Data for (Study ST002457)

(Analysis AN004009)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
10-HAD 1.0870 0.8248 1.1648
10-Hydroxydecanoic acid 0.9791 0.8113 1.2777
14-Methylhexadecanoic acid 0.9700 1.0382 0.9737
1-Aminocyclopropanecarboxylate 0.8504 1.0928 1.0033
1-Methyladenosine 0.9820 1.1875 0.7580
2,4-Dihydroxypteridine 1.3134 0.8803 0.8903
2-Acetamido-2-Deoxy-Beta-D-Glucosylamine 0.7688 0.8494 1.4093
2-Aminoadipate 0.6014 1.3529 0.8635
2-Aminoisobutyrate 0.7668 1.1448 1.0049
2-Aminophenol 0.8779 1.1008 0.9577
2^-Deoxy-5^-Adenosine Monophosphate (dAMP) 1.4457 0.5295 1.2570
2-hydroxy glutarate 1.1613 0.9627 0.9101
2-Hydroxyhexadecanoic acid 1.0684 0.9625 0.9918
2-Methylmaleate 0.9948 1.0191 0.9783
2-Phosphoglycerate 0.6339 1.3088 0.8957
3-(2-Hydroxyphenyl)Propanoate 0.9990 0.7358 1.3641
3-(4-Hydroxyphenyl)Pyruvate 0.4409 1.0949 1.3587
3-Hydroxybutanoate 0.9206 1.0437 1.0094
3-hydroxybutyric acid 0.8285 1.0368 1.0994
3-Hydroxymethylglutarate 0.8841 0.9526 1.1667
3-Hydroxyoctanoic acid 0.9351 0.9578 1.1148
3-Methyl-2-Oxovalerate 0.8344 1.0358 1.0957
3-Methyl-L-Histidine 0.7510 1.0986 1.0823
4-Acetamidobutanoate 0.5894 1.1854 1.1043
4-Guanidinobutanoate 0.8728 1.0973 0.9776
4-Imidazoleacetate 0.7924 0.9742 1.2171
4-Pyridoxate 0.9475 1.1324 0.8639
5-Aminolevulinate 1.5156 0.8328 0.7788
5-Hydroxylysine 0.4581 1.0841 1.3585
5-Methylcytosine 0.8399 1.1161 0.9805
5(Z),8(Z),11(Z)-Eicosatrienoic Acid 1.0125 1.0488 0.9220
6-Carboxyhexanoate 1.2240 1.1388 0.5622
9-Decenoic acid 1.0356 1.0378 0.9169
Acetylcholine 0.7815 0.9712 1.1973
Acetyl CoA 0.9443 1.1507 0.8415
Acetyl-L-carnitine 0.9017 1.0820 0.9733
Adenine 0.8378 1.0878 1.0213
Adenosine 1.3657 0.6428 1.1712
Adenosine 3^,5^-cyclic monophosphate (cAMP) 1.0028 1.0983 0.8624
Adenosine 5^-Diphosphate (ADP) 0.9701 1.0586 0.9457
Adenosine 5^-triphosphate (ATP) 0.9179 1.2194 0.7702
Adenosine Diphosphate Ribose 0.9771 1.0821 0.9071
Adenosine-Monophosphate (AMP) 1.0409 0.9147 1.0815
Adp-Glucose 1.0482 1.0117 0.9418
AICAR 1.0821 0.9295 1.0252
Alanine 0.8942 1.0712 0.9947
Alanine-IS 0.9968 0.9995 1.0035
Allantoin 0.7848 1.0773 1.0820
all-cis-4,7,10,13,16-Docosapentaenoic acid 0.8982 1.0703 0.9923
Allothreonine 0.8929 1.0689 0.9991
Alpha-Hydroxyisobutyrate 0.9073 1.0053 1.0738
Aminoisobutanoate 0.8002 1.1153 1.0163
Arachidic acid 0.9020 1.1984 0.8129
Arachidonic acid 0.9836 1.0115 0.9984
