Data for (Study ST001855)

(Analysis AN003006)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
1,1-Dimethylbiguanide 1.1555 0.8992 0.9454
12-KETE 2.3571 0.6158 0.0271
12-Keto-leukotriene B4 0.1534 1.6362 1.2104
13-L-Hydroperoxylinoleic acid 0.9937 1.0294 0.9769
17a-Estradiol 1.2093 1.3720 0.4187
1-Aminocyclopropanecarboxylic acid 1.0966 0.8230 1.0805
1-Methylhistidine 1.5265 0.6640 0.8095
1-Methylnicotinamide 0.1008 0.9712 1.9280
1-Pyrroline-2-carboxylic acid 1.2070 0.9194 0.8736
1-Pyrroline-4-hydroxy-2-carboxylate 1.1190 0.8380 1.0429
2-Amino-4-oxopentanoic acid 1.9159 0.6366 0.4475
2-Hydroxy-3-oxoadipate 0.5648 1.5980 0.8372
2-Hydroxybutyric acid 0.8791 1.0307 1.0902
2-Ketobutyric acid 1.4146 0.7494 0.8360
3-Carbamoyl-2-phenylpropionaldehyde 1.5959 0.7116 0.6925
3-Indoleacetonitrile 0.6248 0.9463 1.4289
3-Methylindole 0.9838 0.9457 1.0705
4,5-Dihydroorotic acid 0.9796 0.9412 1.0792
4-Acetamidobutanoic acid 1.4717 0.7359 0.7924
4-Guanidinobutanal 0.6423 1.4531 0.9046
4-Hydroxycinnamoylagmatine 0.2403 1.3232 1.4365
4-Oxoglutaramate 1.1604 1.0440 0.7956
4-Pyridoxic acid 0.7818 0.8412 1.3770
5,6-Dihydro-5-fluorouracil 0.8889 1.0255 1.0856
5-Amino-2-oxopentanoic acid 0.9940 0.9988 1.0071
5-Aminolevulinic acid 1.4258 0.7226 0.8516
5-Hydroxylysine 2.1062 0.3231 0.5707
5-phosphonooxy-L-lysine 1.7559 0.2978 0.9463
6-Amino-6-deoxyfutalosine 1.2034 1.0217 0.7749
7,8-Diaminononanoate 0.9264 1.0470 1.0266
9-OxoODE 0.6941 1.3000 1.0059
9(S)-HPODE 1.0215 1.0188 0.9597
Adenine 1.6483 0.7943 0.5573
Adenosine 1.2785 1.1500 0.5715
ADP 1.0214 0.8958 1.0828
Agmatine 2.3701 0.3874 0.2425
Aminoadipic acid 0.8923 0.9661 1.1416
AMP 1.6920 0.5747 0.7332
Argininosuccinic acid 1.0368 0.8556 1.1076
Ascorbate 0.5550 1.1346 1.3104
beta-Alanine 0.7402 1.5887 0.6710
beta-Alanyl-L-arginine 0.6566 0.9227 1.4207
Betaine 1.9833 0.7377 0.2790
(-)-Bornesitol 0.2604 0.7508 1.9888
Carnosine 1.4045 0.8177 0.7778
Choline 0.8435 0.7310 1.4255
Cinnamaldehyde 1.4609 0.9070 0.6322
cis-3-Hydroxy-L-proline 1.6863 0.9527 0.3610
cis-4-Hydroxy-D-proline 1.1396 0.8988 0.9616
CMP 1.6325 0.6968 0.6707
Creatine 0.4937 1.3506 1.1557
Creatinine 0.5975 1.0806 1.3219
Cytosine 1.0738 0.9219 1.0043
Deoxyadenosine 0.5598 1.0703 1.3699
Deoxyuridine 1.8986 0.5160 0.5854
D-Fructose 2.2123 0.3819 0.4057
D-Glucose 1-phosphate 0.6645 1.1140 1.2215
D-Glucuronic Acid 0.9912 1.1150 0.8938
Diacetyl 1.0860 0.5892 1.3248
Dihydrouracil 1.0310 1.0389 0.9301
Docosahexaenoic acid 0.6168 1.4304 0.9527
Dodecanoic acid 0.7594 0.9523 1.2882
D-Xylose 0.7289 0.6559 1.6152
Ectoine 0.6768 1.4828 0.8405
Ergothioneine 1.7427 0.8374 0.4200
Erucic acid 1.5583 0.5899 0.8517
Erythritol 0.9466 1.1416 0.9117
Ethylmethylacetic acid 0.7512 1.0143 1.2346
Formylanthranilic acid 0.9409 1.2662 0.7929
gamma-Aminobutyric acid 0.9284 0.9086 1.1629
gamma-Glutamylalanine 0.6688 1.3836 0.9477
gamma-L-Glutamyl-L-2-aminobutyrate 0.8775 0.8138 1.3087
Gamma-Linolenic acid 1.0118 0.8525 1.1357
Gentamicin C1a 0.4407 1.2744 1.2849
Glycerophosphocholine 0.9022 0.5150 1.5829
GMP 1.4319 0.8883 0.6799
Hydrogen phosphate 0.9169 0.9435 1.1396
Hydroquinone 1.4297 0.4276 1.1427
Hydroxypyruvic acid 1.6410 0.9303 0.4287
Hypotaurine 0.7956 0.6618 1.5426
Hypoxanthine 2.3736 0.4309 0.1955
IMP 1.3718 1.0569 0.5713
Indole 1.0661 0.9715 0.9624
Indoleacetaldehyde 0.9473 0.9510 1.1018
Indoleglycerol phosphate 0.2563 1.1135 1.6301
