Data for (Study ST004424)

(Analysis AN007401)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8
1_3-Bisphosphoglyceric acid 1.0566 1.0724 0.8030 1.0887 0.9064 1.0790 1.0030 0.9931
2_3-Diphosphoglyceric acid 1.0568 1.0755 0.8041 1.0877 0.9018 1.0810 1.0027 0.9928
2-dehydro-D-gluconate 0.9409 1.0670 1.2291 0.9588 0.8676 0.9737 0.9246 1.0288
2-Hydroxy-2-methylbutanedioic acid 0.8450 1.0545 1.0253 1.0673 0.9460 1.1089 0.8997 1.0400
3-phosphoglycerate 0.8965 1.2147 1.2211 1.0534 0.7387 0.9773 0.8860 1.0092
3-phospho-serine 1.0646 1.0057 0.9916 1.0250 0.8569 0.9342 1.0967 1.0189
4-aminobutyrate 1.1729 1.0195 1.3898 0.9005 0.7273 0.7254 0.9951 1.0521
4-phosphopantetheine 1.1735 0.9399 2.3400 0.9044 0.3290 0.6036 0.7848 0.9436
4-phosphopantothenate 0.9156 1.2342 0.9126 1.1310 0.7571 0.9070 1.1207 1.0163
4-Pyridoxic acid 0.8849 1.0751 1.0995 1.0251 0.9844 1.0562 0.8537 1.0158
5-aminopentanoic acid 1.2306 1.2329 0.9626 0.8589 0.6967 0.7779 1.2057 1.0260
5-phosphoribosyl-1-pyrophosphate 1.7022 1.0608 0.7664 0.8276 0.4340 0.4648 1.7300 1.0107
6-phospho-D-gluconate 1.0088 0.9976 1.0020 0.9979 0.9642 1.0813 0.9379 1.0077
acetyl-aspartate 0.9361 1.0182 1.0693 1.0087 0.9153 0.9699 0.9490 1.1001
acetyl-CoA 0.8809 1.2153 0.7330 1.1740 0.8874 0.9157 1.1975 0.9972
Acetyllysine 1.8861 1.7603 0.1233 0.7007 0.1826 0.2267 2.0923 1.0210
adenine 1.0012 1.0242 0.6098 1.2140 1.0577 1.0806 0.9291 1.0626
ADP-D-glucose 1.0748 1.0312 1.0009 1.0492 0.8799 0.9578 0.9744 1.0239
a-ketoglutarate 0.9512 0.9693 1.2467 1.1555 0.7384 0.8417 1.0731 1.0181
alanine/sarcosine 1.3772 1.4908 0.5048 0.8629 0.6285 0.6989 1.4129 1.0179
arginine 1.7262 0.8368 0.9387 0.8174 0.6570 0.7230 1.2592 1.0313
asparagine 0.9964 1.1542 0.9481 0.9709 0.8596 0.8948 1.1618 1.0106
aspartate 0.6753 1.2932 1.0799 0.8782 0.8317 0.8975 1.3280 1.0121
CDP 0.6168 1.0446 0.5354 1.4622 1.2353 1.0698 1.0660 0.9774
CDP-choline 0.9634 1.2728 0.9424 0.9467 0.8151 1.0021 1.0418 1.0117
CDP-ethanolamine 0.8438 0.9753 1.0020 1.0204 0.9739 1.1308 1.0154 1.0288
CMP 0.5470 1.1164 1.1333 1.3907 0.9614 0.7785 1.0522 1.0154
coenzyme A 1.0779 1.2699 1.1863 1.1181 0.6277 0.8796 0.9858 0.8911
creatine 0.8937 1.1079 0.9419 1.0576 0.8474 1.0962 0.9724 1.0621
CTP 0.7646 1.0935 0.7485 1.0302 1.1290 1.1844 1.0682 0.9862
cytidine 0.9504 0.8079 1.2660 0.8800 1.1193 1.1491 0.7817 1.0342
DAL 0.8557 1.1418 0.9479 1.0127 0.7666 1.1146 1.1577 1.0022
dAMP 0.5849 0.9489 1.3217 1.8533 0.8641 0.5162 0.8997 1.0084
dATP 1.4272 0.9621 0.9702 1.0868 0.7957 0.7475 1.0783 0.9491
dCDP 0.8257 0.9373 0.7700 1.5457 1.0099 0.8600 1.0908 0.9705
dCMP 0.7419 1.0385 1.6657 0.9675 0.8591 0.7860 0.9112 1.0226
dCTP 1.1005 0.9945 1.1964 0.9199 0.8268 0.8835 1.0799 0.9988
deoxyuridine 0.9659 1.0639 1.0694 0.9973 1.0486 1.0259 0.9572 0.9039
