ME154681	1.26	0.45	1.49	0.80
PC(20:5/P-16:0)	ME154662	1.32	0.49	1.69	0.50
PG(34:2)	ME154690	1.31	0.61	1.49	0.59
PC(16:0/20:4)	ME154655	1.46	0.44	1.51	0.59
PC(38:5)	ME154683	1.48	0.51	1.39	0.62
3-Hydroxyhexadecanoylcarnitine	ME154451	1.07	0.66	1.52	0.75
Decanoylcarnitine	ME154554	1.03	0.72	1.67	0.58
Dodecanoylcarnitine	ME154568	1.04	0.79	1.61	0.56
Lathosterol	ME154608	1.17	0.73	1.50	0.59
Octanoylcarnitine	ME154646	1.10	0.80	1.48	0.61
2-Arachidonylglycerol	ME154443	0.81	0.81	1.61	0.76
Gamma-glutamyl-Isoleucine	ME154581	0.83	0.66	1.86	0.65
3-Hydroxy-cis-5-tetradecenoylcarnitine	ME154449	0.79	1.01	1.79	0.41
Myristoylcarnitine	ME154636	0.82	1.06	1.74	0.38
Tetradecanoylcarnitine	ME154712	0.83	1.06	1.72	0.40
Dopamine	ME154570	0.95	1.00	1.44	0.61
Glycine	ME154592	0.99	0.92	1.41	0.67
Glycerophosphocholine	ME154591	0.90	1.18	1.38	0.54
Hypoxanthine	ME154601	0.85	1.10	1.56	0.50
Deoxycytidine monophosphate	ME154558	2.00	0.82	0.65	0.53
LysoPC(16:0)	ME154628	2.01	0.83	0.46	0.70
N-acetylserine	ME154639	1.76	0.74	0.64	0.87
Phosphorylcholine	ME154697	1.68	1.01	0.58	0.73
Cytosine	ME154553	1.79	0.80	0.73	0.68
Histamine	ME154596	1.69	0.90	0.76	0.66
Lanosterin	ME154606	1.85	0.59	0.92	0.65
PG(34:1)	ME154689	1.78	0.33	0.80	1.09
PG(44:12)	ME154696	1.92	0.31	0.79	0.98
PC(28:0)	ME154671	1.84	0.51	0.75	0.89
PC(30:2)	ME154676	1.80	0.44	0.83	0.93
PC(28:1)	ME154672	1.88	0.37	0.95	0.80
PC(30:0)	ME154674	1.90	0.44	0.83	0.82
L-Histidine	ME154613	1.59	0.84	1.00	0.57
Hydroxycholesterol Species	ME154598	1.52	0.63	1.27	0.58
PC(16:0/22:6)	ME154656	1.55	0.52	1.27	0.66
Ceramide(d18:1/16:1)	ME154504	1.41	0.60	1.29	0.70
PC(18:3/22:4)	ME154660	1.48	0.57	1.27	0.68
PC(22:6/P-18:0)	ME154665	1.42	0.61	1.14	0.83
Ceramide(d18:1/18:1)	ME154510	1.55	0.70	1.13	0.62
7-Dehydrocholesterol	ME154462	1.52	0.69	1.03	0.76
PC(32:2)	ME154678	1.49	0.68	1.10	0.72
PC(16:0/18:1)	ME154653	1.75	0.44	1.06	0.75
PG(40:8)	ME154695	1.68	0.42	1.15	0.74
PC(24:0/P-18:0)	ME154667	1.66	0.49	1.08	0.78
PC(34:1)	ME154679	1.70	0.45	1.11	0.74
PC(36:1)	ME154682	1.67	0.49	1.11	0.73
PC(16:0/18:2)	ME154654	1.59	0.53	1.15	0.74
PC(18:1/18:1)	ME154659	1.60	0.54	1.12	0.73
PC(26:1)	ME154670	1.55	0.52	1.14	0.79
PC(40:6)	ME154684	1.57	0.48	1.15	0.79
PC(30:1)	ME154675	1.59	0.61	1.01	0.79
Ceramide(d18:1/18:0 OH)	ME154507	1.62	0.55	1.03	0.79
PC(32:1)	ME154677	1.62	0.53	1.08	0.78
PC(28:2)	ME154673	1.69	0.56	0.88	0.88
7-ketocholesterol	ME154463	1.59	0.68	0.88	0.84
PC(16:0/16:0)	ME154652	1.53	0.61	1.00	0.86
Tyramine	ME154724	0.97	0.78	1.28	0.98
Vitamin D3	ME154728	1.04	0.77	1.29	0.89
3-Hydroxylinoleylcarnitine	ME154456	1.01	0.86	1.28	0.86
7-Methylguanosine	ME154464	0.96	0.88	1.35	0.82
Metanephrine	ME154632	0.97	0.93	1.20	0.89
Alanine	ME154474	0.96	0.89	1.22	0.93
Sarcosine	ME154708	0.96	0.89	1.21	0.94
L-Isoleucine	ME154617	1.07	0.84	1.22	0.87
Urea	ME154725	1.06	0.86	1.16	0.92
B-Carotene	ME154480	1.27	0.75	1.22	0.76
Cobalamin	ME154539	1.30	0.69	1.21	0.80
7a-Hydroxycholesterol	ME154461	1.38	0.82	1.15	0.65
Glyceraldehyde	ME154590	1.26	0.85	1.18	0.71
L-Asparagine	ME154607	1.30	0.81	1.19	0.70
L-Tryptophan	ME154625	1.13	0.90	1.22	0.74
L-Phenylalanine	ME154622	1.12	0.88	1.23	0.76
L-Valine	ME154627	1.14	0.86	1.23	0.77
