Data for (Study ST002835)
(Analysis AN004631)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|
| 2-deoxyribose-5P | 1.2704 | 1.4423 | 0.7437 | 1.1668 | 1.0019 | 0.3755 | NA | NA | NA | NA |
| 3-Aminoisobutanoic acid (2-methyl-beta-alanine) | 0.8818 | 0.6615 | 0.7103 | 0.4752 | 0.3977 | 0.4396 | 1.5759 | 1.2969 | 1.8525 | 1.7085 |
| 3-Phosphoglyceric acid | 0.7715 | 0.7813 | 0.7988 | 0.4274 | 0.5817 | 0.6648 | 1.4712 | 0.8189 | 1.7030 | 1.9813 |
| 3-Ureidopropionate | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 6-Phosphono-gluconic acid | 1.9444 | 0.4360 | 1.6725 | 0.9668 | 0.2811 | 0.7432 | 0.8357 | 0.3280 | 1.3856 | 1.4066 |
| Acetylcarnitine | 1.5874 | 1.6399 | 0.4270 | 1.9092 | 1.8365 | 0.6326 | 0.5032 | 0.4006 | 0.5328 | 0.5309 |
| Acetyl-CoA | 1.7495 | 1.4507 | 1.6226 | 1.4427 | 1.4940 | 0.6886 | 0.1406 | 0.0693 | NA | 0.0554 |
| Aconitic acid | 0.9428 | 0.4494 | 0.5467 | 0.7009 | 0.3680 | 0.4768 | 1.5624 | 1.3867 | 1.5624 | 2.0038 |
| Adenosine | 1.5249 | 1.4052 | 2.2581 | 1.5473 | 1.3884 | 1.3052 | 0.1845 | 0.1390 | 0.1126 | 0.1348 |
| Adenosine diphosphate (ADP) | 1.0215 | 0.9029 | 1.0568 | 0.9708 | 0.9505 | 0.9228 | 1.1250 | 0.8410 | 1.0746 | 1.1343 |
| Adenosine monophosphate (AMP) | 0.7327 | 1.0016 | 0.6593 | 0.7679 | 1.0992 | 1.2027 | 1.1553 | 1.1267 | 1.0835 | 1.1712 |
| Adenosine triphosphate (ATP) | 1.1357 | 0.9655 | 0.9651 | 1.0325 | 0.9682 | 0.9583 | 1.0378 | 0.7808 | 0.9632 | 1.1928 |
| Alanine | 1.5976 | 1.2077 | 1.6433 | 1.3719 | 1.0433 | 0.9606 | 0.4868 | 0.6228 | 0.6000 | 0.4660 |
| alpha-Ketoglutaric acid | 0.8230 | 0.6080 | 0.4646 | 0.7582 | 0.5147 | 0.7620 | 1.5081 | 1.3012 | 1.6642 | 1.5962 |
| Arginine | 0.9381 | 1.0357 | 0.8474 | 0.8462 | 0.9800 | 0.9617 | 1.0158 | 1.0965 | 1.1143 | 1.2545 |
| Asparagine | 1.1051 | 1.1099 | 0.9162 | 0.7156 | 0.7959 | 0.8261 | 1.1787 | 0.8630 | 1.2188 | 1.2707 |
| Aspartic acid | 0.2416 | 0.4605 | 0.3171 | 0.1664 | 0.3513 | 0.2950 | 2.1750 | 1.8532 | 2.1704 | 1.9695 |
| Beta-Alanine | 1.3165 | 0.8057 | 0.4183 | 1.0111 | 0.6082 | 0.4879 | 1.3064 | 1.2053 | 1.3621 | 1.4784 |
| Citric acid + Isocitric acid | 0.8623 | 0.7849 | 0.9976 | 0.6348 | 0.5286 | 0.8801 | 1.3018 | 1.1915 | 1.2907 | 1.5276 |
| Citrulline | 1.4303 | 0.1490 | 0.0929 | 0.9894 | 0.1203 | 0.1335 | 1.6839 | 1.9001 | 1.8055 | 1.6952 |
