Data for (Study ST001373)

(Analysis AN002293)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2
10-HYDROXYDECANOATE 1.0607 0.9514
13C2-GLYCINE 1.1601 0.8719
13C2-PHOSPHOENOL PYRUVATE 1.4433 0.6454
13C3-SERINE 1.1653 0.8678
13C4-ALPHA-KETOGLUTARIC ACID 1.1608 0.8713
13C5-D-GLUCOSE 1.1013 0.9189
13C6-D-FRUCTOSE-1,6-BISPHOSPHATE 1.6325 0.6837
13C6-D-FRUCTOSE-6-PHOSPHATE 1.1872 0.8503
13C6-GLUCOSE-6-PHOSPHATE 1.1377 0.8899
2^-DEOXYGUANOSINE 5^-MONOPHOSPHATE 1.4851 0.6119
2-HYDROXYBUTYRIC ACID 0.9346 1.0523
3-(4-HYDROXYPHENYL)LACTATE 0.6901 1.2480
3-(4-HYDROXYPHENYL)PYRUVATE 0.8351 1.1319
3-HYDROXY-3-METHYLGLUTARATE 0.7016 1.2387
3-HYDROXYBUTANOIC ACID 0.9347 1.0523
3-METHYLADENINE 1.1401 0.8880
3-SULFINO-L-ALANINE 1.0705 0.9436
4-ACETAMIDOBUTANOATE 0.6387 1.2890
4-AMINOBUTANOATE 1.6441 0.4847
4-HYDROXY-2-QUINOLINECARBOXYLIC ACID 0.9519 1.0385
4-PYRIDOXATE 0.5255 1.3796
5^-CMP 1.2349 0.8121
5^-METHYLTHIOADENOSINE 1.3098 0.7521
5-OXO-PROLINE 0.8365 1.1308
ADENOSINE 5^-DIPHOSPHATE 1.5147 0.5882
ADENOSINE 5^-DIPHOSPHORIBOSE 1.0486 0.9611
ADENOSINE 5^-MONOPHOSPHATE 1.8607 0.3114
ADIPIC ACID 1.0760 0.8860
ALLANTOIN 0.7910 1.1672
ALPHA-D-GALACTOSE 1-PHOSPHATE;D-MANNOSE 6-PHOSPHATE;D-FRUCTOSE 6-PHOSPHATE;ALPHA-D-GLUCOSE 1-PHOSPHATE 1.2563 0.7950
ALPHA-D-GLUCOSE 0.4278 1.4578
ALPHA-KETOGLUTARIC ACID 1.3198 0.7442
ARABINOSE;D-XYLOSE;D-(-)-ARABINOSE 0.6968 1.2426
ARACHIDIC ACID 1.1225 0.9020
ASPARAGINE 0.7614 1.1909
ASPARTATE 1.5780 0.5376
AZELAIC ACID 1.2004 0.8397
BETAINE;L-NORVALINE 1.8366 0.3307
BETA-NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE 1.3186 0.7451
CAFFEATE 0.9738 1.0209
CAPRYLIC ACID 1.2151 0.8279
CARNOSINE 0.8771 1.0983
CITRACONIC ACID 1.2802 0.7758
CITRATE;ISOCITRIC ACID 0.6025 1.3180
CITRULLINE 0.7833 1.1734
CREATINE 0.9137 1.0690
CREATININE 0.9505 1.0396
CYSTATHIONINE 1.4530 0.0940
CYSTINE 0.3070 1.1386
CYTIDINE 1.0810 0.9352
CYTIDINE 5^-DIPHOSPHATE 1.4167 0.6666
D2-FUMARIC ACID 1.2021 0.8383
D3-LACTATE 1.2686 0.7851
D3-MALIC ACID 1.1039 0.9169
D4-CITRIC ACID 1.1098 0.9122
D4-SUCCINIC ACID 1.2621 0.7903
DECANOATE 1.2161 0.8271
DEOXYCYTIDINE 0.9502 1.0399
DEOXYURIDINE 0.5181 1.3855
D-FRUCTOSE;D-TAGATOSE 0.5065 1.3948
D-GLUCOSE-6-PHOSPHATE 1.6100 0.5120
DIHYDROOROTATE 1.5974 0.5221
D-PANTOTHENIC ACID 1.3135 0.7492
D-RIBOSE 5-PHOSPHATE 1.0529 0.9577
D-(+)-TREHALOSE;D-LACTOSE;MELIBIOSE;MALTOSE;D-(+)-CELLOBIOSE 2.2318 0.0146
ERYTHRITOL 0.7576 1.1939
FOLIC ACID 0.2938 1.4237
FRUCTOSE 1,6-BIPHOSPHATE 1.4259 0.8580
GALACTITOL;MANNITOL;D-SORBITOL 0.9235 1.0612
GALACTURONIC ACID 0.2285 1.6172
GLUCONIC ACID 0.6352 1.2918
GLUTAMIC ACID 1.6654 0.4676
GLUTAMINE 1.9063 0.2750
GLUTARIC ACID 0.9123 1.1169
GLYCERATE 0.7595 1.1924
GLYCEROL 2-PHOSPHATE 1.2205 0.8236
GLYCINE 0.9896 1.0083
GUANOSINE 5^-MONOPHOSPHATE 1.3601 0.7119
HEPTADECANOATE 1.1104 0.9117
