Data for (Study ST004494)
(Analysis AN007536)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|
| 2-phosphoglyceric acid_0 | 1.2419 | 0.2256 | 0.4449 | 0.2782 | 0.3567 | 3.3181 | 0.4786 | 1.0154 | 0.7527 | 0.7806 |
| 2-phosphoglyceric acid_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 2-phosphoglyceric acid_2 | 0.6226 | 1.4253 | 0.1165 | 0.6123 | 0.8034 | 1.1893 | 2.0668 | 0.8227 | 0.5693 | 1.7718 |
| 2-phosphoglyceric acid_3 | 0.8769 | 1.6989 | 0.7916 | 0.5823 | 1.0077 | 0.6088 | 1.7415 | 0.7299 | 0.6255 | 1.3370 |
| 3-phosphoglyceric acid_0 | 1.3833 | 0.1990 | 0.4254 | 0.3473 | 0.2595 | 3.6685 | 0.5456 | 1.2133 | 0.6119 | 0.7301 |
| 3-phosphoglyceric acid_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| 3-phosphoglyceric acid_2 | 0.4495 | 2.2498 | 0.6766 | 0.6689 | 0.8418 | 0.6712 | 1.5228 | 0.6253 | 0.6537 | 1.6405 |
| 3-phosphoglyceric acid_3 | 0.6414 | 1.7505 | 0.6500 | 0.5631 | 0.9601 | 0.5792 | 1.9842 | 0.6561 | 0.5984 | 1.6170 |
| 6-Phosphogluconic acid_0 | 2.1046 | 0.7779 | 2.0302 | 1.6318 | 1.4467 | 0.1783 | 0.1033 | 0.5001 | 0.2387 | 0.1910 |
| 6-Phosphogluconic acid_1 | NA | 2.9960 | NA | NA | NA | NA | 0.0020 | NA | NA | NA |
| 6-Phosphogluconic acid_2 | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA |
| 6-Phosphogluconic acid_3 | NA | NA | NA | NA | NA | NA | 1.3333 | 0.0000 | NA | NA |
| 6-Phosphogluconic acid_4 | NA | 0.0043 | 0.0006 | 0.0011 | 0.0027 | NA | 11.9589 | 0.0033 | 0.0053 | 0.0088 |
| 6-Phosphogluconic acid_5 | NA | 2.9561 | 0.0493 | 0.1544 | 0.9479 | NA | 1.5611 | 0.1380 | 0.1365 | 1.4441 |
| 6-Phosphogluconic acid_6 | 0.0040 | 1.9683 | 0.0713 | 0.2418 | 0.6398 | NA | 1.7118 | 0.8340 | 1.3394 | 2.0669 |
| Dihydroxyacetone phosphate_0 | 1.0433 | 0.4427 | 0.5960 | 0.3398 | 0.2254 | 4.5705 | 0.6142 | 0.5260 | 1.2005 | 0.4416 |
| Dihydroxyacetone phosphate_1 | NA | NA | NA | NA | NA | NA | 1.0000 | NA | NA | NA |
| Dihydroxyacetone phosphate_2 | 2.4770 | 3.5453 | 1.6776 | 0.3022 | 0.0491 | NA | 0.1652 | 0.5280 | 0.0156 | 0.0452 |
| Dihydroxyacetone phosphate_3 | 2.0468 | 2.4739 | 1.5842 | 0.4944 | 0.4324 | 0.0390 | 0.8478 | 1.5396 | 0.2192 | 0.3227 |
| Erythrose, 4-phosphate_0 | 1.7713 | 0.5921 | 1.2328 | 0.8046 | 0.6025 | 1.7943 | 0.7604 | 1.2639 | 0.8438 | 0.7124 |
| Erythrose, 4-phosphate_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose, 4-phosphate_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Erythrose, 4-phosphate_3 | 0.6936 | 1.4032 | 0.5850 | 1.2162 | 1.0424 | 1.5211 | 0.5028 | 1.6262 | 0.8834 | 0.5262 |
| Erythrose, 4-phosphate_4 | 0.8490 | 1.4179 | 0.9149 | 1.0722 | 1.0680 | 0.8142 | 1.0882 | 0.9521 | 0.8002 | 1.0233 |
| Fructose-1,6-bisphosphate_0 | 0.7304 | 0.3837 | 0.4472 | 0.3501 | 0.2717 | 4.1657 | 0.8436 | 0.5721 | 1.2729 | 0.8001 |
| Fructose-1,6-bisphosphate_1 | NA | NA | NA | 0.7806 | NA | NA | 1.2194 | NA | NA | NA |
| Fructose-1,6-bisphosphate_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose-1,6-bisphosphate_3 | 1.5615 | 0.1437 | 1.5441 | 0.5420 | 0.0498 | NA | 0.0003 | 1.8579 | 1.0269 | 0.4727 |
