Data for (Study ST002234)

(Analysis AN003644)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5F6F7F8F9F10
5,10 Methenyl tetrahydrofolate NA NA NA NA NA NA NA NA NA NA
5 Methyl tetrahydrofolate NA NA NA NA NA NA NA NA NA NA
Acetylcarnitine 1.0949 0.8610 1.1428 1.0808 0.4920 1.4628 1.3522 0.7238 1.1430 0.5415
Aconitic acid 1.4634 0.7317 1.2195 1.2195 0.9756 0.7317 1.2195 0.7317 0.7317 0.9756
Adenine 0.9723 0.9255 1.4567 1.4534 0.4678 1.1159 0.9021 1.0190 1.0090 0.6782
Adenosine 1.0000 NA NA NA NA NA NA NA NA NA
Adenosine cyclic monophosphate 0.9930 1.5157 1.5505 0.9233 0.3833 1.3066 1.3240 0.7840 0.2962 0.9233
Adenosine monophosphate 3.3351 1.1129 1.4538 1.1705 1.1614 0.3422 0.4839 0.4317 0.2635 0.2449
Adenosine triphosphate 0.9005 1.1296 1.1154 1.0562 0.8636 1.0974 1.0615 0.8967 0.8711 1.0081
Adipic acid 1.1472 0.8395 1.1662 1.0041 1.0708 0.9182 0.9516 0.8252 0.8133 1.2640
AICAR NA 0.9779 NA NA NA NA NA NA NA 1.0110
Allantoin 1.2986 0.6306 1.3117 1.2748 1.0224 0.9783 0.9630 0.6182 0.7274 1.1750
alpha-Ketoglutaric acid 1.3396 1.0583 1.0674 1.2022 1.0053 0.9554 1.0218 0.7212 0.8970 0.7319
Aminoadipic acid 1.0619 1.0623 1.0646 1.0336 0.9599 1.0196 1.0098 0.8678 0.8549 1.0657
Aminobenzoic acid NA NA NA NA NA NA NA NA NA NA
Aminobutyric acid NA NA NA NA NA NA NA NA NA NA
Anthranillic acid 0.7407 NA NA NA 1.1728 NA NA NA NA NA
Arabitol 1.0053 1.1784 1.0739 0.6897 1.0603 0.9496 1.4553 0.6476 0.4677 1.4723
Arginine 1.2686 0.5184 1.2400 1.0078 0.8434 0.9429 1.2733 0.7186 0.7014 1.4857
Argininosuccinic acid 0.9850 1.1305 1.0800 0.9428 0.8887 1.1162 1.0143 0.9341 0.8139 1.0943
Asparagine 1.0842 1.3638 1.4698 1.1516 0.8191 0.7678 1.0491 0.6250 0.6033 1.0663
Aspartic Acid 0.9682 0.9334 1.1004 0.8935 0.9698 1.1289 1.2064 0.8191 0.7817 1.1987
Butyrylcarnitine 1.3676 1.3874 1.1375 0.8883 0.7376 1.1012 0.9552 0.6745 0.7298 1.0060
Canavanine NA NA NA NA NA NA NA NA NA NA
Carnitine 1.2596 1.2402 1.1451 1.1486 0.9645 0.9866 0.8633 0.6729 0.4849 1.2342
Chenodeoxycholic acid NA NA NA NA NA NA NA NA NA NA
Cholic acid NA NA NA NA NA NA NA NA NA NA
cis-Aconitic acid NA NA NA NA NA NA NA NA NA NA
Citramalic acid 1.1807 1.0536 1.2799 1.0384 0.9649 0.8552 0.9532 0.7922 0.7572 1.1247
Citric acid+Isocitric acid 1.3583 0.6462 1.0773 0.8981 1.0202 0.9659 1.1141 0.7305 0.7421 1.4474
Citrulline 1.4009 0.2469 1.9752 0.8515 0.1368 0.5260 0.7764 NA 0.6678 2.0018
Creatine 1.1088 1.3645 1.3071 0.9404 0.8297 1.0784 1.0345 0.8058 0.6988 0.8320
Creatine phosphate 0.9324 1.0385 1.0071 1.0011 1.3214 1.0218 1.0472 0.8442 0.8190 0.9672
