Clustering data with hclust algorithm for 2HG concentration in human IDH1m cells (Study ST000824)
Amino, Aminopropyl HILIC NEGATIVE ION MODE (Analysis AN001310)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|---|
| D-FRUCTOSE, 1,6-BIS(DIHYDROGEN PHOSPHATE) | ME221564 | 0.26 | 0.48 | 2.54 | 1.52 | 0.46 | 0.47 | 0.46 | 1.63 |
| GLYCERATE 3-PHOSPHATE | ME221575 | 0.49 | 0.61 | 2.37 | 1.37 | 0.72 | 0.60 | 0.38 | 1.26 |
| NADP-REDUCED | ME221565 | 1.58 | 1.67 | 1.15 | 1.41 | 0.27 | 0.29 | 0.25 | 0.66 |
| ADENOSINE TRIPHOSPHATE | ME221570 | 1.16 | 1.32 | 1.44 | 1.30 | 0.32 | 0.55 | 0.83 | 1.02 |
| NADH | ME221567 | 0.78 | 1.31 | 0.98 | 1.91 | 0.38 | 0.27 | 0.61 | 1.18 |
| FAD | ME221568 | 0.94 | 1.10 | 0.76 | 0.88 | 1.95 | 0.14 | 0.68 | 1.51 |
| MALIC ACID | ME221569 | 0.96 | 1.23 | 0.75 | 0.44 | 1.43 | 0.89 | 1.23 | 0.81 |
| CITRIC ACID | ME221566 | 1.13 | 1.21 | 0.80 | 0.92 | 0.94 | 0.35 | 0.84 | 1.76 |
| SUCROSE | ME221572 | 1.09 | 1.50 | 0.99 | 0.93 | 0.78 | 0.60 | 0.78 | 1.25 |
| RIBOSE PHOSPHATE | ME221576 | 0.95 | 0.81 | 1.25 | 1.13 | 1.50 | 0.63 | 0.43 | 1.16 |
| PHOSPHOENOLPYRUVATE | ME221559 | 1.02 | 1.21 | 1.16 | 1.16 | 0.88 | 0.91 | 0.46 | 1.02 |
| ACETOACETYL-COA | ME221578 | 1.03 | 0.98 | 1.15 | 0.92 | 1.19 | 1.31 | 0.58 | 0.70 |
| COENZYME II | ME221562 | 1.06 | 1.00 | 1.11 | 0.87 | 1.26 | 1.11 | 0.63 | 0.84 |
| ADENOSINE 5^-MONOPHOSPHATE | ME221574 | 1.94 | 1.61 | 0.49 | 0.46 | 1.86 | 0.87 | 0.18 | 0.32 |
| 6-PHOSPHOGLUCONIC ACID | ME221577 | 1.78 | 1.36 | 0.57 | 0.49 | 1.49 | 0.42 | 0.34 | 1.34 |
| D-ERYTHROSE 4-PHOSPHATE | ME221560 | 2.00 | 1.78 | 0.67 | 0.59 | 1.11 | 0.34 | 0.30 | 0.98 |
| ROBISON ESTER | ME221571 | 1.99 | 1.74 | 0.66 | 0.62 | 1.04 | 0.41 | 0.33 | 0.98 |
| BETA-NAD+ | ME221561 | 1.46 | 1.90 | 1.01 | 0.98 | 0.63 | 0.43 | 0.63 | 0.83 |
| ADENOSINE 5^-DIPHOSPHATE | ME221573 | 1.68 | 1.79 | 0.80 | 0.78 | 0.83 | 0.68 | 0.43 | 0.82 |
| SEDOHEPTULOSE 7-PHOSPHATE | ME221563 | 1.80 | 2.02 | 0.87 | 0.72 | 0.66 | 0.37 | 0.36 | 0.99 |
Factors:
| F1 | Cell line:MGG8 | IDH1-R132H EXPRESSION:NO | IDH1-R132H INHIBITOR:NO |
| F2 | Cell line:MGG8 | IDH1-R132H EXPRESSION:NO | IDH1-R132H INHIBITOR:YES |
| F3 | Cell line:MGG8 | IDH1-R132H EXPRESSION:YES | IDH1-R132H INHIBITOR:NO |
| F4 | Cell line:MGG8 | IDH1-R132H EXPRESSION:YES | IDH1-R132H INHIBITOR:YES |
| F5 | Cell line:SJGBM2 | IDH1-R132H EXPRESSION:NO | IDH1-R132H INHIBITOR:NO |
| F6 | Cell line:SJGBM2 | IDH1-R132H EXPRESSION:NO | IDH1-R132H INHIBITOR:YES |
| F7 | Cell line:SJGBM2 | IDH1-R132H EXPRESSION:YES | IDH1-R132H INHIBITOR:NO |
| F8 | Cell line:SJGBM2 | IDH1-R132H EXPRESSION:YES | IDH1-R132H INHIBITOR:YES |