dGDP/ADP 0.9037 1.0699 0.3244 1.5074 1.1297 1.0171 1.0459 1.0013
D-gluconate 1.0228 1.1510 1.1012 1.0618 0.7385 0.8151 1.0493 1.0452
D-glucosamine-1/6-phosphate 0.9536 1.0378 1.0591 1.0152 0.9228 1.0337 0.9486 1.0219
dGMP/AMP 0.6918 1.1044 0.4406 1.7771 1.1402 0.8077 1.0153 1.0171
dGTP/ATP 1.2239 1.0823 0.5737 1.0257 0.9473 1.1409 1.0627 0.9577
dihydroorotate 6.0334 0.2312 0.0614 0.1065 0.0893 0.0994 0.1840 1.1461
dihydroxy-acetone-phosphate 0.9410 1.0849 1.4416 0.7726 0.7523 1.0979 0.8755 1.0257
DLH 1.3150 2.7930 0.0433 0.7823 0.1882 0.2068 1.6338 1.0282
DL-Pipecolic Acid 1.9477 0.9248 0.5021 0.6162 0.3342 0.6006 2.0570 1.0131
DLS 1.4166 2.4461 0.1085 0.8785 0.1606 0.1597 1.8298 1.0002
D-sedoheptulose-1/7-phosphate 1.0754 0.9419 1.1230 0.9225 0.9227 1.0040 0.9694 1.0308
dTDP 0.4105 0.9094 1.5142 1.5881 0.8982 0.6219 1.0534 1.0032
dTMP 0.2406 0.6046 3.1604 1.2574 0.6744 0.4455 0.5859 1.0234
dTTP 0.5460 0.8294 2.3881 0.8515 0.7358 0.6528 0.9757 1.0155
FAD 0.9578 1.0043 0.7386 1.0118 1.1863 1.1468 0.8456 1.0816
folate 0.9279 1.0417 1.1297 1.0040 0.8867 1.0393 0.9379 1.0246
fructose-1-6-bisphosphate 1.0278 1.0514 1.1171 0.9098 0.8183 1.0984 0.9582 1.0142
fructose-6-phosphate 1.1016 1.0739 0.8511 0.9377 0.8875 1.1727 0.9496 1.0194
fumarate 1.2455 1.0722 1.3199 0.8047 0.5664 0.7490 1.2017 1.0305
GDP 1.0210 0.9758 0.2428 1.6376 1.1064 0.9019 1.1011 1.0099
glucono-lactone 0.9375 1.0726 1.0335 1.0615 0.8263 1.0479 1.0134 1.0055
glucose-1-phosphate 1.1017 1.0739 0.8511 0.9378 0.8876 1.1725 0.9495 1.0195
glutamate 1.1307 1.0046 1.3251 0.8971 0.7810 0.8543 0.9687 1.0288
glutamine 0.9800 1.0332 1.0375 1.0000 0.8859 0.9888 1.0612 1.0099
glutathione 1.0562 1.0333 0.9925 0.9653 0.8330 1.0297 1.0498 1.0301
glutathione disulfide 1.0088 0.9384 1.0803 1.0210 0.9010 0.8959 1.1318 1.0171
glycerate 1.0979 1.1496 0.9424 1.0363 0.7488 0.9502 1.0523 1.0168
glycodeoxycholic acid? 1.0915 1.1535 0.9133 0.9632 0.7389 0.6656 1.4876 0.9898
GMP 1.0754 1.1808 0.2484 1.5158 0.9402 0.7410 1.2877 1.0082
GTP 1.5951 1.1120 0.5058 1.0665 0.9013 1.1481 1.1353 0.6520
guanine 1.2995 1.1434 0.2361 1.5656 1.0641 0.8720 0.8128 1.0049
Hexose 0.6279 0.6800 2.8652 0.7307 0.7339 0.7127 0.5339 1.0868
hexose-phosphate 1.1017 1.0740 0.8511 0.9375 0.8876 1.1729 0.9492 1.0194
histidine 1.2246 1.6694 0.7009 0.8181 0.6017 0.6636 1.2907 1.0233
hydroxyproline/Aminolevulinate 1.0115 1.0903 1.0292 0.9971 0.8623 0.9667 1.0144 1.0213
hypoxanthine 0.9862 1.0976 0.9944 1.0074 0.9501 1.0542 0.8890 1.0158
IDP 0.8582 0.9317 1.0837 1.1610 0.9254 1.1338 0.8131 1.0699
IDS 0.3266 2.0468 1.5536 0.8771 0.8611 0.6823 0.6059 1.0349
IMP 1.0463 1.1035 1.0797 1.0419 0.8293 0.9611 0.9165 1.0162
inosine 0.9533 1.0536 1.0441 1.0226 0.9168 1.0357 0.9398 1.0255
