Data for (Study ST002263)

(Analysis AN003696)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Metabolite	F1	F2	F3	F4	F5	F6
1-(1Z-Octadecenyl)-sn-glycero-3-phosphocholine	1.8047	0.9067	1.0828	0.4592	1.1869	0.5804
1,2-Diarachidonoyl-sn-glycero-3-phosphocholine	0.9591	1.0981	1.1765	0.7661	1.3405	0.7038
1,2-Dihexadecanoyl-sn-glycero-3-phosphocholine	1.1068	1.0130	1.0223	0.8162	1.0325	1.0148
1,2-Dilinoleoyl-sn-glycero-3-phosphocholine	1.0528	0.9571	1.0493	0.9742	1.0769	0.9020
1,2-Dipalmitoleoyl-sn-glycero-3-phosphocholine	1.0029	0.7704	0.8213	1.0899	1.0220	1.2488
1_Acetylcarnitine_d3	0.9960	1.0039	1.0313	0.9966	0.9712	1.0089
1_Carnitine_d3	1.0138	0.9845	1.0221	0.9774	1.0171	0.9907
1_CUDA	0.9888	0.9283	1.0151	0.9621	1.0746	1.0350
1_D3-1-Methylnicotinamide	0.9455	1.0499	0.9697	0.9526	1.0247	1.0500
1_D9-Choline iSTD	0.9831	1.0442	0.9757	0.9430	1.0352	1.0126
1_Glutamine_d5	0.9891	1.0200	0.9758	0.9689	1.0235	1.0166
1-Heptadecanoyl-sn-glycero-3-phosphocholine	1.3629	0.9271	1.1037	0.7377	1.1827	0.7119
1-Hexadecanoyl-2-sn-glycero-3-phosphate	0.7383	1.1253	0.3727	0.9343	0.8670	1.8055
1-Hexadecyl-sn-glycero-3-phosphocholine	1.3663	1.0278	1.1342	0.7059	1.0590	0.7404
1_HippuricAcid-d5	0.9994	1.0281	0.9805	1.0447	0.9603	0.9821
1_Lysine-d8	0.9833	1.0304	1.0125	1.0991	0.8515	1.0264
1_Methionine_d8	0.9898	1.0320	0.9859	1.0221	0.9968	0.9700
1-Methyladenosine	0.8909	1.1004	1.1739	1.0448	0.9641	0.8694
1-Methylhistamine	1.1015	1.0819	1.0668	0.6599	1.5349	0.5718
1-Methyl-L-histidine	1.4117	1.2878	0.8998	0.5610	1.3320	0.4826
1-Oleoyl-2-myristoyl-sn-glycero-3-phosphocholine	0.8398	0.6117	0.5423	1.2210	0.7566	1.9141
1-Oleoyl-sn-glycero-3-phosphocholine	1.1256	1.0649	0.9823	0.8100	1.0790	0.9336
1-Oleoyl-sn-glycero-3-phosphoethanolamine	0.9140	1.2030	0.7405	1.0106	1.1472	0.9197
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphoserine	1.2192	0.8470	1.1129	0.8014	1.1080	0.9396
1-Palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine	0.9882	1.1077	0.8731	0.9255	1.0951	0.9786
1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine	1.1112	1.0501	0.6046	1.0275	0.9431	1.1648
1-Palmitoyl-2-linoleoyl-sn-glycero-3-phosphocholine	1.0187	0.8123	0.9139	1.0126	1.0766	1.1444
1-Palmitoyl-sn-glycero-3-phosphocholine	1.1707	0.8580	0.8753	0.9562	0.9369	1.1718
1_Phenylalanine-d8	0.9801	1.0013	0.9912	1.0036	0.9893	1.0323