HEPTANOIC ACID 1.1336 0.8931
HIPPURATE 0.5296 1.3763
HOMOGENTISATE 0.2284 1.6173
HOMOVANILLATE 0.9775 1.0180
HYDROXYPROLINE 0.8736 1.1011
HYPOTAURINE 1.1413 0.8870
INOSINE 1.2961 0.7631
INOSINE 5^-PHOSPHATE 1.0881 0.9295
ISOLEUCINE;LEUCINE;NORLEUCINE 0.9877 1.0099
ITACONATE 1.5303 0.5757
LACTATE 0.6972 1.2422
LAURIC ACID 0.8816 1.0947
LINOLEATE 1.1981 0.8415
MALATE 1.6213 0.5030
MALEIC ACID;FUMARATE 1.6446 0.4843
MALONATE 0.7885 1.1692
MANDELIC ACID;2-HYDROXYPHENYLACETIC ACID;2^,4^-DIHYDROXYACETOPHENONE;3-HYDROXYPHENYLACETATE;RESORCINOL MONOACETATE 0.8903 1.0878
MESO-TARTARIC ACID 0.4092 1.4727
METHIONINE 1.1062 0.9150
METHYL-2-OXOVALERIC ACID 0.6335 1.2932
METHYL ACETOACETATE 1.0501 0.9599
METHYL JASMONATE 1.4471 0.6423
MEVALONIC ACID 1.4094 0.5906
MYO-INOSITOL 0.7491 1.2007
MYRISTIC ACID 1.0588 0.9530
N-ACETYL-DL-GLUTAMIC ACID 1.3496 0.7203
N-ACETYL-DL-METHIONINE 1.1951 0.8439
N-ACETYLGLYCINE 1.2555 0.7956
N-ACETYL-L-ALANINE 1.1285 0.8972
N-ACETYL-L-ASPARTIC ACID 1.2315 0.8148
N-ACETYLNEURAMINATE 0.8508 1.1193
NAD 0.9817 1.0146
N-ALPHA-ACETYL-L-ASPARAGINE 1.0599 0.9521
NONANOATE 1.2744 0.7805
O-ACETYL-L-SERINE;N-ACETYL-DL-SERINE 1.2688 0.7850
OMEGA-HYDROXYDODECANOIC ACID 1.1557 0.8754
O-PHOSPHORYLETHANOLAMINE 1.9287 0.2570
OPHTHALMIC ACID 1.6179 0.5057
OROTATE 1.5130 0.5896
OXALIC ACID 0.3043 1.5565
PALMITATE 1.1531 0.8775
PALMITOLEIC ACID 1.0485 0.9612
PENTANOATE 1.1046 0.9164
PETROSELINIC ACID;ELAIDIC ACID;OLEATE 1.1041 0.9167
PHENYLACETIC ACID 0.8868 1.0905
PHENYLALANINE 1.0688 0.9449
PHOSPHOCHOLINE 1.5424 0.5661
PHOSPHOCREATINE 0.9168 1.0666
PHOSPHO(ENOL)PYRUVIC ACID 1.0217 0.9826
PHOSPHOGLYCERIC ACID 1.1138 0.9090
PIMELIC ACID 1.0615 0.9508
PROLINE 1.1562 0.8750
PROPIONATE 1.2055 0.8356
PTERIN 1.1074 0.9141
PURINE 1.0652 0.9479
PYRIDINE DICARBOXYLATE 1.0389 0.9708
PYRIDOXAL 5^-PHOSPHATE 0.9210 1.0632
QUINATE 0.9446 1.0443
RAC-GLYCEROL 1-MYRISTATE 1.2419 0.8065
S-(5^-ADENOSYL)-L-HOMOCYSTEINE 1.2044 0.8364
SERINE 1.4664 0.6269
SHIKIMATE 1.1382 0.8894
SN-GLYCEROL 3-PHOSPHATE 1.1031 0.9175
SODIUM BENZOATE 1.2043 0.8366
STEARATE 1.1564 0.8749
SUCCINIC ACID 1.1961 0.8431
TARTARIC ACID 0.5290 1.3768
TAURINE 1.2040 0.8368
THREONINE;HOMOSERINE;L-ALLOTHREONINE 1.0273 0.9782
TRYPTOPHAN 1.0254 0.9797
TYROSINE 0.9506 1.0395
URATE 0.4028 1.4778
URIDINE 5^-DIPHOSPHATE 1.3975 0.6820
URIDINE 5^-DIPHOSPHOGLUCOSE;URIDINE 5^-DIPHOSPHOGALACTOSE 1.0397 0.9683
URIDINE 5^-DIPHOSPHO-N-ACETYLGALACTOSAMINE;URIDINE 5^-DIPHOSPHO-N-ACETYLGLUCOSAMINE 0.9644 1.0285
URIDINE-5-MONOPHOSPHATE 1.4467 0.6427
UROCANATE 0.9911 1.0071
VALINE 1.0600 0.9520
XANTHINE 1.0161 0.9871
XANTHOSINE 1.2496 0.8003
XYLITOL;RIBITOL;L-ARABITOL 2.1959 0.0433
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Factors:

F1Genotype:Sirt2 Knockout
F2Genotype:Wild-type
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