Data for (Study ST002231)
(Analysis AN003640)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 1-Aminocyclopropanecarboxylate | 0.9199 | 0.9655 | 1.0426 | 1.0827 | NA | 0.9141 |
| 1-Methyladenosine | 0.9200 | 1.0622 | 1.1362 | 0.8952 | NA | 0.8918 |
| 1-Methylhistidine | 0.8522 | 0.9482 | 1.0296 | 1.2026 | NA | 0.7395 |
| 1-Phenylethanol | 0.9249 | 0.9094 | 1.2742 | 0.8799 | NA | 1.2474 |
| 2-(3-Carboxy-3-aminopropyl)-histidine | 0.5974 | 1.1628 | 0.7699 | 1.5100 | NA | 0.2197 |
| 2-Quinolinecarboxylate | 0.9681 | 0.6111 | 1.5689 | 0.8930 | NA | 0.6712 |
| 3-Hydroxycarnitine (4:0) | 1.3486 | 1.0105 | 0.7494 | 0.9155 | NA | 0.8074 |
| 3-Hydroxycarnitine (5:0) | 0.6905 | 1.6538 | 0.5643 | 1.1047 | NA | 0.8936 |
| 3-Hydroxycarnitine (6:0) | 0.6613 | 0.8642 | 0.6812 | 1.8142 | NA | 0.8331 |
| 3-Hydroxycarnitine (8:0) | 0.5949 | 0.8780 | 0.7460 | 1.8031 | NA | 0.8246 |
| 3-Methyladenine | 0.8916 | 1.1014 | 1.1076 | 0.8599 | NA | 1.3158 |
| 4-Acetamidobutanoate | 0.9357 | 0.9919 | 1.0524 | 1.0121 | NA | 1.0636 |
| 4-Guanidinobutanoate | 0.9157 | 1.0548 | 0.9215 | 1.1150 | NA | 0.9442 |
| 4-Imidazoleacetate | 0.7776 | 1.1531 | 0.7813 | 1.2943 | NA | 0.9497 |
| 5-Hydroxylysine | 1.1531 | 1.1184 | 0.8433 | 0.8929 | NA | 0.9377 |
| 5-Hydroxytryptophan | 0.9757 | 0.9036 | 1.1908 | 0.9140 | NA | 1.1270 |
| 5-Methylcytosine | 1.0443 | 0.9288 | 1.1805 | 0.8886 | NA | 0.6619 |
| 6-Phosphonogluconolactone | 0.5315 | 0.9373 | 0.9454 | 1.6037 | NA | 0.8564 |
| Acetylaminoadipate | 0.5622 | 0.8140 | 1.4333 | 1.2092 | NA | 0.8506 |
| Acetylcarnitine | 1.1819 | 0.8470 | 1.0872 | 0.8947 | NA | 0.9135 |
| Adenine | 0.7999 | 0.8618 | 1.1082 | 1.1449 | NA | 1.6825 |
| Adenosine | 1.0235 | 0.7788 | 1.1554 | 1.0824 | NA | 0.6786 |
| Adenosine monophosphate | 0.7986 | 0.6547 | 1.1967 | 1.3811 | NA | 0.7510 |
| ADP-ribose | 0.8160 | 0.7120 | 1.0267 | 1.4312 | NA | 1.1129 |
| Agmatine sulfate | 0.9903 | 0.9685 | 0.9548 | 1.0860 | NA | 1.0033 |
| Alanine | 0.9826 | 0.8991 | 1.0846 | 1.0456 | NA | 0.9043 |
| Ala-Tyr | 0.5836 | 0.6852 | 1.2497 | 1.4735 | NA | 1.0637 |
| Aminoadipate | 0.7235 | 1.5973 | 0.8177 | 0.8767 | NA | 0.8789 |
| Aminocaprylate | 0.9466 | 1.3251 | 0.9207 | 0.8272 | NA | 0.8429 |