isoleucine 1.0342 1.1838 1.1603 0.8867 0.7948 0.9256 0.9863 1.0213
Kynurenine 0.9554 1.1370 1.0128 1.0046 0.8173 0.9978 1.0258 1.0370
lactate 1.1031 1.2325 0.8048 0.9145 0.8075 1.0148 1.0846 1.0287
L-arginino-succinate 1.3776 0.9226 1.1630 0.7798 0.6788 0.8287 1.2596 0.9925
LD 1.0479 1.3647 0.6954 1.0046 0.9262 0.9050 1.0332 1.0172
leucine 1.1141 1.4728 1.0452 0.7792 0.6765 0.8224 1.0555 1.0257
lysine 2.1217 1.1456 0.3920 0.6111 0.3378 0.9272 1.4486 1.0121
malate 1.2447 1.0786 1.3123 0.8001 0.5585 0.7451 1.2087 1.0389
maleic acid 1.2436 1.0721 1.3174 0.8041 0.5666 0.7496 1.2060 1.0304
methionine 0.9226 1.4255 1.1012 0.8028 0.8225 1.0150 0.8833 1.0204
myo-inositol 1.1949 1.3682 0.6842 0.8763 0.6697 1.0345 1.1331 1.0294
N-acetyl-glucosamine-1/6-phosphate 1.2920 1.0345 0.7658 1.0594 0.8892 0.8920 1.0547 1.0093
N-acetyl-glutamate 0.9054 1.0220 1.2450 0.8912 0.9699 1.0789 0.8515 1.0271
N-acetyl-glutamine 1.3026 0.9692 0.8242 0.8993 0.7236 0.7635 1.4777 1.0299
N-Acetyl-L-alanine 0.9272 1.3468 0.9311 0.9502 0.8486 0.8005 1.1786 1.0128
N-acetyl-L-ornithine 1.2424 2.5504 0.1136 0.7868 0.2412 0.2455 1.8178 1.0018
NAD+ 1.0242 1.0325 0.9191 1.0088 0.9493 1.0209 1.0006 1.0335
NADH 0.8468 1.1009 1.6125 0.6078 0.7596 1.3312 0.7501 0.9933
NADP+ 0.9106 1.0319 1.0126 1.0933 0.9762 1.0600 0.8863 1.0218
NADPH 0.7499 1.1031 1.3065 0.7502 0.8574 1.3856 0.7879 1.0446
N-carbamoyl-L-aspartate 4.8150 0.4184 0.1442 0.1997 0.1787 0.2066 0.4148 1.4671
nicotinamide mononucleotide 0.9021 1.0387 1.4058 0.8944 0.8255 0.9164 0.9892 1.0210
nicotinate 0.8720 1.2681 0.9397 1.1657 0.8865 1.0147 0.8551 0.9987
O-acetyl-L-serine 1.1472 1.0002 1.3377 0.8881 0.7751 0.8530 0.9612 1.0282
Octulose 8/1P 0.9910 1.0151 0.9780 1.0267 0.9131 1.0179 1.0211 1.0278
Octulose Bisphosphate 1.2550 1.0937 0.4999 0.9763 0.8427 1.0967 1.2193 1.0123
orotate 1.4565 1.0629 0.5910 0.9265 0.9181 0.8756 1.1499 1.0147
pantothenate 1.0396 1.0861 1.2242 0.9210 0.8002 0.9535 0.9431 1.0242
PD 2.3924 1.2324 0.1530 0.6518 0.1355 0.1289 2.2622 1.0330
PE 1.3685 3.0832 0.1199 0.4816 0.1964 0.1645 1.5647 1.0159
PEE 1.1337 3.1576 0.1748 0.5484 0.2021 0.2829 1.4809 1.0147
PEEK 1.6553 1.6840 0.1317 0.6922 0.1340 0.3219 2.3197 1.0459
Phenol Red 1.0164 1.3074 1.0651 0.8597 0.7560 0.8757 1.1088 1.0081
phenylalanine 1.1951 1.3628 0.9394 0.8004 0.6795 0.8197 1.1786 1.0183
phosphoenolpyruvate 0.8975 1.1427 1.2137 1.1401 0.7350 0.9520 0.8828 1.0271
proline 1.0639 1.5729 0.7914 0.9511 0.6972 0.7844 1.1120 1.0204
PTT 2.0101 1.8939 0.1525 0.6592 0.1192 0.1571 2.0076 1.0003
PVNF 1.5742 1.1234 0.0114 1.0514 0.1094 0.0609 3.1263 0.9572
pyridoxine 1.0967 1.3560 1.0459 0.8615 0.7243 0.9654 0.9359 1.0107
Pyroglutamic acid 0.8291 1.0495 1.2713 1.0565 0.9113 0.9321 0.9046 1.0342
