Clustering data with hclust algorithm for MuRF1-Related Metabolic Alterations in HL-1 Cardiomyocyte Induced by Cyclic Stretch (Study ST000924)
GC POSITIVE ION MODE (Analysis AN001517)| Metabolite | Structure | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 |
|---|---|---|---|---|---|---|---|---|---|
| Hexuronic acid | ME233562 | NA | NA | 0.98 | NA | NA | 1.02 | 1.03 | 1.00 |
| Thymine | ME233599 | NA | 0.99 | NA | 1.04 | 1.09 | 0.94 | NA | NA |
| beta-Monopalmitin | ME233540 | 0.98 | 1.03 | NA | 1.03 | 0.99 | 0.97 | NA | NA |
| Serotonin | ME233594 | 0.95 | 1.02 | NA | 1.02 | 1.02 | 0.99 | NA | NA |
| N-Methylalanine/2-Aminobutanoic acid/N-Ethylglycine | ME233578 | 1.02 | NA | NA | 1.02 | 1.00 | NA | 0.99 | 0.98 |
| 5-(Hydroxymethyl)furfural | ME233525 | NA | 1.01 | 0.99 | 1.00 | 1.00 | 0.98 | NA | 1.04 |
| Norepinephrine/Methyltryptamine | ME233580 | 1.04 | 1.02 | 1.00 | 0.98 | 0.99 | 0.98 | 0.99 | NA |
| Pentonic acids | ME233585 | 1.00 | 1.00 | 0.98 | 0.99 | 1.02 | 1.01 | NA | NA |
| 2-Ethylhexanoic acid | ME233516 | 0.97 | 1.01 | 0.99 | NA | 1.03 | 1.00 | 0.97 | NA |
| 6-Aminohexanoic acid/delta-Aminolevulinic acid | ME233527 | 0.97 | 0.99 | 1.03 | NA | 1.00 | 0.99 | 1.05 | 0.95 |
| Putrescine | ME233590 | 0.96 | 0.99 | 1.03 | NA | 1.00 | 1.00 | 1.05 | 0.95 |
| Hydroxyprolines | ME233564 | 1.01 | NA | 1.00 | 1.00 | 0.99 | 1.01 | 1.00 | 0.99 |
| 3-Phenyllactic acid | ME233523 | 0.99 | 0.98 | 1.04 | 1.07 | 0.95 | 0.99 | 0.95 | 1.06 |
| 4-Hydroxyphenylpyruvic acid | ME233524 | 0.96 | 1.03 | 0.92 | 1.02 | 1.05 | 0.98 | 1.02 | 0.97 |
| Methylglutamic acid | ME233575 | 1.00 | 1.04 | 1.00 | 0.89 | 1.04 | 0.97 | 1.01 | 0.98 |
| Glycerol 1-phosphate | ME233558 | 1.00 | 1.03 | 1.00 | 0.93 | 1.03 | 1.02 | 1.00 | 0.99 |
| Uracil | ME233602 | 1.03 | 1.05 | 1.02 | 0.89 | 1.03 | 1.03 | 0.99 | 0.96 |
| Ketopentoses | ME233567 | 1.04 | 1.07 | 1.01 | 0.99 | 1.01 | 1.02 | 0.94 | 0.98 |
| 2-Hydroxybutyric acid | ME233517 | 1.00 | 1.02 | 1.01 | 1.02 | 1.03 | 1.00 | 1.00 | 0.91 |
| Maltose or similar disaccharide | ME233572 | 0.96 | 0.97 | 1.01 | 1.00 | 1.03 | 1.02 | 1.00 | 1.01 |
| Nicotinamide | ME233579 | 1.00 | 1.02 | 1.01 | 1.00 | 0.96 | 1.01 | 0.97 | 1.01 |
| Arginine | ME233535 | 1.01 | 1.05 | 0.99 | 1.01 | 0.99 | 1.01 | 0.98 | 0.97 |
| Phosphoric acid | ME233587 | 0.98 | 1.01 | 0.99 | 1.03 | 1.00 | 0.99 | 0.98 | 1.02 |
| 2-Hydroxyvaleric acid | ME233519 | 0.99 | 0.99 | 1.01 | 1.04 | 0.99 | 0.98 | 0.99 | 1.00 |
| Glycolic acid | ME233560 | 0.99 | 1.00 | 1.00 | 1.04 | 1.02 | 1.00 | 0.98 | 0.99 |
| Benzoic acid | ME233538 | 0.99 | 1.03 | 1.01 | 0.97 | 1.02 | 1.02 | 0.97 | 1.00 |
| beta-Alanine | ME233539 | 0.97 | 1.04 | 1.02 | 0.97 | 1.02 | 1.02 | 0.99 | 0.98 |
| Pseudouridine | ME233589 | 0.99 | 1.01 | 1.02 | 0.99 | 1.02 | 1.00 | 0.99 | 0.96 |
| Glutamine | ME233555 | 1.00 | 1.04 | 1.00 | 0.97 | 1.02 | 1.01 | 0.99 | 0.97 |
| Xanthine | ME233606 | 1.00 | 1.03 | 0.99 | 0.99 | 1.03 | 1.01 | 1.00 | 0.96 |