Inosine 1.8843 0.5900 0.5257
Isocitric acid 0.6179 1.0693 1.3128
Isonicotinic acid 1.0453 1.0346 0.9201
Isovaleric acid 0.8126 1.0980 1.0894
Ketoleucine 0.9961 0.9511 1.0528
L-2,4-diaminobutyric acid 0.9386 0.9941 1.0673
L-Alanine 0.9537 0.9299 1.1165
L-alpha-Aminobutyric acid 0.5628 0.8768 1.5603
L-Arabinose 2.2237 0.2564 0.5199
L-Arginine 1.0845 0.9962 0.9193
L-Asparagine 0.7310 1.1398 1.1292
L-Aspartic acid 0.9976 0.9523 1.0501
L-Carnitine 0.7201 0.8803 1.3996
L-Cysteine 1.3655 0.7869 0.8476
L-Cystine 2.1784 0.3559 0.4657
L-Fucose 1.2130 1.1044 0.6826
L-Glutamic acid 1.1000 0.8200 1.0800
L-Glutamic gamma-semialdehyde 0.8919 0.9695 1.1385
L-Glutamine 0.8844 1.0621 1.0535
L-Histidine 0.9814 0.7291 1.2895
L-Homophenylalanine 0.7056 1.0985 1.1959
L-Isoleucine 1.0027 0.8974 1.0999
Lithocholic acid 1.6210 0.6385 0.7406
L-Kynurenine 0.8120 1.0827 1.1054
L-Leucine 0.9591 0.9571 1.0838
L-Lysine 1.2363 0.8725 0.8912
L-Methionine 0.8691 1.0142 1.1168
L-Methionine S-oxide 1.3443 0.5987 1.0570
L-Phenylalanine 0.0018 1.8652 1.1330
L-Pipecolic acid 0.1993 1.0532 1.7475
L-Proline 0.8387 1.9456 0.2156
Lumichrome 1.5361 0.6053 0.8585
L-Valine 1.1554 0.8981 0.9465
Maleic acid 0.4570 1.3541 1.1888
Mannitol 0.8564 1.4936 0.6500
Methyl jasmonate 1.4716 0.8001 0.7283
N6-Acetyl-L-lysine 1.5818 0.8412 0.5770
N-Acetylglutamic acid 0.6545 1.1320 1.2136
N-Acetyl-L-phenylalanine 1.4840 0.6878 0.8282
N-Acetylornithine 0.9842 1.2108 0.8050
N-Carbamoylputrescine 0.1767 0.9089 1.9144
Niacinamide 1.2360 0.8611 0.9029
Nicotinuric acid 0.7471 1.0914 1.1615
Norepinephrine 0.6104 1.0014 1.3882
Oleic acid 0.6020 1.2701 1.1279
Ornithine 1.3476 0.8255 0.8270
Oxoglutaric acid 1.2561 1.0615 0.6824
Palmitic acid 1.0365 0.9368 1.0268
PC(18:3(6Z,9Z,12Z)/18:3(6Z,9Z,12Z)) 2.7817 0.0173 0.2010
Phenol 1.4232 0.9755 0.6013
Phenylacetylglycine 0.7262 0.8071 1.4667
Phosphohydroxypyruvic acid 0.5631 0.6504 1.7865
Phthalic acid 0.3302 0.5877 2.0821
Pimelic acid 0.0457 2.9306 0.0238
Piperidine 0.9659 0.9487 1.0855
Porphobilinogen 0.9175 1.0656 1.0169
Prostaglandin F2a 0.4518 1.3862 1.1619
Prostaglandin G2 0.5324 1.1646 1.3030
Prostaglandin I2 0.1890 1.5836 1.2274
Putrescine 0.3417 1.7334 0.9248
Pyroglutamic acid 1.3061 0.9254 0.7685
Pyrrole-2-carboxylic acid 2.6672 0.1275 0.2054
Pyrrolidonecarboxylic acid 2.1286 0.4500 0.4213
Pyrroline hydroxycarboxylic acid 2.8036 0.1583 0.0381
Quinolinic acid 1.4437 0.7358 0.8205
(R)-5,6-Dihydrothymine 1.2004 1.0595 0.7401
(S)-1-Pyrroline-5-carboxylate 1.0524 1.0262 0.9214
Saccharopine 0.6781 1.3941 0.9278
Salicylic acid 1.0318 0.9963 0.9718
Se-Methylselenocysteine 1.3096 0.9634 0.7270
Sorbitol 0.9024 0.8079 1.2897
Spermidine 0.9004 1.0550 1.0446
Sphingosine 1.2880 0.8107 0.9013
Stearic acid 1.1174 0.8928 0.9898
Stearidonic acid 1.0628 0.9906 0.9466
Taurine 0.7840 1.0729 1.1431
Thiamine 1.3044 0.7026 0.9930
Thymine 1.0344 1.0266 0.9390
Tryptophanol 1.2769 0.8155 0.9076
Tyramine 1.0476 1.0586 0.8938
Tyrosol 1.4973 0.8071 0.6957
UDP-N-acetyl-D-mannosamine 1.7320 1.2476 0.0203
UMP 1.9877 0.8857 0.1265
Uracil 0.7935 1.1138 1.0927
Uridine 1.4033 0.7814 0.8153
Vanillylmandelic acid 0.9462 1.0688 0.9850
Xanthine 0.6436 1.2283 1.1280
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Factors:

F1surgery:sham | FG-4592(10 mg/kg):-
F2surgery:UIR | FG-4592(10 mg/kg):-
F3surgery:UIR | FG-4592(10 mg/kg):10
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