Data for Heatshock response of C. elegans using IROA (I) (Study ST000040)
(Analysis AN000061)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| 11-Hydroxy-9-tridecenoic acid | 0.9506 | NA | 1.0494 | NA |
| 1,2,3-Trihydroxybenzene | 0.6663 | 1.5882 | 0.4569 | 1.2885 |
| 1H-Indole-3-carboxaldehyde | 0.7332 | 1.3497 | 0.7396 | 1.1775 |
| 1-Methylguanosine | 1.0184 | 1.1058 | 1.1867 | 0.6891 |
| 1-Methylinosine | 1.2976 | 0.6376 | 1.6492 | 0.4156 |
| 1-Pyrroline-2-carboxylic acid | 1.1859 | 0.0867 | 1.3870 | 0.1947 |
| 1-(sn-Glycero-3-phospho)-1D-myo-inositol | 0.9738 | 0.0420 | 1.4634 | 0.2093 |
| 2-Aminobenzoic acid | 0.7655 | 1.2345 | NA | NA |
| 2-Aminomuconic acid | 0.4913 | 0.8392 | 1.1563 | 1.2901 |
| 2-Furoic acid | 1.4351 | 1.6911 | 0.1487 | 0.1619 |
| (±)-2-Hydroxy-4-(methylthio)butanoic acid | 1.2528 | NA | 0.7472 | NA |
| 2-Hydroxyadipic acid | 1.3814 | 1.1255 | 0.4209 | 0.8188 |
| 2-Isopropylmalic acid | NA | NA | 0.8496 | 1.1504 |
| 2-Ketobutyric acid | 0.9090 | 1.0914 | 0.8124 | 1.1872 |
| 2-Keto-glutaramic acid | 0.8498 | 1.9350 | 0.4829 | 0.9285 |
| 2-(Methylthio)pyrazine | 0.7690 | NA | 1.2310 | NA |
| 3-(2-Hydroxyphenyl)propanoic acid | 0.9910 | 1.0090 | NA | NA |
| 3-Dehydrocarnitine | 0.4784 | 0.3026 | 1.9706 | 0.9436 |
| 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid | 0.3170 | 0.3951 | 1.7078 | 1.5801 |
| 3-Hydroxy-2-methyl-[R-(R,S)]-butanoic acid | 0.2655 | 0.6054 | 1.1841 | 1.6628 |
| 3-Hydroxyanthranilic acid | 0.8774 | 1.1226 | NA | NA |
| 3-Hydroxyisoheptanoic acid | NA | NA | 1.3035 | 0.6965 |
| 3-Methyladenine | 1.0200 | 0.9800 | NA | NA |
| 3-Methylguanine | 1.3073 | 0.5108 | 1.5406 | 0.7020 |
| 4-Hydroxy-2-oxoglutaric acid | 1.3338 | 1.5956 | 0.3628 | 0.7078 |
| 4-Hydroxybenzoic acid | 0.2088 | 1.3176 | 0.6301 | 1.8435 |
| 4-Hydroxybutyric acid | 1.4755 | 1.4105 | 0.0894 | 0.1385 |
| 4-Hydroxyphenylacetylglutamine | 1.0345 | 0.9655 | NA | NA |
| 4-Pyridoxic acid | NA | NA | 0.5838 | 1.4162 |
| 5-Aminolevulinic acid | 0.0409 | 0.0450 | 1.1602 | 1.3183 |
| 5-Hexyltetrahydro-2-oxo-3-furancarboxylic acid | 0.0570 | 0.3038 | 0.9225 | 1.4873 |
| 5-Hydroxyisourate | 1.6060 | 1.3405 | 0.0330 | 0.0741 |
| 5-L-Glutamyl-L-alanine | 0.7333 | 1.2667 | NA | NA |
| 5^-Methylthioadenosine | 0.9455 | 1.0545 | NA | NA |
| 5-Thymidylic acid | 1.0837 | 0.9163 | NA | NA |
