Data for (Study ST004441)
(Analysis AN007437)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2/3-Phospho-D-glycerate | 0.0975 | 0.6758 | 0.0746 | 0.3396 | 1.0459 | 1.6018 | 1.5897 | 1.2800 | 1.2164 | 1.3591 | 0.9956 | 0.6340 | 1.2726 | 1.3995 | 0.7895 | 1.6283 |
| 2-Aminomuconate | 0.2323 | 0.2853 | 0.3038 | 0.3487 | 1.3528 | 0.8709 | 1.1252 | 1.9083 | 1.2649 | 1.6088 | 1.5864 | 0.9228 | 0.8184 | 1.1217 | 0.6581 | 1.5917 |
| 2-Hydroxyglutarate | 0.3381 | 0.5422 | 0.4545 | 0.5116 | 0.6128 | 0.6745 | 0.7459 | 0.7814 | 1.1031 | 1.5578 | 1.1739 | 1.0532 | 1.8758 | 1.4192 | 1.5401 | 1.6156 |
| 2-Oxoglutarate | 0.4657 | 0.5186 | 0.2208 | 0.5568 | 0.6972 | 0.6892 | 0.8094 | 0.8083 | 1.3531 | 1.4157 | 1.1996 | 1.0050 | 2.0577 | 1.2352 | 1.1712 | 1.7965 |
| 5^-Phosphoribosyl-N-formylglycinamide | 0.0005 | 0.3318 | 0.0005 | 0.0005 | 0.3473 | 0.7546 | 0.8930 | 0.9684 | 1.6310 | 2.3583 | 2.5967 | 1.0159 | 1.7515 | 0.5145 | 1.3615 | 1.4738 |
| Adenine | 1.0556 | 1.1989 | 0.6329 | 0.8357 | 1.0507 | 1.0078 | 0.9611 | 1.1396 | 1.0172 | 1.1820 | 1.0333 | 0.5870 | 1.2316 | 1.1039 | 1.1857 | 0.7772 |
| ADP | 0.6006 | 1.1980 | 0.7491 | 1.0780 | 0.5147 | 0.8420 | 0.7520 | 0.6206 | 1.1049 | 1.4007 | 1.3265 | 0.8557 | 1.1578 | 1.1882 | 0.9206 | 1.6908 |
| Allantoate | 0.2834 | 0.4919 | 0.4197 | 0.4413 | 0.9174 | 1.3507 | 1.4309 | 1.3865 | 1.4076 | 1.7200 | 1.0661 | 1.1138 | 1.0458 | 0.9492 | 0.9719 | 1.0038 |
| AMP | 0.2486 | 0.4245 | 0.2102 | 0.4674 | 0.5508 | 0.4730 | 0.7689 | 0.5321 | 1.1930 | 1.9441 | 1.8070 | 1.3434 | 1.5388 | 1.4883 | 0.9174 | 2.0924 |
| Ascorbate | 0.4403 | 0.6308 | 0.4016 | 0.6254 | 1.4502 | 0.3170 | 1.0750 | 0.5141 | 1.3303 | 0.9631 | 0.9914 | 1.5361 | 1.7958 | 1.4247 | 1.3675 | 1.1367 |
| ATP | 0.5317 | 1.4924 | 0.6333 | 1.5287 | 0.2783 | 0.6247 | 0.9082 | 0.8548 | 0.9976 | 1.5358 | 1.1442 | 0.7508 | 1.2388 | 1.0090 | 0.6055 | 1.8662 |
| CDP | 0.9508 | 1.1803 | 1.0453 | 1.4797 | 0.7413 | 0.7352 | 0.7747 | 0.6608 | 0.9438 | 1.0919 | 1.1447 | 0.8177 | 1.3771 | 1.0790 | 0.7431 | 1.2345 |
| CMP-N-acetylneuraminate | 0.5675 | 0.7493 | 0.4775 | 0.7108 | 1.1013 | 0.4136 | 1.1975 | 0.8990 | 1.1823 | 1.2833 | 1.2440 | 1.1339 | 1.4519 | 1.3396 | 0.9670 | 1.2815 |
| CTP | 1.2666 | 1.5100 | 1.4600 | 2.2123 | 0.3700 | 0.8275 | 0.7135 | 0.7304 | 0.7126 | 0.9347 | 0.7990 | 0.7687 | 0.9925 | 0.7109 | 0.5604 | 1.4309 |
| D-Arabitol/Xylitol/Ribitol | 0.1644 | 0.1371 | 0.1457 | 0.1310 | 1.6114 | 1.9375 | 1.9989 | 2.0410 | 1.0880 | 1.2197 | 1.0427 | 1.1824 | 0.9506 | 0.8578 | 0.6616 | 0.8303 |
