Data for (Study ST002376)

(Analysis AN003871)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2
1-Aminocyclopentanecarboxylic acid 1.0000 NA
1-Aminocyclopropane-1-carboxylic acid 0.8312 1.1688
1H-Imidazole-4-propionic acid 0.8232 1.2652
1-Methyl-4-imidazoleacetic acid 0.7443 1.2557
1-Methyladenosine 1.0422 0.9578
1-Methylhistamine 0.8873 1.0901
1-Methylnicotinamide 1.3599 0.6401
1-Pyrroline 5-carboxylic acid 1.2405 0.7595
2,3-Diaminopropionic acid 0.6950 1.1220
2,4-Diaminobutyric acid 0.7840 1.2160
2,6-Diaminopimelic acid 1.0708 0.8230
2-Amino-2-(hydroxymethyl)-1,3-propanediol 0.9006 1.1326
2-Aminoadipic acid 1.2208 0.7792
2-Aminoisobutyric acid 0.8822 1.1178
2^-Deoxycytidine 0.6350 1.3650
2-Methylserine 0.9049 1.0951
3-Amino-2-piperidone 1.0916 0.7711
3-Aminobutyric acid 1.3234 0.6766
3-Aminoisobutyric acid 1.0019 0.9981
3-Methylhistidine 1.3719 0.6281
4-Amino-3-hydroxybutyric acid 1.0029 0.9825
4-Guanidinobutyric acid 1.5038 0.4962
5,6,7,8-Tetrahydrobiopterin 1.0559 0.9441
5-Aminovaleric acid 1.4800 0.5200
5^-Deoxy-5^-methylthioadenosine 0.8325 1.1675
6-Aminohexanoic acid 1.0000 NA
7,8-Dihydrobiopterin 1.1610 0.8390
7-Methylguanine 1.0133 0.9600
Acetoacetamide 1.0000 NA
Adenine 1.0838 0.9162
Adenosine 1.2553 0.7447
ADMA 1.2081 0.7919
Ala 0.8537 1.1463
Ala-Ala 0.9993 1.0007
allo-Threonine 1.0479 0.8802
Aminoacetone NA 1.0000
Anserine_divalent 1.1889 0.8111
Arg 1.1268 0.8732
Arg-Glu 0.9169 1.0623
Argininosuccinic acid 1.1212 0.8788
Asn 0.9222 1.0778
Asp 0.9901 1.0099
Betaine 0.6026 1.3974
Betaine aldehyde_+H2O 1.2341 0.7659
Betonicine 0.8776 1.3060
Butyrylcarnitine 0.7773 1.2227
Carboxymethyllysine 1.2442 0.7558
Carnitine 1.0890 0.9110
Carnosine 1.0274 0.9863
Choline 0.8848 1.1152
cis-4-Hydroxyproline 1.2000 0.8000
Citrulline 1.1235 0.8765
Creatine 1.0488 0.9512
Creatinine 1.0752 0.9248
Cys 1.0788 0.9212
Cystathionine 0.6471 1.3529
Cysteine glutathione disulfide 0.9172 1.0828
Cytidine 0.7708 1.2292
Cytosine NA 1.0000
Diethanolamine 0.9463 1.0537
Dyphylline 0.8673 1.1327
Ectoine 0.9944 1.0167
Ergothioneine 1.1733 0.8267
Ethanolamine 0.9826 1.0174
GABA 1.1250 0.8750
Gln 1.0172 0.9828
Glu 1.1831 0.8169
Gluconolactone 0.8243 1.1757
Glucosamine 0.8674 1.1326
Glu-Glu 1.0156 0.9896
Glutathione (GSH) 0.9839 1.0161
Glutathione (GSSG)_divalent 1.0980 0.9020
Gly 1.1620 0.8380
Glycerol 0.9310 1.0690
Glycerophosphocholine 0.5850 1.4150
Gly-Gly 0.9886 1.0114
Gly-Leu 0.7645 1.2355
Guanidinosuccinic acid 1.2128 0.7872
Guanidoacetic acid 0.9040 1.0960
Guanine 1.1414 0.8586
Guanosine 1.1394 0.8606
Hexylamine 3.0111 0.4972
His 0.9473 1.0527
Histamine 0.9778 1.0222
Homoarginine 1.0337 0.9663
Homocarnosine 0.9593 1.1019
Homocitrulline 1.4391 0.5609