Pyrophosphate 1.0853 1.0564 0.8283 1.0652 0.8604 1.1055 1.0474 0.9636
pyruvate 0.8648 1.6456 0.6135 0.9449 0.8711 1.0777 0.9507 1.0237
Ribose-5-phosphate 1.2393 1.0585 0.9174 0.9906 0.6892 0.9476 1.1223 1.0264
ribose-phosphate 1.2312 1.0701 0.9214 0.9845 0.6949 0.9536 1.1158 1.0213
ribulose-5-phosphate 1.0945 1.3429 0.9351 0.9423 0.7093 0.9910 0.9747 1.0076
S-adenosyl-L-homocysteine 1.0297 0.9817 0.8256 1.0386 0.8969 1.0278 1.2095 0.9927
SD 1.4596 1.9322 0.3891 0.8276 0.4234 0.3804 1.5460 1.0312
SDL 1.4166 2.4461 0.1085 0.8785 0.1606 0.1596 1.8298 1.0002
Sedoheptulose bisphosphate 1.1118 1.0621 0.9271 0.8937 0.8916 1.1158 0.9871 1.0080
serine 1.0994 1.1049 0.9825 0.9413 0.7957 0.8680 1.1804 1.0209
SID 1.4154 2.4408 0.1087 0.8778 0.1612 0.1588 1.8381 0.9994
sn-glycerol-3-phosphate 1.1329 1.1166 1.3191 0.8772 0.6240 0.9468 0.9422 1.0310
succinate/Methylmalonic acid 0.9381 1.1529 1.6232 0.8561 0.5534 0.7787 1.0486 1.0369
succinyl-CoA/methylmalonyl-CoA 0.9722 1.3116 0.5522 1.3756 0.7037 0.7589 1.2706 1.0413
taurine 0.9590 1.0246 0.9418 1.0889 0.9260 1.0054 1.0439 1.0079
thiamine 1.0636 0.9769 1.0255 0.9331 0.8955 1.1126 0.9866 1.0048
Thiamine pyrophosphate 1.0323 1.0799 0.6894 1.1491 0.9705 0.9967 1.0458 1.0273
threonine/homoserine 1.2720 1.1068 0.8664 0.9059 0.7392 0.7901 1.3088 1.0081
tryptophan 1.0713 1.1691 0.9855 0.8887 0.8830 0.8567 1.0998 1.0346
tyrosine 1.0289 1.2139 1.0665 0.8844 0.8205 0.9324 1.0288 1.0185
UDP 0.4570 0.9935 0.4095 1.8753 1.1750 0.8796 1.2177 0.9943
UDP-D-glucose 0.9438 1.0121 1.0421 1.0084 0.9827 1.0348 0.9514 1.0186
UDP-D-glucuronate 0.9476 1.0262 1.0250 1.0618 0.9449 1.0669 0.8966 1.0232
UDP-N-acetyl-glucosamine 0.9167 1.0339 0.9155 1.0866 0.9771 0.9885 1.0647 1.0127
UMP 0.4957 1.2004 0.6940 1.5720 0.9376 0.7102 1.3805 1.0072
UTP 0.6336 1.0619 0.8288 1.0786 1.0572 1.0753 1.2765 0.9910
valine 1.2227 1.2249 0.9564 0.8534 0.6922 0.7729 1.2517 1.0194
VD 1.5778 1.8017 0.3806 0.7395 0.4098 0.3597 1.7108 1.0151
xanthosine 1.3307 0.9896 0.7992 0.9889 0.7202 0.7735 1.3458 1.0391
xanthosine-5-phosphate 0.7249 0.6130 3.0511 0.6251 0.6692 0.6196 0.6736 1.0176
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:10nM Atovaquone
F2Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:Compound 16
F3Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:Compound 19
F4Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:Compound 33
F5Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:Compound 35
F6Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:Compound 4
F7Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:DMSO
F8Sample source:Cultured Plasmodium falciparum 3D7 MR4 | Treatment:Pooled Quality Control
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