Creatinine 1.4492 1.1101 1.4359 1.1596 0.6954 1.0459 1.0705 0.4369 0.6781 0.9184
Cystathionine 1.4438 1.3329 1.3900 1.7604 0.6738 0.6627 0.7839 0.4312 0.2870 1.2342
Cystine 0.9802 0.2923 0.6058 0.9503 1.2370 0.5331 0.9619 0.4369 0.6000 3.4026
Cytidine 1.1395 NA 1.1208 0.9786 0.7690 NA 0.9417 0.8724 0.9284 1.0795
Cytidine monophosphate 2.5735 1.3104 1.6742 1.1853 0.9263 0.5231 0.5826 0.5616 0.3770 0.2860
Cytidine triphosphate 0.9469 1.1013 1.0869 1.0578 0.8881 1.0517 1.0448 0.9315 0.9292 0.9619
Cytosine NA NA NA NA NA NA NA NA NA NA
Dehydroshikimic acid 1.3648 0.9245 1.1447 0.7484 0.7925 1.2327 1.1006 1.2327 0.2201 1.1447
Deoxyadenosine NA NA NA NA NA NA NA NA NA NA
Deoxyadenosine monophosphate 2.1849 0.6858 0.5219 0.8800 0.9771 1.2745 1.1197 1.3382 0.5887 0.7647
Deoxyadenosine triphosphate 0.8557 NA 1.0217 1.1480 0.7526 1.4252 1.3150 0.3308 NA 1.1766
Deoxycholic acid NA NA NA NA NA NA NA NA NA NA
Deoxycytidine NA NA NA NA NA NA NA NA NA NA
Deoxycytidine monophosphate 1.5094 1.0650 1.1987 1.1077 1.0217 0.9610 1.0903 0.6517 0.6416 0.7529
Deoxycytidine triphosphate NA NA NA NA 0.1192 0.5561 0.7661 1.0498 0.7207 2.9224
Deoxyguanosine NA NA NA NA NA NA NA NA NA NA
Deoxyinosine NA NA NA NA NA NA NA NA NA NA
Deoxy-(methylthio)adenosine 1.3073 1.1163 1.5071 1.1046 0.8549 0.8578 1.0047 0.6492 0.6933 0.9048
Deoxyribose NA NA NA NA NA NA NA NA NA NA
Deoxyribose phosphate 0.9237 1.0285 1.0890 1.0136 0.9711 1.0305 1.0233 0.9706 0.9932 0.9565
Deoxythymidine triphosphate 0.6244 1.5560 1.6290 1.0610 0.4783 1.4215 1.3657 0.5236 0.4617 0.8788
Deoxyuridine 1.4438 0.6305 1.1666 1.0996 0.8742 0.7645 1.0966 0.6122 1.1575 1.1544
Deoxyuridine triphosphate NA NA NA NA NA NA NA NA NA NA
Dihydrofolate NA NA NA NA NA NA NA NA NA NA
Dihydroorotic acid NA NA NA NA NA NA NA NA NA NA
Dihydroxyacetone phosphate 1.4092 1.2813 1.5331 0.9951 1.0767 0.8730 0.9642 0.7196 0.4564 0.6915
Dihydroxybenzoic acid NA NA NA NA NA NA NA NA NA NA
Dihydroxyisovalerate 1.7812 1.1520 1.7715 0.8422 1.0165 0.6583 0.7454 0.4743 0.4356 1.1229
Dimethyl Succinic acid 0.7650 0.6557 0.4098 2.7049 NA NA 0.1639 NA NA NA
Epicatechin NA NA NA NA NA NA NA NA NA NA
Erythro-dihydrosphingosine 1.1129 0.9812 1.2745 0.9317 1.0364 0.8925 1.0810 0.9005 0.7923 0.9971
Flavin adenine dinucleotide 0.9927 0.9986 1.0228 1.0115 0.9879 1.0039 0.9924 0.9934 0.9965 1.0005
Folic Acid 1.4630 0.5552 0.9279 0.6990 0.8460 1.2094 1.1847 0.9913 0.7423 1.3811
Folinic acid NA NA NA NA NA NA NA NA NA NA
