Data for (Study ST003825)
(Analysis AN007477)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 2-hydroxyglutarate | 1.0152 | 0.9680 | 0.9439 | 1.0729 |
| 3-phosphoglycerate | 1.1120 | 1.0430 | 1.0085 | 0.8365 |
| acetylcarnitine | 1.0213 | 0.7706 | 1.3479 | 0.8603 |
| Acetyl.CoA | 0.9505 | 1.1827 | 0.9697 | 0.8971 |
| ADP | 0.9437 | 1.1976 | 0.8959 | 0.9628 |
| alanine | 1.2342 | 0.6148 | 1.3508 | 0.8002 |
| arginine | 1.0563 | 1.0683 | 0.9864 | 0.8891 |
| argininosuccinate | 0.9974 | 0.8663 | 1.0495 | 1.0868 |
| asparagine | 1.0688 | 1.1186 | 0.8505 | 0.9620 |
| aspartate | 1.2772 | 1.2450 | 1.0267 | 0.4510 |
| asymmetric.dimethylarginine | 1.0646 | 1.0622 | 0.9534 | 0.9198 |
| beta.alanine | 0.9949 | 0.7120 | 1.1846 | 1.1086 |
| Butyrylcarnitine | 0.9818 | 0.9328 | 1.0396 | 1.0458 |
| C5.Carnitines | 0.3807 | 0.5319 | 1.0337 | 2.0536 |
| Carbamoyl Aspartic Acid | NA | 0.8333 | 0.1519 | 2.0148 |
| carnitine | 0.8040 | 1.0446 | 0.9810 | 1.1704 |
| carnosine | 0.7134 | 0.9902 | 1.3533 | 0.9431 |
| CDP | 1.3593 | 0.9218 | 1.0831 | 0.6357 |
| cis.aconitate | 1.1867 | 1.0491 | 0.8835 | 0.8807 |
| citrate | 1.3075 | 0.9736 | 1.0148 | 0.7041 |
| citrulline | 1.0488 | 1.0192 | 0.9428 | 0.9892 |
| creatine | 0.9809 | 1.1070 | 0.9561 | 0.9559 |
| creatinine | 0.9648 | 0.9787 | 1.0841 | 0.9724 |
| cystathionine | 0.9880 | 1.0617 | 1.0182 | 0.9321 |
| Cysteine_Ellmans_conjugated | 0.9098 | 0.8875 | 1.3624 | 0.8403 |
| dihydroorotate | 0.1083 | 1.0895 | 0.0853 | 2.4120 |
| dihydroxyacetone_phosphate | 0.4702 | 0.8218 | 1.0339 | 1.6740 |
| FAD | 1.0314 | 1.1011 | 0.9566 | 0.9110 |
| fructose | 1.1127 | 1.0230 | 0.8621 | 1.0022 |
| Fructose.1.6.bisphosphate | 1.1341 | 1.1258 | 0.9544 | 0.7856 |
| fumarate | 0.9602 | 0.8740 | 1.1074 | 1.0584 |
| GDP | 0.9398 | 1.0579 | 0.8782 | 1.1242 |
| glutamate | 1.0354 | 1.2317 | 0.8826 | 0.8502 |
| glutamine | 1.1919 | 1.1642 | 0.9718 | 0.6722 |
| glycerate | 1.1708 | 0.9794 | 0.8748 | 0.9749 |
| Glycerol.3.Phosphate | 0.1735 | 1.0497 | 0.4650 | 2.3118 |
| Glycerophosphocholine | 1.2137 | 1.4112 | 0.7401 | 0.6350 |
| glycine | 1.0522 | 1.0321 | 1.0267 | 0.8889 |
| GSH_Ellmans | 1.0058 | 1.1039 | 0.9538 | 0.9365 |
| GSSG | 0.9557 | 1.2074 | 0.9223 | 0.9147 |
| histidine | 1.0054 | 1.1033 | 0.9513 | 0.9399 |
