Data for (Study ST002375)

(Analysis AN003870)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
1-Methyladenosine 0.6166 1.3210 0.9850 1.0774
1-Methyl-Histidine 0.8558 1.3151 0.7396 1.0894
1-pyrroline-5-carboxylate(P5C) 0.8089 1.0507 0.9695 1.1709
2,3-Diphosphoglyceric acid 0.9870 1.0639 0.8529 1.0962
2-Aminooctanoic acid 1.2155 1.2759 0.7501 0.7584
2-Hydroxy-2-methylbutanedioic acid 0.9163 1.1575 0.8408 1.0855
2-hydroxygluterate 0.6501 0.9908 0.9960 1.3630
2-oxobutanoate 1.0316 0.9507 1.0055 1.0121
3-phosphoglycerate 1.0405 1.0360 0.9925 0.9311
3-phospho-serine 0.0608 0.1500 0.3755 3.4137
4-aminobutyrate 0.8139 1.0654 0.8843 1.2364
acetoacetate 1.0391 0.9893 0.9664 1.0052
Acetylcarnitine DL 0.5852 0.8106 1.2841 1.3201
acetyl-CoA_pos 0.8454 1.2534 0.9000 1.0012
Acetyllysine 0.9337 1.1031 0.9024 1.0608
aconitate 0.8181 1.0839 0.9336 1.1643
adenine 0.5415 1.4744 0.7351 1.2490
adenosine 0.5957 1.1276 1.1018 1.1749
ADP_neg 0.7044 1.1913 0.9604 1.1439
AICAR_aminoimidazole carboxamide ribonucleotide 3.3044 0.1680 0.4491 0.0785
a-ketoglutarate 1.0133 1.0063 0.9845 0.9959
a-Ketoglutarate_PH 1.1449 0.9052 0.9325 1.0174
alanine 1.4848 0.6962 0.9399 0.8791
allantoin 0.8543 1.1423 0.9305 1.0728
AMP 0.8233 1.0946 0.9793 1.1029
anthranilate 0.9118 1.1747 0.9599 0.9536
arginine 1.0510 1.0176 0.8286 1.1029
asparagine 0.9037 1.0662 0.9811 1.0490
aspartate 1.1968 1.5733 0.5195 0.7104
ATP_neg 0.7484 1.1454 1.0114 1.0948
beta-Hydroxybutyrate 0.7062 1.2122 0.9372 1.1444
betaine 1.0136 1.0614 0.9480 0.9771
Carbamoyl phosphate 1.1574 0.4748 1.2282 1.1395
carnitine 0.9968 1.1028 0.9019 0.9985
cholesteryl sulfate 1.1089 1.0033 0.9372 0.9506
choline 0.7106 1.2406 0.9260 1.1227
citrate 0.8814 1.0907 0.7774 1.2504
citrate-isocitrate 0.8421 1.1210 0.8081 1.2288
citrulline 1.0012 1.1104 0.9094 0.9790
CMP 0.9488 1.1551 0.9431 0.9529
creatine 0.9279 1.1146 0.8489 1.1086
creatinine 0.8859 1.1155 0.9816 1.0170
CTP_neg 1.0647 1.1317 0.7538 1.0499
cyclic-AMP 1.1644 1.3260 0.7085 0.8010
Cystine 0.8657 1.1841 0.9682 0.9821
cytidine 0.9215 1.1324 0.7531 1.1930
cytosine 1.0460 0.9387 1.0219 0.9934
dAMP 0.9192 1.1302 0.8320 1.1186
deoxyribose-phosphate 0.8608 1.1494 0.8990 1.0908
deoxyuridine 0.6269 1.4397 0.6979 1.2355
dGDP_neg 0.7258 1.1347 0.9839 1.1556
dGTP 0.7595 1.0846 1.0451 1.1107
dimethylglycine 0.7162 1.2467 0.9318 1.1052
DL-Pipecolic acid 0.7292 1.0297 1.0630 1.1781
D-sedoheptulose-1-7-phosphate 0.9429 2.1387 0.4494 0.4691
FAD 1.0327 1.0021 1.0286 0.9366
fructose-1,6-bisphosphate 0.9479 2.5460 0.2871 0.2190
Glucose_neg 0.8712 1.0508 1.0337 1.0443
glutamate 0.6648 1.0052 1.0671 1.2628
glutamine 0.8139 1.0183 1.0458 1.1220
glutathione 0.9329 1.0649 0.9289 1.0733
glutathione disulfide_neg 0.7385 1.0934 1.0033 1.1648
glutathione disulfide_pos 0.7432 1.0872 1.0186 1.1510
glutathione_neg 0.9064 0.9795 0.9572 1.1569
Glycerophosphocholine 0.4664 1.0903 1.2137 1.2296
glycine 0.9860 1.0178 0.9104 1.0858
glycolate 0.9904 0.9795 1.0011 1.0290
glyoxylate 0.9724 0.9843 1.0044 1.0390
GMP 0.6424 1.1515 1.0639 1.1421
GTP_neg 0.7639 1.2257 0.9494 1.0610
guanidinosuccinate 0.9418 1.0441 0.9442 1.0699
guanosine 5-diphosphate,3-diphosphate 1.0573 1.3919 0.6968 0.8540
hexose-phosphate 0.9149 1.7328 0.6846 0.6677
histidine 0.8666 1.1572 0.9245 1.0518
homocysteine 1.1503 1.6093 0.5620 0.6784