Arginine 0.8838 1.1117 0.9481
Argininosuccinate 0.8833 1.0699 1.0059
Asparagine 0.9589 0.9769 1.0677
Aspartate 0.8347 1.1679 0.9138
Behenic acid 0.3994 1.4588 0.8796
Beta-Alanine 0.8570 0.9862 1.1441
Beta-Glycerophosphate 0.7523 1.1782 0.9717
beta-Hydroxyisovaleric acid 0.9885 0.8758 1.1809
Betaine 1.2191 0.9476 0.8804
Beta-Nicotinamide Adenine Dinucleotide 0.7783 1.1654 0.9666
Butyryl-L-carnitine 1.1875 0.8829 0.9969
Carnitine 0.9370 1.0354 1.0064
Carnosine 0.9930 1.1773 0.7623
CDP-Ethanolamine 1.1317 0.9265 0.9858
cis-11-Eicosenoic acid 1.1276 0.9909 0.9008
Cis-4-Hydroxy-D-Proline 0.6858 1.0882 1.1536
cis-5-Dodecenoic acid 1.0782 0.9422 1.0110
cis-7,10,13,16-Docosatetraenoic acid 0.9014 1.1027 0.9450
cis-Aconitate 0.8184 1.1475 0.9561
Citicoline 0.8919 0.9399 1.1773
Citrate 0.8663 1.0522 1.0452
Citrulline 0.6399 1.2680 0.9466
Coenzyme A 1.0101 1.0263 0.9549
Corticosterone 0.5073 1.2367 1.0441
Creatine 0.9111 1.0633 0.9907
Creatinine 0.7480 1.1634 0.9958
Cyclic AMP 1.0449 1.0239 0.9278
Cystathionine 0.6134 1.3167 0.9028
Cystine 0.6712 0.8364 1.5126
Cytidine 1.1896 0.8635 1.0218
Cytidine 2^,3^-Cyclic Phosphate 0.4700 1.7178 0.0503
Cytidine Diphosphate (CDP) 0.9389 1.1491 0.8485
Cytidine Monophosphate (CMP) 1.3610 0.8880 0.8381
Decanoic acid 1.0883 0.8156 1.1762
Deoxycarnitine 1.0588 0.9457 1.0232
Deoxycytidine 0.7349 1.2509 0.8869
Deoxycytidine-Diphosphate (dCDP) 0.5975 1.1561 1.1164
Deoxycytidine Monophosphate (dCMP) 1.5673 0.7778 0.8091
Deoxyguanosine 1.3657 0.6428 1.1712
Deoxyguanosine diphosphate (dGDP) 0.9670 1.0711 0.9312
Deoxyguanosine-Monophosphate (dGMP) 1.0409 0.9147 1.0815
Deoxyguanosine triphosphate (dGTP) 0.9326 1.2033 0.7794
Deoxyribose 0.9076 0.9166 1.1955
Deoxyuridine 0.6301 1.0729 1.2234
Dethiobiotin 0.7333 1.1078 1.0852
D-Glucosamine 6-phosphate 1.2208 0.8823 0.9686
Dihydrobiopterin 1.1642 0.9077 0.9832
Dihydronicotinamide-adenine dinucleotide phosphate (NADPH) 0.8242 1.4058 0.5959
Dihydroorotate 1.0276 1.0818 0.8633
Dihydroxyacetone Phosphate (DHAP) 1.2683 0.8851 0.9232
Dimethylarginine 0.6561 1.1930 1.0356
Dimethylglycine 0.9295 0.9856 1.0816
Docosahexaenoic Acid 0.9369 1.0568 0.9771
Docosatrienoic Acid 0.9999 1.2602 0.6655
D-Ribose 5-Phosphate 1.2466 0.8289 1.0195
D-Sedoheptulose 0.8621 0.9965 1.1254
Eicosapentaenoate 0.9860 0.9477 1.0842
Erucic acid 0.9282 1.1609 0.8416
FAD (Flavin adenine dinucleotide) 1.0237 1.0166 0.9565