Fructose 1,6-biphosphate 1.9936 1.2295 1.3413 1.0515 0.8852 0.8294 0.7690 0.7325 0.5270 0.6410
Galactosamine NA NA NA NA NA NA NA NA NA NA
gamma-Glu-Cys 0.9731 0.9558 1.1468 0.9964 0.9868 1.0647 1.1879 0.7684 0.7354 1.1848
Glucoheptonic acid 1.1074 0.8734 1.2216 0.6089 1.1752 0.6115 1.1629 NA 0.9887 1.1180
Glucosamine 6-phosphate NA NA NA NA NA NA NA NA NA NA
Glutamic acid 1.1275 1.0694 1.2355 1.1305 0.8619 1.0014 1.0448 0.7829 0.7244 1.0219
Glutamine 1.2123 0.9587 1.2260 1.1557 0.8737 0.8997 0.9902 0.7240 0.6409 1.3188
Gluthathione oxidized 1.1307 1.7375 1.3981 1.2704 0.5342 0.9072 0.8186 0.8948 0.6658 0.6427
Glyceric acid 1.2320 0.6507 1.1899 1.0759 1.0573 0.9321 0.9569 0.7561 0.8342 1.3151
Glycine 1.1163 1.0703 1.1398 1.0847 0.8969 0.9842 1.0425 0.7639 0.7089 1.1924
Guanidobutyric acid NA NA NA NA NA NA NA NA NA NA
Guanine NA NA NA NA NA NA NA NA NA NA
Guanosine 3.2686 1.0907 1.6023 1.0587 0.9735 0.3695 0.2842 0.3127 0.2825 0.2771
Guanosine cyclic monophosphate NA NA NA NA NA NA NA NA NA NA
Guanosine triphosphate 0.8974 1.1948 1.1856 1.0814 0.7917 1.0950 1.0973 0.8451 0.8032 1.0085
Hexose 1.2869 0.7926 1.0742 1.0689 0.9375 1.0353 0.9081 0.7964 0.7948 1.3053
Hexose 1-phosphate 1.0962 1.3706 1.5965 1.1595 0.6903 1.0537 1.0279 0.6821 0.5722 0.7510
Hexose 6-phosphate 1.1343 1.2708 1.4898 1.1489 0.7540 0.9318 1.0683 0.7284 0.6235 0.8503
Histidine 1.2128 0.8279 1.2034 1.1132 0.9490 0.9208 1.0411 0.7053 0.7384 1.2882
Homocitrate 1.4119 0.7951 1.1241 0.8293 1.1172 0.9801 1.0281 0.9184 0.6443 1.1515
Homocystine NA NA NA NA NA NA NA NA NA NA
Homoserine 1.0489 0.5073 0.9255 1.3590 0.7954 1.4680 0.5387 0.6011 0.8077 1.9038
Hydroxyanthranilic acid NA NA NA NA NA NA NA NA NA NA
Hydroxybenzoic acid NA NA NA NA NA NA NA NA NA NA
Hydroxyethylindole NA NA NA NA NA NA NA NA NA NA
Hydroxy-glutamic acid 1.0686 1.0766 0.9673 1.0901 0.9506 1.0367 1.0542 0.8142 0.8509 1.0909
Hydroxyglutaric acid 1.1786 1.0656 1.1720 1.0094 0.9037 0.9705 0.9566 0.8159 0.8311 1.0967
Hydroxy hippuric acid NA NA NA NA NA NA NA NA NA NA
Hydroxy-indoleacetic acid NA NA NA NA NA NA NA NA NA NA
Hydroxy-kynurenine NA NA NA NA NA NA NA NA NA NA
Hydroxynicotinic acid NA NA NA NA NA NA NA NA NA NA
Hydroxyphenylacetic acid NA NA NA NA NA NA NA NA NA NA
Hydroxyphenyl-pyruvic acid NA NA NA NA NA NA NA NA NA NA
Hydroxy-proline NA NA NA NA NA NA NA NA NA NA
Hypoxanthine 1.0733 0.9516 1.0258 0.9879 1.0003 0.9605 1.0229 0.9141 0.9630 1.1007
Indoleacetic acid NA NA NA NA NA NA NA NA NA NA
Indoline-2-carboxylate NA NA NA NA NA NA NA NA NA NA
Inosine NA NA NA NA NA NA NA NA NA NA