1_Serine-d8	0.9887	1.0485	0.9757	1.0162	0.9955	0.9693
1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine	1.3153	0.8236	1.3004	0.8334	0.8906	0.9118
1-Stearoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine	1.0961	0.8834	0.6907	1.0093	1.0119	1.2312
1-Stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine	1.0683	0.8143	1.2666	1.0280	0.8749	1.0145
1_TMAO_d9	0.9762	1.0244	1.0028	0.9683	1.0232	1.0058
1_Tryptophan-d5	0.9651	1.0459	0.9744	1.0284	0.9837	0.9961
2-Arachidonoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine	0.9047	0.8210	0.8842	1.2196	1.0621	1.0795
2-Arachidonoylglycerol	0.8905	1.3479	0.8030	0.9977	1.0360	0.8756
2-Docosahexaenoyl-1-stearoyl-sn-glycero-3-phosphoserine	1.0889	1.1180	0.8376	0.8619	1.1755	0.8775
2-Indolinone	0.9266	1.0355	0.5799	0.3795	2.1820	0.7914
2-Linoleoyl-1-palmitoyl-sn-glycero-3-phosphoethanolamine	1.0497	0.7564	0.9171	1.1566	1.1572	0.9423
2-Methylbutyryl-L-carnitine	0.6739	0.9019	0.8436	1.3746	0.6267	1.5401
(2R)-3-Hydroxyisovaleroylcarnitine	1.0651	0.8954	1.2866	1.1220	0.6491	1.0535
3-Dehydrocarnitine	1.0315	1.5584	0.6784	0.8031	1.0548	0.7933
3-Guanidinopropionic acid	0.9839	0.6543	1.0253	1.1810	0.9876	1.1742
3-Hydroxybutyrylcarnitine	0.9762	1.4367	1.0742	0.7130	1.0590	0.7595
3-Methylglutarylcarnitine	0.5243	1.0202	3.2228	0.9134	0.4113	0.4637
3-Methylhistidine	1.3784	1.3275	0.6741	0.5668	1.4111	0.5606
4-Guanidinobutyric acid	0.6470	0.3464	1.3075	1.3908	0.4730	1.9122
4-IMIDAZOLEACETIC ACID	0.7639	0.7274	1.0234	1.0539	0.9149	1.5223
4-Pyridoxic acid	0.7799	1.2448	0.7760	0.8979	1.1678	1.0777
5^-Methylthioadenosine	1.0621	1.0520	1.2251	0.8671	0.9915	0.8585
Acetylcarnitine	1.0949	0.9457	1.3944	0.9202	0.7828	0.9606
Adenine	0.8037	1.1157	1.0880	1.0567	0.7647	1.1931
Adenosine	1.1911	1.0099	1.2049	0.7379	1.0190	0.8886
Adenosine 5^-diphosphoribose	1.0973	1.1307	1.0370	0.9166	1.1020	0.7257
Adipoyl-L-carnitine	0.9231	2.0036	1.7374	0.3257	0.4990	0.6956
Ala-Gln	1.0613	1.0027	0.8067	1.2521	0.9623	0.8666
Ala-Lys	0.7829	1.6019	0.4595	0.7607	1.5296	0.7302
Alanine	0.7814	1.0753	0.9824	0.9590	1.0463	1.1512
AMP	1.1611	1.0650	1.0329	0.8794	0.9599	0.9100
Arg-Ala	0.9141	1.5926	0.6420	0.5872	1.5808	0.5938
Arginine	0.9790	1.0432	1.0043	1.0831	0.8786	1.0128
Arg-Tyr	1.0964	1.4455	0.7589	0.4607	1.5305	0.6478
Aspartic acid	1.2972	1.0812	1.1776	0.5721	1.1785	0.7378