| Aldopentoses | ME233529 | 1.01 | 1.01 | 0.97 | 1.01 | 0.99 | 1.03 | 1.00 | 1.00 |
| Aminomalonic acid | ME233534 | 0.99 | 1.02 | 0.98 | 0.98 | 1.02 | 1.02 | 0.99 | 0.99 |
| Pyridoxine | ME233591 | 1.00 | 1.00 | 0.97 | 0.98 | 1.02 | 1.02 | 0.99 | 1.01 |
| Cholesterol | ME233542 | 0.98 | 0.99 | 0.99 | 1.01 | 1.01 | 1.02 | 0.98 | 1.02 |
| Palmitic acid | ME233582 | 0.99 | 1.00 | 1.00 | 1.00 | 1.01 | 1.01 | 0.98 | 1.01 |
| Myristic acid or Pentadecanol | ME233577 | 0.99 | 1.02 | 1.01 | 1.01 | 0.99 | 1.00 | 0.99 | 0.99 |
| 2-Deoxyglucose | ME233515 | 0.99 | 1.02 | 1.01 | 1.00 | 0.99 | 0.99 | 0.99 | 1.01 |
| Glyceric acid | ME233556 | 0.99 | 1.03 | 1.01 | 1.00 | 1.00 | 0.99 | 0.99 | 1.00 |
| gamma-Aminobutyric acid | ME233551 | 1.00 | 1.01 | 1.00 | 1.00 | 1.03 | 1.00 | 0.97 | 0.99 |
| Glycerol | ME233557 | 1.01 | 1.01 | 1.00 | 1.00 | 1.02 | 1.00 | 0.97 | 1.00 |
| Ethanolamine | ME233548 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 | 1.02 | 1.00 | 0.99 |
| Asparagine | ME233536 | 1.00 | 1.01 | 0.98 | 0.99 | 1.02 | 1.01 | 1.00 | 1.00 |
| Histidine | ME233563 | 1.00 | 1.00 | 1.00 | 0.98 | 1.01 | 1.01 | 1.00 | 1.00 |
| Leucine | ME233569 | 1.00 | 1.01 | 0.99 | 0.98 | 1.01 | 1.01 | 1.00 | 1.00 |
| 2-Ketoleucine/ketoisoleucine | ME233520 | 1.00 | 1.02 | 1.01 | 0.99 | 1.01 | 1.00 | 0.99 | 0.98 |
| 2-Ketovaline | ME233521 | 1.00 | 1.01 | 1.01 | 0.99 | 1.01 | 1.00 | 0.99 | 0.98 |
| Isomaltose or similar disaccharide | ME233566 | 1.00 | 1.00 | 1.00 | 0.99 | 1.02 | 1.01 | 0.99 | 0.99 |
| Pyruvic acid | ME233592 | 1.00 | 1.01 | 1.00 | 0.98 | 1.02 | 1.01 | 1.00 | 0.98 |
| beta-Monostearin | ME233541 | 0.99 | 1.01 | 1.00 | 1.00 | 1.02 | 1.01 | 0.99 | 0.98 |
| 2-Hydroxypyridine | ME233518 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.01 | 1.00 | 0.99 |
| Uric acid | ME233604 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.01 | 1.00 | 0.98 |
| Myoinositol | ME233576 | 1.00 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 |
| Glycine | ME233559 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| Threonine | ME233598 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| Alanine | ME233528 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Lactic acid | ME233568 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Tyrosine | ME233601 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| Lysine | ME233570 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| Proline | ME233588 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 1.00 |
| Stearic acid | ME233595 | 0.99 | 1.01 | 1.00 | 1.00 | 1.01 | 1.01 | 0.99 | 1.00 |
| Fumaric acid | ME233550 | 0.99 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 |
| Malic acid | ME233571 | 0.99 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 |
| alpha-Monopalmitin | ME233532 | 0.99 | 1.01 | 1.00 | 1.00 | 1.02 | 1.00 | 0.99 | 0.99 |
