Data for Metabolomics of intensive weight management clinic (IWMC) weight loss (Study ST000744)
(Analysis AN001164)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 |
|---|---|---|---|---|---|---|---|---|---|---|
| 16:0-18:0 PC (M+CL)- | 1.3964 | 0.6665 | 0.9698 | 0.8954 | 0.9780 | 1.1145 | 1.0010 | 0.9346 | NA | 1.2343 |
| 16:0 LYSO PC (M+CL)- | 2.1328 | 0.6875 | 0.8526 | 1.1710 | 0.8369 | 0.8071 | 0.9121 | 0.8778 | 0.8826 | 0.9938 |
| 18:0 LYSO-PE (M-H)- | 1.1895 | 1.1983 | 1.1692 | 0.8524 | 0.7691 | 0.8213 | 1.0281 | 0.9853 | 1.1784 | 0.9917 |
| 1-METHYLADENOSINE (M+CL)- | 0.9286 | 0.9704 | 1.0888 | 0.9758 | 0.8273 | 1.2142 | 0.7790 | 0.9995 | 1.1150 | 1.0322 |
| 1-METHYLURIC ACID (2M-H)- | NA | 0.3672 | 1.2072 | 1.8938 | NA | 0.3557 | NA | 0.3808 | 1.0642 | NA |
| 1-METHYLURIC ACID (M-H)- | 0.2510 | 0.6605 | 1.1419 | 2.2053 | 0.2373 | 1.1430 | 0.6739 | 0.9965 | 1.4019 | 0.1597 |
| 1-METHYLXANTHINE (M-H)- | 1.2369 | 0.4971 | 1.9294 | 2.4910 | 0.0487 | 0.3123 | 0.8570 | 0.8157 | 0.0729 | 0.0794 |
| 24:0 SM (D18:1/24:0) (M+CL)- | 0.6146 | 1.5288 | 0.8310 | 1.1249 | 0.9395 | 0.8855 | 1.5487 | 1.2310 | 0.7810 | 0.6465 |
| 2-DEOXY-D-GLUCOSE (M+CL)- | 3.2990 | NA | 0.9281 | NA | 0.1440 | 0.3659 | NA | NA | 0.4732 | 0.0174 |
| 2-HYDROXY-3-METHYLBUTYRIC ACID (M-H)- | 0.8271 | 0.8842 | 1.1641 | 0.8885 | 1.3214 | 1.5130 | 0.6487 | 0.8068 | 0.9650 | 0.5113 |
| 2-HYDROXYBUTYRIC ACID (M-H)- | 1.0599 | 0.8138 | 0.6807 | 0.7401 | 1.7469 | 1.2418 | 1.0301 | 1.1274 | 0.9973 | 0.6469 |
| 2-METHYLMALEIC ACID (M-H)- | 0.7984 | 1.0774 | 1.8038 | 0.8759 | 0.7228 | 0.6542 | 0.4942 | 1.0306 | 0.8053 | 1.5966 |
| 3-(4-HYDROXYPHENYL)LACTIC ACID (M-H)- | 0.5544 | 0.8237 | 1.1218 | 0.8612 | 1.0732 | 1.2325 | 0.8071 | 1.0537 | 1.6623 | 0.6742 |
| 3-HYDROXY-3-METHYLGLUTARIC ACID (M-H)- | 0.7955 | 1.0503 | 1.2043 | 0.9361 | 0.6928 | 1.0957 | 1.0584 | 0.9525 | 1.3406 | 0.7874 |
| 3-METHYL-2-OXOPENTANOIC ACID (M-H)- | 1.0087 | 0.8511 | 0.9138 | 0.9010 | 1.1039 | 1.3656 | 0.9899 | 0.9421 | 1.1850 | 0.6894 |
| 3-METHYLXANTHINE (M-H)- | 1.9241 | 0.3388 | 1.5902 | 2.5153 | 0.1371 | 0.7645 | 0.6294 | 0.9271 | 0.2099 | 0.0472 |
