Data for (Study ST002999)
(Analysis AN004926)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Adenosine triphosphate (ATP) | 0.9543 | 1.0503 | 1.2222 | 1.8244 | 0.6454 | 0.6180 | 0.6136 | NA | 0.7075 | 1.3609 | 1.4381 | 1.1756 | 0.8443 | 0.8256 | 0.7196 |
| Citric acid | 2.1997 | 0.1557 | 0.1062 | 0.8957 | 0.1045 | 0.0962 | 0.9361 | NA | 3.0093 | 0.0886 | 0.1503 | 3.2843 | 0.0816 | 0.1454 | 2.7465 |
| D-Glucose 6-phosphate | NA | 0.9600 | 0.5782 | NA | 0.9943 | 0.5401 | NA | NA | NA | 1.7391 | 0.9052 | NA | 1.4963 | 0.7868 | NA |
| D-Glyceraldehyde 3-phosphate | 1.3741 | 0.5782 | 0.7640 | 0.7977 | 0.7965 | 0.4978 | 0.1115 | NA | 1.4603 | 1.2975 | 1.5633 | 1.6777 | 1.4913 | 1.1253 | 0.4647 |
| D-Glycerate 3-phosphate | 1.2398 | 0.2375 | 1.0005 | 0.8843 | 0.4783 | 0.5822 | 0.5127 | NA | 1.3437 | 0.7445 | 1.9988 | 1.9268 | 0.8892 | 1.1484 | 1.0133 |
| Fumaric acid | 1.3121 | 0.1400 | 0.7155 | 2.3565 | 0.2013 | 0.3214 | 1.8053 | NA | 1.0337 | 0.6977 | 0.9188 | 1.7345 | 0.4039 | 0.6323 | 1.7269 |
| Guanosine triphosphate (GTP) | 1.7504 | 0.9740 | 0.9177 | 1.3767 | 0.4810 | 0.3539 | 0.5977 | NA | 1.3353 | 1.2035 | 1.2342 | 1.5524 | 0.6981 | 0.6327 | 0.8925 |
| L-Glutamate | 0.4928 | 1.5313 | 0.9903 | 1.6657 | 0.8088 | 0.4708 | 0.7742 | NA | 0.4094 | 1.6330 | 1.1207 | 1.8500 | 0.7248 | 0.4696 | 1.0586 |
| L-Glutamine | 1.8245 | NA | NA | 0.3771 | NA | NA | 0.3630 | NA | 2.1595 | NA | NA | 0.5850 | NA | NA | 0.6910 |
| L-Lactic acid | 1.2416 | 0.5703 | 1.7508 | 1.4390 | 0.1761 | 0.3175 | 0.2792 | NA | 1.3111 | 0.6284 | 2.2255 | 2.4337 | 0.2531 | 0.7569 | 0.6168 |
| L-Malic acid | 0.7583 | 0.3047 | 0.8709 | 2.5370 | 0.2632 | 0.4735 | 0.0011 | NA | 1.3848 | 0.8536 | 1.1032 | 2.4814 | 0.4763 | 0.7628 | 1.7291 |
| L-Serine | 1.5649 | 0.3908 | 0.3289 | 1.7691 | 0.4530 | 0.5934 | 1.5262 | NA | 1.4834 | 0.5099 | 0.1900 | 2.1195 | 0.3189 | 0.3320 | 2.4200 |
| Oxoglutaric acid | 0.1869 | 1.4321 | 0.7704 | 1.9567 | 1.1283 | 0.7308 | 2.3779 | NA | 0.1791 | 1.3646 | 0.8299 | 0.4578 | 0.6504 | 0.6365 | 1.2986 |
| Pyruvate | 0.6918 | 1.0730 | 0.7193 | 1.5492 | 0.1680 | 0.1174 | 0.7435 | NA | 0.6360 | 0.8725 | 0.4878 | 3.7979 | 0.3082 | 0.2400 | 2.5953 |
| Succinic acid | 1.2439 | 0.8781 | 0.8716 | 1.6984 | 0.2649 | 0.3514 | 0.7713 | NA | 1.4573 | 0.8921 | 1.0383 | 2.1736 | 0.4810 | 0.5151 | 1.3630 |
| Uridine triphosphate (UTP) | 0.4662 | 1.6873 | 1.5759 | 1.5044 | 0.7176 | 0.6598 | 0.2334 | NA | 0.3548 | 2.1165 | 1.7276 | 0.4036 | 1.0513 | 0.9504 | 0.2956 |
Factors:
| F1 | Genotype:Empty vector | Treatment:CB-839 | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F2 | Genotype:Empty vector | Treatment:DMSO | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F3 | Genotype:Empty vector | Treatment:DMSO | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F4 | Genotype:Empty vector | Treatment:DMSO | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F5 | Genotype:Empty vector | Treatment:Romidepsin | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F6 | Genotype:Empty vector | Treatment:Romidepsin | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F7 | Genotype:Empty vector | Treatment:Romidepsin | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F8 | Genotype:NA | Treatment:NA | Timepoint:NA | Tracer:NA |
| F9 | Genotype:NRF2 overexpression | Treatment:CB-839 | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F10 | Genotype:NRF2 overexpression | Treatment:DMSO | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F11 | Genotype:NRF2 overexpression | Treatment:DMSO | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F12 | Genotype:NRF2 overexpression | Treatment:DMSO | Timepoint:8 hours | Tracer:U-C13 Glutamine |
| F13 | Genotype:NRF2 overexpression | Treatment:Romidepsin | Timepoint:1 hour | Tracer:U-C13 Glucose |
| F14 | Genotype:NRF2 overexpression | Treatment:Romidepsin | Timepoint:24 hours | Tracer:U-C13 Glucose |
| F15 | Genotype:NRF2 overexpression | Treatment:Romidepsin | Timepoint:8 hours | Tracer:U-C13 Glutamine |