Benzyldimethyltetradecylammonium cation	0.6966	0.6633	3.0415	0.6594	0.6705	0.7791
Betaine	0.8676	1.2835	0.7083	0.8292	1.2396	0.9989
Betaine aldehyde cation	1.0670	0.9064	0.8288	1.3624	1.0364	0.7563
C18+M160T67	0.7591	0.6045	1.0370	1.3317	0.9669	1.3100
Carnitine	1.0008	1.3033	0.7949	0.9541	1.0146	0.8811
Carnosine	1.1777	1.4431	0.6521	0.3852	1.7799	0.4750
Choline [M]+	0.9555	0.8517	1.0464	1.2610	0.9416	0.9554
Citrulline	1.1910	0.8620	1.0490	0.8822	1.2404	0.7876
Creatine	1.0705	1.2086	0.9954	0.7121	1.2759	0.7364
Creatinine	1.1218	0.9361	0.9849	0.8056	1.2276	0.9202
Cystathionine	0.7398	0.6199	1.5906	1.2733	0.6009	1.3231
CYTIDINE 5^-DIPHOSPHOCHOLINE	0.9859	0.9230	1.0137	0.9924	1.1205	0.9679
Cytidine-5^-monophosphate	1.3193	1.2897	1.1041	0.5646	0.9547	0.7936
Cytosine	0.6026	0.9532	0.6079	1.4061	0.6758	1.6563
Decanoyl-L-carnitine	0.8563	0.8896	2.0740	0.7695	0.6888	0.9903
DEOXYCARNITINE	0.9043	0.9107	1.0958	0.9878	1.0176	1.1077
Equol	0.1823	0.2532	1.2304	1.5004	0.2245	1.8845
Ergothioneine	1.3827	1.2331	0.8355	0.7487	0.8878	0.8711
Ethanolamine	1.3157	0.9175	1.2094	0.9613	0.8746	0.7739
FAD	1.1104	1.1392	0.8761	0.8113	1.1122	0.9199
gamma-Glutamyl-cysteine	0.7225	1.4777	1.1782	0.9710	0.8785	0.8167
Gln-Ala	1.0041	2.0261	0.5585	0.3085	1.7023	0.2900
Gln-Gly	1.1266	1.5753	0.5650	0.5359	1.6092	0.4792
Gln-Thr	1.0264	1.5884	0.6747	0.6511	1.4296	0.5483
Glucose-1-phosphate	1.1183	1.3548	1.0273	0.6811	0.8869	0.9384
Glucose-6-phosphate	1.0825	1.4688	1.0056	0.6078	0.9778	0.8589
Glutamic acid	1.1495	1.5360	1.1893	0.5933	1.0842	0.4950
Glutamine	1.1113	1.0720	0.8928	1.0742	1.0252	0.7978
Glutathione (oxidized)	1.0516	1.1174	0.8043	0.6920	1.3734	0.9124
Glutathione (reduced)	0.9883	1.2194	0.8693	0.8669	0.9757	1.0478
Glycocholic acid	0.6414	3.8738	0.1742	0.2092	0.4946	0.2005
Guanidinosuccinic acid	0.4020	1.1577	0.8628	0.5769	1.8674	1.0989
Guanosine 5^-monophosphate	1.2061	1.1286	0.9754	0.7954	1.0220	0.8664
Hexanoyl-L-carnitine	1.1964	0.6871	1.0721	0.8417	0.3373	1.8834
His-Ala	1.1115	1.4860	0.7921	0.5889	1.4344	0.5352
Histamine	0.1965	0.4319	2.6109	0.0862	2.9525	0.1247
Histidine	0.9172	0.9705	1.0347	1.2402	0.7146	1.1316
HYPOTAURINE	0.6816	0.7255	1.0751	1.5731	0.5947	1.3688
Hypoxanthine	0.7953	1.4486	0.8550	0.9828	1.1163	0.7658
Inosine	0.7274	1.4451	0.8349	1.0357	1.0840	0.8316
Inosine-5^-monophosphate	1.1918	1.1297	0.8957	0.8844	0.9885	0.8839