Fructose 6-Phosphate 0.8494 1.0454 1.0693
Galactosamine 1.0404 0.9883 0.9807
Galactose 1-Phosphate 0.8430 1.0506 1.0679
Galacturonate 0.2396 1.0548 1.5899
gamma-Glutamylcysteine 0.6166 0.9971 1.3395
Glucosamine 1.0395 0.9886 0.9811
Glucose 1.0167 0.9884 1.0013
Glucose 6-Phosphate 0.8646 1.0512 1.0481
Glucose-IS 0.9947 1.0028 1.0008
Glutamate 0.9010 1.0532 1.0135
Glutamate -IS 1.0255 0.9799 1.0054
Glutamine 0.7884 1.2088 0.8981
Glutamine - IS 1.0882 0.9261 1.0244
Glutarate 0.7253 1.1012 1.1012
Glutarylcarnitine 0.3861 1.4226 0.9560
Glutathione disulfide (GSSG) 1.5044 0.8256 0.7985
Glutathione Reduced (GSH) 1.0384 1.0712 0.8685
Glyceraldehyde 3-phosphate 1.6522 0.7045 0.8356
Glycerol 0.9367 0.9521 1.1213
Glycerol 3-Phosphate 0.7473 1.1795 0.9744
Glycine 0.9145 0.9961 1.0801
Glycolate 1.0036 0.9979 0.9996
Guadinoacetate 0.7484 1.1558 1.0059
Guanidinoacetate 0.7484 1.1558 1.0059
Guanidinosuccinate 0.2302 1.2159 1.2805
Guanine 1.1683 0.9247 0.9563
Guanosine 1.3370 0.7177 1.0934
Guanosine Diphosphate (GDP) 0.8508 1.1144 0.9732
Guanosine Diphosphate Mannose 1.0396 0.9905 0.9783
Guanosine Monophosphate (GMP) 1.1315 0.9627 0.9362
Gulonolactone 0.4746 1.2621 1.0993
Hippurate 0.9947 0.9931 1.0141
Histamine 0.8503 1.2133 0.8377
Histidine 0.9446 0.9006 1.1852
Homocysteine 0.6906 1.3511 0.7879
Homoserine 0.8929 1.0689 0.9991
Hydroxyproline 0.6858 1.0882 1.1536
Hypotaurine 1.0521 0.9472 1.0270
Hypoxanthine 1.1870 0.9028 0.9700
Indoxyl Sulfate 1.1071 0.8297 1.1405
Inosine 1.2327 0.8006 1.0706
Inosine-Monophosphate (IMP) 1.2634 0.8269 1.0076
Isoleucine 0.7610 1.0713 1.1111
Kynurenate 0.4112 1.4736 0.8640
Kynurenine 0.8486 1.0224 1.1017
Lactate 1.0484 0.9866 0.9761
Lactate -IS 1.0062 0.9973 0.9983
Lauric acid 1.8403 0.6242 0.7815
Lauroylcarnitine 0.8000 1.1324 0.9930
L-Cysteic Acid 0.9969 0.9733 1.0394
L-Dopa (3,4-Dihydroxyphenylalanine) 1.4027 0.9817 0.7231
Leucine 0.8597 0.9622 1.1747
Lignoceric acid 0.6299 1.4082 0.7625
Linoleic acid 1.2649 0.9422 0.8476
Linolenic acid 1.4086 0.8117 0.9014
Lumichrome 0.9954 0.8111 1.3015
Lysine 0.8913 1.0120 1.0786
Malate 0.9278 0.9742 1.0987
Mannitol/Sorbitol 0.2331 0.3179 2.6089
Methionine 0.8634 1.0698 1.0235
Methylarginine 0.8017 1.0775 1.0669
Methyl Galactoside 1.5073 0.5967 1.1107
Methylthioadenosine 1.0085 0.9877 1.0095
Methyl Vanillate 1.0909 0.9090 1.0455
Mevalonate 0.7437 0.9536 1.2881
Monoethylmalonate 1.1571 0.9116 0.9841