| alpha-Monostearin | ME233533 | 0.99 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 | 0.99 |
| Methionine | ME233573 | 1.01 | 1.01 | 1.00 | 0.99 | 1.01 | 1.00 | 0.99 | 0.99 |
| Ornithine | ME233581 | 1.01 | 1.01 | 0.99 | 0.99 | 1.01 | 1.00 | 0.99 | 0.99 |
| Isoleucine | ME233565 | 1.00 | 1.01 | 1.00 | 0.99 | 1.01 | 1.01 | 0.99 | 0.99 |
| Cysteine/Creatinine (co-elution) | ME233544 | 1.00 | 1.01 | 1.00 | 0.99 | 1.01 | 1.00 | 1.00 | 0.99 |
| Glutamic acid | ME233554 | 1.00 | 1.01 | 1.00 | 0.99 | 1.01 | 1.00 | 0.99 | 0.99 |
| Erythronic acid/Threonic acid | ME233547 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 0.99 |
| Phenylalanine | ME233586 | 1.00 | 1.01 | 1.00 | 1.00 | 1.00 | 1.00 | 0.99 | 0.99 |
| Urea | ME233603 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Threitol/Erythritol | ME233597 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Serine | ME233593 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Gluconic acid or similar sugar acid | ME233552 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Hexitols | ME233561 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Pantothenic acid | ME233583 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.98 | 0.99 |
| Succinic acid | ME233596 | 1.00 | 1.02 | 1.00 | 1.00 | 1.01 | 1.00 | 0.98 | 0.99 |
| Fructose or similar ketohexose | ME233549 | 1.00 | 1.01 | 1.00 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 |
| alpha Ketoglutaric acid | ME233531 | 1.00 | 1.01 | 0.99 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 |
| Valine | ME233605 | 1.00 | 1.01 | 0.99 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 |
| Cystine | ME233546 | 1.00 | 1.01 | 0.99 | 1.00 | 1.01 | 1.01 | 0.99 | 0.99 |
| Aspartic Acid | ME233537 | 1.00 | 1.02 | 0.99 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Tryptophan | ME233600 | 1.00 | 1.01 | 0.99 | 1.00 | 1.01 | 1.00 | 0.99 | 0.99 |
| Citric acid/isocitric acid | ME233543 | 1.01 | 1.00 | 1.01 | 1.00 | 1.01 | 0.99 | 1.00 | 0.99 |
| Pentitols | ME233584 | 1.00 | 1.01 | 1.00 | 1.01 | 1.00 | 0.99 | 1.00 | 0.99 |
| Allantoin | ME233530 | 1.00 | 1.00 | 0.99 | 1.00 | 1.00 | 1.00 | 1.01 | 1.00 |
| Glucose and other aldohexoses | ME233553 | 0.99 | 1.00 | 1.01 | 0.99 | 1.00 | 1.00 | 1.00 | 1.00 |
| 3-Indolelactic acid/tryptophan | ME233522 | 1.01 | 1.01 | 1.02 | 1.04 | 0.99 | 0.94 | 0.98 | 0.98 |
| Methionine sulfoxide | ME233574 | 0.97 | 1.02 | 1.01 | 1.03 | 1.02 | 0.96 | 0.96 | 1.03 |
Factors:
| F1 | type:Ad.shMuRF1 | Stretch Cycle:15 min cyclic stretch |
| F2 | type:Ad.shMuRF1 | Stretch Cycle:30 min cyclic stretch |
| F3 | type:Ad.shMuRF1 | Stretch Cycle:60 min cyclic stretch |
| F4 | type:Ad.shMuRF1 | Stretch Cycle:No stretch |
| F5 | type:Ad.shRNA Scramble | Stretch Cycle:15 min cyclic stretch |
| F6 | type:Ad.shRNA Scramble | Stretch Cycle:30 min cyclic stretch |
| F7 | type:Ad.shRNA Scramble | Stretch Cycle:60 min cyclic stretch |
| F8 | type:Ad.shRNA Scramble | Stretch Cycle:No stretch |