Isoleucine	0.9466	1.0486	1.1438	1.1008	0.9459	0.8503
Isomer of Taurocholic acid	0.9112	1.1187	1.7193	0.8768	0.7978	0.7560
L-Arachidonoylcarnitine	1.1610	1.5571	1.2232	0.7475	0.8538	0.5132
Leucine	0.9491	1.1021	1.0126	0.9916	1.1399	0.8080
L-Glutarylcarnitine	1.3714	1.4998	1.0028	0.6631	0.7371	0.7266
Linoleoylcarnitine	1.1497	0.8519	1.9900	0.8746	0.7787	0.6026
Lysine	0.9550	1.0213	1.1992	1.3169	0.6704	0.8870
Maltose	0.6087	1.4999	0.5112	0.6147	1.6274	1.0159
Maltotriose	0.6520	1.5873	0.6075	0.7655	1.3369	0.9527
Methacholine cation	1.3856	1.6742	0.3266	0.2899	1.8078	0.3475
Methionine	0.9217	1.2875	0.8775	1.0116	1.1104	0.7607
Myristoyl-L-carnitine	1.1823	0.6020	2.1238	0.9239	0.3940	1.0550
N6,N6-dimethyllysine	1.4325	1.2015	1.0290	0.2880	1.2824	0.7738
N-Acetyl-D-lactosamine	1.4107	1.0914	1.2311	0.6420	1.0163	0.6662
N-Acetyl-glutamine	1.1999	0.7299	1.4998	0.9883	0.8659	0.8411
N-Acetylhistidine	0.9867	0.5033	1.2595	0.9327	1.1553	1.2273
NAD+	0.8981	0.6381	1.2633	1.1201	0.7260	1.4202
NALPHA-ACETYL-L-LYSINE	0.9006	0.7049	1.7304	1.0574	0.6246	1.1647
N-epsilon-Acetyllysine	0.8400	0.8636	1.1262	1.1490	0.8401	1.2126
NEPSILON,NEPSILON,NEPSILON-TRIMETHYLLYSINE	0.9858	1.1575	1.0270	0.9238	1.1665	0.7462
Nicotinamide	1.0468	1.1682	0.9657	0.9730	1.0878	0.7500
Nicotinamide riboside cation	0.8969	1.0514	1.6482	1.1720	0.8556	0.5380
N-Methylalanine	1.0140	1.3028	0.7300	0.7950	1.1240	0.9667
N-Methyllysine	1.2268	0.9928	0.9825	0.6459	1.2176	0.9301
N-Methylproline	1.1147	1.1400	0.6134	0.8366	1.3364	0.8622
N,N-Diethyl-2-aminoethanol	0.9864	0.7792	1.0680	1.0966	0.9838	1.1030
N,N-Dimethylarginine	0.8504	1.0024	1.3502	0.9242	1.0860	0.8743
N-omega-Acetylhistamine	1.1719	1.1014	0.4822	0.4823	2.2300	0.4027
Nudifloramide	1.7597	0.9120	0.9579	0.7543	0.8249	0.7807
Octanoylcarnitine	1.2142	0.6280	1.3411	0.7688	0.4631	1.6700
Oleoyl-L-carnitine	1.2253	0.8388	1.9488	0.9934	0.4525	0.7784
OPHTHALMIC ACID	1.4729	2.3058	0.8119	0.1281	1.0516	0.1827
Ornithine	0.9798	1.3646	0.9660	0.9928	0.8651	0.8232
Palmitoylcarnitine	1.5402	0.8381	1.5371	0.8171	0.5378	0.8639
Palmitoyleicosapentaenoyl phosphatidylcholine	0.8884	0.6581	0.8698	1.2113	0.9272	1.4127
Palmitoyl sphingomyelin	1.3303	1.0470	1.0076	0.7367	1.1811	0.6992
Pantothenic acid	0.8435	1.3805	0.9234	0.9339	1.1170	0.7827
Phenylalanine	1.0408	1.1458	1.0354	1.0101	0.9762	0.8005
Phosphocholine	1.3833	0.3105	1.2017	0.9916	0.9891	1.1742