| Fructose-1,6-bisphosphate_4 | 7.7344 | 2.2310 | 0.9369 | NA | 0.0250 | NA | 0.0237 | 0.7152 | 0.0068 | 0.0040 |
| Fructose-1,6-bisphosphate_5 | 1.0214 | 2.7284 | 1.0607 | 0.5327 | 0.5682 | NA | 0.4190 | 0.8885 | 0.7285 | 0.2830 |
| Fructose-1,6-bisphosphate_6 | 1.4649 | 1.9640 | 1.2702 | 0.8778 | 0.8584 | 0.0097 | 0.6722 | 1.4227 | 0.6770 | 0.5051 |
| Fructose-6-phosphate_0 | 1.8042 | 0.4165 | 1.1414 | 0.7255 | 0.4363 | 2.6330 | 0.4487 | 1.4331 | 0.6144 | 0.3470 |
| Fructose-6-phosphate_1 | 1.2476 | NA | 1.0696 | NA | NA | 1.0117 | NA | 0.9123 | 0.8405 | NA |
| Fructose-6-phosphate_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Fructose-6-phosphate_3 | 1.5799 | 0.6455 | 0.6437 | 0.7505 | 0.7135 | 1.9915 | 0.5082 | 1.2054 | 1.0254 | 0.2532 |
| Fructose-6-phosphate_4 | NA | 2.6135 | NA | NA | NA | 3.3742 | 0.0029 | NA | NA | 0.0031 |
| Fructose-6-phosphate_5 | 0.7210 | 1.8213 | 0.8127 | 0.9620 | 1.0920 | 0.5131 | 1.4820 | 0.7733 | 0.8532 | 0.9693 |
| Fructose-6-phosphate_6 | 0.7223 | 1.7135 | 0.8646 | 0.9953 | 1.1539 | 0.5534 | 1.3581 | 0.7843 | 0.8575 | 0.9971 |
| Glucose 6-phosphate_0 | 1.1622 | 0.9589 | 0.9682 | 0.8486 | 0.7996 | 1.3453 | 0.8912 | 1.1028 | 1.0342 | 0.8889 |
| Glucose 6-phosphate_1 | NA | 0.9293 | 0.5848 | 1.2889 | 0.7878 | 2.1750 | 0.5235 | 0.6814 | 0.4466 | 0.8711 |
| Glucose 6-phosphate_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Glucose 6-phosphate_3 | 1.2270 | 0.9336 | 0.8486 | 1.1052 | 0.8236 | 1.5469 | 0.3868 | 1.3104 | 1.1881 | 0.6300 |
| Glucose 6-phosphate_4 | 1.1277 | 1.0866 | 0.6738 | 1.4750 | 0.7123 | 1.2264 | 0.4014 | 1.3545 | 1.2892 | 0.3538 |
| Glucose 6-phosphate_5 | 0.7942 | 1.6042 | 0.8297 | 1.0922 | 1.1880 | 0.5678 | 1.0657 | 0.8493 | 0.9399 | 1.0689 |
| Glucose 6-phosphate_6 | 0.7690 | 1.5993 | 0.8318 | 1.1345 | 1.2031 | 0.5372 | 1.0732 | 0.8336 | 0.8952 | 1.1231 |
| Lactic acid_0 | 2.0278 | 0.4359 | 1.1380 | 0.9008 | 0.6903 | 0.6204 | 0.4202 | 1.6616 | 0.9853 | 1.1197 |
| Lactic acid_1 | 1.0606 | 1.3104 | 0.6534 | 1.2728 | 0.6634 | NA | 0.9938 | 1.1156 | 0.7084 | 1.2955 |
| Lactic acid_2 | 0.4995 | 2.2978 | 0.6190 | 1.1935 | 1.1982 | 0.3615 | 1.5293 | 0.4923 | 0.6143 | 0.7157 |
| Lactic acid_3 | 0.5665 | 2.5119 | 0.6459 | 1.1843 | 1.3043 | 0.1051 | 1.6269 | 0.4782 | 0.6126 | 0.7405 |
| Phosphoenolpyruvic acid_0 | 0.6488 | NA | 0.2218 | NA | NA | 1.7876 | NA | 0.3787 | NA | NA |
| Phosphoenolpyruvic acid_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Phosphoenolpyruvic acid_2 | 0.0011 | 0.0017 | 0.1004 | 0.0011 | 0.0011 | 0.0011 | 0.0842 | 33.2317 | 0.0011 | 0.0011 |
| Phosphoenolpyruvic acid_3 | 0.9270 | 1.6687 | 0.8530 | 0.6775 | 0.8027 | 0.6123 | 1.7077 | 0.5116 | 0.8241 | 1.1712 |
| Pyruvic acid_0 | 1.2866 | 0.5485 | 0.5312 | 0.5003 | 0.4709 | 2.3309 | 0.6793 | 1.8924 | 0.4656 | 1.2944 |
| Pyruvic acid_1 | 0.6576 | 0.8567 | 0.7619 | 0.9920 | 1.6770 | 1.4065 | 0.6708 | 1.0362 | 1.2168 | 0.4466 |
| Pyruvic acid_2 | 1.1254 | 1.0481 | NA | NA | NA | NA | 0.9902 | NA | NA | 0.8078 |
