Data for (Study ST004468)
(Analysis AN007491)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2.hydroxyglutarate | NA | NA | NA | NA | NA | NA | NA | 1.0965 | 1.0677 | 0.8243 | 1.1479 | 0.5342 | 1.0950 | 1.2344 |
| 2.oxobutyric_acid | NA | NA | NA | NA | NA | NA | NA | 1.1784 | 0.9942 | 0.7765 | 0.8725 | 0.9235 | 1.0023 | 1.2527 |
| 3.phosphoglycerate | 2.8832 | 1.5661 | 0.6859 | 0.6764 | 0.5510 | 2.1925 | 1.1878 | 0.7252 | 0.5496 | 0.7355 | 0.8073 | 0.6739 | 0.4160 | 0.3496 |
| 3.ureidopropionate | 1.5528 | 1.7734 | 1.2735 | 1.6987 | 1.4039 | 1.5385 | 1.6936 | 0.5226 | 0.4425 | 0.3375 | 0.3887 | 0.3945 | 0.4417 | 0.5381 |
| acetylcarnitine | NA | NA | NA | NA | NA | NA | NA | 1.2193 | 0.8160 | 0.8722 | 0.7296 | 1.1647 | 0.9894 | 1.2090 |
| Acetyl.CoA | NA | NA | NA | NA | NA | NA | NA | 0.8062 | 1.5831 | 0.8424 | 0.4774 | 0.9416 | 1.3010 | 1.0482 |
| acetylglutamate | NA | NA | NA | NA | NA | NA | NA | 1.2148 | 1.0911 | 0.7378 | 1.0612 | 0.8125 | 1.1101 | 0.9725 |
| acetylserine | NA | NA | NA | NA | NA | NA | NA | 0.8789 | 1.5473 | 0.9474 | 0.5211 | 1.0375 | 0.8649 | 1.2028 |
| adenine | NA | NA | NA | NA | NA | NA | NA | 1.1199 | 1.1049 | 1.0229 | 0.6020 | 0.8519 | 0.9853 | 1.3132 |
| ADP | 0.4493 | 0.6337 | 0.6258 | 0.1363 | 0.6127 | 1.0442 | 0.8319 | 1.0447 | 1.5831 | 1.5113 | 0.8449 | 1.4351 | 1.6278 | 1.6191 |
| AICAR | 1.3732 | 0.2696 | 1.5493 | 0.1176 | 2.9110 | 2.0389 | 0.3702 | 0.3210 | 0.1470 | 0.5210 | 0.2578 | 2.5316 | 1.4597 | 0.1321 |
| alanine | NA | NA | NA | NA | NA | NA | NA | 1.1652 | 0.8457 | 0.8728 | 1.2611 | 1.0392 | 0.9315 | 0.8845 |
| AMP | NA | NA | NA | NA | NA | NA | NA | 0.7716 | 0.9554 | 1.3897 | 1.0146 | 1.0963 | 0.9385 | 0.8340 |
| arginine | 0.8691 | 0.6029 | 0.5107 | 0.6921 | 0.6354 | 0.6959 | 0.9036 | 1.4978 | 1.3999 | 1.0564 | 1.2240 | 0.9935 | 1.4301 | 1.4886 |
| argininosuccinate | NA | NA | NA | NA | NA | NA | NA | 0.7750 | 1.1447 | 1.1082 | 0.7196 | 0.9272 | 1.1617 | 1.1635 |
| asparagine | 0.4603 | 0.5268 | 0.3785 | 0.5043 | 0.4167 | 0.4565 | 0.5027 | 1.7265 | 1.6317 | 1.2069 | 1.3825 | 1.1544 | 1.8147 | 1.8376 |
| aspartate | 2.3257 | 1.2731 | 0.1567 | 0.1355 | 0.1388 | 3.3704 | 2.8950 | 0.6810 | 0.5475 | 0.1566 | 0.2063 | 0.1491 | 1.0420 | 0.9225 |
| asymmetric.dimethylarginine (ADMA) | 0.6907 | 0.4390 | 1.1809 | 2.0955 | 1.1989 | 0.8334 | 0.5616 | NA | NA | NA | NA | NA | NA | NA |
| ATP | 0.4455 | 0.7027 | 0.5989 | 0.1601 | 0.5730 | 0.8542 | 0.9413 | 1.2808 | 1.7192 | 1.2715 | 0.7857 | 1.2530 | 1.7597 | 1.6545 |
| beta.alanine | NA | NA | NA | NA | NA | NA | NA | 1.1139 | 0.8921 | 0.9050 | 1.1329 | 0.8936 | 0.9633 | 1.0993 |
