Data for (Study ST002218)

(Analysis AN003627)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
2/3-phosphoglycerate 1.0495 1.1787 1.0216 0.7501
2-hydroxyglutarate 0.9318 0.8687 1.3630 0.8365
2-oxoglutarate 0.6680 0.7425 1.4890 1.1004
3-phosphoserine 0.2952 0.4377 1.6443 1.6228
4-hydroxyphenyllactate 1.0851 0.9627 1.1460 0.8062
4-hydroxyphenylpyruvate 1.5046 1.1486 0.7110 0.6358
4-hydroxyproline 0.8966 1.0588 1.0664 0.9782
6-phosphogluconate 0.7728 1.0452 1.3367 0.8453
acetyl-CoA 0.7714 1.1784 1.1940 0.8562
aconitate 0.5361 0.6768 1.5073 1.2799
adenosine 1.1859 1.2363 0.8035 0.7744
adenylosuccinate 1.0890 2.8872 0.0107 0.0130
ADP 0.9834 1.0037 1.0701 0.9428
ADP-ribose 1.2763 1.4887 0.6677 0.5673
alanine 0.8655 0.9960 1.1382 1.0003
AMP 1.0844 1.3506 0.7177 0.8473
arginine 1.0872 1.2376 0.9579 0.7172
argininosuccinate 1.9671 1.9785 0.0297 0.0246
asparagine 1.0735 1.3710 0.7927 0.7628
aspartate 0.2643 0.3772 1.8141 1.5445
ATP 0.8883 1.0338 1.1915 0.8863
beta-alanine 0.8753 1.5103 1.0210 0.5934
betaine 0.6367 1.1230 1.4756 0.7648
carnitine 0.6867 1.4204 1.2460 0.6469
carnitine C14 0.3727 2.3377 0.9460 0.3435
carnitine C14:1 0.8169 1.4815 1.0829 0.6187
carnitine C16 0.6156 2.2194 0.8343 0.3308
carnitine C16:1 0.2808 2.5308 0.8449 0.3435
carnitine C2 1.0445 1.8597 0.6575 0.4382
carnitine C3 0.1734 0.2657 2.5743 0.9865
carnitine C4 0.4328 0.8978 1.6702 0.9991
carnitine C5 0.4820 0.6935 2.0655 0.7590
carnitine C6 0.9069 1.7555 0.7462 0.5913
carnosine 0.9666 1.2875 1.0480 0.6979
CDP 0.7163 0.9443 1.3502 0.9891
choline 1.1892 2.2767 0.3499 0.1842
citicoline 1.3496 1.4543 0.8195 0.3765
citrate 0.7059 0.8797 1.2172 1.1972
citrulline 1.1434 1.1708 0.7856 0.9002
CMP 0.6689 1.1681 1.2243 0.9387
CMP-acetylneuraminate 1.1273 1.3066 1.0419 0.5243
Coenzyme A 1.4450 1.2560 0.8538 0.4451
creatine 0.9218 1.1452 1.0794 0.8536
creatinine 0.9370 1.2844 1.0642 0.7144
CTP 0.6624 0.9936 1.4463 0.8977
cyclic ADP-ribose 1.0264 1.2420 1.0261 0.7055
cyclic AMP 0.8766 1.2837 1.1591 0.6806
cystathionine 0.3588 0.3359 0.9416 2.3637
cysteate 0.8759 2.6300 0.2859 0.2082
cysteinylglycine 1.3500 1.4411 0.4990 0.7098
cytidine 0.7110 1.1913 1.3353 0.7625
cytosine 0.7692 1.1158 1.2832 0.8318
dCTP 0.4282 0.6340 1.8037 1.1341
deoxycarnitine 1.0106 1.6687 0.8100 0.5106
dihydroorotate 1.2645 1.4662 0.7866 0.4827
dihydroxyacetone phosphate 1.0803 1.3182 0.8860 0.7155
dTMP 0.8104 0.7844 1.2433 1.1619
dTTP 0.5784 0.7529 1.5978 1.0708
flavin adenine dinucleotide 1.0896 1.4604 0.8223 0.6277
fructose 6-phosphate 1.0956 1.3693 0.9968 0.5383
fructose bisphosphate 1.1694 1.4322 0.8774 0.5211
fumarate 1.5596 2.1664 0.1563 0.1177
gamma-glutamylcysteine 1.3431 2.4786 0.0804 0.0980
gamma-glutamylglutamate 0.8047 1.1160 1.0363 1.0430
gamma-glutamylproline 0.9611 1.2593 0.8211 0.9585
GDP 1.0950 1.3426 0.8929 0.6695
GDP-fucose 1.1723 1.5530 0.7669 0.5078
GDP-glucose 1.0839 1.3019 1.0182 0.5960
gluconate 0.9186 0.8913 1.2632 0.9269
glucose 0.9218 1.1430 1.1731 0.7621
glucose 6-phosphate 1.0205 1.5348 0.8911 0.5536
glucuronate 1.2258 1.5142 0.6823 0.5777
glutamate 0.5661 0.6119 1.7028 1.1192
glutamine 1.0246 1.1817 0.9060 0.8877
glutathione reduced 1.2816 1.4267 0.5625 0.7293
glyceraldehyde 3-phosphate 1.4103 1.6013 0.7188 0.2696
glycerol 3-phosphate 0.9579 1.5790 0.7192 0.7438
glycerylphosphorylcholine 1.0231 1.2255 1.2487 0.5027
Glycerylphosphorylethanolamine 1.0191 1.6155 0.9896 0.3757
glycine 1.0505 1.4143 0.9174 0.6177