Myo-Inositol 0.9532 1.0170 1.0176
Myristic acid 0.9661 0.9924 1.0401
Myristoleic acid 1.1301 0.7849 1.1819
Myristoyl-carnitine 0.8688 1.1283 0.9384
N6-(Delta2-Isopentenyl)-Adenine 0.9237 1.0643 0.9782
N(6)-Methyllysine 0.7939 1.1241 1.0097
N-Acetylalanine 1.0636 0.9647 0.9930
N-Acetylasparagine 0.5164 1.3522 0.9389
N-Acetylaspartate 0.9638 0.9785 1.0612
N-Acetylcysteine 0.8797 1.3590 0.5966
N-Acetylglucosamine 0.5511 1.1009 1.2541
N-Acetylglutamate 1.0025 1.1030 0.8562
N-Acetylglycine 0.7728 1.1470 0.9967
N-Acetylleucine 0.3554 1.4470 0.9494
N-Acetyl-L-glutamine 0.1928 1.5996 0.8818
N-Acetylmethionine 0.7295 1.2651 0.8723
N-Acetylneuraminate 0.3046 1.2549 1.2579
N-Acetylphenylalanine 0.7863 1.0675 1.0941
N-Acetylputrescine 0.6682 1.4328 0.6952
N-Acetylserine 0.9691 0.9556 1.0881
N-Alpha-Acetyllysine 0.4272 1.2527 1.1538
N-Amidino-L-Aspartate 0.2302 1.2159 1.2805
Nervonic acid 0.5708 1.3465 0.8991
N-Formyl-L-Methionine 0.4826 1.3674 0.9476
Nicotinamide 1.1214 0.9311 0.9885
Nicotinamide adenine dinucleotide phosphate (NADP+) 0.7601 1.2840 0.8195
Nicotinamide adenine dinucleotide reduced (NADH) 0.8072 1.1927 0.9038
N-Metyl-Alanine 0.8555 0.9983 1.1287
Norvaline 0.9166 0.9808 1.0994
Oleic acid 1.1356 0.9543 0.9442
Omega-Hydroxydodecanoate 0.8158 0.9810 1.1849
O-Phosphoethanolamine 1.1033 0.9813 0.9354
O-Phosphoserine 0.7509 1.3443 0.7445
Ophthalmate 0.4263 1.4362 0.9023
Ornithine 0.8786 1.0068 1.0969
Orotate 1.0638 0.9470 1.0171
O-Succinyl-Homoserine 0.4741 1.1429 1.2636
Oxoglutarate 0.6225 1.0512 1.2599
Oxoproline 0.7041 1.0239 1.2261
Palmitate 0.9004 1.1262 0.9137
Palmitoleic acid 1.0977 0.8936 1.0608
Pantothenate 0.8426 1.0790 1.0291
Pentadecanoic acid 1.0180 0.9092 1.1091
Pentanoate 1.0841 0.9227 1.0326
Phenylalanine 0.8940 1.0632 1.0058
Phenylpyruvate 0.3384 0.6915 1.8818
Phosphocreatine 0.4338 1.5640 0.7198
Phosphoenolpyruvate 0.6305 1.2505 0.9789
Phosphorylcholine 1.2749 0.8691 0.9395
Phosphoserine 0.7509 1.3443 0.7445
Pipecolate 0.8288 1.0416 1.0926
Proline 0.8569 1.0190 1.0991
Propionyl-carnitine 0.6079 1.2012 1.0665
Pterin 1.2177 0.9791 0.8654
Pyridoxal 0.9709 1.0098 1.0119
Pyrophosphomevalonate 1.1478 1.0922 0.7439
Pyruvate 1.1709 0.7978 1.1285
Pyruvate - IS 1.0274 0.9871 0.9937
Quinolinate 0.9323 1.0631 0.9726
Quinoline 0.5671 1.4803 0.7184
Raffinose 1.3458 0.9096 0.8216
Retinoate 0.7254 1.0570 1.1619
Rhamnose 1.0087 0.9420 1.0721