| 4-METHYL-2-OXOPENTANOIC ACID (M-H)- | 0.8899 | 0.7265 | 0.8891 | 0.9429 | 1.2156 | 1.3451 | 1.0262 | 1.0091 | 1.1686 | 0.6746 |
| 4-PYRIDOXIC ACID (M-H)- | 0.6336 | 0.5034 | 0.9144 | 0.7009 | 0.6396 | 1.0894 | 1.3328 | 2.3499 | 1.1276 | 1.2286 |
| 5-HYDROXY OMEPRAZOLE (M-H)- | NA | NA | 1.0000 | NA | NA | NA | NA | NA | NA | NA |
| ADIPIC ACID (M-H)- | 0.7450 | 0.9982 | 1.0583 | 0.8614 | 0.6856 | 1.1841 | 1.3547 | 1.0920 | 1.3269 | 0.8391 |
| ARACHIDONIC ACID (M-H)- | 0.9222 | 0.9521 | 0.9671 | 1.0157 | 1.0794 | 0.9950 | 1.0112 | 1.0971 | 1.1554 | 0.7849 |
| AZELAIC ACID (M-H)- | 0.8381 | 1.2435 | 1.0478 | 1.0256 | 0.8064 | 1.3540 | 1.0108 | 0.8432 | 0.9932 | 0.6837 |
| BILIVERDIN (M-H)- | 0.7616 | 0.4891 | 0.7064 | 1.0130 | 1.3564 | 1.5075 | 1.2017 | 1.3141 | 0.8129 | 0.6860 |
| CHOLIC ACID (M-H)- | NA | NA | 3.6570 | 0.4025 | NA | 0.3365 | 0.2449 | 0.4403 | 0.0826 | NA |
| CIS-11-EICOSENOIC ACID (M-H)- | 1.0303 | 1.8932 | 0.9483 | 0.7639 | 0.9116 | 1.0495 | 0.9887 | 0.6146 | 1.4168 | 0.6902 |
| CITRAMALIC ACID (M-H)- | 0.6496 | 1.2215 | 1.3870 | 1.0496 | 0.9563 | 0.9543 | 0.3130 | 0.8999 | 1.7304 | 0.6399 |
| CITRIC ACID (M-H)- | 1.1757 | 1.8941 | 0.8808 | 1.0445 | 1.0030 | 0.6942 | 0.7739 | 0.6799 | 1.1632 | 0.9167 |
| CORTISOL (M+CL)- | 0.7669 | 0.9406 | 1.6266 | 0.8993 | 0.9081 | 1.0992 | 0.8975 | 0.6320 | 1.2441 | 0.4563 |
| CORTISONE (M+CL)- | 0.7984 | 0.9295 | 1.0607 | 1.0071 | 1.1656 | 1.2180 | 1.0084 | 0.9286 | 0.9343 | 0.6570 |
| DEHYDROEPIANDROSTERONE SULFATE (M-H)- | 1.4687 | 0.5874 | 0.6261 | 1.0171 | 0.7497 | 1.4737 | 0.8604 | 1.9896 | 0.8519 | 0.6205 |
| DEOXYADENOSINE (M+CL)- | 1.1242 | 0.8992 | 0.8433 | 0.7825 | 1.4201 | 1.3121 | 1.1191 | 1.0163 | 0.8687 | 0.6224 |
| DEOXYCHOLIC ACID (M+CL)- | 1.3816 | 1.3626 | 1.3505 | 1.0137 | 1.1466 | 0.6953 | 0.5257 | 0.9307 | 1.1292 | 0.4187 |
| DEOXYCHOLIC ACID (M-H)- | 1.5357 | 1.4848 | 1.2877 | 0.9477 | 1.2773 | 0.6025 | 0.5121 | 1.0772 | 0.7234 | 0.5202 |
| DEOXYURIDINE (M+CL)- | 0.8097 | 0.7593 | 0.8327 | 0.9117 | 1.0958 | 1.5283 | 1.2055 | 0.6406 | 0.9306 | 1.4591 |
| DIPALMITOYL PHOSPHATIDYLETHANOLAMINE (M-H)- | 1.8655 | 1.3425 | 0.8278 | 0.6266 | 0.9770 | 1.0304 | 0.9343 | 0.7282 | 1.0832 | 1.1266 |