| CMP | 0.9979 | 0.9330 | 0.5888 | 1.1998 | 1.3736 | 0.7121 | 1.0832 | 1.1170 | 1.0255 | 0.9692 |
| Creatine | 1.4323 | 1.2412 | 1.5050 | 1.3319 | 1.0761 | 1.0498 | 0.4592 | 0.5846 | 0.5276 | 0.4179 |
| Cysteine | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| cystine | 1.5931 | 1.2668 | 2.6929 | 0.9128 | 1.0076 | 0.8539 | 0.3930 | 0.3430 | 0.3163 | 0.6207 |
| Cytidine 5^-triphosphate | 1.2722 | 0.9991 | 0.9676 | 1.3038 | 1.0093 | 0.8468 | 0.9393 | 0.7822 | 0.8330 | 1.0468 |
| Cytosine | 0.8155 | 0.6886 | 0.4036 | 0.8293 | 0.7333 | 0.4692 | 1.3075 | 1.8167 | 1.5430 | 1.3932 |
| d-ADP | 1.4536 | 1.3142 | 1.1688 | 0.5085 | 0.6671 | 0.6203 | NA | NA | NA | 1.4698 |
| d-AMP | 1.7080 | 1.1806 | 1.9181 | 0.2779 | 1.3839 | 0.1176 | NA | NA | 0.0487 | 0.0841 |
| d-ATP | 0.8874 | 0.4372 | 0.3099 | 0.2098 | 0.1578 | 0.1132 | 2.6430 | 0.2464 | 2.5125 | 1.9804 |
| d-CDP | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| d-CMP | 1.4746 | 1.0634 | 1.0352 | 1.1799 | 1.1424 | 0.9720 | 0.6161 | 0.8546 | 1.0421 | 0.6198 |
| Deoxyguanosine diphosphate | 1.2429 | 1.0791 | 0.9561 | 1.0369 | 0.9459 | 0.9662 | 1.1324 | 0.7275 | 0.8787 | 1.0342 |
| d-GMP | 0.9013 | 0.8871 | 0.7667 | 0.9946 | 0.9453 | 0.7540 | 1.0927 | 1.3995 | 1.1220 | 1.1369 |
| d-GTP | 1.2063 | 1.2535 | 0.4733 | 1.2232 | 1.2976 | 0.9225 | 1.0738 | 0.8574 | 1.0409 | 0.7203 |
| Dihydrouracil | 1.5196 | 1.2753 | 1.5343 | 1.3680 | 1.1032 | 1.1213 | 0.4691 | 0.5974 | 0.5567 | 0.4551 |
| Erythrose 4-P | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Farnesyl -PP | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| "Fructose1,6-bisphosphate" | 0.5088 | 0.2944 | 0.4889 | 0.2813 | 0.1977 | 0.2918 | 1.8607 | 0.9465 | 2.4804 | 2.6494 |
| Fumaric acid | 0.3258 | 0.3311 | 0.3803 | 0.1912 | 0.2824 | 0.3296 | 1.9502 | 1.4353 | 2.1382 | 2.6358 |
| Glucosamine-6-phosphate | 1.2606 | 1.0628 | 1.0445 | 0.8513 | 0.7223 | 0.7998 | 1.1331 | 0.9411 | 1.0703 | 1.1142 |
| glucose | 0.8926 | 0.7813 | 2.3711 | 0.8192 | 1.0832 | 0.9439 | 0.8920 | 0.6874 | 0.7777 | 0.7156 |
| Glucuronic acid | 0.8932 | 0.8216 | 0.7323 | 0.7979 | 0.8217 | 0.6608 | 1.2637 | 1.4030 | 1.3614 | 1.4984 |
| Glutamic acid | 1.0768 | 1.1802 | 1.0900 | 0.6237 | 0.7173 | 0.9197 | 1.0826 | 0.9428 | 1.1483 | 1.2185 |
| Glutamine | 1.0019 | 1.1149 | 1.0045 | 0.7590 | 0.8077 | 0.9448 | 1.0782 | 0.9214 | 1.1566 | 1.2109 |