Riboflavin 1.0101 1.1592 0.7723
Ribose 0.8011 1.0374 1.1227
Ricinoleic acid 0.9940 1.0053 0.9980
S-Adenosylhomocysteine 1.0504 0.9443 1.0324
S-Adenosylmethionine 0.8979 1.0583 1.0091
Sarcosine 1.0263 0.9894 0.9915
Sedoheptulose-7-phosphate (D) 0.9007 1.0056 1.0792
Serine 0.9039 1.0265 1.0477
Serotonin 1.2249 0.3917 1.6396
Sn-Glycero-3-Phosphocholine 1.2293 0.9598 0.8547
Sphinganine 0.9098 1.2908 0.6790
Sphingomyelin 0.8112 1.1553 0.9516
Stachydrine (nv) 1.0420 0.8119 1.2219
Stachyose 1.4994 0.9016 0.6984
Stearic acid 0.8616 1.1532 0.9104
Succinate 0.9341 1.0201 1.0300
Succinyladenosine 0.7142 1.0506 1.1806
Succinylaminoimidazole carboxamide riboside (SAICAr) 1.1263 0.9473 0.9619
Succinylcysteine 0.7766 1.0962 1.0631
Sucrose 1.0390 0.9601 1.0207
Tartrate 0.5616 1.1521 1.1744
Taurine 1.0478 0.9923 0.9687
Thiamine Monophosphate 1.0221 0.9730 1.0178
Thiamine Pyrophosphate 0.7834 1.1749 0.9490
Threitol 0.8264 1.0542 1.0774
Threonine 0.8929 1.0689 0.9991
Thymidine 0.7713 1.2050 0.9182
Thymidine-Monophosphate (TMP) 1.6977 0.6148 0.9192
Thymine 0.8973 1.0677 0.9968
Trans-4-Hydroxy-L-Proline 0.6858 1.0882 1.1536
Trehalose 1.0468 0.9688 1.0020
Tridecanoic acid 1.0651 0.7824 1.2422
Trigonelline 0.9543 1.0189 1.0140
Trimethyllysine 0.9347 1.0059 1.0490
Tryptophan 0.7967 1.2362 0.8531
Tyrosine 0.8964 1.0333 1.0448
Undecanoic acid 1.1998 0.7116 1.2217
Uracil 1.1491 0.8214 1.1151
Urate 0.8694 0.9779 1.1447
Ureidopropionate 0.7191 1.0923 1.1189
Uridine 0.9733 0.8958 1.1666
Uridine 5^-Diphosphate (UDP) 0.9311 1.0742 0.9582
Uridine-5-triphosphate (UTP) 0.8851 1.2440 0.7650
Uridine Diphosphategalactose 1.2471 0.9419 0.8637
Uridine Diphosphate Glucose 1.2471 0.9419 0.8637
Uridine Diphosphate Glucuronic Acid 1.1329 1.0214 0.8543
Uridine Diphosphate-N-Acetylgalactosamine 1.0906 0.9498 0.9898
Uridine Diphosphate-N-Acetylglucosamine 1.0906 0.9498 0.9898
Uridine Monophosphate (UMP) 1.4019 0.8273 0.8858
Urocanate 0.5487 1.2707 1.0227
Valine 0.9167 0.9807 1.0995
Xanthosine 0.6865 1.2751 0.8960
Xanthosine-Monophosphate 0.1834 0.8720 1.7884
Xanthurenate 0.5657 1.6267 0.5183
Ximeninic Acid 1.4086 0.8117 0.9014
Xylitol/Ribitol/Arabitol 0.7985 1.1307 0.9966
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Genotype:Tsc1-knockout | Treatment:none
F2Genotype:Tsc1-knockout | Treatment:rapamycin
F3Genotype:Wild-type | Treatment:none
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