Data for (Study ST000307)

(Analysis AN000487)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6
2^,4^-DIHYDROXYACETOPHENONE 0.6538 1.4069 0.6686 1.5395 1.1070 0.6241
2-HYDROXYPHENYLACETIC ACID 0.4553 0.9452 0.3614 1.1470 2.8613 0.2299
3-(2-HYDROXYPHENYL)PROPANOATE 0.3382 4.9285 0.0806 0.2541 0.1010 0.2975
3-HYDROXYPHENYLACETATE 1.0474 2.2184 0.5010 1.4474 0.4180 0.3677
3-METHYL-2-OXOVALERIC ACID 0.3525 4.1264 0.2153 0.4584 0.4680 0.3794
3-SULFINO-L-ALANINE 3.4235 0.0338 1.1554 0.2654 0.7012 0.4208
4-COUMARATE 0.7093 1.8283 0.7294 0.7906 1.2415 0.7009
4-GUANIDINOBUTANOATE 1.4237 1.4636 0.7691 1.4403 0.5202 0.3832
4-METHYL-2-OXO-PENTANOIC ACID 0.3282 4.1251 0.3650 0.3498 0.4734 0.3585
4-PYRIDOXATE 0.4912 2.5004 0.3637 2.0007 0.3701 0.2740
ADENINE 0.7365 0.9552 0.6246 0.9375 1.8770 0.8692
ALDOPENTOSE 1.3259 0.1355 0.9491 0.0560 3.4101 0.1233
ALLANTOIN 2.2177 0.3687 1.3934 0.6067 0.7499 0.4743
ALPHA-HYDROXYISOBUTYRIC ACID 0.4663 3.3551 0.4865 0.5314 0.6170 0.5437
AZELAIC ACID 0.9329 1.8350 0.4812 1.6885 0.5138 0.5486
C12H22O11-DISACCHARIDE-(6C/6C; GLC-GLC/GLC-FRC/GAL-GLC) 1.9552 0.0262 0.7113 1.1616 1.9215 0.2242
C6H12O6-HEXOSE/KETOSE/INOSITOL 0.9454 0.0483 0.9330 0.0861 3.9179 0.0694
CITRAMALATE 1.4142 2.3570 0.5956 0.2071 1.0210 0.4051
CREATINE 2.4688 0.0151 1.2124 0.2883 0.8254 1.1900
CYTIDINE 0.6394 2.4703 0.2782 0.2050 1.9652 0.4419
Disaccharide (6C/6C) 2.2900 0.1610 0.9573 1.1236 1.1314 0.3368
ETHYLMALONIC ACID 1.0969 1.6454 0.7152 0.4735 1.5244 0.5446
GLUCONIC ACID 1.9187 0.3043 0.9577 0.0841 2.4820 0.2532
GLUTARATE 1.4861 1.0915 0.7188 0.5206 1.5094 0.6737
GLYCERALDEHYDE/LACTATE 0.9552 0.8674 0.7916 0.9930 1.5354 0.8575
GLYCOLATE 0.7389 0.5744 0.8231 1.5933 1.7456 0.5246
GUANINE 2.5931 0.1761 0.9148 0.3286 1.0709 0.9166
GUANOSINE 5^-MONOPHOSPHATE 1.4173 0.5533 0.1043 NA 1.9817 0.3078
hexose alcohol 2.6345 0.1995 1.3965 0.5957 0.8683 0.3055
HOMOVANILLATE 0.7054 4.5201 0.1703 0.3214 0.0759 0.2069
HYPOXANTHINE 1.5613 0.1490 1.0273 0.2653 2.2602 0.7369
ISOCITRIC ACID 2.2008 1.0243 2.1336 0.3173 0.1438 0.1802
L-GLUTAMINE 1.6147 0.5803 0.7410 0.6452 1.8487 0.5700
L-METHIONINE 0.6600 0.5994 0.0940 0.1685 4.2231 0.2549
L-PHENYLALANINE 1.0677 0.7743 0.3265 0.2844 3.2987 0.2483
L-TYROSINE 1.6444 1.4289 0.6501 0.4290 1.4777 0.3699
MALONIC ACID 2.5460 0.2257 1.1500 0.5589 1.1456 0.3739
MEVALOLACTONE 0.6285 3.7923 0.2698 0.8467 0.2788 0.1839
N-ACETYL-DL-GLUTAMIC ACID 0.6088 3.9151 0.2838 0.2928 0.6627 0.2369
N-ACETYL-DL-SERINE 1.7635 1.2290 0.8343 0.7755 0.7365 0.6612
N-ACETYLGLYCINE 0.9973 1.7136 0.7391 0.4643 0.7215 1.3643
N-ACETYL-L-ASPARTIC ACID 2.8533 1.1867 0.9338 0.1862 0.4563 0.3836
N-ACETYL-L-LEUCINE 0.3314 4.4487 0.2658 0.2999 0.3553 0.2989
NICOTINATE 0.2919 4.2821 0.2502 0.1345 0.9657 0.0756
N-METHYL-D-ASPARTIC ACID 0.6953 0.4707 0.6245 0.2249 3.6983 0.2862
O-ACETYL-L-SERINE 0.6732 1.1682 0.3640 0.2657 3.2262 0.3028
(R)-MALATE 1.8768 1.6440 1.0562 0.1303 0.9278 0.3649
Salicylic Acid-d4 0.9742 0.9870 0.9766 0.9018 1.1259 1.0344
SUCCINATE 0.9522 3.1801 0.5150 0.2817 0.6461 0.4249
Succinic Acid-d4 1.0344 0.8859 1.0791 0.9700 1.0391 0.9915
THREONINE/HOMOSERINE 0.9555 0.4796 0.6160 0.5011 3.0646 0.3833
THYMIDINE 5^-MONOPHOSPHATE 0.2333 0.0226 0.0014 0.0002 3.3099 0.0951
URACIL 0.3958 2.8052 0.2086 0.3066 1.8291 0.4546
URATE 2.0073 0.7567 0.9199 0.6887 0.9549 0.6726
URIDINE 0.9950 2.5718 0.3133 0.2394 1.4101 0.4704
UROCANATE 1.7653 1.3817 0.7302 0.7861 0.5958 0.7409
XANTHINE 1.0749 0.6044 0.5895 0.2826 2.9564 0.4922
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Factors:

F1Strain:CRBN +/+ | Treatment:anti-CD3 & anti-CD28 stimulation
F2Strain:CRBN -/- | Treatment:anti-CD3 & anti-CD28 stimulation
F3Strain:CRBN +/+ | Treatment:anti-CD3 stimulation
F4Strain:CRBN -/- | Treatment:anti-CD3 stimulation
F5Strain:CRBN +/+ | Treatment:unstimulated
F6Strain:CRBN -/- | Treatment:unstimulated
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