| 7-Aminomethyl-7-carbaguanine | 1.4208 | 1.2748 | 0.6842 | 0.6202 |
| 7-Methylxanthine | NA | NA | 0.8822 | 1.1178 |
| 8-Hydroxy-7-methylguanine | 0.9212 | 1.0788 | NA | NA |
| 8-Hydroxyguanine | 1.0079 | 0.9921 | NA | NA |
| Acaciabiuronic acid | NA | NA | 1.0501 | 0.9499 |
| Adenine | 0.9778 | 1.0222 | NA | NA |
| Adenosine | 0.3828 | 0.2513 | 0.9914 | 1.4639 |
| Adenosine monophosphate | 1.8534 | 1.9113 | 0.0101 | 0.2252 |
| Alanyl-Isoleucine | 0.8617 | 1.1383 | NA | NA |
| Allantoic acid | 0.3967 | 0.4177 | 1.6399 | 1.5457 |
| Allantoin | NA | NA | 1.1211 | 0.8789 |
| Allocystathionine | 0.8435 | 1.1565 | NA | NA |
| Allysine | NA | NA | 1.0313 | 0.9687 |
| Alpha-ketoisovaleric acid | 0.0845 | 0.1324 | 0.5947 | 1.8511 |
| Alpha-N-Phenylacetyl-L-glutamine | 0.1387 | 0.0868 | 2.0793 | 1.2516 |
| Aminoadipic acid | 1.2607 | 2.4364 | 0.1885 | 0.1144 |
| Arabinonic acid | 0.7872 | 1.4136 | 0.8811 | 0.9182 |
| Arachidonic acid | 0.9267 | 1.0733 | NA | NA |
| ascr1 | 1.6471 | 1.8129 | 0.2631 | 0.2769 |
| ascr10 | 0.6925 | 2.2601 | 0.4497 | 0.2802 |
| ascr11 | 0.4308 | 1.2456 | 1.1160 | 1.2076 |
| ascr18 | 0.4401 | 1.5599 | NA | NA |
| ascr5 | 0.4040 | 0.3099 | 2.1204 | 1.1658 |
| ascr7 | 1.1528 | 1.2841 | 0.1259 | 0.1264 |
| beta-D-3-Ribofuranosyluric acid | 0.9091 | 1.0909 | NA | NA |
| beta-D-Glucopyranosyl anthranilate | 0.8007 | 1.1993 | NA | NA |
| Biotin | 0.9258 | 1.0742 | NA | NA |
| Butyric acid | NA | NA | 0.9941 | 1.0059 |
| CDP-Ethanolamine | 0.5594 | 1.4406 | NA | NA |
| cis-Aconitic acid | 0.8528 | 1.1472 | NA | NA |
| Citramalic acid | 1.9842 | 2.0592 | 0.9895 | 0.4997 |
| Citric acid | 0.9525 | 1.4468 | 0.5796 | 1.0212 |
| Cyclic AMP | NA | NA | 0.8096 | 1.1904 |
| Cyclic GMP | NA | NA | 0.8067 | 1.1933 |
| Cytidine | NA | NA | 0.6438 | 1.3562 |
| Cytidine 2^,3^-cyclic phosphate | NA | NA | 0.8767 | 1.1233 |
| Cytidine monophosphate | 0.8340 | 1.1660 | NA | NA |
| dCMP | 1.5344 | 1.8234 | 0.2650 | 0.3771 |
| Decarbamoylgonyautoxin III | NA | NA | 0.8726 | 1.1274 |
| Deoxyadenosine monophosphate | 0.9079 | 1.3769 | 0.7818 | 0.9333 |
| Deoxyribose | 0.2534 | 1.6765 | 0.5378 | 1.5089 |
| D-Erythrose 4-phosphate | 1.0386 | 0.9614 | NA | NA |
| D-Glucose | 1.5008 | 1.2488 | 0.2046 | 0.2962 |
| Diacetyl | 0.7556 | 1.2444 | NA | NA |