Inosine monophosphate 1.0121 1.0006 1.0933 1.0301 0.9276 0.9768 1.0154 0.9793 0.9436 1.0211
Inosine triphosphate 0.7032 1.3948 1.3407 1.1760 0.5751 1.2902 1.1921 0.6841 0.6092 1.0347
Isoleucine 1.4296 0.8409 0.9167 1.1406 0.9594 0.9118 1.2564 0.7699 0.7969 0.9778
Isopentyl acetate 1.2424 0.3761 1.0778 1.2350 0.8589 0.9094 1.4969 1.2275 0.8607 0.4603
Isopropylmalic acid NA NA NA NA NA NA NA NA NA NA
Isovalerylcarnitine NA NA NA NA NA NA NA NA NA NA
Itaconic acid 1.4423 1.0092 1.6377 0.9844 0.9795 0.8239 0.7850 0.6131 0.7367 0.9882
Ketobutyrate 0.9320 0.9791 1.3247 1.1001 0.9554 1.0206 0.9916 0.8971 0.9311 0.8683
Ketovaleric acid 0.4879 0.8692 0.8405 0.8335 0.7754 1.5328 1.1839 1.0701 0.9804 1.4265
Kynurenic acid NA NA NA NA NA NA NA NA NA NA
Kynurenine NA NA NA NA NA NA NA NA NA NA
Lactic acid 1.3141 0.9344 1.0403 1.0381 1.0483 0.9347 1.0275 0.7396 0.7470 1.1759
Leucine 1.3564 0.8562 1.1611 1.1623 0.9961 0.9002 1.0395 0.6612 0.7419 1.1251
Lipoamide NA NA NA NA NA NA NA NA NA NA
Maleic acid 1.2610 0.7145 1.1534 1.6179 1.3242 0.8485 0.5899 0.5600 0.7122 1.2184
Malic acid 0.9614 1.0453 0.9978 0.9647 0.9435 1.0984 1.0432 0.9609 0.9687 1.0162
Malonic acid NA NA NA NA NA 0.1629 NA NA NA 1.4185
Methionine 1.2575 0.9159 1.2063 1.1563 0.8979 0.9073 1.0050 0.6804 0.7024 1.2710
Methoxytryptamine NA NA NA NA NA NA NA NA NA NA
Methylglutaric acid NA NA NA NA NA NA NA NA NA NA
Mevalonic acid NA NA NA NA NA NA NA NA NA NA
Mevalonolactone NA NA NA NA NA NA NA NA NA 1.0000
Muconic acid NA NA NA NA NA NA NA NA NA NA
Muricholic acid NA NA NA NA NA NA NA NA NA NA
Myristoylcarnitine 1.1878 0.4183 1.3825 0.6451 0.4626 1.7949 1.0093 0.4208 1.5071 0.6055
N-Acetyl galactosamine NA NA NA NA NA NA NA NA NA NA
N-Acetyl-glucosamine phosphate 1.6565 0.7602 1.2821 1.1081 0.6921 1.0098 0.7072 0.2950 0.6694 1.5846
N-Acetylglutamic acid 1.5091 2.4851 1.8595 1.4095 0.3144 0.8051 0.5550 0.3982 0.1952 0.4688
N-Acetylneuraminic acid 1.0419 1.1738 1.2161 1.0508 0.8219 1.0049 1.0416 0.8973 0.8227 0.9290
N-Carbamoyl-aspartic acid 1.3987 1.0831 0.9373 1.2868 0.9574 1.0341 0.8774 0.7179 0.7216 0.9857
N-Carbamyl-glutamic acid 1.1467 0.9200 1.1200 0.9067 0.9733 1.0400 0.9733 0.8533 0.8533 1.2133
N-Formyl-Tyrosine 0.9008 0.8327 1.2263 0.9841 0.9235 0.7948 0.9765 1.1506 0.7381 1.3853
Nicotinamide adenine dinucleotide 1.0751 1.2331 1.3350 1.1463 0.8167 1.0246 1.0005 0.7876 0.7002 0.8808
Nicotinamide mononucleotide NA NA NA NA NA NA NA NA NA NA
Nicotinic acid NA NA NA NA NA NA NA NA NA NA