| Aminoisobutanoate | 0.9848 | 0.9149 | 1.0335 | 1.0784 | NA | 0.9068 |
| Anserine | 0.9960 | 0.8816 | 1.3449 | 0.7856 | NA | 0.9347 |
| Arg-Ala | 0.7963 | 0.3743 | 1.5240 | 1.3438 | NA | 0.6923 |
| Arginine | 1.0003 | 0.9825 | 0.9532 | 1.0719 | NA | 0.9358 |
| Argininosuccinate | 1.2183 | 1.0916 | 0.8612 | 0.8472 | NA | 0.8537 |
| Asparagine | 0.9527 | 0.6567 | 1.3509 | 1.0568 | NA | 0.8631 |
| Aspartylglycosamine | 1.0306 | 0.7204 | 1.1636 | 1.1066 | NA | 0.8307 |
| Asp-Pro | 0.7923 | 1.0239 | 0.9197 | 1.2728 | NA | 0.9299 |
| Betaine | 0.7744 | 1.0729 | 0.9542 | 1.2200 | NA | 0.8278 |
| Carnitine | 0.5724 | 1.2827 | 0.7147 | 1.4388 | NA | 0.9309 |
| Carnitine (12:0) | 1.2595 | 0.3556 | 1.6366 | 0.6420 | NA | 1.1264 |
| Carnitine (14:0) | 1.2106 | 0.5017 | 1.4564 | 0.8136 | NA | 1.1418 |
| Carnitine (16:0) | 0.7245 | 0.6617 | 1.4378 | 1.1903 | NA | 0.8851 |
| Carnitine (16:1) | 0.8971 | 0.9269 | 1.3198 | 0.8461 | NA | 1.0815 |
| Carnitine (18:1) | 0.8040 | 0.6326 | 1.4358 | 1.1280 | NA | 0.9964 |
| Carnitine (3:0) | 0.7144 | 1.5737 | 0.6465 | 1.0822 | NA | 0.8664 |
| Carnitine (5:0) | 0.6763 | 1.6994 | 0.5979 | 1.0345 | NA | 0.9351 |
| Carnitine (6:0) | 1.3941 | 0.8305 | 0.8252 | 0.9699 | NA | 0.8430 |
| Carnitine (8:0) | 1.3432 | 0.7786 | 0.9032 | 0.9726 | NA | 1.0197 |
| Carnitine (glutaryl) | 1.0221 | 0.8957 | 1.2341 | 0.8565 | NA | 0.9328 |
| Carnosine | 1.0188 | 0.6449 | 1.5007 | 0.8530 | NA | 0.8608 |
| Ciliatine | 0.7341 | 1.4782 | 0.8189 | 1.0868 | NA | 0.5264 |
| Citrulline | 0.8126 | 0.5991 | 1.3493 | 1.2511 | NA | 0.9033 |
| Creatine | 0.9518 | 1.1140 | 0.8437 | 1.1015 | NA | 0.9112 |
| Creatinine | 0.9660 | 0.9101 | 1.1364 | 1.0040 | NA | 0.8684 |
| Cys-Gly | 0.9673 | 1.1020 | 0.8954 | 1.0672 | NA | 0.7451 |
| Cystathionine | 0.6327 | 0.7642 | 1.0731 | 1.5476 | NA | 0.8595 |
| Deoxyadenosine | 1.8910 | 0.3304 | 1.5018 | 0.2930 | NA | 0.8711 |
| Deoxyadenosine diphosphate | 1.1456 | 0.3635 | 1.7056 | 0.7984 | NA | 0.2586 |
| Deoxycarnitine | 0.8910 | 1.0206 | 0.9433 | 1.1572 | NA | 0.9029 |
| Deoxyguanosine | 1.0259 | 0.7779 | 1.1562 | 1.0791 | NA | 0.6873 |
| Deoxyguanosine monophosphate | 0.8271 | 0.6461 | 1.2007 | 1.3581 | NA | 0.7444 |