Pipecolic acid	1.0245	0.8720	0.9021	1.0605	1.0231	1.0934
Proline	1.0304	1.0849	0.9923	1.0179	0.9845	0.8881
Propionylcarnitine; [M+H]+; HCD (NCE 20-30-40%)	0.6342	1.0643	0.8360	1.3009	0.7992	1.3244
Protoporphyrin IX	0.7946	0.9796	0.6503	1.2737	0.8293	1.3850
Putrescine	0.7851	0.5574	0.6893	1.6601	0.4163	1.8141
Pyridoxamine	1.2316	1.0062	1.3262	0.7348	0.8468	0.9359
(R)-Butyrylcarnitine	1.1668	0.9275	1.2131	0.9372	0.5216	1.2871
Riboflavin	0.9406	1.0361	1.0417	1.1100	1.0362	0.8458
S-Adenosyl-homocysteine	1.0663	1.2582	1.1074	0.9983	0.8817	0.7149
S-Adenosyl-methionine	0.9404	1.0213	1.4898	0.7755	0.7986	1.0968
Sarcosine	0.7475	0.9834	0.6251	1.3270	0.9448	1.2785
Ser-Arg	1.1598	1.7759	0.7570	0.3053	1.3899	0.5514
Serine	0.8520	1.1773	1.0355	0.9424	1.2422	0.7595
SEROTONIN	0.4551	0.8056	1.3853	0.9859	1.0224	1.4420
SN-GLYCERO-3-PHOSPHOCHOLINE	0.8403	0.8804	1.0576	1.2688	1.1944	0.7730
Stachydrine	0.7108	1.1791	0.4645	0.7433	1.8270	0.9414
Stearoyl-L-carnitine	1.0596	1.1818	1.5788	0.9628	0.5806	0.7811
Targinine	0.8541	0.9855	1.3798	0.8125	0.9954	1.0676
Taurine	1.2370	0.6008	1.0240	1.3091	0.3509	1.4841
Taurocholic acid	0.9004	2.4581	0.6053	0.8462	0.5678	0.5235
Tauroursodeoxycholic acid	1.4613	2.6400	0.4587	0.4608	0.5196	0.3243
Thiamine Cation	0.8763	1.2471	0.8026	0.7751	1.4742	0.7753
Thiamine monophosphate	1.2001	1.2594	0.9514	0.6785	1.4090	0.4895
Threonine	1.0225	1.1534	1.0132	0.9472	1.0550	0.8120
TMAO	0.4657	0.7251	1.4065	0.7630	2.1025	0.6388
TRIGONELLINE	0.7331	0.5582	1.1309	1.2797	0.9710	1.3598
Tryptophan	1.0295	1.0847	1.1424	0.9931	0.9858	0.8000
Tyrosine	0.9463	1.3226	0.9916	0.9912	1.1345	0.6117
UMP	1.2328	0.9005	1.2850	0.9761	0.9184	0.7585
Uracil	0.9195	1.1091	0.6848	1.0798	1.0209	1.1071
Urea	1.0017	0.9238	0.9399	0.8764	1.1339	1.1093
Uridine-5-diphosphoacetylglucosamine	1.1172	1.2418	1.0800	0.7315	1.0061	0.8435
Val-Arg	1.0213	1.3576	0.6701	0.8512	1.1374	0.8800
Xanthosine	0.9178	1.2116	0.5626	1.0988	1.0142	1.0856

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1	Genotype:Klb Knockout | Treatment:ad libitum feeding
F2	Genotype:Klb Knockout | Treatment:intermittent fasting
F3	Genotype:Tbx3 Knockout | Treatment:ad libitum feeding
F4	Genotype:Tbx3 Knockout | Treatment:intermittent fasting
F5	Genotype:Wild-type | Treatment:ad libitum feeding
F6	Genotype:Wild-type | Treatment:intermittent fasting