| Diaminopimelic acid | 1.0958 | 1.6280 | 0.3041 | 0.7308 |
| Dihydrothymine | 0.6777 | 1.3223 | NA | NA |
| Dimethyl fukiic acid | 0.8510 | 1.1490 | NA | NA |
| Dipropyl disulfide | 1.1140 | 0.8860 | NA | NA |
| D-Leucic acid | 1.5811 | 1.4652 | 0.6075 | 0.3461 |
| D-Ribulose 5-phosphate | 0.8794 | 0.9503 | 0.5370 | 1.5055 |
| Erythrose | 1.2040 | 1.3234 | 0.6380 | 0.8345 |
| Fagomine | 0.9354 | 1.0646 | NA | NA |
| Flavin Mononucleotide | 0.9032 | 1.0968 | NA | NA |
| Formiminoglutamic acid | 0.7925 | 1.3367 | 1.0107 | 0.8924 |
| Fructose 6-phosphate | 0.5251 | 0.6816 | 1.7042 | 1.0891 |
| Fucose 1-phosphate | NA | NA | 0.7148 | 1.2852 |
| Fumaric acid | 0.5849 | 1.4151 | NA | NA |
| Galactosylglycerol | 0.9572 | 1.1537 | 0.8299 | 1.1146 |
| Gamma-Aminobutyric acid | 2.5530 | 1.4023 | 0.0150 | 0.0297 |
| Gamma Glutamylglutamic acid | NA | NA | 0.7234 | 1.2766 |
| Garcinia acid | NA | NA | 0.7110 | 1.2890 |
| Gluconic acid | 1.4013 | 1.3154 | 0.6230 | 0.6603 |
| Glucosamine 6-phosphate | 0.0301 | 0.0361 | 1.6812 | 1.7692 |
| Glutaric acid | 0.1715 | 0.2861 | 1.8277 | 1.7147 |
| Glutathione | 1.0365 | 0.9635 | NA | NA |
| Glycerol tributanoate | 0.2669 | 3.1870 | 0.1491 | 0.3970 |
| Glycerylphosphorylethanolamine | 0.9880 | 1.0120 | NA | NA |
| Glycyl-L-leucine | 1.5305 | 1.7420 | 0.2599 | 0.4676 |
| Glycylproline | 0.9101 | 1.4530 | 0.5188 | 1.1181 |
| Guanine | 1.0423 | 0.9577 | NA | NA |
| Guanosine | 1.9051 | 1.4234 | 0.2711 | 0.4004 |
| Guanosine monophosphate | 1.2079 | 1.2352 | 0.2072 | 1.3497 |
| Histamine | 1.1197 | 0.8803 | NA | NA |
| Homocysteinesulfinic acid | 0.3273 | 0.1449 | 2.5349 | 0.9930 |
| Hydantoin-5-propionic acid | NA | NA | 0.6777 | 1.3223 |
| Hydroxyphenyllactic acid | 1.7326 | 0.8386 | 0.9602 | 0.4686 |
| Hydroxyprolyl-Valine | 0.1099 | 0.1557 | 1.5086 | 1.3586 |
| Hypoxanthine | 1.5905 | 1.9369 | 0.1486 | 0.3240 |
| icas9 | 2.2524 | 1.2382 | 0.2374 | 0.2719 |
| Ifosfamide | 0.9761 | 1.0239 | NA | NA |
| Ilicifolinoside A | 1.6721 | 1.0859 | 0.3304 | 0.5326 |
| Imidazoleacetic acid riboside | 1.0771 | 1.3936 | 0.0638 | 0.0532 |
| Inosine | 2.0045 | 1.9718 | 0.0019 | 0.0218 |
| Inositol cyclic phosphate | 0.8046 | 1.1954 | NA | NA |
| Isoleucyl-Tyrosine | 1.1268 | 1.1162 | 0.8809 | 0.8761 |
| Isopentenyl pyrophosphate | NA | NA | 0.4033 | 1.5967 |
| Isopropyl citrate | 1.3710 | 0.9276 | 0.8253 | 0.7765 |