| Deoxyinosine monophosphate | 1.0300 | 0.8095 | 1.1465 | 0.9893 | NA | 1.1972 |
| Diphthamide | 1.7439 | 0.6109 | 1.0493 | 0.3357 | NA | 0.1964 |
| Formylglycine | 1.1160 | 0.5550 | 1.3677 | 0.6712 | NA | NA |
| Gamma-aminobutyrate | 0.9063 | 1.1003 | 0.9129 | 1.0922 | NA | 0.9063 |
| Glucose 1-phosphate | 0.5966 | 1.1282 | 0.8655 | 1.4267 | NA | 0.8641 |
| Glu-Gln | 0.8724 | 0.8606 | 1.2480 | 1.0189 | NA | 1.0010 |
| Glu-Pro | 0.7142 | 0.9485 | 0.9638 | 1.3841 | NA | 0.9146 |
| Glutamate | 0.7876 | 1.2361 | 0.8624 | 1.1278 | NA | 0.8882 |
| Glutathione | 0.9993 | 1.0571 | 0.9420 | 1.0242 | NA | 0.8189 |
| Glutathione disulfide | 0.8956 | 1.1556 | 0.8935 | 1.0506 | NA | 1.0375 |
| Glycerophosphocholine | 1.0210 | 0.7941 | 1.1608 | 1.0776 | NA | 0.5725 |
| Glycine | 0.9350 | 0.8024 | 1.1050 | 1.1768 | NA | 0.8465 |
| Guanidinoacetate | 0.9057 | 1.3431 | 1.0049 | 0.7258 | NA | 1.1639 |
| Guanidinosuccinate | 0.7279 | NA | 1.4656 | 0.0196 | NA | 0.4317 |
| Guanine | 0.9597 | 0.9333 | 1.0466 | 1.1204 | NA | 0.5208 |
| Guanosine | 0.3920 | 0.6456 | 1.0645 | 1.9009 | NA | 0.4326 |
| Hexosamines | 1.1717 | 1.1145 | 0.9704 | 0.7303 | NA | 1.1050 |
| Histamine | 1.0245 | 0.9761 | 0.9778 | 1.0291 | NA | 0.9404 |
| Histidine | 0.9449 | 0.9981 | 1.0510 | 1.0111 | NA | 0.9596 |
| Homoarginine | 1.0463 | 0.8755 | 1.0358 | 1.0232 | NA | 1.1531 |
| Hypotaurine | 1.0096 | 1.1377 | 0.8556 | 1.0108 | NA | 0.8902 |
| Hypoxanthine | 1.4061 | 0.5883 | 1.4485 | 0.5497 | NA | 1.0591 |
| Indole | 2.0495 | 0.5600 | 0.4543 | 0.6470 | NA | 3.3138 |
| Indole-3-acrylate | 0.8962 | 0.9098 | 1.0603 | 1.1458 | NA | 0.9028 |
| Isoleucine | 0.9327 | 0.9053 | 1.0718 | 1.1037 | NA | 0.8931 |
| Kynurenate | 1.0693 | 0.8744 | 1.2497 | 0.8135 | NA | 0.9446 |
| Kynurenine | 0.8029 | 0.8618 | 0.9830 | 1.3610 | NA | 0.9296 |
| Leucine | 0.9266 | 0.9246 | 1.0686 | 1.0916 | NA | 0.9082 |
| Leu-Leu | 0.6385 | 0.7235 | 1.2580 | 1.4356 | NA | 0.5548 |
| Leu-Pro | 0.8997 | 0.8245 | 1.1791 | 1.1168 | NA | 0.8391 |
| Lysine | 0.9545 | 0.9850 | 0.9446 | 1.1257 | NA | 0.9217 |
| Lyso-PC (16:0) | 1.1089 | 0.8708 | 1.0757 | 0.9539 | NA | 0.9263 |
| Lyso-PC (17:0) | 1.1931 | 1.0721 | 0.9121 | 0.8349 | NA | 0.9021 |
| Lyso-PC (18:0) | 1.1019 | 0.9167 | 1.0795 | 0.9191 | NA | 0.8620 |