| DOCOSAHEXAENOIC ACID (M-H)- | 0.5390 | 0.7194 | 0.8537 | 0.9879 | 1.1187 | 0.9467 | 1.8483 | 1.9492 | 0.7405 | 0.4224 |
| EPIBRASSINOLIDE [ISTD] (M+CL)- | 0.9820 | 1.0494 | 1.0166 | 1.0170 | 1.0572 | 1.0487 | 1.1144 | 1.0330 | 0.9911 | 0.6040 |
| ERUCIC ACID (M-H)- | 0.8819 | 0.6960 | 0.6732 | 1.0221 | 2.1012 | 1.0677 | 0.9912 | 0.5772 | 0.9683 | 0.7524 |
| GALACTARIC ACID (M-H)- | 0.5778 | 0.1569 | 0.4294 | 1.2533 | 0.3540 | 0.6719 | 1.0247 | 1.7388 | 0.5612 | 3.8256 |
| GLUCOSE (M+CL)- | 1.1187 | 0.6744 | 0.9895 | 0.9028 | 0.9274 | 0.9299 | 1.1239 | 0.8555 | 0.7974 | 1.8594 |
| GLYCOCHOLIC ACID (M-H)- | 0.4161 | 0.9265 | 1.5143 | 0.5326 | 0.6041 | 0.9091 | 2.0840 | 2.0593 | 0.7092 | 0.3968 |
| HEPTADECANOIC ACID (M-H)- | 1.0728 | 1.6407 | 1.1332 | 0.6188 | 0.9397 | 0.8532 | 1.3856 | 0.8743 | 0.9510 | 0.8823 |
| HIPPURIC ACID (M-H)- | 1.0885 | 0.4276 | 1.7770 | 2.0665 | 0.4696 | 0.4246 | 0.4158 | 0.8481 | 0.6894 | 0.5020 |
| HYODEOXYCHOLIC ACID (M-H)- | 0.8808 | 1.3604 | 1.0779 | 0.8678 | 0.8368 | 0.8629 | 1.4345 | 1.0324 | 1.0708 | 0.7801 |
| IBUPROFEN CARBOXYLIC ACID (M-H)- | 0.0536 | NA | NA | NA | NA | NA | NA | NA | NA | 1.9464 |
| IBUPROFEN (M-H)- | 0.0439 | NA | NA | 0.0064 | NA | NA | NA | NA | NA | 2.9497 |
| ISOCITRIC ACID (M-H)- | 0.2834 | 0.2479 | 1.1628 | 1.2734 | 1.1477 | 0.7971 | 1.3059 | 1.4102 | 1.1015 | 0.8615 |
| L-[15N]ANTHRANILIC ACID [ISTD] (M-H)- | 1.1220 | 0.9288 | 1.0819 | 0.9142 | 1.0791 | 1.1099 | 0.9285 | 0.9983 | 1.1540 | 0.5928 |
| LAURIC ACID (M-H)- | 0.7786 | 1.9360 | 1.2353 | 1.0235 | 0.6929 | 1.1249 | 0.6087 | 0.7974 | 0.8561 | 0.6489 |
| LINOLEIC ACID (M-H)- | 0.8858 | 1.0710 | 1.0661 | 1.0385 | 0.8199 | 0.9960 | 1.0716 | 1.1028 | 1.2341 | 0.7015 |
| L-TRYPTOPHAN-15N2 [ISTD] (M-H)- | 1.2096 | 0.8694 | 1.0051 | 0.9857 | 1.0932 | 1.1529 | 1.0614 | 0.9535 | 1.0846 | 0.4707 |
| MALIC ACID (M-H)- | 1.2523 | 0.6610 | 0.9562 | 0.8075 | 1.1498 | 1.1201 | 0.9808 | 1.0870 | 0.9696 | 1.1172 |
| MEVALONIC ACID (M-H)- | 1.1642 | 1.1352 | 0.8588 | 1.4181 | 1.1461 | 0.9800 | 0.6539 | 1.0828 | 1.0258 | 0.4173 |
| MYRISTIC ACID (M-H)- | 0.7465 | 1.6147 | 1.3234 | 0.8725 | 0.8368 | 0.8256 | 1.2531 | 1.2959 | 0.7356 | 0.4689 |