glycylglycine 0.8562 1.3421 1.1592 0.6426
GMP 1.1492 1.3993 0.7817 0.6698
GTP 1.0639 1.4363 0.8894 0.6105
guanidinoacetate 0.9054 1.3498 1.1180 0.6267
guanosine 0.8459 1.7745 0.8999 0.4797
histidine 1.0568 1.0885 0.8595 0.9951
homoarginine 1.0993 1.3210 0.9116 0.6681
homocitrulline 0.9755 1.1930 1.1121 0.7194
homocysteine 1.0562 1.1454 1.0012 0.7971
hypotaurine 0.9273 1.4448 1.0037 0.6242
IMP 1.2286 1.6444 0.5725 0.5546
inosine 1.1081 1.4409 0.7824 0.6687
inositol 0.7869 1.6101 0.8284 0.7746
isoleucine 1.0532 1.2017 1.0384 0.7066
ketoleucine 0.8705 1.1086 1.3584 0.6626
ketovaline 0.8347 1.0380 1.3297 0.7976
kynurenine 0.9920 1.2049 1.0904 0.7128
lactate 1.3058 1.6167 0.7215 0.3560
leucine 1.0996 1.2567 0.9669 0.6768
lysine 1.0946 1.4131 0.9254 0.5670
malate 0.2490 0.4416 1.8697 1.4397
methionine 1.0703 1.1419 0.9129 0.8748
methylthioadenosine 0.9176 0.8991 1.0669 1.1164
N6,N6,N6-trimethyllysine 1.2831 1.6170 0.5966 0.5033
N-acetylarginine 1.2475 1.3845 0.6537 0.7144
N-acetylaspartate 0.2414 0.2731 3.1479 0.3375
N-acetylaspartylglutamate 0.4631 0.5841 1.6250 1.3277
N-acetylglutamate 0.3402 0.3838 1.9776 1.2984
N-acetylhexosamine phosphate 0.8059 1.5373 0.9361 0.7207
N-acetylhistidine 0.9547 1.3295 1.0941 0.6217
N-acetylneuranimic acid 1.2231 1.2261 0.8968 0.6541
N-acetylserine 0.5594 0.9176 1.3756 1.1474
NAD 1.0044 1.1943 1.0660 0.7353
NADH 1.3711 2.0168 0.4587 0.1534
NADP 1.4163 1.5079 0.6505 0.4253
NADPH 0.8467 1.1312 1.1218 0.9004
N-carbamoylaspartate 0.8819 0.9233 1.2131 0.9817
N,N-dimethylarginine 1.2023 1.3089 0.8350 0.6538
ophthalmate 0.0686 0.0504 2.7553 1.1257
ornithine 0.8961 1.2067 0.9986 0.8985
orotate 0.8985 1.8495 0.6507 0.6013
orotidine 0.4605 0.6661 1.8170 1.0564
oxidized glutathione 1.2699 1.4307 0.6935 0.6059
pantothenate 1.1842 1.6336 0.6692 0.5130
pentose phosphate 0.9373 1.2942 1.0420 0.7265
phenylalanine 1.0766 1.1989 1.0296 0.6950
phosphocholine 0.7977 0.9800 1.2344 0.9879
phosphocreatine 0.1641 0.3727 2.1852 1.2780
phosphoenolpyruvate 1.3435 2.0094 0.3420 0.3051
proline 0.5601 0.5965 1.5296 1.3137
pyridoxine 0.9370 1.2215 1.1501 0.6914
pyroglutamate 0.9922 1.3148 1.0224 0.6706
pyruvate 0.7330 1.1640 1.3344 0.7687
S-(2-succinyl)cysteine 1.9095 2.0837 0.0033 0.0035
S-adenosylhomocysteine 0.8292 1.5271 1.0169 0.6268
S-adenosylmethionine 1.0739 1.0677 0.9257 0.9327
SAICAR 0.7248 3.2269 0.0290 0.0194
sarcosine 1.1744 1.6693 0.8933 0.2630
sedoheptulose 7-phosphate 0.9928 0.8759 1.4335 0.6978
serine 1.0332 1.3831 0.9142 0.6695
S-Succinylglutathione 1.8675 2.0864 0.0196 0.0265
succinate 1.6196 1.9209 0.3123 0.1472
succinyladenosine 1.8144 2.1561 0.0127 0.0168
taurine 0.9047 1.2709 1.0733 0.7511
threonine 1.0490 1.2963 0.9282 0.7265
tryptophan 1.0935 1.2964 0.9985 0.6116
tyrosine 1.0793 1.2231 1.0094 0.6882
UDP 0.7818 1.0173 1.2416 0.9593
UDP-GlcNac 0.9995 1.4399 0.8865 0.6741
UDP-glucose 0.8520 1.1863 1.1335 0.8282
UMP 0.8201 1.8408 0.7017 0.6375
uric acid 0.9617 1.6265 0.8780 0.5338
uridine 0.8706 1.4477 1.0352 0.6465
UTP 0.6869 1.1250 1.3602 0.8279
valine 1.0741 1.2299 1.0202 0.6759
xanthine 0.9930 1.2783 1.0688 0.6599
xanthosine 1.0524 1.3266 0.9850 0.6360
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Factors:

F1Genotype:Fh1-/- CL1 | Treatment:Cas9
F2Genotype:Fh1-/- CL1 | Treatment:sg1Hira
F3Genotype:Fh1 fl/fl | Treatment:Cas9
F4Genotype:Fh1 fl/fl | Treatment:sg1Hira
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