| Lyso-PC (18:1) | 1.0381 | 0.9888 | 0.9524 | 1.0281 | NA | 0.9407 |
| Lyso-PC (18:2) | 1.0743 | 0.9811 | 0.9210 | 1.0322 | NA | 0.9310 |
| Lyso-PC (22:4) | 1.2521 | 1.1343 | 0.8946 | 0.7095 | NA | 1.0760 |
| Lyso-PE (16:0) | 1.0025 | 0.8065 | 1.1654 | 1.0390 | NA | 0.8929 |
| Lyso-PE (18:0) | 1.1293 | 0.9607 | 1.0070 | 0.9170 | NA | 0.8884 |
| Lyso-PE (18:1) | 1.0317 | 0.8851 | 1.1129 | 0.9773 | NA | 0.9444 |
| Lyso-PE (20:4) | 0.9126 | 0.8898 | 1.3233 | 0.8957 | NA | 0.8286 |
| Methionine | 0.9133 | 0.9111 | 1.0693 | 1.1200 | NA | 0.8906 |
| Methyl 4-aminobutyrate | 0.9669 | 0.8737 | 1.1058 | 1.0696 | NA | 0.8718 |
| Met-Leu | 0.7227 | 1.1491 | 0.7931 | 1.3635 | NA | 0.7726 |
| N6-(delta2-Isopentenyl)-adenine | 1.1948 | 0.8583 | 1.0667 | 0.9055 | NA | 0.7976 |
| N-Acetylglutamate | 0.8742 | 1.2403 | 0.8941 | 0.9653 | NA | 1.2095 |
| N-Acetylhexosamine | 0.6889 | 0.8281 | 0.9059 | 1.5280 | NA | 1.3925 |
| N-Acetylneuraminate | 1.8622 | 0.1347 | 1.7995 | 0.2153 | NA | 0.9062 |
| NAD+ | 0.9172 | 0.8903 | 1.0439 | 1.1658 | NA | 0.8626 |
| NADP+ | 0.7485 | 0.9373 | 1.0033 | 1.3484 | NA | 0.6997 |
| N-alpha-Acetyllysine | 1.3922 | 1.5656 | 0.3507 | 0.7521 | NA | 0.5153 |
| Nicotinamide | 0.9818 | 0.9897 | 1.1299 | 0.8979 | NA | 1.0053 |
| Nicotinamide mononucleotide | 0.6697 | 0.3735 | 1.7382 | 1.1236 | NA | 0.5073 |
| N-Methylglutamate | 0.9287 | 1.0796 | 1.0693 | 0.9017 | NA | 1.1659 |
| N,N-Dimethylarginine | 0.9648 | 0.7686 | 1.1344 | 1.1505 | NA | 0.8540 |
| N,N-Dimethyllysine | 0.9687 | 0.9320 | 0.9706 | 1.1348 | NA | 0.9512 |
| N,N,N-Trimethyllysine | 1.1946 | 0.6695 | 1.2735 | 0.8590 | NA | 1.0271 |
| O-Acetylserine | 0.6066 | 1.4824 | 0.4883 | 1.4500 | NA | 0.7817 |
| Oleamide | 1.0146 | 0.9008 | 0.9251 | 1.1678 | NA | 0.9332 |
| Ornithine | 1.1888 | 0.8819 | 1.0338 | 0.7855 | NA | 1.8796 |
| O-Succinyl homoserine | 0.4650 | 0.6568 | 1.1561 | 1.7314 | NA | 0.9263 |
| Pantothenate | 0.8382 | 0.9121 | 1.1361 | 1.1281 | NA | 0.8842 |
| PC (32:0) | 1.1559 | 1.0869 | 0.8874 | 0.8959 | NA | 0.7916 |
| PC (32:1) | 1.0388 | 1.0653 | 0.8909 | 1.0264 | NA | 0.8289 |
| PC (32:2) | 1.0050 | 1.2502 | 0.6991 | 1.0652 | NA | 0.8445 |