| Butyrylcarnitine | 1.4131 | 1.4333 | 0.3096 | 0.1252 | 0.2836 | 1.5894 | 1.7184 | 0.9417 | 1.1496 | 1.1046 | 0.5432 | 1.1432 | 1.0599 | 1.1853 |
| carnitine | NA | NA | NA | NA | NA | NA | NA | 0.7899 | 0.9627 | 1.2073 | 1.0201 | 1.1451 | 1.0095 | 0.8655 |
| CDP | 1.4020 | 0.7906 | 0.2992 | 0.5114 | 0.3074 | 1.4631 | 0.7591 | 1.2397 | 1.2100 | 1.0871 | 1.0154 | 1.0024 | 1.4507 | 1.4620 |
| citrate | NA | NA | NA | NA | NA | NA | NA | 1.3384 | 1.3254 | 0.3528 | 0.3136 | 0.2995 | 1.7564 | 1.6140 |
| CMP | 1.2788 | 1.0581 | 1.0431 | 1.6068 | 0.9997 | 1.5228 | 0.8329 | 0.6454 | 0.4350 | 1.1450 | 1.1529 | 0.8306 | 0.7987 | 0.6502 |
| creatine | 1.8325 | 1.6703 | 1.7599 | 2.5718 | 1.8565 | 1.3317 | 2.1021 | 0.0990 | 0.1289 | 0.1307 | 0.1566 | 0.1425 | 0.1155 | 0.1019 |
| CTP | 1.1671 | 0.4553 | 0.0999 | 0.2987 | 0.1134 | 1.0708 | 0.5509 | 1.9299 | 1.5234 | 1.0152 | 1.4090 | 1.0246 | 1.7366 | 1.6054 |
| cystathionine | NA | NA | NA | NA | NA | NA | NA | 1.2593 | 0.6886 | 0.9003 | 0.9232 | 0.6724 | 1.2863 | 1.2698 |
| dihydroorotate | 0.0726 | 0.1442 | 3.4501 | 1.5535 | 3.8433 | 0.1003 | 0.1593 | 0.0866 | 0.2487 | 1.7607 | 0.5430 | 1.8537 | 0.0643 | 0.1198 |
| dihydroxyacetone_phosphate | NA | NA | NA | NA | NA | NA | NA | 0.5503 | 0.4322 | 1.5046 | 2.9527 | 1.2143 | 0.2053 | 0.1405 |
| D.RIBOSE.5.PHOSPHATE | 0.3986 | 0.3866 | 1.4579 | 1.6960 | 1.4261 | 0.3066 | 0.3015 | 1.2352 | 0.9452 | 1.1885 | 2.1556 | 1.0499 | 0.6385 | 0.8136 |
| Fructose.1.6.bisphosphate | NA | NA | NA | NA | NA | NA | NA | 0.7435 | 0.8346 | 1.1692 | 1.6485 | 1.1277 | 0.7122 | 0.7644 |
| Fructose-6-phosphate/Glucose-1-phosphate/Glucose-6-phosphate | 0.7622 | 0.3523 | 0.7897 | 0.9127 | 0.7368 | 0.4324 | 0.3349 | 0.7789 | 0.9590 | 2.2080 | 2.2777 | 2.2518 | 0.6357 | 0.5678 |
| fumarate | NA | NA | NA | NA | NA | NA | NA | 0.8301 | 1.2450 | 1.1404 | 0.6207 | 0.9774 | 1.0800 | 1.1064 |
| gamma.aminobutyric_acid | NA | NA | NA | NA | NA | NA | NA | 0.8625 | 0.9097 | 1.0341 | 0.9472 | 0.9769 | 1.2342 | 1.0355 |
| GDP | 0.2837 | 0.2999 | 0.5482 | 0.4398 | 0.5413 | 0.5425 | 0.2740 | 1.3416 | 1.6411 | 1.7771 | 1.2442 | 1.6807 | 1.7023 | 1.6835 |
| Glucose.6.phosphate | 1.7161 | 0.7399 | 1.8706 | 2.0572 | 1.5202 | 0.8461 | 0.7510 | 0.5616 | 0.6327 | 0.7579 | 0.7785 | 0.7045 | 0.6034 | 0.4957 |
| glutamate | NA | NA | NA | NA | NA | NA | NA | 1.1151 | 1.2097 | 0.7704 | 0.8089 | 0.7814 | 1.2031 | 1.1114 |
| glutamine | 0.6424 | 0.8587 | 0.5910 | 0.7861 | 0.6425 | 0.7122 | 0.8315 | 1.4755 | 1.3655 | 1.0449 | 1.2102 | 0.9544 | 1.4784 | 1.4069 |