| Glutathione oxidized | 1.1455 | 1.1474 | 1.1432 | 1.1083 | 1.0974 | 1.1936 | 0.7844 | 0.7436 | 0.8535 | 0.7832 |
| Glutathione (reduced) | 0.0571 | 0.1965 | 0.0607 | 0.0232 | 0.1487 | 0.0993 | 1.8534 | 0.6627 | 4.0234 | 2.8749 |
| Glyceraldehyde 3-phosphate + DHAP | 0.5410 | 0.2803 | 0.2891 | 0.4259 | 0.3179 | 0.2282 | 1.7558 | 0.9536 | 2.4937 | 2.7146 |
| glycerol | 1.5789 | 0.4456 | 0.3856 | 1.3992 | 0.4482 | 0.4512 | 1.4857 | 1.1775 | 1.0427 | 1.5856 |
| Glycine | 1.0022 | 0.6204 | 0.6991 | 0.6168 | 0.6328 | 0.8169 | 1.4034 | 1.4631 | 1.1230 | 1.6223 |
| Glyoxylic acid | 0.6548 | 0.4349 | 0.2984 | 0.6258 | 0.4839 | 0.5671 | 1.6746 | 1.7216 | 1.9680 | 1.5708 |
| GMP | 0.9791 | 0.6501 | 0.2701 | 1.0087 | 1.0135 | 0.3884 | 1.3550 | 1.3244 | 1.3220 | 1.6886 |
| Guanosine | 1.4173 | 1.0272 | 0.7646 | 2.3028 | 1.7667 | 1.1616 | 0.4109 | 0.6023 | 0.3088 | 0.2378 |
| Guanosine triphosphate (GTP) | 1.6384 | 1.0901 | 1.0849 | 1.4348 | 1.0318 | 1.0525 | 0.7800 | 0.4868 | 0.5817 | 0.8190 |
| Hexose-phosphate | 1.3086 | 0.4724 | 1.9163 | 0.8669 | 0.3740 | 0.6612 | 0.8071 | 0.7292 | 1.5354 | 1.3289 |
| Histidine | 0.6574 | 0.3530 | 0.4845 | 0.4173 | 0.7876 | 0.3397 | 1.3983 | 1.3513 | 1.8928 | 1.8071 |
| IMP | 0.7529 | 0.7185 | 1.4542 | 0.6146 | 0.4406 | 0.5881 | 1.2913 | 1.1076 | 1.3250 | 1.7072 |
| Inositol | 0.2023 | 0.1857 | 0.1462 | 0.2229 | 0.2222 | 0.1786 | 2.0854 | 2.3611 | 2.1235 | 2.2721 |
| Isoleucine | 0.8812 | 0.9179 | 0.9814 | 0.7017 | 0.7691 | 0.8301 | 1.0620 | 1.1153 | 1.4302 | 1.3111 |
| Itaconic Acid | 0.9138 | 0.5728 | 0.6111 | 0.6930 | 0.5328 | 0.6317 | 1.5088 | 1.2856 | 1.5200 | 1.7303 |
| Lactic Acid | 0.7465 | 0.2067 | 0.0024 | 0.7233 | 0.2359 | 0.2629 | 2.3559 | 1.3782 | 1.8149 | 2.2733 |
| Leucine | 0.8065 | 0.8312 | 0.9315 | 0.6068 | 0.6532 | 0.8513 | 1.3445 | 1.0718 | 1.3640 | 1.5393 |
| Lysine | 0.7344 | 0.8065 | 0.4347 | 0.7620 | 0.7544 | 0.6866 | 1.4191 | 1.5212 | 1.1851 | 1.6960 |
| Malic acid | 0.3855 | 0.4016 | 0.4934 | 0.2276 | 0.2654 | 0.3829 | 1.9577 | 1.4700 | 2.1332 | 2.2827 |
| Methionine | 0.5435 | 0.8642 | 0.7081 | 0.5432 | 0.8273 | 0.9648 | 1.3687 | 1.2257 | 1.5195 | 1.4349 |
| Mevalonic acid | 0.4334 | 1.1139 | 0.7282 | 1.8402 | 0.4773 | 0.7278 | 2.0566 | 0.8300 | 1.0484 | 0.7441 |