| MYRISTOLEIC ACID (M-H)- | 0.4908 | 0.9792 | 1.1558 | 1.0505 | 1.9408 | 0.5936 | 0.7610 | 1.1616 | 0.7243 | 0.3380 |
| N-ACETYL-D-GLUCOSAMINE (M+CL)- | 1.1569 | 0.9873 | 1.1718 | 1.1023 | 0.7478 | 0.9869 | 1.2966 | 0.9542 | 0.7399 | 0.7085 |
| N-ACETYL-L-ALANINE (M-H)- | 0.8901 | 1.0739 | 0.9563 | 0.8943 | 1.0566 | 1.0858 | 1.2565 | 0.9557 | 1.0496 | 0.8593 |
| NAPROXEN (M-H)- | 0.0630 | 3.8266 | NA | NA | 0.2625 | NA | 0.7414 | NA | 0.1066 | NA |
| NERVONIC ACID (M-H)- | 0.9990 | 1.0629 | 0.8388 | 0.7199 | 1.3231 | 1.1537 | 1.5150 | 0.7195 | 1.1457 | 0.7252 |
| N-ETHYLMALEIMIDE (M-H)- | NA | NA | 1.0049 | 1.6218 | 0.5867 | 0.4335 | NA | 0.9116 | 0.7543 | NA |
| OLEIC ACID (M-H)- | 1.0054 | 1.2119 | 1.0269 | 0.8196 | 0.9709 | 1.0291 | 1.0817 | 0.9067 | 1.3512 | 0.7501 |
| OXALOACETIC ACID (M-H)-[-H2O] | 0.8091 | 0.8974 | 0.8822 | 0.8996 | 0.9433 | 1.2794 | 1.2488 | 1.0910 | 0.9800 | 0.9461 |
| PALMITIC ACID (M-H)- | 1.1594 | 1.3141 | 1.0836 | 0.7168 | 0.9696 | 1.0272 | 1.0855 | 0.8497 | 1.2964 | 0.6989 |
| PALMITOLEIC ACID (M-H)- | 0.7696 | 1.1478 | 1.3472 | 1.0094 | 0.7652 | 0.7634 | 1.3857 | 1.4241 | 0.8379 | 0.4289 |
| PANTOTHENIC ACID (M-H)- | 0.9757 | 0.7963 | 1.1301 | 0.7561 | 0.9226 | 1.0110 | 0.6209 | 1.5184 | 1.2304 | 1.1469 |
| PHENYLALANINE (M-H)- | 0.7659 | 0.8944 | 1.0744 | 1.0106 | 1.1758 | 1.3003 | 0.8133 | 1.1258 | 0.8902 | 0.6263 |
| PHYTANIC ACID (M-H)- | 0.9896 | 2.1482 | 1.0107 | 0.9503 | 0.6295 | 1.0267 | 1.1602 | 0.7126 | 0.9788 | 0.6043 |
| RIBITOL (M+CL)- | 0.7336 | 0.6850 | 1.1800 | 1.2570 | 0.9205 | 0.9986 | 0.9193 | 1.5630 | 0.6948 | 0.6515 |
| RIBOFLAVIN (M+CL)- | 0.9540 | NA | 0.3856 | NA | 0.3586 | 0.5857 | 0.5906 | 4.2124 | NA | 0.5274 |
| S-ADENOSYL-L-HOMOCYSTEINE (M-H)- | 0.9566 | 1.2556 | 0.8852 | 0.7994 | 0.7249 | 1.5033 | 0.8659 | 1.0162 | 0.7901 | 1.4139 |
| SALICYLATE #2 (M-H)- | 0.0463 | 0.2223 | 0.4437 | 0.1430 | 0.6755 | 0.1623 | 1.9099 | 0.0795 | 7.1398 | 1.0096 |
| SALICYLURIC ACID (M-H)- | NA | 0.2947 | 0.3337 | 0.1433 | 0.5289 | NA | 1.0973 | NA | 6.2203 | 0.7370 |
| STEARIC ACID (M-H)- | 1.3246 | 1.8946 | 0.9074 | 0.6544 | 0.9553 | 0.9553 | 1.2915 | 0.7034 | 1.1379 | 0.6584 |