| Dehydroascorbate | 0.4581 | 0.4068 | 0.3361 | 0.8802 | 0.5933 | 0.4351 | 0.3227 | 1.0027 | 0.6254 | 2.3030 | 1.8167 | 1.5327 | 1.4999 | 1.1335 | 1.0816 | 1.5722 |
| D-Fructose 1-6-bisphosphate | 0.0599 | 0.2761 | 0.0854 | 0.1842 | 2.0302 | 4.5770 | 3.4524 | 2.6299 | 0.4274 | 0.6590 | 0.5300 | 0.3747 | 0.1889 | 0.1573 | 0.1395 | 0.2284 |
| D-Glucose | 0.8013 | 0.8005 | 0.9212 | 0.8187 | 1.2980 | 1.1287 | 1.1555 | 1.0897 | 1.2035 | 1.4725 | 1.0543 | 0.9822 | 0.8580 | 0.8194 | 0.7484 | 0.8482 |
| D-Glyceraldehyde 3-phosphate/Glycerone phosphate | 0.0561 | 0.2275 | 0.0888 | 0.0763 | 1.8791 | 1.8265 | 1.7101 | 2.2977 | 1.0270 | 1.2637 | 1.0401 | 1.1349 | 0.7738 | 0.7637 | 0.7882 | 1.0464 |
| D-Hexose-phosphate | 0.0770 | 0.1616 | 0.0859 | 0.1376 | 2.3973 | 2.5995 | 2.9816 | 3.0709 | 0.7975 | 0.9034 | 0.8891 | 0.7806 | 0.2688 | 0.2386 | 0.2579 | 0.3526 |
| Dimethylglycine | 0.3564 | 0.5270 | 0.2898 | 0.4391 | 0.4165 | 0.7271 | 0.9487 | 1.1972 | 1.0823 | 1.9925 | 1.2664 | 1.3107 | 1.5670 | 0.6715 | 1.6990 | 1.5089 |
| Diphosphate | 1.5037 | 1.0466 | 1.3596 | 1.2558 | 1.0828 | 1.0153 | 0.8342 | 0.9951 | 0.9078 | 0.8263 | 0.8231 | 1.0390 | 0.8056 | 0.7364 | 0.9591 | 0.8096 |
| FA(10:0) | 1.0778 | 1.0717 | 1.1844 | 0.8487 | 1.1714 | 1.1076 | 1.0801 | 0.7639 | 0.9951 | 1.0146 | 1.0102 | 0.6506 | 0.9609 | 1.0638 | 1.0324 | 0.9669 |
| FA(12:0) | 0.8196 | 1.3508 | 1.0111 | 0.7305 | 0.9997 | 0.8650 | 1.3514 | 0.7816 | 1.2941 | 0.8858 | 0.8929 | 0.7405 | 1.1982 | 0.9147 | 1.2636 | 0.9006 |
| FA(14:0) | 0.9498 | 1.1679 | 0.9455 | 0.9626 | 0.9365 | 0.8939 | 1.0273 | 0.8750 | 1.1537 | 0.8911 | 0.9449 | 0.9081 | 1.0019 | 1.0386 | 1.3633 | 0.9398 |
| FA(14:1) | 0.8178 | 0.7773 | 0.8049 | 0.6611 | 0.9187 | 0.8659 | 1.0560 | 1.0848 | 1.1592 | 1.0908 | 1.1110 | 0.8984 | 1.1856 | 1.1461 | 1.3869 | 1.0356 |
| FA(16:0) | 1.0122 | 1.2069 | 1.0989 | 0.9050 | 0.8509 | 0.8831 | 0.9480 | 0.9798 | 1.2605 | 0.8157 | 0.8042 | 0.9098 | 1.0776 | 0.9509 | 1.3236 | 0.9731 |
| FA(16:1) | 0.7594 | 1.1067 | 0.7628 | 0.8085 | 1.1966 | 0.9308 | 0.8446 | 0.9551 | 1.0723 | 1.0968 | 1.0690 | 1.0426 | 1.0816 | 0.9169 | 1.3250 | 1.0313 |
| FA(18:0) | 0.9498 | 1.4294 | 1.2580 | 1.0845 | 0.9491 | 1.0068 | 1.1895 | 1.0935 | 1.1191 | 0.7919 | 0.8661 | 0.9369 | 1.2458 | 1.0730 | 0.0212 | 0.9856 |
| FA(18:1) | 0.8605 | 0.9417 | 0.9560 | 0.8463 | 1.0620 | 1.0322 | 1.1615 | 1.0570 | 1.1244 | 1.0628 | 0.9755 | 1.0236 | 0.9620 | 0.8546 | 1.0715 | 1.0083 |
