Clustering data with hclust algorithm for Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part II) (Study ST000911)
Reversed phase POSITIVE ION MODE (Analysis AN001481)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|---|
| DG (36:2) | ME230711 | 0.54 | 3.50 | 0.47 | 1.50 | 0.47 | 0.46 |
| PC (36:2) | ME230718 | 0.67 | 0.52 | 1.85 | 0.57 | 0.78 | 0.41 |
| TG (58:2) | ME230746 | 1.15 | 0.60 | 0.83 | 1.06 | 1.20 | NA |
| CE (18:2) | ME230709 | 0.80 | 0.46 | 1.25 | 0.79 | 1.63 | 0.58 |
| PC (36:3) B | ME230719 | 0.73 | 0.59 | 1.34 | 0.73 | 1.50 | 0.57 |
| PC (34:2) | ME230716 | 0.93 | 0.59 | 1.29 | 0.70 | 1.31 | 0.57 |
| PC (36:1) | ME230717 | 0.85 | 0.84 | 1.23 | 0.77 | 1.28 | 0.56 |
| PC (36:4) B | ME230720 | 0.87 | 0.79 | 0.97 | 0.84 | 1.68 | 0.82 |
| SM (d42:2) A | ME230729 | 0.88 | 0.84 | 0.91 | 0.90 | 1.58 | 1.05 |
| TG (48:1) | ME230731 | 1.18 | 0.84 | 0.93 | 0.81 | 1.30 | 0.71 |
| PC (32:1) | ME230714 | 0.94 | 0.80 | 1.02 | 0.87 | 1.47 | 0.74 |
| PC (38:6) A | ME230724 | 1.00 | 0.84 | 0.98 | 0.84 | 1.44 | 0.74 |
| PC (30:0) | ME230713 | 0.90 | 0.86 | 1.04 | 0.83 | 1.53 | 0.62 |
| PC (38:4) A | ME230722 | 0.86 | 0.83 | 1.08 | 0.82 | 1.48 | 0.74 |
| PC 32:0; | ME230726 | 0.96 | 0.96 | 0.97 | 0.83 | 1.48 | 0.67 |
| SM (d36:2) | ME230728 | 0.89 | 0.92 | 1.05 | 0.90 | 1.42 | 0.60 |
| PC (34:1) | ME230715 | 0.95 | 0.94 | 1.00 | 0.90 | 1.38 | 0.65 |
| PC (36:4) C | ME230721 | 0.96 | 0.92 | 1.00 | 0.94 | 1.33 | 0.68 |
| Cholesterol | ME230710 | 0.96 | 0.85 | 1.11 | 0.84 | 1.18 | 0.84 |
| SM (d36:1) | ME230727 | 0.93 | 1.04 | 1.00 | 0.95 | 1.26 | 0.72 |
| PC (38:5) A | ME230723 | 0.93 | 0.97 | 1.02 | 0.84 | 1.29 | 0.86 |
| PC (p-34:0) or PC (o-34:1) | ME230725 | 0.91 | 0.94 | 1.03 | 0.90 | 1.31 | 0.82 |
| 1_CE (22:1) iSTD | ME230695 | 1.01 | 0.96 | 1.01 | 0.97 | 0.97 | 1.12 |
| 1_TG (17:0/17:1/17:0) d5 iSTD | ME230708 | 1.02 | 0.96 | 1.00 | 0.93 | 1.00 | 1.13 |
| 1_DG (18:1/2:0/0:0) iSTD | ME230700 | 1.03 | 1.05 | 0.98 | 1.00 | 0.99 | 0.90 |
| TG 54:0; TG(18:0/18:0/18:0); | ME230748 | 1.07 | 1.06 | 0.96 | 0.97 | 1.02 | 0.84 |
| 1_LPE (17:1) iSTD | ME230702 | 1.08 | 1.00 | 1.01 | 0.94 | 0.93 | 0.95 |