| PC (34:1) | 1.0322 | 0.9652 | 1.0743 | 0.9367 | NA | 0.9328 |
| PC (34:2) | 1.0121 | 1.1251 | 0.8688 | 1.0131 | NA | 0.8477 |
| PC (36:1) | 1.0491 | 1.0444 | 1.0319 | 0.8894 | NA | 0.8808 |
| PC (36:2) | 1.0159 | 1.0495 | 0.9852 | 0.9589 | NA | 0.9232 |
| PC (36:4) | 1.1464 | 0.9508 | 1.0846 | 0.8393 | NA | 0.8308 |
| PC (36:5) | 1.0887 | 0.9990 | 1.0386 | 0.8826 | NA | 0.9283 |
| PC (38:4) | 1.1827 | 1.0661 | 0.9701 | 0.8075 | NA | 0.7889 |
| PC (38:5) | 1.1783 | 1.0499 | 0.9723 | 0.8198 | NA | 0.8376 |
| PC (40:4) | 1.2511 | 1.1013 | 0.9218 | 0.7392 | NA | 0.8926 |
| PC (40:5) | 1.2384 | 1.1130 | 0.9103 | 0.7533 | NA | 0.8796 |
| PC (40:6) | 1.2079 | 1.0845 | 0.9442 | 0.7835 | NA | 0.8393 |
| PC (40:8) | 1.1244 | 0.9157 | 1.4004 | 0.6048 | NA | 0.6376 |
| PC (44:8) | 1.8827 | 1.1593 | 0.6312 | 0.2502 | NA | 0.2462 |
| PE (32:0) | 1.1310 | 1.2407 | 0.7591 | 0.8977 | NA | 0.7716 |
| PE (34:1) | 1.0356 | 1.2523 | 0.7661 | 0.9629 | NA | 0.8654 |
| PE (34:2) | 1.1249 | 1.1054 | 0.8127 | 0.9716 | NA | 0.8824 |
| PE (36:1) | 1.0933 | 1.0977 | 0.9148 | 0.9116 | NA | 0.8601 |
| PE (36:2) | 1.1378 | 1.1367 | 0.8545 | 0.8839 | NA | 0.8974 |
| PE (36:3) | 1.1639 | 1.0511 | 0.9105 | 0.8962 | NA | 0.8263 |
| PE (38:1) | 1.1350 | 1.2000 | 0.8678 | 0.8152 | NA | 0.8558 |
| PE (38:3) | 1.2224 | 1.1333 | 0.8465 | 0.8212 | NA | 0.8130 |
| PE (38:4) | 1.1985 | 1.0480 | 0.9871 | 0.7638 | NA | 1.0203 |
| PE (38:6) | 1.2820 | 0.9073 | 1.0525 | 0.7548 | NA | 1.0269 |
| PE (40:5) | 1.2804 | 1.0606 | 0.9410 | 0.7261 | NA | 0.9345 |
| PE (40:7) | 1.4184 | 0.8887 | 1.0786 | 0.6319 | NA | 0.8591 |
| Phenylalanine | 0.9206 | 0.9294 | 1.0494 | 1.1106 | NA | 0.9199 |
| Phosphoethanolamine | 1.2096 | 0.1740 | 2.1144 | 0.5215 | NA | 0.8446 |
| Phosphorylcholine | 1.1124 | 1.3363 | 0.7900 | 0.7645 | NA | 0.9748 |
| Phosphoserine | 2.1682 | 0.2807 | 1.3433 | 0.2416 | NA | 0.7296 |
| Pipecolate | 0.7423 | 1.2824 | 0.8963 | 1.0881 | NA | 0.9273 |
| Platelet-activating factor | 1.0936 | 0.9197 | 1.0726 | 0.9308 | NA | 0.8666 |
| Proline | 0.8937 | 1.0098 | 0.9845 | 1.1280 | NA | 0.8724 |
| Pyridoxal | 1.1232 | 0.8476 | 1.2333 | 0.8355 | NA | 0.6834 |
| Pyridoxamine | 0.9153 | 1.0703 | 0.9866 | 1.0188 | NA | 1.0726 |