Nicotinic acid mononucleotide NA 1.0000 NA NA NA NA NA NA NA NA
Octanoylcarnitine NA NA NA NA NA NA NA NA NA NA
O-Phosphorylethanolamine 0.5379 1.0879 2.3271 0.6436 0.3317 0.7725 1.1861 1.6630 0.9416 0.5087
Orotic acid 1.1204 0.9893 0.9893 1.0847 1.0132 0.9536 0.9893 0.8820 0.9178 1.0906
Oxamic acid 1.2740 0.8639 1.6251 1.6289 0.7183 0.8616 0.6339 1.1004 1.2338 0.3541
Palmitoylcarnitine 1.5307 0.1941 1.2667 0.5731 0.3311 2.2432 1.1898 0.4085 1.8601 0.1227
Pantothenic acid 1.0801 0.9585 1.3574 1.0173 0.8767 1.0115 1.1480 0.8130 0.7182 1.0194
Pentahydroxyhexanoic acid 1.1704 1.3016 1.4152 1.1222 0.7599 1.0625 0.9339 0.7092 0.6624 0.8626
Pentose 1.2685 0.7596 1.0541 1.0256 0.9074 1.0006 1.0475 0.8029 0.8000 1.3338
Phenolred 1.2767 0.6023 1.0952 1.0083 0.9766 0.9816 1.0635 0.7635 0.8410 1.3912
Phenylalanine 1.1881 0.8994 1.1679 1.0807 0.9346 0.9241 1.0180 0.7859 0.7761 1.2253
Phenylpyruvic acid 1.0303 0.9545 1.1818 1.3333 0.9091 0.6970 0.9242 1.0606 0.9394 0.9697
Phosphoenolpyruvic acid Results 0.8534 0.8489 1.0684 0.9379 0.9857 1.2953 1.5847 0.7178 0.9386 0.7693
Phosphoglyceric acid 1.2259 1.0531 1.1297 1.0360 0.9321 0.9563 1.0152 0.9015 0.8580 0.8921
Phospho-Serine 0.8968 0.9201 1.3921 1.1462 0.5186 1.3123 0.9625 1.0357 1.2372 0.5786
Prephenic acid 1.0156 1.1044 1.0924 1.0199 0.7585 0.9810 1.1079 0.9731 0.9628 0.9764
Proline 1.5445 1.7081 0.8439 1.1057 0.8498 1.2836 0.8145 0.2800 0.5625 0.7057
Propionylcarnitine NA NA NA NA NA NA NA NA NA NA
Pyridinedicarboxylic acid NA NA NA NA NA NA NA NA NA NA
Pyridoxal 5 phosphate 1.1684 1.5445 1.5465 1.0889 0.6684 0.9837 0.8980 0.8038 0.5763 0.7215
Pyridoxal hydrochloride 1.2401 1.4412 1.3833 0.9537 0.7252 1.0695 0.8318 0.7648 0.5941 0.9963
Pyridoxamine NA NA NA NA NA NA NA NA NA NA
Pyridoxic acid 0.7563 0.2101 0.6723 0.9034 0.9034 1.0504 1.3235 0.8193 1.1555 2.2059
Pyridoxine 1.3390 0.7433 1.1526 1.0509 0.8940 0.9826 1.0766 0.6768 0.7703 1.3139
Pyruvic acid 1.4182 0.8345 1.0581 1.1695 1.0797 1.0416 1.3021 0.5000 0.6648 0.9314
Quinic acid 0.9265 1.6881 1.5572 1.1739 0.4366 0.8974 0.4075 1.0818 0.9605 0.4851
Quinolinediol NA NA NA NA NA NA NA NA NA NA
Riboflavin 1.1041 0.8477 1.0963 1.0675 0.7483 1.0623 1.1669 0.6986 0.5861 1.6222
Ribonic acid gamma lactone 1.2677 0.7791 0.7593 0.8977 NA 2.0165 0.7084 0.7595 1.0161 0.3555
Ribose 5-phosphate 1.4804 1.0202 1.0886 0.9481 1.2441 0.8654 1.0176 0.6996 0.4639 1.1722
S-Adenosyl-homocysteine 1.2495 1.5381 1.2330 1.2660 0.7588 0.9608 0.9856 0.6062 0.6268 0.7753
Salicylic acid 1.0938 1.0673 1.2070 1.2487 0.9077 0.8999 0.8785 0.8133 0.8764 1.0073