| 1_Sphingosine (d17:1) iSTD | ME230707 | 1.05 | 1.01 | 0.99 | 0.95 | 0.95 | 1.05 |
| 1_SM (d35:1) iSTD | ME230706 | 1.02 | 1.05 | 0.99 | 0.97 | 0.99 | 0.99 |
| 1_LPC (17:0) iSTD | ME230701 | 1.01 | 1.07 | 0.98 | 0.98 | 0.99 | 0.98 |
| 1_PC (25:0) iSTD | ME230704 | 1.02 | 1.06 | 0.99 | 0.98 | 0.98 | 0.98 |
| 1_Ceramide C17 iSTD | ME230696 | 1.01 | 1.03 | 0.99 | 0.99 | 1.00 | 1.01 |
| 1_Cholesterol d7 iSTD | ME230697 | 1.01 | 1.04 | 0.99 | 0.97 | 1.00 | 1.01 |
| 1_CUDA (pos) iSTD | ME230698 | 1.02 | 1.03 | 0.99 | 0.98 | 0.98 | 0.99 |
| 1_DG (12:0/12:0/0:0) iSTD | ME230699 | 1.02 | 1.03 | 0.99 | 0.97 | 1.00 | 0.98 |
| 1_MG (17:0/0:0/0:0) iSTD | ME230703 | 1.00 | 1.02 | 0.99 | 1.00 | 1.00 | 1.03 |
| 1_PE (17:0/17:0) iSTD | ME230705 | 1.00 | 1.04 | 0.99 | 0.97 | 1.00 | 1.05 |
| TG (60:2) | ME230747 | 1.25 | 0.70 | 1.00 | 0.92 | 1.22 | 0.35 |
| TG (49:2) | ME230734 | 1.39 | 0.96 | 0.96 | 0.76 | 0.85 | 0.70 |
| TG (46:1) | ME230730 | 1.31 | 0.80 | 0.90 | 0.91 | 1.16 | 0.58 |
| TG (49:1) | ME230733 | 1.31 | 0.82 | 0.96 | 0.86 | 1.09 | 0.53 |
| TG (54:3) | ME230742 | 1.29 | 0.89 | 0.98 | 0.88 | 0.96 | 0.61 |
| TG (48:2) | ME230732 | 1.38 | 0.83 | 0.88 | 0.91 | 1.05 | 0.61 |
| TG (51:2) | ME230736 | 1.40 | 0.76 | 0.91 | 0.92 | 1.02 | 0.60 |
| TG (52:4) | ME230740 | 1.41 | 0.81 | 0.90 | 0.91 | 0.95 | 0.67 |
| TG (54:4) | ME230743 | 1.34 | 0.74 | 0.98 | 0.92 | 0.94 | 0.66 |
| TG (54:5) A | ME230744 | 1.38 | 0.76 | 0.93 | 0.95 | 0.93 | 0.69 |
| TG (52:1) | ME230737 | 1.26 | 0.86 | 1.00 | 0.78 | 0.98 | 0.84 |
| TG (54:2) | ME230741 | 1.23 | 0.84 | 1.01 | 0.82 | 1.04 | 0.70 |
| TG (56:2) | ME230745 | 1.23 | 0.87 | 0.98 | 0.82 | 1.07 | 0.71 |
| TG (50:2) | ME230735 | 1.31 | 0.69 | 0.94 | 0.84 | 1.18 | 0.70 |
| TG (52:2) | ME230738 | 1.25 | 0.76 | 0.95 | 0.90 | 1.09 | 0.77 |
| TG (52:3) | ME230739 | 1.34 | 0.69 | 0.95 | 0.91 | 1.03 | 0.73 |
Factors:
| F1 | Diagnosis:MECFS | Sex:FEMALE |
| F2 | Diagnosis:MECFS | Sex:MALE |
| F3 | Diagnosis:MS | Sex:FEMALE |
| F4 | Diagnosis:MS | Sex:MALE |
| F5 | Diagnosis:ND | Sex:FEMALE |
| F6 | Diagnosis:ND | Sex:MALE |