| Isoxanthopterin | 0.8982 | 1.1018 | NA | NA |
| Itaconic acid | 1.1649 | 1.2762 | 0.7880 | 0.9915 |
| Ketoleucine | 1.5301 | 1.4861 | 0.3302 | 0.6537 |
| L-Acetopine | 1.4480 | 1.5149 | 0.0363 | 0.0380 |
| L-Acetylcarnitine | 1.0083 | 0.9917 | NA | NA |
| L-Arginine | 0.9606 | 1.5368 | 0.0024 | 0.0080 |
| L-Asparagine | 0.6171 | 1.3829 | NA | NA |
| L-Aspartate-semialdehyde | 1.1057 | 1.6504 | 0.6495 | 0.5944 |
| L-Aspartic acid | 0.4647 | 1.1659 | 0.9316 | 1.4378 |
| L-Coprine | 0.5764 | 1.4236 | NA | NA |
| L-Glutamic acid | 1.7699 | 2.2289 | 0.0003 | 0.0009 |
| L-Glutamine | 1.0286 | 1.9602 | 0.0094 | 0.0130 |
| L-Histidine | 1.1757 | 1.3179 | 0.0096 | 0.0160 |
| L-Leucine | 0.9970 | 1.0030 | NA | NA |
| L-L-Homoglutathione | 1.0824 | 0.9176 | NA | NA |
| L-Lysine | 1.1970 | 1.6913 | 0.0235 | 0.2001 |
| L-Malic acid | NA | NA | 0.6787 | 1.3213 |
| L-Methionine | 1.1783 | 0.8217 | NA | NA |
| Lotaustralin | 0.8302 | 1.1698 | NA | NA |
| L-Phenylalanine | 1.9877 | 1.9734 | 0.0127 | 0.0262 |
| L-Proline | 0.6625 | 1.3375 | NA | NA |
| L-Threonine | 0.4927 | 1.5073 | NA | NA |
| L-Tryptophan | 1.6154 | 1.8243 | 0.1812 | 0.3791 |
| L-Tyrosine | 2.2551 | 1.7208 | 0.0089 | 0.0152 |
| L-Valine | 0.9428 | 0.9182 | 1.0266 | 1.1125 |
| LysoPC(14:0) | 0.9047 | 1.0953 | NA | NA |
| LysoPC(14:1(9Z)) | 1.1053 | 0.8947 | NA | NA |
| LysoPC(15:0) | 0.8857 | 1.1143 | NA | NA |
| LysoPE(0:0/14:0) | 0.9073 | 1.0927 | NA | NA |
| LysoPE(0:0/14:1(9Z)) | 1.3254 | 0.6746 | NA | NA |
| LysoPE(0:0/15:0) | 1.2124 | 0.7876 | NA | NA |
| LysoPE(0:0/16:0) | 0.8577 | 1.1423 | NA | NA |
| LysoPE(0:0/16:1(9Z)) | 1.1355 | 0.8645 | NA | NA |
| LysoPE(0:0/18:1(11Z)) | 0.8453 | 1.1547 | NA | NA |
| LysoPE(0:0/18:2(9Z,12Z)) | 0.9975 | 1.0025 | NA | NA |
| LysoPE(0:0/20:2(11Z,14Z)) | 1.1031 | 0.8969 | NA | NA |
| LysoPE(0:0/20:3(11Z,14Z,17Z)) | 0.8361 | 1.1639 | NA | NA |
| LysoPE(0:0/20:4(5Z,8Z,11Z,14Z)) | 0.8004 | 1.1996 | NA | NA |
| LysoPE(0:0/20:5(5Z,8Z,11Z,14Z,17Z)) | 0.9160 | 1.0840 | NA | NA |
| Mannitol | NA | NA | 0.3747 | 1.6253 |
| Metaxalone | 0.9049 | 1.0951 | NA | NA |
| Methionyl-Serine | 1.0661 | 1.4559 | 0.1828 | 0.2514 |
| Methylpyrazine | 0.7234 | 0.7308 | 0.9499 | 1.5960 |
| Mevalonic acid | 0.0240 | 0.6977 | 0.0488 | 3.2295 |
| N-(1-Deoxy-1-fructosyl)methionine | 1.2193 | 1.5763 | 0.6148 | 0.5896 |
