Metabolomics Workbench : NIH Data Repository

Clustering data with hclust algorithm for Diet, genetics and gut microbiome drive dynamic changes in plasma metabolites [cecal] (Study ST000880)

HILIC NEGATIVE ION MODE (Analysis AN001434)

Metabolite	Structure	F1	F2	F3	F4	F5	F6	F7	F8	F9	F10	F11	F12
Xanthurenic acid	ME227332	0.10	0.16	0.11	1.87	0.94	0.53	4.80	0.83	0.97	0.27	0.81	0.39
Fructose-6-phosphate	ME227301	4.86	4.26	0.62	0.04	0.03	0.09	0.04	0.10	0.06	0.02	0.05	0.04
Glucuronic acid	ME227297	0.31	0.36	0.26	0.44	0.87	0.39	0.15	0.08	0.11	4.27	0.81	3.75
Sorbitol	ME227322	1.13	1.40	1.07	0.41	0.17	0.31	0.26	0.14	0.16	4.54	0.14	2.30
Guanosine	ME227300	1.27	0.48	1.34	0.18	0.07	0.18	0.42	0.28	0.39	2.74	0.18	4.55
Orotic acid	ME227315	0.95	1.19	1.93	0.67	1.31	0.39	0.18	0.08	0.68	0.86	1.35	2.63
Citric acid	ME227285	2.12	0.96	2.30	0.26	0.41	0.37	0.44	0.51	0.69	1.73	0.45	2.09
Cytidine	ME227288	1.72	1.03	1.17	0.10	0.04	0.08	0.82	0.78	1.25	1.55	0.20	3.30
Uridine	ME227330	1.79	0.90	1.89	0.39	0.24	0.42	0.69	0.61	0.69	1.13	0.25	3.22
Uric acid	ME227329	0.55	0.37	1.24	2.33	0.32	2.69	0.28	0.40	0.36	1.13	0.26	2.14
taurodeoxycholate-taurochenodeoxycholate	ME227326	0.51	0.20	0.02	0.65	0.92	1.08	1.38	1.95	2.94	0.54	0.82	0.73
3-hydroxykynurenate	ME227268	NA	NA	NA	0.74	1.05	0.95	1.66	0.49	1.76	0.92	0.90	0.40
Taurocholic acid	ME227325	0.21	0.16	0.01	1.40	1.59	1.44	1.11	0.76	0.99	1.21	1.53	1.33
Alpha-hydoxy butyric acid	ME227278	0.93	1.19	0.82	0.74	3.16	0.45	0.67	0.53	0.87	0.83	0.83	0.92
Folic acid	ME227293	0.56	NA	NA	1.10	1.43	0.78	NA	NA	NA	1.06	0.74	1.00
Isocitric acid	ME227306	0.57	0.73	0.56	1.17	1.87	0.87	0.21	0.57	0.18	2.01	1.21	1.85
Lactic acid	ME227308	0.54	1.34	0.61	1.50	1.45	0.86	0.66	0.45	0.56	1.48	0.60	1.86
beta-hydroxybutyric acid	ME227281	0.57	0.48	0.19	2.85	1.74	0.30	0.26	0.11	0.10	2.39	1.21	1.39
Indoxyl sulfate	ME227304	0.01	0.13	NA	2.01	1.66	0.04	0.68	0.66	NA	1.48	1.74	0.03
Cholic acid	ME227284	0.69	2.57	0.26	0.12	0.36	0.21	1.02	1.77	2.56	NA	0.00	NA
Glycocholic Acid	ME227298	0.64	1.87	0.26	0.34	0.30	0.65	0.99	1.62	3.75	0.30	0.37	0.73
3-hydroxybenzoate	ME227267	1.24	0.84	1.13	0.05	0.13	0.05	2.53	0.69	2.59	0.60	1.05	0.90
hydroxyphenylacetate	ME227302	1.31	1.10	1.53	0.88	0.49	0.22	3.29	1.72	0.75	0.19	0.30	0.16
Erythrose 4-phosphate	ME227291	1.52	1.80	0.24	NA	NA	0.12	NA	NA	0.04	NA	0.06	0.05
phosphotyrosine	ME227319	2.16	1.29	NA	0.44	NA	NA	0.51	NA	0.71	0.51	NA	NA
Chenodeoxycholic Acid	ME227283	1.42	1.34	0.80	NA	NA	0.02	0.65	1.54	1.92	NA	0.01	NA
NAD+	ME227312	1.10	0.50	1.96	NA	NA	NA	0.72	0.23	0.91	NA	NA	NA
4-Hydroxyphenylpyruvic acid	ME227271	1.73	0.86	0.91	NA	NA	NA	0.74	1.03	0.59	NA	NA	NA
Lithocholic acid	ME227310	1.25	0.98	1.01	NA	NA	NA	0.51	0.47	1.28	NA	NA	NA
Oxoglutaric acid	ME227279	1.68	0.74	1.22	NA	NA	NA	0.66	0.57	1.05	NA	NA	NA
Quinolinic acid	ME227321	0.69	1.54	2.82	1.13	0.82	0.41	0.90	0.60	0.81	1.17	1.02	0.53
Succinic acid	ME227323	0.90	2.61	1.65	1.21	1.46	0.65	1.03	0.50	0.87	0.13	1.05	0.10
4-Hydroxybenzaldehyde	ME227270	2.91	1.42	0.95	0.37	0.57	0.38	0.84	1.07	1.26	0.63	0.43	1.16
Cystathionine	ME227287	1.09	1.80	0.80	0.53	0.60	0.59	0.94	NA	0.86	1.06	0.54	1.79