| Mevalonic acid 5-P | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| N-Acetyl-glucosamine 1-phosphate | 0.8404 | 0.6139 | 0.6668 | 0.5471 | 0.8904 | 0.4996 | 1.7363 | 1.4046 | 1.2072 | 1.5936 |
| N-Acetylneuraminic acid | 0.5086 | 0.2867 | 0.3836 | 0.3196 | 0.5928 | 0.4946 | 1.7075 | 1.8649 | 1.7957 | 2.0460 |
| NAD+ | 0.9530 | 0.9389 | 1.0185 | 0.8327 | 0.9012 | 0.9583 | 1.0613 | 1.0446 | 1.0895 | 1.2020 |
| NADH | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| NADP+ | 1.4377 | 1.5098 | 1.1751 | 1.4588 | 1.8856 | 1.2708 | 0.3181 | 0.3382 | 0.2656 | 0.3402 |
| NADPH | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Niacin (NA) | 0.9073 | 0.6985 | 0.5640 | 0.6216 | 0.8477 | 0.8966 | 0.8754 | 0.9181 | 1.0189 | 2.6519 |
| NMN | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ornithine | 0.6796 | 0.7279 | 0.4495 | 0.5565 | 0.8987 | 0.5756 | 1.5317 | 1.4195 | 1.2498 | 1.9113 |
| Oxaloacetate | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| pantothenic acid | 2.1373 | 0.7050 | 0.6441 | 1.8627 | 0.6327 | 0.6933 | 0.3618 | 0.9011 | 1.4832 | 0.5789 |
| "Pentose - Phosphate (ribose, ribulose and xylulose)" | 1.9252 | 0.6518 | 1.1180 | 1.2854 | 0.4764 | 0.5137 | 0.8618 | 0.5173 | 1.3932 | 1.2572 |
| Phenylalanine | 0.8681 | 0.7842 | 0.7261 | 0.7401 | 0.7129 | 0.6942 | 1.3596 | 1.1560 | 1.4539 | 1.5049 |
| Phenylpyruvate | 0.6774 | 0.6689 | 0.4436 | 0.7745 | 0.8208 | 0.6443 | 1.7485 | 1.3162 | 1.3233 | 1.5826 |
| Phosphocreatine | 1.3693 | 1.3490 | 1.2793 | 1.2907 | 1.3086 | 1.2776 | 0.5213 | 0.5590 | 0.5173 | 0.5280 |
| Phosphoenolpyruvic acid | 0.4004 | 0.8866 | 0.5146 | 0.2185 | 0.8516 | 0.6996 | 1.7897 | 0.9854 | 1.7213 | 1.9324 |
| Proline | 0.6355 | 0.7328 | 0.6648 | 0.5837 | 0.6523 | 0.7061 | 1.4302 | 1.4877 | 1.6045 | 1.5023 |
| Pyruvic acid | 0.3560 | 0.4202 | 0.4152 | 0.3084 | 0.2856 | 0.3273 | 2.0131 | 1.4675 | 2.4147 | 1.9920 |
| Sedoheptulose 7-P | 2.3596 | 0.5397 | 0.7987 | 1.7943 | 0.6669 | 0.5203 | 0.4833 | 0.3788 | 1.1220 | 0.9933 |
| Serine | 1.0731 | 1.0058 | 0.9518 | 0.6672 | 0.6247 | 0.6285 | 0.9455 | 1.2441 | 1.5701 | 1.2891 |
| Succinic acid | 1.0437 | 0.5150 | 0.7900 | 0.8042 | 0.8746 | 1.0330 | 1.1762 | 0.9795 | 1.1451 | 1.6387 |
| SuccinylCoA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Threonine | 1.0992 | 0.9745 | 1.4785 | 0.7016 | 0.7711 | 0.7071 | 1.1144 | 0.8992 | 1.0844 | 1.1701 |