| Glycerol.3.Phosphate | 0.0422 | 0.1636 | 2.1335 | 2.3157 | 2.1425 | 0.0718 | 0.0715 | 0.3908 | 0.5958 | 1.7812 | 2.1346 | 1.7003 | 0.2326 | 0.2238 |
| Glycerophosphocholine | NA | NA | NA | NA | NA | NA | NA | 0.8976 | 1.3184 | 0.7433 | 0.7052 | 0.9002 | 1.3176 | 1.1176 |
| glycine | 1.4690 | 1.5933 | 1.3923 | 1.4388 | 1.1896 | 1.3080 | 1.3679 | 0.7113 | 0.5918 | 0.4715 | 0.6862 | 0.4945 | 0.6415 | 0.6443 |
| GMP | 0.1879 | 0.3477 | 1.8124 | 2.4764 | 1.5374 | 0.3570 | 0.3280 | 0.8409 | 0.7907 | 1.3357 | 1.1671 | 1.1687 | 0.8262 | 0.8237 |
| GSH_Ellmans | 0.7994 | 0.9746 | 0.9096 | 0.9097 | 0.8880 | 0.9752 | 0.9158 | 1.1575 | 1.1868 | 1.0801 | 1.0250 | 1.0659 | 1.0824 | 1.0302 |
| GSSG | NA | NA | NA | NA | NA | NA | NA | 1.0134 | 0.9788 | 1.1209 | 0.9525 | 1.1151 | 1.0099 | 0.8094 |
| GTP | 0.3974 | 0.4025 | 0.5539 | 0.2877 | 0.5673 | 0.8377 | 0.4331 | 1.4347 | 1.6154 | 1.5047 | 1.2895 | 1.5445 | 1.6013 | 1.5302 |
| guanidinoacetate | 0.7538 | 0.6255 | 1.0875 | 1.9329 | 1.1587 | 0.5452 | 0.8963 | NA | NA | NA | NA | NA | NA | NA |
| guanine | NA | NA | NA | NA | NA | NA | NA | 0.8960 | 1.2376 | 1.0756 | 0.6003 | 0.9230 | 0.8971 | 1.3704 |
| histidine | NA | NA | NA | NA | NA | NA | NA | 1.0501 | 1.0495 | 0.8874 | 1.1615 | 0.8338 | 1.0219 | 0.9958 |
| hypotaurine | 0.8094 | 1.0773 | 0.8784 | 1.3735 | 0.9678 | 0.9181 | 0.9754 | NA | NA | NA | NA | NA | NA | NA |
| hypoxanthine | 0.7342 | 1.9894 | 0.6881 | 0.9755 | 0.6178 | 0.7809 | 1.2141 | NA | NA | NA | NA | NA | NA | NA |
| IMP | 0.3838 | 0.2651 | 5.0619 | 0.5207 | 4.9332 | 0.2018 | 0.1467 | 0.1899 | 0.0678 | 0.8614 | 0.5078 | 0.7375 | 0.0802 | 0.0423 |
| isoleucine | 0.7537 | 0.9009 | 0.8825 | 0.9594 | 0.7850 | 0.5572 | 0.9127 | 1.5121 | 1.4239 | 0.9283 | 1.0415 | 1.2276 | 0.8735 | 1.2417 |
| Itaconic.Acid | 0.8937 | 1.7554 | 0.7543 | 0.7435 | 0.9277 | 1.0253 | 0.9002 | NA | NA | NA | NA | NA | NA | NA |
| leucine | 0.8664 | 1.1551 | 0.9456 | 1.2933 | 0.9564 | 0.7303 | 1.0529 | NA | NA | NA | NA | NA | NA | NA |
| lysine | 0.9712 | 0.6969 | 0.9644 | 1.0218 | 0.9397 | 0.7432 | 0.7088 | 1.3594 | 1.1858 | 0.9215 | 1.1249 | 0.8355 | 1.2067 | 1.3203 |
| malate | 0.9006 | 1.4234 | 0.5922 | 0.3531 | 0.6860 | 1.4657 | 1.5789 | NA | NA | NA | NA | NA | NA | NA |
| methionine | 0.8195 | 1.3077 | 0.9697 | 1.0898 | 0.9127 | 0.7145 | 1.1862 | NA | NA | NA | NA | NA | NA | NA |
| Methionine.sulfoxide | 0.7066 | 1.0486 | 0.6729 | 0.7789 | 0.7810 | 0.6188 | 1.0811 | 1.1215 | 1.4728 | 1.0766 | 1.0794 | 1.0096 | 1.2924 | 1.2597 |