| homocitrulline | 0.9178 | 1.0531 | 1.0148 | 1.0143 |
| hypotaurine | 1.0587 | 0.9021 | 0.9232 | 1.1160 |
| IMP | 0.3224 | 0.5694 | 0.5924 | 2.5157 |
| isoleucine | 0.8825 | 1.2448 | 0.8702 | 1.0026 |
| kynurenine | 0.7747 | 0.9231 | 1.2225 | 1.0797 |
| leucine | 0.9443 | 1.3080 | 0.7700 | 0.9777 |
| lysine | 0.9847 | 1.0393 | 1.1245 | 0.8515 |
| malate | 1.0294 | 0.8635 | 1.0854 | 1.0218 |
| mannose | 1.1094 | 1.0263 | 0.8624 | 1.0019 |
| methionine | 1.0285 | 1.1637 | 0.9504 | 0.8574 |
| Methionine.sulfoxide | 1.0218 | 1.1278 | 0.9400 | 0.9103 |
| methylthioadenosine | 1.0501 | 0.9748 | 1.0682 | 0.9070 |
| NAD. | 1.0576 | 1.0464 | 1.0245 | 0.8714 |
| NADH | 0.6262 | 1.0730 | 0.8526 | 1.4482 |
| NADP | 0.9663 | 1.1916 | 0.9299 | 0.9122 |
| NADPH | 1.0755 | 1.1272 | 0.8953 | 0.9019 |
| niacinamide | 1.0527 | 0.7402 | 1.3255 | 0.8816 |
| ornithine | 1.0161 | 1.1311 | 1.0293 | 0.8235 |
| palmitate | 0.9551 | 1.1692 | 0.8906 | 0.9851 |
| phosphocholine | 1.0369 | 1.2411 | 0.8351 | 0.8868 |
| phosphocreatine | 0.9391 | 1.2273 | 0.8639 | 0.9697 |
| phosphoenolpyruvate | 1.4500 | 0.9772 | 1.1323 | 0.4405 |
| proline | 0.8506 | 1.0482 | 0.9736 | 1.1276 |
| propionylcarnitine | 1.1575 | 0.9055 | 1.1563 | 0.7807 |
| Pyridoxine | 0.9957 | 0.9518 | 1.0832 | 0.9693 |
| S.Adenosyl.L.Homocysteine | 1.1334 | 1.0583 | 1.0423 | 0.7661 |
| S.Adenosyl.L.methionine | 1.0461 | 1.0786 | 0.9430 | 0.9323 |
| sarcosine | 1.2360 | 0.6101 | 1.3502 | 0.8036 |
| serine | 1.1354 | 0.9612 | 1.1643 | 0.7390 |
| succinate | 0.7650 | 0.8371 | 1.1354 | 1.2626 |
| threonine | 1.0969 | 1.0614 | 1.0256 | 0.8161 |
| trans.urocanate | 1.0604 | 1.1240 | 0.9023 | 0.9132 |
| tryptophan | 1.0316 | 1.1164 | 0.9935 | 0.8585 |
| tyrosine | 1.0468 | 1.1548 | 0.9336 | 0.8649 |
| UDP | 1.4547 | 0.8365 | 1.1298 | 0.5790 |
| UDP.GlcNAc | 1.5870 | 0.7865 | 1.1722 | 0.4543 |
| xanthosine | 1.0632 | 1.0864 | 0.8551 | 0.9953 |
Factors:
| F1 | Sample source:SEM leukemia cells | sgRNA:Intergenic1 | treatment2:PyruvateAndUridine |
| F2 | Sample source:SEM leukemia cells | sgRNA:Intergenic1 | treatment2:Vehicle |
| F3 | Sample source:SEM leukemia cells | sgRNA:SLC31A1 guide #2 | treatment2:PyruvateAndUridine |
| F4 | Sample source:SEM leukemia cells | sgRNA:SLC31A1 guide #2 | treatment2:Vehicle |