| N-(1-Deoxy-1-fructosyl)phenylalanine | 1.1303 | 0.8697 | NA | NA |
| N-(1-Deoxy-1-fructosyl)tyrosine | NA | NA | 1.0454 | 0.9546 |
| N2-Succinyl-L-ornithine | 1.8396 | 1.9107 | 0.1249 | 0.1248 |
| N6-Carbamoyl-L-threonyladenosine | 0.8595 | 1.1405 | NA | NA |
| N-a-Acetyl-L-arginine | 1.4617 | 1.8084 | 0.3560 | 0.3739 |
| N-Acetylcystathionine | 1.6781 | 1.2313 | 0.0961 | 0.0852 |
| N-Acetyl-D-glucosamine | 1.5041 | 0.6199 | 1.2447 | 0.6313 |
| N-Acetylglutamic acid | NA | NA | 0.8763 | 1.1237 |
| N-Acetylglutamine | 1.6413 | 1.6182 | 0.2017 | 0.1189 |
| N-Acetylhistamine | 0.9769 | 1.0231 | NA | NA |
| N-Acetylhistidine | 2.0214 | 1.8706 | 0.0606 | 0.0474 |
| N-Acetyl-L-aspartic acid | 1.1062 | 0.8938 | NA | NA |
| N-Acetyl-L-phenylalanine | 1.1683 | 0.9665 | 1.1867 | 0.7235 |
| N-Acetyl-L-tyrosine | 1.0616 | 0.9382 | 1.0768 | 0.9233 |
| N-Acetylornithine | 0.6371 | 0.7182 | 1.1219 | 1.0930 |
| Nebularine | 0.8773 | 1.1227 | NA | NA |
| N^-Formylkynurenine | NA | NA | 0.9395 | 1.0605 |
| N-gamma-L-Glutamyl-L-methionine | 1.5337 | 1.9145 | 0.2847 | 0.2671 |
| N-Gluconyl ethanolamine phosphate | NA | NA | 1.3453 | 0.6547 |
| Nicotinic acid | 1.8396 | 2.0539 | 0.0342 | 0.0723 |
| N-Methylcalystegine C1 | 1.0921 | 0.9079 | NA | NA |
| Norfuraneol | 0.9734 | 0.9135 | 1.0474 | 1.0658 |
| Octafluorocyclobutane | 0.6998 | 1.3002 | NA | NA |
| Ophthalmic acid | 1.0267 | 0.9733 | NA | NA |
| Ornithine | 1.0941 | 0.9059 | NA | NA |
| Orotic acid | NA | NA | 1.2306 | 0.7694 |
| Oxitriptan | 0.9213 | 1.0787 | NA | NA |
| Oxoadipic acid | 0.1841 | 0.1210 | 1.5196 | 2.1753 |
| Oxoglutaric acid | NA | NA | 1.0060 | 0.9940 |
| Pantetheine | 0.8594 | 1.1406 | NA | NA |
| Pantothenic acid | 1.6617 | 1.6334 | 0.3229 | 0.3820 |
| Pectic acid | 0.4753 | 0.4447 | 1.8880 | 1.1920 |
| Phaseolic acid | 0.8458 | 0.8831 | 0.9781 | 1.2930 |
| Phosphodimethylethanolamine | 1.2627 | 1.3435 | 0.3363 | 1.0575 |
| Pimelic acid | NA | NA | 1.2207 | 0.7793 |
| Polyethylene glycol | 1.0131 | 0.9869 | NA | NA |
| Porphobilinogen | 1.0266 | 0.9494 | 1.0871 | 0.9370 |
| Prenyl glucoside | 0.6892 | 1.6388 | 0.7158 | 0.9562 |
| Prolylhydroxyproline | 0.8446 | 1.1554 | NA | NA |
| Prunasin | 1.3235 | 0.6765 | NA | NA |
| Pterin | 1.5762 | 1.4958 | 0.3957 | 0.5323 |