| Pyridoxine | 0.8684 | 0.9603 | 1.0976 | 1.0817 | NA | 0.9359 |
| Quinoline | 0.9731 | 0.9094 | 1.0487 | 1.0651 | NA | 1.0296 |
| S-Acetylthioethanolamine | 1.3368 | 0.8873 | 1.0698 | 0.7109 | NA | 0.9618 |
| S-Adenosylhomocysteine | 0.8135 | 1.1594 | 0.8174 | 1.2192 | NA | 0.9235 |
| S-Adenosylmethionine | 0.9295 | 0.8335 | 1.0831 | 1.1636 | NA | 0.9219 |
| Ser-Arg | 1.0321 | 0.7209 | 1.2397 | 1.0116 | NA | 0.9654 |
| Serine | 1.0655 | 0.7017 | 1.3267 | 0.9038 | NA | 1.0189 |
| SM (d18:1/14:0) | 1.1777 | 0.9781 | 0.9238 | 0.9521 | NA | 0.7459 |
| SM (d18:1/16:0) | 1.0601 | 1.0488 | 0.9613 | 0.9650 | NA | 0.7183 |
| SM (d18:1/18:0) | 0.9888 | 0.8913 | 1.2316 | 0.9314 | NA | 0.6554 |
| SM (d18:1/18:1) | 1.0129 | 0.8836 | 1.0956 | 1.0358 | NA | 0.7763 |
| S-Methylthioadenosine | 0.8186 | 1.1169 | 0.8290 | 1.2184 | NA | 1.1371 |
| Sphinganine | 1.0135 | 1.0538 | 0.8302 | 1.1175 | NA | 0.8798 |
| Sphingosine | 1.0116 | 0.9557 | 0.9047 | 1.1383 | NA | 0.9183 |
| Stachydrine | 0.8322 | 1.0820 | 0.9366 | 1.1596 | NA | 0.9162 |
| Taurine | 0.9955 | 1.1203 | 0.8800 | 1.0188 | NA | 0.8835 |
| Theanine | 0.9357 | 0.8721 | 1.1197 | 1.0955 | NA | 0.8165 |
| Thiamine | 0.7038 | 0.9191 | 1.1694 | 1.1533 | NA | 1.4345 |
| Thr-Arg | 0.9231 | 0.7425 | 1.2613 | 1.0757 | NA | 0.9796 |
| Threonine | 0.9011 | 0.9529 | 1.0504 | 1.1043 | NA | 0.9298 |
| Thymidine | 0.8774 | 0.8513 | 1.1885 | 1.0570 | NA | 1.0838 |
| Thymidine diphosphate | 1.0208 | 0.9829 | 0.9259 | 1.0468 | NA | 1.1355 |
| trans-4-Hydroxyproline | 0.8922 | 0.9031 | 1.1850 | 1.0541 | NA | 0.7249 |
| Trigonelline | 0.5966 | 0.8411 | 1.3899 | 1.1874 | NA | 0.8798 |
| Tryptophan | 0.8981 | 0.9193 | 1.0516 | 1.1453 | NA | 0.8859 |
| Tyr-Arg | 0.8940 | 1.1599 | 0.8917 | 1.0713 | NA | 0.8654 |
| Tyrosine | 0.9698 | 0.9910 | 0.9691 | 1.0768 | NA | 0.9459 |
| Urocanate | 0.7756 | 1.5167 | 0.5605 | 0.7021 | NA | 4.5609 |
| Val-Lys | 0.8134 | 0.7180 | 1.2353 | 1.2418 | NA | 0.9309 |
Factors:
| F1 | Genotype:HOG EV | Treatment:BAY2402234 |
| F2 | Genotype:HOG EV | Treatment:DMSO |
| F3 | Genotype:HOG R132H | Treatment:BAY2402234 |
| F4 | Genotype:HOG R132H | Treatment:DMSO |
| F5 | Genotype:N/A | Treatment:N/A |
| F6 | Genotype:Pooled Sample | Treatment:N/A |