| FA(18:2) | 0.6061 | 0.9126 | 1.1117 | 0.5451 | 0.7879 | 0.5751 | 1.0586 | 0.8512 | 2.7203 | 0.7108 | 0.7257 | 0.9396 | 2.0778 | 0.8310 | 0.8561 | 0.6905 |
| FA(20:3) | 0.5368 | 0.7150 | 0.4621 | 0.8269 | 1.7999 | 0.9218 | 0.8785 | 1.1750 | 1.0699 | 1.0954 | 1.3342 | 1.0843 | 0.8925 | 0.7698 | 1.2163 | 1.2213 |
| FA(20:4) | 0.6945 | 0.8239 | 0.6752 | 0.7144 | 1.6205 | 0.9164 | 1.1795 | 1.1316 | 0.9845 | 1.2187 | 1.1800 | 1.0228 | 0.9255 | 0.7801 | 1.0110 | 1.1213 |
| FA(20:5) | 0.6620 | 0.8200 | 0.6935 | 0.7306 | 2.0420 | 1.1249 | 1.2324 | 1.4395 | 0.8433 | 1.2288 | 1.0501 | 1.0085 | 0.8574 | 0.5814 | 0.9061 | 0.7795 |
| FA(22:5) | 0.5552 | 0.9236 | 0.6302 | 0.8929 | 1.4020 | 0.9928 | 1.0343 | 1.2926 | 0.8016 | 1.1873 | 1.1412 | 1.1734 | 1.1250 | 0.7727 | 1.1808 | 0.8943 |
| FA(22:6) | 0.8031 | 1.0097 | 0.7582 | 0.9189 | 1.5469 | 1.0233 | 1.1023 | 1.1252 | 1.0443 | 1.0401 | 1.1124 | 0.8559 | 0.9055 | 0.7398 | 0.9346 | 1.0798 |
| FA(5:0) | 1.1901 | 1.0110 | 0.8937 | 1.2667 | 0.6553 | 1.3753 | 1.1530 | 0.9062 | 1.1744 | 1.2481 | 1.0408 | 0.7524 | 0.8310 | 0.6274 | 1.3541 | 0.5204 |
| FA(6:0) | 0.9637 | 1.1628 | 1.0634 | 1.0159 | 1.0802 | 1.0487 | 1.0900 | 0.8740 | 1.0971 | 0.9198 | 0.9442 | 0.8912 | 0.9205 | 1.0266 | 0.9670 | 0.9349 |
| FA(7:0) | 1.1349 | 1.0756 | 1.2637 | 0.7748 | 1.0540 | 1.2804 | 1.0172 | 0.8145 | 1.0067 | 0.9868 | 1.0992 | 0.6814 | 0.9245 | 1.0137 | 1.0280 | 0.8447 |
| FA(8:0) | 0.7641 | 1.3638 | 1.0224 | 1.2543 | 0.9650 | 1.1407 | 0.7027 | 0.7684 | 0.7959 | 0.8488 | 0.9472 | 0.6655 | 1.1309 | 1.0269 | 1.3915 | 1.2119 |
| FA(9:0) | 0.6720 | 0.9696 | 0.7969 | 0.8860 | 1.0221 | 1.0513 | 1.1939 | 1.0008 | 1.0731 | 1.1211 | 1.0796 | 0.9256 | 1.0380 | 1.0065 | 1.0799 | 1.0837 |
| Fumarate | 0.1959 | 0.2495 | 0.2345 | 0.1692 | 0.9011 | 1.5043 | 1.4917 | 1.3932 | 1.5651 | 1.9480 | 1.3169 | 1.3806 | 0.9771 | 0.8573 | 0.7986 | 1.0170 |
| GDP | 0.3115 | 0.6410 | 0.6407 | 0.9460 | 0.5745 | 0.6413 | 0.9287 | 0.9055 | 1.0302 | 1.5542 | 1.2774 | 0.9756 | 1.6544 | 0.9771 | 1.0367 | 1.9053 |
| Glutathione | 0.4913 | 0.9931 | 0.6953 | 0.8453 | 0.6285 | 1.0828 | 1.0106 | 1.1286 | 1.0584 | 1.3710 | 1.0261 | 0.7229 | 1.3272 | 1.0152 | 1.0823 | 1.5215 |
| Glutathione disulfide | 0.2652 | 0.5462 | 0.3859 | 0.4798 | 1.1865 | 1.0738 | 1.1781 | 1.0280 | 1.2395 | 1.3771 | 1.3859 | 1.2309 | 1.0652 | 1.0420 | 1.0739 | 1.4421 |
| Glycerol 3-phosphate | 0.3666 | 0.6971 | 0.4990 | 0.5444 | 0.5076 | 0.5758 | 0.6954 | 0.7072 | 1.2697 | 1.7180 | 1.3400 | 1.1497 | 1.5874 | 1.2757 | 1.3830 | 1.6833 |