hydroxyphenylpyruvate 0.7540 0.9616 1.2006 1.0838
hydroxyproline 0.8201 1.0772 0.9700 1.1327
IDP_neg 0.6714 1.1485 1.0089 1.1712
IMP 0.9859 0.8981 0.9917 1.1243
inosine 0.6768 0.6354 1.2809 1.4069
isocitrate 0.9163 0.9364 1.2587 0.8887
Itaconate_pos 0.7943 1.0555 0.9884 1.1618
lactate 0.8196 1.4780 0.8521 0.8503
L-Cys-Gly 0.7810 1.0404 0.8023 1.3762
leucine-isoleucine 0.8396 1.1356 0.9479 1.0769
lysine 1.0238 0.9990 0.8990 1.0781
malate 0.7305 1.1666 1.0847 1.0182
Maltose 0.7810 0.9801 1.6295 0.6094
methionine 0.9244 1.0160 1.0029 1.0567
Methionine sulfoxide 0.9080 1.1548 0.8997 1.0375
Methylmalonic acid 0.9286 1.0204 1.0195 1.0315
myo-inositol 0.7180 0.7969 1.1753 1.3097
N6-Acetyl-L-lysine 0.9274 1.0994 0.9111 1.0620
N-acetyl-glucosamine 1.0492 1.0788 0.8718 1.0002
N-acetyl-glucosamine-1-phosphate 0.9233 0.8743 1.1128 1.0896
N-acetyl-glutamate 1.5404 1.2388 0.0606 1.1602
N-acetyl-glutamine 0.8084 1.1616 0.9011 1.1288
N-Acetyl-L-alanine 0.9559 1.1218 0.8807 1.0416
NADH 1.0518 1.9933 0.4611 0.4938
NAD+_neg 0.8909 1.2457 0.8917 0.9717
NADP+_neg 0.8758 1.1653 0.9073 1.0516
NAD+_pos 0.8360 1.3097 0.8769 0.9774
NADP+_pos 0.8892 1.1318 0.8947 1.0843
Ng,NG-dimethyl-L-arginine 0.9175 1.1956 0.8524 1.0346
nicotinamide 0.8193 1.4159 0.7853 0.9795
O-acetyl-L-serine 0.7979 1.1652 0.9394 1.0975
octulose-monophosphate (O8P-O1P) 0.9874 1.9819 0.4837 0.5471
ornithine 0.9106 1.2582 0.8060 1.0252
p-aminobenzoate 1.0878 0.8680 1.0281 1.0161
pantothenate 0.8632 1.3347 0.7407 1.0613
phenylalanine 0.9124 1.0331 0.9930 1.0615
Phenyllactic acid 0.8555 0.8323 1.0435 1.2687
Phenylpropiolic acid 0.8151 1.0147 1.0600 1.1103
Phosphorylcholine 0.4071 0.9612 1.2390 1.3927
p-hydroxybenzoate 1.0269 1.0911 0.8299 1.0521
proline 1.0278 1.1051 0.9334 0.9336
Pyroglutamic acid 0.8249 1.2159 0.9348 1.0244
ribose-phosphate 2.1156 0.9117 0.4771 0.4956
S-adenosyl-L-homocysteine_neg 0.8065 1.3376 0.8333 1.0225
S-adenosyl-L-homoCysteine_pos 0.7782 1.5199 0.6552 1.0467
S-adenosyl-L-methionine 1.0144 1.0430 0.8264 1.1162
sarcosine 1.4710 0.7293 0.9359 0.8638
serine 0.2024 1.2669 0.4742 2.0566
shikimate 0.9977 0.9921 0.9385 1.0717
S-methyl-5-thioadenosine 0.8212 1.4230 0.6798 1.0761
sn-glycerol-3-phosphate 0.5185 0.9790 1.1861 1.3164
spermidine 0.8860 0.8605 1.4627 0.7908
succinate 0.9317 1.0571 0.9924 1.0188
taurine 0.8940 1.0416 1.0019 1.0624
Taurodeoxycholic acid 0.9771 0.9336 1.0178 1.0716
thiamine 0.8184 0.9815 1.1167 1.0833
Thiamine pyrophosphate 1.0139 1.0798 0.8648 1.0414
threonine 0.9680 1.0112 0.9942 1.0266
thymidine 0.2988 1.9707 0.6586 1.0719
thymine 1.0264 0.9623 0.8521 1.1592
trehalose-sucrose 0.8609 1.1039 1.3675 0.6677
tryptophan 0.5843 0.8903 1.2365 1.2889
tyrosine 0.9626 1.0533 0.9805 1.0037
UDP-D-glucose 1.2467 1.0721 0.8091 0.8721
UDP-N-acetyl-glucosamine 1.0716 0.9886 0.9825 0.9572
UDP_neg 1.2454 1.0675 0.7775 0.9097
UMP 1.0023 1.2524 0.7178 1.0275
Urea 1.0657 0.9632 0.9973 0.9739
uridine 1.2358 0.9946 0.7316 1.0380
UTP_neg 1.3373 1.0315 0.7696 0.8616
valine 0.9448 0.9610 0.9332 1.1610
xanthine 0.7667 1.1426 0.8790 1.2117
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Factors:

F1Treatment:GOT1 KO_Serine-free
F2Treatment:GOT1 KO_Serine-replete
F3Treatment:WT_Serine-free
F4Treatment:WT_Serine-replete
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