Sedoheptulose-7-phosphate NA NA NA NA NA NA NA NA NA NA
Serine 1.2521 0.9966 1.1818 1.2101 0.9008 0.9205 0.9268 0.7103 0.6421 1.2588
Shikimic acid NA NA NA NA NA NA NA NA NA NA
Succinic acid 1.3255 0.6936 1.2026 1.0035 1.0144 0.8853 1.1044 0.6529 0.7280 1.3898
Taurine 1.0743 1.1858 1.0516 0.9919 0.8908 1.2118 1.0369 0.7774 0.7388 1.0406
Taurocholic acid 1.0568 0.8928 1.0340 1.0111 0.9958 0.9958 1.0187 0.9233 0.9424 1.1293
Tauro-muriocholic acid NA NA NA NA NA NA NA NA NA NA
Thiamine 1.2080 0.9114 1.1945 1.0391 0.9360 0.8869 1.0714 0.7793 0.7697 1.2036
Threonine 1.2200 1.0187 1.2038 1.2014 0.8939 0.8901 0.9549 0.7029 0.6851 1.2293
Thymidine 1.1015 0.8236 1.3898 1.1324 0.8339 0.6022 0.8390 0.9986 0.9420 1.3177
Thymine 1.3752 0.9961 0.9388 NA 0.9256 0.9785 0.9917 0.9785 0.9521 0.9917
Tryptophan 1.3171 0.7981 1.3918 1.2805 0.8193 0.8587 1.0692 0.5305 0.4733 1.4614
Tyrosine 1.2215 0.8456 1.3078 1.0989 0.9022 0.9003 1.0576 0.7650 0.7113 1.1897
Uracil 1.3191 0.7620 0.9992 0.8756 0.8955 0.9450 1.1228 0.8373 1.0309 1.2127
Uric acid 2.0082 0.5330 0.6528 0.9798 1.0185 0.7539 1.2519 0.6690 0.3957 1.7374
Uridine 2.0516 0.5540 1.8597 1.0662 0.8151 0.5682 0.7017 0.2653 0.6808 1.4375
Uridine diphosphohexose 1.0780 1.1243 1.2937 1.0602 0.8412 1.0424 1.0715 0.7757 0.7245 0.9885
Uridine monophosphate 2.9470 1.0052 1.5065 1.1499 1.2928 0.4074 0.5791 0.4484 0.3545 0.3092
Uridine triphosphate 0.8865 1.1563 1.2238 1.0876 0.8053 1.0653 1.1144 0.8408 0.7835 1.0364
Valine 1.1731 0.8754 1.1227 1.1157 0.9265 1.0153 1.0190 0.7311 0.7501 1.2710
Vanillic acid 0.9306 0.9306 1.9102 0.8571 0.8816 NA NA 0.7837 1.0776 0.9714
Xanthine 1.4453 0.7779 0.9433 1.0211 0.8876 0.8683 1.1489 0.8102 0.8937 1.2038
Xanthosine 1.0664 1.0427 1.1295 1.0190 0.9400 1.0111 1.0821 0.8531 0.8531 1.0032
Xanthurenic acid NA NA NA NA NA NA NA NA NA NA
Xylitol 0.9827 0.6352 1.7699 0.8665 1.0509 0.5125 1.5707 1.1251 0.3542 1.3981
Xylulose 5-phosphate 1.1362 1.0571 1.0865 1.0093 1.2257 0.9530 1.0725 0.7853 0.6393 1.0352
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Factors:

F1Genotype:PRDX1 KO | Treatment:Etop-0h
F2Genotype:PRDX1 KO | Treatment:Etop-24h
F3Genotype:PRDX1 KO | Treatment:Etop-8h
F4Genotype:PRDX1 KO | Treatment:Untreated
F5Genotype:WT | Treatment:Etop-0h
F6Genotype:WT | Treatment:Etop-24h
F7Genotype:WT | Treatment:Etop-8h
F8Genotype:WT | Treatment:Noco-18h
F9Genotype:WT | Treatment:Noco-23h
F10Genotype:WT | Treatment:Untreated
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