| Thymidine | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Thymidine triphosphate | 1.3128 | 0.5344 | 0.3773 | 0.4380 | 0.2193 | 0.1701 | 2.1693 | 0.1998 | 2.1064 | 2.4726 |
| Thymine | 1.1405 | 1.2915 | 0.3173 | 1.1642 | 0.6662 | 0.5638 | 1.1020 | 1.1446 | 1.0368 | 1.5731 |
| TMP | 2.8856 | 1.0854 | 0.9977 | 2.7541 | 0.4774 | 0.4811 | 0.1087 | 0.4081 | 0.2279 | 0.0797 |
| Tryptophan | 0.1872 | 0.5753 | 0.7590 | 0.2529 | 0.5219 | 0.7199 | 1.8271 | 1.3228 | 1.7468 | 2.0870 |
| Tyrosine | 0.7234 | 0.8141 | 0.8145 | 0.5766 | 0.7722 | 0.9223 | 1.4173 | 1.1293 | 1.3477 | 1.4825 |
| UDP-GlcNAc | 0.9243 | 0.8909 | 1.0572 | 0.9035 | 0.8767 | 0.9380 | 1.0466 | 0.8736 | 1.2342 | 1.2551 |
| Uracil | 0.9499 | 0.0672 | 0.0254 | 0.9927 | 0.0701 | 0.0499 | 2.1903 | 1.7438 | 1.7694 | 2.1413 |
| Uridine | 3.7210 | 1.3008 | 0.1900 | 3.4012 | 0.9503 | 0.1701 | 0.0254 | 0.1327 | 0.0779 | 0.0307 |
| Uridine 5^-diphosphate (UDP) | 0.8022 | 0.6931 | 0.7655 | 0.7279 | 0.6303 | 0.6062 | 1.4015 | 1.0480 | 1.6609 | 1.6644 |
| Uridine 5^-triphosphate | 1.1721 | 1.1480 | 1.1053 | 1.0081 | 0.9777 | 1.0142 | 0.9068 | 0.5265 | 0.9460 | 1.1952 |
| Uridine diphosphate glucose | 0.6489 | 0.5229 | 0.7010 | 0.5545 | 0.4478 | 0.5447 | 1.6326 | 1.1092 | 1.9291 | 1.9094 |
| Uridine monophosphate | 0.5352 | 0.5080 | 0.5114 | 0.5276 | 0.9023 | 0.5062 | 1.5542 | 1.3730 | 1.8386 | 1.7434 |
| Valine | 1.1656 | 1.1501 | 1.0032 | 0.9977 | 0.9946 | 1.1151 | 0.9127 | 0.8718 | 0.8628 | 0.9265 |
| Xanthine | 1.1129 | 0.1007 | 0.0866 | 1.0781 | 0.1133 | 0.1337 | 1.6782 | 1.8852 | 2.1934 | 1.6177 |
Factors:
| F1 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 0h as ctrl |
| F2 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 1h |
| F3 | cell line:ICC13-7 | treatment:control | labeling status:13C6-Glucose Isotopic tracing 24h |
| F4 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 0h as ctrl |
| F5 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 1h |
| F6 | cell line:ICC13-7 | treatment:Infigratinib | labeling status:13C6-Glucose Isotopic tracing 24h |
| F7 | cell line:ICC21 | treatment:Afatinib | labeling status:N/A |
| F8 | cell line:ICC21 | treatment:Combo | labeling status:N/A |
| F9 | cell line:ICC21 | treatment:control | labeling status:N/A |
| F10 | cell line:ICC21 | treatment:Infigratinib | labeling status:N/A |