| Pyruvic acid_3 | 1.2341 | 1.6660 | 1.1726 | 0.7289 | 1.2930 | 0.8482 | 1.2016 | 0.4614 | 0.4448 | 0.9494 |
| Ribose 5-phosphate_0 | 2.5046 | 0.1453 | 0.9089 | 0.7549 | 0.2896 | 3.3530 | 0.2407 | 0.4915 | 0.8608 | 0.4508 |
| Ribose 5-phosphate_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose 5-phosphate_2 | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose 5-phosphate_3 | 1.0000 | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Ribose 5-phosphate_4 | 0.0051 | 9.6968 | 0.0043 | 0.0072 | 0.0079 | 0.0038 | 0.0097 | 0.0036 | 0.0051 | 0.0077 |
| Ribose 5-phosphate_5 | 0.6576 | 2.0844 | 0.6414 | 0.8773 | 1.2624 | 0.5857 | 1.5482 | 0.5312 | 0.6767 | 1.1351 |
| Sedoheptulose 7-phosphate_0 | 1.4264 | NA | 0.6680 | 0.1083 | NA | 1.5059 | NA | 0.6462 | NA | NA |
| Sedoheptulose 7-phosphate_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Sedoheptulose 7-phosphate_2 | NA | NA | NA | NA | NA | 1.9997 | NA | NA | 0.0003 | NA |
| Sedoheptulose 7-phosphate_3 | 0.7330 | NA | NA | NA | NA | 1.8032 | NA | 0.5164 | 0.3057 | NA |
| Sedoheptulose 7-phosphate_4 | 1.2070 | 0.3520 | 0.8180 | 0.6312 | 0.6078 | 2.0080 | NA | 1.4085 | 0.6192 | 0.3244 |
| Sedoheptulose 7-phosphate_5 | 1.9747 | 0.0017 | 1.0517 | 1.2894 | 0.7063 | 2.3906 | 0.0011 | 0.9191 | 1.0167 | 0.0011 |
| Sedoheptulose 7-phosphate_6 | 1.0254 | 1.3155 | 1.0324 | 1.1390 | 1.0692 | 1.0995 | 0.6669 | 1.1912 | 0.7659 | 0.6366 |
| Sedoheptulose 7-phosphate_7 | 0.8590 | 1.5276 | 0.9231 | 1.1437 | 1.2064 | 0.6242 | 0.9504 | 1.0343 | 0.7347 | 0.9304 |
| Xylulose 5-phosphate_0 | 2.6773 | NA | 1.0002 | 0.1442 | 0.0217 | 2.7372 | 0.9016 | 1.2835 | 0.1833 | 0.0510 |
| Xylulose 5-phosphate_1 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Xylulose 5-phosphate_2 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Xylulose 5-phosphate_3 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
| Xylulose 5-phosphate_4 | NA | 6.2299 | 0.0017 | 0.0017 | 0.0017 | NA | 0.0109 | 0.0035 | 0.0017 | 0.0023 |
| Xylulose 5-phosphate_5 | 0.3820 | 3.3995 | 0.3395 | 0.3260 | 0.6367 | 0.2758 | 3.1726 | 0.5845 | 0.2823 | 0.6013 |
Factors:
| F1 | Genotype:TIGAR-knockout | Treatment:13C Glc | Time:1H | Sample source:HT29 CL.16E cells |
| F2 | Genotype:TIGAR-knockout | Treatment:13C Glc | Time:24H | Sample source:HT29 CL.16E cells |
| F3 | Genotype:TIGAR-knockout | Treatment:13C Glc | Time:2H | Sample source:HT29 CL.16E cells |
| F4 | Genotype:TIGAR-knockout | Treatment:13C Glc | Time:4H | Sample source:HT29 CL.16E cells |
| F5 | Genotype:TIGAR-knockout | Treatment:13C Glc | Time:8H | Sample source:HT29 CL.16E cells |
| F6 | Genotype:Wild-type | Treatment:13C Glc | Time:1H | Sample source:HT29 CL.16E cells |
| F7 | Genotype:Wild-type | Treatment:13C Glc | Time:24H | Sample source:HT29 CL.16E cells |
| F8 | Genotype:Wild-type | Treatment:13C Glc | Time:2H | Sample source:HT29 CL.16E cells |
| F9 | Genotype:Wild-type | Treatment:13C Glc | Time:4H | Sample source:HT29 CL.16E cells |
| F10 | Genotype:Wild-type | Treatment:13C Glc | Time:8H | Sample source:HT29 CL.16E cells |