| SUCCINIC ACID (M-H)- | 0.8419 | 0.7289 | 1.2760 | 1.1997 | 0.8461 | 0.9906 | 0.9889 | 1.5122 | 0.4738 | 0.7480 |
| THEOPHYLLINE (M-H)- | 0.4197 | 0.7638 | 1.5024 | 2.4756 | 0.5225 | 0.5951 | 0.4510 | 1.4083 | 0.7181 | 0.1912 |
| THYROXINE (M-H)- | 1.1986 | 1.0132 | 1.2194 | 0.7614 | 0.9023 | 0.9523 | 0.7414 | 0.7158 | 1.4750 | 1.2250 |
| TRANS-ACONITIC ACID (M-H)- | 0.8647 | 0.8491 | 0.9367 | 1.1242 | 1.1647 | 0.8278 | 0.9262 | 1.1801 | 0.9236 | 1.0599 |
| TRYPTOPHAN (2M-H)- | 1.1247 | 0.6343 | 0.9705 | 1.0829 | 1.0911 | 1.5294 | 0.8400 | 0.8453 | 1.0946 | 0.4234 |
| TRYPTOPHAN (M-H)- | 1.1306 | 0.7280 | 0.9849 | 1.0615 | 1.0716 | 1.3723 | 0.9149 | 0.8936 | 1.0910 | 0.4830 |
| TYROSINE (M-H)- | 0.8593 | 1.0460 | 1.0863 | 1.0323 | 1.0904 | 1.2052 | 0.8081 | 1.0309 | 0.7923 | 0.7829 |
| URIC ACID (M-H)- | 0.8453 | 0.9951 | 1.0439 | 1.0160 | 1.1079 | 1.2986 | 1.0785 | 1.1914 | 0.4889 | 0.6712 |
| URIDINE (M+CL)- | 0.8352 | 0.9652 | 1.0372 | 1.1717 | 1.0498 | 1.2172 | 0.8438 | 1.2441 | 0.6581 | 0.6354 |
| XANTHINE (M-H)- | 0.6137 | 1.0781 | 0.9733 | 1.1531 | 1.0198 | 1.1157 | 1.1195 | 1.6467 | 0.3389 | 0.4167 |
| XANTHOSINE (M-H)- | NA | 0.0550 | 0.0591 | 0.0776 | 0.0486 | 0.0602 | 0.0452 | 0.0630 | 7.1026 | NA |
| ZEATIN [ISTD] (M+CL)- | 1.0315 | 1.0315 | 1.0423 | 1.0197 | 1.0392 | 0.9732 | 1.0420 | 1.0154 | 1.0728 | 0.6642 |
| ZEATIN [ISTD] (M-H)- | 1.0323 | 1.0723 | 1.0289 | 1.0253 | 1.0289 | 1.0065 | 1.1533 | 1.0072 | 0.9725 | 0.6008 |
Factors:
| F1 | Gender:female | Glycemic status:Diabetic | Neuropathy:Neuropathy |
| F2 | Gender:female | Glycemic status:Diabetic | Neuropathy:no neuropathy |
| F3 | Gender:female | Glycemic status:Pre-diabetic | Neuropathy:Neuropathy |
| F4 | Gender:female | Glycemic status:Pre-diabetic | Neuropathy:no neuropathy |
| F5 | Gender:male | Glycemic status:Diabetic | Neuropathy:Neuropathy |
| F6 | Gender:male | Glycemic status:Diabetic | Neuropathy:no neuropathy |
| F7 | Gender:male | Glycemic status:Normoglycemic | Neuropathy:Neuropathy |
| F8 | Gender:male | Glycemic status:Normoglycemic | Neuropathy:no neuropathy |
| F9 | Gender:male | Glycemic status:Pre-diabetic | Neuropathy:Neuropathy |
| F10 | Gender:male | Glycemic status:Pre-diabetic | Neuropathy:no neuropathy |