| GTP | 0.6857 | 0.8203 | 0.6974 | 1.1956 | 0.3923 | 0.6129 | 0.8753 | 0.8453 | 1.0529 | 1.4493 | 1.2574 | 0.9352 | 1.4099 | 1.0534 | 0.7258 | 1.9913 |
| Hypoxanthine | 0.6240 | 0.6030 | 0.3697 | 0.6120 | 0.5045 | 0.9755 | 0.8259 | 1.0540 | 1.1464 | 1.8578 | 1.5136 | 0.9453 | 1.4837 | 0.9340 | 0.6480 | 1.9027 |
| Inosine | 0.0037 | 0.1394 | 0.1103 | 0.1152 | 0.0037 | 0.0037 | 1.9744 | 1.9804 | 0.0037 | 1.6653 | 1.8936 | 0.0037 | 1.4832 | 2.2470 | 2.6736 | 1.6991 |
| Lactate | 0.6868 | 0.7265 | 0.6751 | 0.6949 | 0.9292 | 1.0906 | 1.0569 | 1.1115 | 1.5233 | 1.3140 | 1.4475 | 1.4749 | 0.8376 | 0.8144 | 0.7434 | 0.8735 |
| L-aspartate | 0.6338 | 0.4686 | 0.3926 | 0.6105 | 1.1638 | 1.2241 | 1.1572 | 1.4451 | 1.5343 | 1.5522 | 1.2854 | 1.3455 | 0.9034 | 0.7625 | 0.7759 | 0.7451 |
| L-methionine | 0.5522 | 0.4535 | 0.8565 | 0.5463 | 1.1607 | 1.1394 | 1.2484 | 1.0818 | 1.1865 | 1.4850 | 1.3979 | 1.1250 | 1.2726 | 1.0545 | 0.5364 | 0.9033 |
| Malate | 0.1969 | 0.2606 | 0.2008 | 0.1943 | 0.9881 | 0.9041 | 1.3520 | 1.5532 | 1.5925 | 1.9287 | 1.5497 | 1.4417 | 1.1277 | 0.9159 | 0.8100 | 0.9838 |
| Mannitol/Sorbitol/Glucitol/Iditol | 0.3344 | 0.3414 | 0.3349 | 0.2484 | 2.5612 | 2.6038 | 2.7890 | 2.8426 | 0.8412 | 0.8332 | 0.6853 | 0.6675 | 0.2282 | 0.2505 | 0.1835 | 0.2549 |
| NADP+ | 1.6673 | 1.2330 | 1.1428 | 1.4617 | 0.1897 | 0.5880 | 0.0049 | 0.1353 | 0.7023 | 0.7728 | 0.5187 | 0.4349 | 1.6085 | 1.1368 | 1.0616 | 3.3417 |
| Pantothenate | 0.6880 | 0.9138 | 0.6961 | 0.8867 | 0.7401 | 1.0018 | 0.7463 | 0.8722 | 1.1911 | 1.0838 | 1.4374 | 0.8782 | 1.2874 | 1.2094 | 0.9138 | 1.4538 |
| Phosphate | 1.1588 | 1.0825 | 1.1187 | 1.0445 | 0.9408 | 1.0239 | 0.9268 | 0.9757 | 0.9748 | 0.9771 | 0.9245 | 0.9193 | 0.9706 | 1.0392 | 0.9631 | 0.9596 |
| Phosphocreatine | 0.3018 | 0.2904 | 0.3791 | 0.2736 | 2.0936 | 3.2436 | 2.4225 | 1.8095 | 0.4814 | 1.3313 | 0.4662 | 0.5868 | 0.6126 | 0.5401 | 0.4526 | 0.7149 |
| Phosphoethanolamine | 0.7293 | 0.8679 | 0.6249 | 0.9412 | 0.9749 | 0.8496 | 1.1440 | 0.8647 | 0.9774 | 1.4205 | 1.0784 | 0.9971 | 1.2800 | 0.9496 | 1.0789 | 1.2219 |
| Pyruvate | 0.4862 | 0.7300 | 0.6545 | 0.6252 | 1.4360 | 1.5887 | 1.7858 | 0.9746 | 1.4497 | 0.7428 | 1.4665 | 0.6021 | 0.8781 | 1.0724 | 0.7930 | 0.7143 |
| Sphinganine 1-phosphate | 0.6684 | 1.0890 | 0.8282 | 1.2007 | 0.8709 | 0.9141 | 1.2015 | 1.0439 | 1.3943 | 0.6416 | 0.7480 | 0.7807 | 1.1489 | 0.9535 | 1.4974 | 1.0187 |