Methylcysteine	ME154635	1.14	0.82	1.26	0.78
L-Glutamine	ME154611	1.14	0.84	1.21	0.81
L-Lysine	ME154619	1.15	0.85	1.21	0.79
9-Decenoylcarnitine	ME154465	1.15	0.89	1.11	0.84
L-Methionine	ME154620	1.17	0.88	1.16	0.80
L-Serine	ME154624	1.21	0.90	1.32	0.57
DHC(18:1/16:0)	ME154562	1.17	0.85	1.32	0.66
Purine	ME154700	1.14	0.90	1.26	0.71
Corticosterone	ME154544	1.16	0.91	1.27	0.66
Indole	ME154602	1.16	0.91	1.26	0.67
24,25-Dihydrolanosterol	ME154441	1.22	0.75	1.36	0.67
Methionine sulfoxide	ME154633	1.20	0.79	1.33	0.69
24,25-Epoxycholesterol	ME154442	1.17	0.76	1.32	0.75
Niacinamide	ME154640	1.14	0.75	1.31	0.81
Retinol	ME154704	0.96	0.81	1.44	0.80
Amphetamine	ME154476	1.08	0.84	1.39	0.68
L-Tyrosine	ME154626	1.06	0.82	1.40	0.71
Retinal	ME154703	1.08	0.79	1.37	0.76
Dodecenoylcarnitine	ME154569	1.03	0.80	1.41	0.76
Zymosterol	ME154730	1.05	0.79	1.39	0.77
Gluconolactone	ME154588	1.40	1.04	1.04	0.52
1-Methyladenosine	ME154436	1.32	1.05	0.94	0.68
Creatinine	ME154546	1.32	0.96	0.99	0.73
3, 5-Tetradecadiencarnitine	ME154446	1.20	1.00	1.17	0.63
Cysteine	ME154549	1.17	1.02	1.07	0.73
Alpha-Tocopherol	ME154475	1.38	0.73	1.00	0.89
Desmosterol	ME154561	1.33	0.74	1.06	0.87
Dimethylglycine	ME154566	1.31	0.82	1.04	0.83
Hydroxyproline	ME154600	1.31	0.80	1.06	0.83
Vitamin K2	ME154729	1.35	0.81	1.09	0.74
1-Methylhistidine	ME154438	1.41	0.80	1.04	0.75
1-Pyrroline-5-carboxylic acid	ME154440	1.36	0.82	1.03	0.78
Propionylcarnitine	ME154699	1.39	0.87	0.89	0.86
Butyrylcarnitine	ME154498	1.37	0.88	0.94	0.82
Isovalerylcarnitine	ME154604	1.36	0.88	0.94	0.82
Dimethyl-L-arginine	ME154567	1.46	0.83	0.94	0.78
5,6-trans-25-Hydroxyvitamin D3	ME154458	1.44	0.77	0.96	0.84
Ceramide(d18:1/16:0 OH)	ME154501	1.46	0.75	1.00	0.79
Cyanocobalamin	ME154547	1.21	0.86	1.07	0.86
Betaine	ME154482	1.24	0.80	1.11	0.86
Choline	ME154538	1.23	0.81	1.10	0.86
Ornithine	ME154650	1.22	0.82	1.10	0.87
L-Proline	ME154623	1.19	0.91	1.03	0.87
THC 18:1/16:0	ME154714	1.26	0.91	1.01	0.82
O-Phosphotyrosine	ME154649	1.13	0.84	1.06	0.97
Carnosine	ME154499	1.13	0.84	1.10	0.93
Trimethylamine-N-oxide	ME154723	1.15	0.81	1.10	0.93
Adipoylcarnitine	ME154472	1.17	0.71	1.12	1.00
Arachidonyl carnitine	ME154479	1.14	0.76	1.06	1.04
PC(22:1)	ME154664	1.29	0.93	0.85	0.93
L-Cystathionine	ME154610	1.35	0.80	0.88	0.98
Ureidopropionic acid	ME154726	1.31	0.74	0.89	1.06
3-Hydroxyiso-/butyrylcarnitine	ME154454	1.51	0.74	0.69	1.06
Malonylcarnitine	ME154630	1.46	0.74	0.75	1.05
Deoxyadenosine monophosphate	ME154557	1.42	0.79	0.75	1.04
L-Acetylcarnitine	ME154605	1.42	0.77	0.76	1.04
Acetylcholine	ME154467	1.47	0.89	0.81	0.82
3-Hydroxydodecanoylcarnitine	ME154450	1.57	0.82	0.76	0.85
3-Hydroxyisovaleryl Carnitine	ME154455	1.55	0.79	0.77	0.89
L-Carnitine	ME154609	1.61	0.73	0.78	0.88
O-succinylcarnitine	ME154651	1.55	0.75	0.77	0.94
3,3^,5^-Triiodothyronine	ME154447	1.18	1.13	0.76	0.93
beta-Alanine	ME154481	1.41	1.02	0.74	0.83
Cortisone	ME154545	1.41	1.10	0.77	0.73
Biotin	ME154485	1.08	0.81	0.97	1.14
PC(26:0)	ME154669	1.39	0.51	0.88	1.22

Factors:

F1	Time:24hr \| Treatment:Control
F2	Time:24hr \| Treatment:Englerin (100 nM)
F3	Time:48hr \| Treatment:Control
F4	Time:48hr \| Treatment:Englerin (100 nM)

Data matrix