Sucrose	ME227324	2.32	1.68	0.91	0.59	0.64	0.56	0.47	0.51	0.47	1.71	0.76	1.34
Adenine	ME227274	1.99	1.65	1.50	1.24	0.78	1.81	0.86	0.62	0.59	0.48	0.35	0.26
Guanine	ME227299	1.35	1.79	1.66	1.20	0.13	0.94	1.22	0.91	1.25	0.69	0.20	0.83
Aminoadipic acid	ME227265	1.47	1.22	1.71	0.56	0.45	0.82	1.61	0.59	1.77	0.36	0.48	0.52
Oxalic acid	ME227316	1.75	1.20	1.36	0.58	1.16	0.42	1.78	0.75	1.22	0.45	0.90	0.51
Kynurenine	ME227307	1.06	1.05	0.67	0.84	0.84	0.59	0.94	0.79	1.53	1.43	NA	0.96
inosine-15N4 (Internal standard)	ME227263	0.77	0.95	0.58	1.09	1.27	1.15	0.69	1.01	0.95	1.15	1.20	1.08
glycocholate-d4 (Internal standard)	ME227264	1.12	1.10	0.94	0.97	1.09	0.97	0.88	1.04	1.08	0.92	0.92	0.94
thymine-d4 (Internal standard)	ME227262	0.95	0.98	0.80	0.98	1.25	1.05	0.81	1.03	1.01	1.02	1.12	0.95
Adipic acid	ME227275	1.58	1.10	1.36	0.82	0.97	0.73	0.89	0.84	1.02	0.98	0.96	0.77
Propionic acid	ME227320	1.22	1.05	1.49	0.78	1.20	0.52	0.71	0.66	1.14	0.59	1.56	0.95
Lactose	ME227309	2.29	3.18	1.84	0.22	0.20	0.19	0.18	0.19	0.20	1.65	0.33	1.73
Inosine	ME227305	3.45	1.00	3.72	0.15	0.09	0.30	0.60	0.45	0.38	1.00	0.19	1.35
CMP	ME227286	2.42	1.42	2.49	0.38	0.48	NA	0.49	0.37	0.27	0.12	0.23	NA
dTMP	ME227290	3.15	0.83	1.98	0.17	0.49	NA	0.48	0.34	0.59	NA	0.30	NA
dCMP	ME227289	2.79	1.57	2.26	1.23	0.90	0.06	1.70	0.36	0.57	0.31	0.50	0.06
Hexose	ME227294	2.90	3.03	2.34	0.09	0.09	0.06	1.41	1.02	1.01	0.10	0.15	0.13
Uracil	ME227328	2.50	1.90	2.89	0.34	0.29	0.15	1.31	1.00	1.18	0.31	0.33	0.27
Hypoxanthine	ME227303	2.66	2.49	2.79	0.27	0.13	0.20	1.50	0.96	1.20	0.09	0.09	0.07
Nicotinic acid	ME227313	2.64	2.43	2.88	0.53	0.39	0.20	1.25	0.81	0.93	0.17	0.15	0.09
Thymine	ME227327	1.91	1.62	2.44	0.41	0.36	0.28	1.18	0.93	0.97	0.81	0.32	1.12
3-methyladipate-pimelate	ME227269	2.04	2.10	2.72	0.48	0.61	0.46	1.08	0.59	0.98	0.35	0.57	0.44
4-Pyridoxic acid	ME227272	2.45	2.05	2.59	0.66	0.57	0.39	0.87	0.51	0.74	0.47	0.66	0.43
Gentisic acid	ME227296	3.17	3.44	3.21	0.03	0.10	0.03	0.06	0.19	0.07	NA	0.02	NA
fumarate/maleate	ME227295	2.35	2.30	3.31	0.30	0.91	0.40	0.37	0.48	0.37	0.39	0.44	0.49
Malic acid	ME227311	2.89	3.04	3.81	0.18	0.52	0.17	0.31	0.38	0.35	0.30	0.31	0.43
Pantothenic acid	ME227317	1.57	2.27	3.92	0.30	0.27	0.21	0.88	1.19	1.50	0.14	0.29	0.20
Xanthine	ME227331	2.44	1.77	3.85	0.52	0.08	0.92	0.78	0.78	0.93	0.32	0.05	0.27
2-hydroxyglutaric acid	ME227266	3.14	1.58	4.52	0.10	0.38	0.05	1.10	0.66	1.16	0.03	0.13	0.04
Glycerol 3-phosphate	ME227277	2.38	1.47	4.39	0.55	0.49	0.05	0.78	0.73	0.28	0.13	0.17	0.03

Factors:

F1	Diet:Chow \| Treatment:none \| Strain:129Jax
F2	Diet:Chow \| Treatment:none \| Strain:129Tac
F3	Diet:Chow \| Treatment:none \| Strain:B6Jax
F4	Diet:HFD \| Treatment:metronidazole \| Strain:129Jax
F5	Diet:HFD \| Treatment:metronidazole \| Strain:129Tac
F6	Diet:HFD \| Treatment:metronidazole \| Strain:B6Jax
F7	Diet:HFD \| Treatment:placebo \| Strain:129Jax
F8	Diet:HFD \| Treatment:placebo \| Strain:129Tac
F9	Diet:HFD \| Treatment:placebo \| Strain:B6Jax
F10	Diet:HFD \| Treatment:vancomycin \| Strain:129Jax
F11	Diet:HFD \| Treatment:vancomycin \| Strain:129Tac
F12	Diet:HFD \| Treatment:vancomycin \| Strain:B6Jax

Data matrix