| methylthioadenosine | NA | NA | NA | NA | NA | NA | NA | 1.0641 | 1.1836 | 0.9974 | 0.3927 | 1.2310 | 0.9273 | 1.2039 |
| myo.inositol | 0.6823 | 0.5988 | 0.8782 | 1.0025 | 0.8014 | 1.0200 | 0.9806 | 1.1376 | 1.0058 | 1.2272 | 1.2578 | 1.1963 | 1.1351 | 1.0764 |
| N.acetylglutamine | 1.9572 | 2.1094 | 1.2451 | 2.1625 | 1.3858 | 1.4539 | 2.5776 | 0.1637 | 0.1795 | 0.1258 | 0.1742 | 0.1277 | 0.1845 | 0.1530 |
| NAD | 0.7623 | 1.2620 | 0.5344 | 0.6973 | 0.5502 | 0.8235 | 0.9978 | 1.4089 | 1.4511 | 0.9685 | 1.0346 | 0.8756 | 1.3882 | 1.2455 |
| NADH | NA | NA | NA | NA | NA | NA | NA | 0.6499 | 0.9106 | 1.3875 | 1.3840 | 1.2347 | 0.7174 | 0.7158 |
| NADP | NA | NA | NA | NA | NA | NA | NA | 0.9556 | 1.3151 | 0.8916 | 0.7743 | 0.8600 | 1.1276 | 1.0756 |
| NADPH | 0.5791 | 0.8412 | 0.4637 | 0.4540 | 0.5365 | 0.7629 | 0.7928 | 1.5783 | 1.4497 | 1.2363 | 1.2710 | 0.9170 | 1.5856 | 1.5319 |
| niacinamide | NA | NA | NA | NA | NA | NA | NA | 1.2084 | 1.2625 | 0.9946 | 0.6528 | 1.2415 | 0.7523 | 0.8880 |
| ornithine | NA | NA | NA | NA | NA | NA | NA | 1.0637 | 1.0739 | 0.7508 | 0.9251 | 0.7102 | 1.0915 | 1.3849 |
| palmitate | NA | NA | NA | NA | NA | NA | NA | 1.4394 | 0.8000 | 0.6694 | 0.5695 | 0.9744 | 0.7332 | 1.8140 |
| phosphocholine | NA | NA | NA | NA | NA | NA | NA | 1.0674 | 1.2079 | 0.7974 | 0.6345 | 0.7611 | 1.3046 | 1.2271 |
| phosphocreatine | 0.7137 | 0.7574 | 1.3220 | 1.0138 | 1.3147 | 0.9259 | 0.9524 | NA | NA | NA | NA | NA | NA | NA |
| phosphoenolpyruvate | 4.1066 | 2.0142 | 0.2991 | 0.4059 | 0.2783 | 2.6244 | 1.8262 | 0.5611 | 0.2841 | 0.3370 | 0.4592 | 0.2938 | 0.2725 | 0.2378 |
| phosphoethanolamine | NA | NA | NA | NA | NA | NA | NA | 1.2289 | 0.6048 | 0.8349 | 3.0611 | 0.6318 | 0.3298 | 0.3086 |
| proline | NA | NA | NA | NA | NA | NA | NA | 0.7860 | 1.5405 | 0.8942 | 0.7015 | 1.1120 | 0.9799 | 0.9858 |
| Pyridoxine | 1.0155 | 1.4159 | 0.8796 | 0.9771 | 0.7929 | 1.0156 | 1.2998 | 1.0789 | 1.0809 | 0.8232 | 0.6537 | 1.0573 | 0.8338 | 1.0757 |
| quinolinic_acid | NA | NA | NA | NA | NA | NA | NA | 1.3236 | 0.9885 | 0.7331 | 1.0008 | 0.8469 | 1.0961 | 1.0110 |
| saccharopine | 0.1516 | 0.1196 | 3.6843 | 4.0100 | 3.8117 | 0.2155 | 0.1981 | 0.2983 | 0.2506 | 0.2382 | 0.2177 | 0.1621 | 0.3494 | 0.2928 |
| S.Adenosyl.L.Homocysteine | 0.9964 | 2.0339 | 0.4719 | 0.4659 | 0.6067 | 0.8747 | 1.5504 | NA | NA | NA | NA | NA | NA | NA |
| S.Adenosyl.L.methionine | 0.6916 | 0.8168 | 0.4721 | 0.2551 | 0.4945 | 0.7687 | 0.8490 | 1.4184 | 1.5959 | 1.1452 | 1.0844 | 1.0559 | 1.6862 | 1.6662 |