| Pyridine N-oxide glucuronide | 1.6593 | 1.8222 | 0.1645 | 0.3539 |
| Pyridoxal | NA | NA | 0.7764 | 1.2236 |
| Pyridoxal 5^-phosphate | 0.7576 | 1.2424 | NA | NA |
| Pyroglutamic acid | 0.8260 | 1.1740 | NA | NA |
| Pyrrole-2-carboxylic acid | 0.6546 | 1.3454 | NA | NA |
| Retinyl ester | 0.9538 | 1.0462 | NA | NA |
| Riboflavin | 0.8259 | 1.1741 | NA | NA |
| (S)-2-Aceto-2-hydroxybutanoic acid | 0.3325 | 1.7401 | 0.2959 | 1.6315 |
| (S)-9-Hydroxy-10-undecenoic acid | 0.7410 | 1.8721 | 0.8537 | 0.6682 |
| Saccharopine | 1.6959 | 1.5963 | 0.3141 | 0.3937 |
| S-Adenosylhomocysteine | 0.9644 | 1.0356 | NA | NA |
| Sarmentosin | 0.8875 | 1.1125 | NA | NA |
| S-Carboxymethyl-L-cysteine | 1.5528 | 1.5452 | 0.3193 | 0.5828 |
| Sebacic acid | NA | NA | 1.2727 | 0.7273 |
| Sepiapterin | 0.9079 | 1.0921 | NA | NA |
| Succinic acid | 0.7830 | 1.2170 | NA | NA |
| Succinic anhydride | 0.7285 | 1.2715 | NA | NA |
| Succinyladenosine | 1.2992 | 1.9937 | 0.3093 | 0.3979 |
| Sucrose | 1.1510 | 0.8446 | 1.0914 | 0.9129 |
| Tetrahydropentoxyline | 1.3565 | 1.5884 | 0.0493 | 0.0609 |
| Thiomorpholine 3-carboxylate | 0.4617 | 0.3538 | 1.1615 | 1.2333 |
| Threonic acid | 1.2286 | 2.0720 | 0.2543 | 0.4452 |
| Tiglic acid | NA | NA | 0.9708 | 1.0292 |
| trans-Cinnamic acid | 0.9103 | 1.0897 | NA | NA |
| Undecanedioic acid | NA | NA | 0.8618 | 1.1382 |
| Uracil | NA | NA | 1.1517 | 0.8483 |
| Ureidosuccinic acid | NA | NA | 0.9488 | 1.0512 |
| Uric acid | 1.8332 | 1.5373 | 0.1856 | 0.4439 |
| Uridine | NA | NA | 1.2080 | 0.7920 |
| Uridine 2^,3^-cyclic phosphate | 0.1052 | 0.1064 | 1.6117 | 2.1767 |
| Uridine 5^-monophosphate | 1.4084 | 1.9945 | 0.0350 | 0.5621 |
| Uridine diphosphate glucose | 0.8946 | 1.1054 | NA | NA |
| Uridine diphosphate-N-acetylglucosamine | 0.8436 | 1.1564 | NA | NA |
| Urocanic acid | 0.6175 | 0.6962 | 1.0862 | 1.6001 |
| Vinylacetylglycine | 0.9038 | 0.9323 | 0.9953 | 1.1685 |
| Wybutoxine | 1.1794 | 0.8206 | NA | NA |
| Xanthine | 1.8692 | 2.0557 | 0.0333 | 0.0418 |
| Xanthosine | 0.9142 | 1.2342 | 0.7481 | 1.1034 |
| Zalcitabine | 1.1011 | 0.8989 | NA | NA |
Factors:
| F1 | Heat shock:control | Metabolome:endometabolome |
| F2 | Heat shock:control | Metabolome:exometabolome |
| F3 | Heat shock:heat shock | Metabolome:endometabolome |
| F4 | Heat shock:heat shock | Metabolome:exometabolome |