| Sphingosine 1-phosphate | 0.4500 | 0.5598 | 0.6608 | 0.2964 | 0.8476 | 0.5508 | 0.9292 | 0.6879 | 1.3715 | 1.2991 | 1.5408 | 1.4472 | 1.2413 | 1.2630 | 1.3482 | 1.5066 |
| Succinate | 0.7723 | 0.8012 | 0.8129 | 0.6941 | 0.8473 | 1.0126 | 0.8749 | 1.0521 | 1.6338 | 1.4768 | 1.5574 | 0.8533 | 0.6991 | 1.0156 | 0.8666 | 1.0302 |
| Taurine | 0.2076 | 0.6998 | 0.2115 | 0.3521 | 0.3719 | 1.0274 | 1.1232 | 1.1592 | 1.2568 | 1.6451 | 1.2331 | 1.1720 | 1.7486 | 1.2822 | 0.5262 | 1.9832 |
| trans-4-Hydroxy-L-proline | 0.4369 | 0.3782 | 0.2388 | 0.2196 | 0.8301 | 1.3708 | 1.3131 | 1.5889 | 1.4139 | 1.8886 | 1.1365 | 1.0232 | 1.2880 | 0.9495 | 0.6713 | 1.2524 |
| UDP | 0.7349 | 1.1278 | 0.8106 | 1.2722 | 0.5123 | 0.7451 | 0.6371 | 0.6882 | 0.8893 | 1.3810 | 1.1335 | 0.8555 | 1.3834 | 1.1074 | 1.0205 | 1.7012 |
| UDP-N-acetyl-D-glucosamine | 1.4645 | 2.2287 | 1.7474 | 2.3367 | 0.5323 | 0.5412 | 0.6894 | 0.6247 | 0.5575 | 0.8630 | 0.7737 | 0.6744 | 0.7676 | 0.7294 | 0.5476 | 0.9218 |
| UTP | 0.8547 | 1.3175 | 1.0198 | 1.7400 | 0.5067 | 0.8008 | 0.7135 | 0.8016 | 0.8319 | 1.1299 | 0.9947 | 0.7614 | 1.1500 | 1.1323 | 0.7740 | 1.4712 |
Factors:
| F1 | Treatment:100 nM HHT | Timepoint:24h | Sample source:MDS-L Cells | Injection order:12 |
| F2 | Treatment:100 nM HHT | Timepoint:24h | Sample source:MDS-L Cells | Injection order:19 |
| F3 | Treatment:100 nM HHT | Timepoint:24h | Sample source:MDS-L Cells | Injection order:24 |
| F4 | Treatment:100 nM HHT | Timepoint:24h | Sample source:MDS-L Cells | Injection order:4 |
| F5 | Treatment:100 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:21 |
| F6 | Treatment:100 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:31 |
| F7 | Treatment:100 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:32 |
| F8 | Treatment:100 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:6 |
| F9 | Treatment:1 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:13 |
| F10 | Treatment:1 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:16 |
| F11 | Treatment:1 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:17 |
| F12 | Treatment:1 nM OT82 | Timepoint:24h | Sample source:MDS-L Cells | Injection order:3 |
| F13 | Treatment:Untreated | Timepoint:24h | Sample source:MDS-L Cells | Injection order:10 |
| F14 | Treatment:Untreated | Timepoint:24h | Sample source:MDS-L Cells | Injection order:18 |
| F15 | Treatment:Untreated | Timepoint:24h | Sample source:MDS-L Cells | Injection order:22 |
| F16 | Treatment:Untreated | Timepoint:24h | Sample source:MDS-L Cells | Injection order:7 |