| sarcosine | 1.2347 | 1.1051 | 0.6467 | 0.8383 | 0.6795 | 1.4550 | 1.5160 | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose.7.phosphate | 0.0407 | 0.1147 | 0.9703 | 0.4202 | 0.8570 | 0.1027 | 0.0851 | 0.6437 | 0.9921 | 2.9631 | 2.9033 | 2.8024 | 0.5577 | 0.5469 |
| serine | 0.6724 | 0.7615 | 0.6098 | 0.7495 | 0.6523 | 0.6584 | 0.7796 | 1.4957 | 1.3549 | 0.9529 | 1.3061 | 0.9497 | 1.4491 | 1.6082 |
| succinate | 0.8026 | 1.5562 | 2.1341 | 1.1897 | 2.2781 | 1.0518 | 0.8159 | 0.6127 | 0.6048 | 0.5541 | 0.6745 | 0.4481 | 0.6360 | 0.6415 |
| taurine | 0.8612 | 1.0667 | 0.9926 | 1.2993 | 0.9006 | 1.0464 | 0.8331 | NA | NA | NA | NA | NA | NA | NA |
| threonine | 0.9189 | 1.4084 | 0.8780 | 1.0095 | 0.8058 | 0.6599 | 1.3196 | NA | NA | NA | NA | NA | NA | NA |
| tryptophan | 0.8552 | 1.2363 | 0.9686 | 1.1072 | 0.9162 | 0.7356 | 1.1809 | NA | NA | NA | NA | NA | NA | NA |
| tyrosine | 0.7759 | 1.3658 | 0.8645 | 0.9410 | 0.9524 | 0.6892 | 1.1061 | 0.9384 | 1.3685 | 1.0857 | 0.8096 | 0.9673 | 1.0249 | 1.1106 |
| UDP | NA | NA | NA | NA | NA | NA | NA | 1.0766 | 0.9223 | 0.9092 | 1.0270 | 0.8740 | 1.0900 | 1.1009 |
| UDP.GlcNAc | 1.1764 | 0.8923 | 0.1255 | 0.2993 | 0.1252 | 1.0962 | 1.0844 | 1.6796 | 1.4250 | 0.7781 | 1.0342 | 0.6753 | 1.8479 | 1.7605 |
| UDP.hexose | NA | NA | NA | NA | NA | NA | NA | 1.3595 | 1.0625 | 0.7102 | 0.9209 | 0.6575 | 1.1611 | 1.1283 |
| UMP | 1.1228 | 0.6079 | 0.3357 | 1.2025 | 0.3488 | 0.9156 | 0.7840 | 0.8305 | 0.9375 | 1.5883 | 2.0910 | 1.4650 | 0.7451 | 1.0254 |
| Ureidosuccinic_acid | 0.0163 | 0.0065 | 3.4547 | 1.0268 | 2.5569 | 0.0326 | 0.0223 | 0.1681 | 0.2770 | 2.3574 | 1.3612 | 2.3714 | 0.1808 | 0.1680 |
| UTP | 1.4323 | 0.5102 | 0.0830 | 0.3498 | 0.0874 | 1.0193 | 0.6433 | 2.0479 | 1.4182 | 0.9323 | 1.5277 | 0.9434 | 1.5878 | 1.4172 |
Factors:
| F1 | Sample source:NALM6 leukemia cells | treatment:6MP |
| F2 | Sample source:NALM6 leukemia cells | treatment:ADDA5 |
| F3 | Sample source:NALM6 leukemia cells | treatment:BCS |
| F4 | Sample source:NALM6 leukemia cells | treatment:BCS+6MP |
| F5 | Sample source:NALM6 leukemia cells | treatment:BCS+MTX |
| F6 | Sample source:NALM6 leukemia cells | treatment:MTX |
| F7 | Sample source:NALM6 leukemia cells | treatment:Vehicle |
| F8 | Sample source:SEM leukemia cells | treatment:6MP |
| F9 | Sample source:SEM leukemia cells | treatment:ADDA5 |
| F10 | Sample source:SEM leukemia cells | treatment:BCS |
| F11 | Sample source:SEM leukemia cells | treatment:BCS+6MP |
| F12 | Sample source:SEM leukemia cells | treatment:BCS+MTX |
| F13 | Sample source:SEM leukemia cells | treatment:MTX |
| F14 | Sample source:SEM leukemia cells | treatment:Vehicle |