Homoserine 0.5078 1.4922
Hydroxyproline 0.8337 1.1663
Hypotaurine 0.9714 1.0286
Hypoxanthine 1.0682 0.9318
Ile 1.0547 0.9453
Imidazolelactic acid 0.7041 1.2959
Inosine 1.0156 0.9844
Isoglutamic acid 0.8796 1.1204
Isovalerylcarnitine 0.6458 1.3542
Kynurenine 1.1100 0.8900
Leu 1.0265 0.9735
Lys 1.1339 0.8661
Malonylcarnitine 1.0181 0.9819
Met 0.7391 1.2609
Methionine sulfoxide 0.7333 1.2667
Methylguanidine 1.0699 0.8603
Metronidazole 1.1708 0.8292
N1-Methyl-4-pyridone-5-carboxamide 1.0928 0.8886
N5-Ethylglutamine 1.5206 0.4794
N6-Acetyllysine 1.0093 0.9907
N6-Methyllysine 1.1549 0.8451
N8-Acetylspermidine 1.2201 0.7799
N-Acetylgalactosamine or N-Acetylmannosamine 0.9415 1.0488
N-Acetylglucosylamine 0.8412 1.1324
N-Acetylhistidine 0.8911 1.1089
N-Acetyllysine 1.0239 0.9761
N-Acetylornithine 1.0137 0.9863
N-Acetylputrescine NA 1.0000
N-Acetylserine 0.9055 1.1182
N-Ethylmaleimide_+H2O 1.0566 0.8302
Nicotinamide 1.0087 0.9913
N-Methylalanine NA 1.0000
NMN 1.2305 0.7695
N,N-Dimethylglycine 0.8605 1.1395
Nω-Methylarginine 1.0486 0.9514
O-Acetylcarnitine 1.0632 0.9368
Octanoylcarnitine 1.0561 0.9439
Ophthalmic acid 0.2236 1.7764
Ornithine 0.9446 1.0554
Phe 0.9451 1.0549
Phosphorylcholine 0.8406 1.1594
Pipecolic acid 1.3707 0.6293
Piperidine 0.8760 1.1240
Pro 0.9108 1.0892
Pterin NA 1.0000
Putrescine 0.7605 1.2395
Pyridoxal 1.0372 0.9628
Pyridoxamine 1.0000 NA
Pyridoxamine 5^-phosphate 1.1927 0.8073
Riboflavin 1.0124 0.9851
Saccharopine 1.0799 0.9201
S-Adenosylhomocysteine 1.1578 0.8422
S-Adenosylmethionine 0.8038 1.1962
Sarcosine 0.9411 1.0589
SDMA 1.2432 0.7568
Ser 1.0267 0.9733
Ser-Glu 0.8841 1.1159
Serotonin 1.1006 0.8994
S-Lactoylglutathione 0.8567 1.1433
S-Methylglutathione 1.0000 1.0000
S-Methylmethionine 1.3747 0.6253
Spermidine 1.1060 0.8940
Spermine 1.0172 0.9828
Stachydrine 1.3014 0.6986
Taurine 1.1341 0.8659
Taurocyamine 0.5456 1.4544
Theobromine 0.8387 1.1613
Thiamine 1.1176 0.8824
Thiamine phosphate 1.2021 0.7979
Thiaproline 1.0319 0.9681
Thr 0.9718 1.0282
threo-β-Methylaspartic acid 0.9870 1.0130
trans-Glutaconic acid 0.6636 1.3364
Triethanolamine 0.9585 1.0415
Trigonelline 0.8344 1.1656
Trimethylamine 0.6278 1.3101
Trimethylamine N-oxide 0.7739 1.2261
Trp 0.9363 1.0637
Tyr 0.9747 1.0253
Tyr-Arg_divalent 1.0699 0.9301
Tyrosine methyl ester 1.0000 NA
Uracil 0.8991 1.1009
Urea 1.2353 0.7647
Uridine 0.8872 1.1128
Urocanic acid 0.8099 1.1268
Val 1.1082 0.8918
β-Ala 0.9130 1.0870
β-Ala-Lys 1.0633 0.9367
γ-Butyrobetaine 1.1811 0.8189
γ-Glu-2-aminobutyric acid 0.1807 1.6145
γ-Glu-Cys 0.8200 1.1800
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Factors:

F1Genotype:Pnpla8-knockout
F2Genotype:Wild-type
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