RefMet Compound Details

RefMet ID, RefMet name, exact mass and formula
RefMet ID	RM0157861
RefMet name	GDP-mannose
Systematic name	{[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}({[hydroxy({[(2R,3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy})phosphoryl]oxy})phosphinic acid
Synonyms	PubChem Synonyms
Exact mass	605.077161 (neutral)	Calculate m/z: (Choose adduct) [M+H]+ [M+H-H2O]+ [M.]+ [M+2H]2+ [M+3H]3+ [M+4H]4+ [M+K]+ [M+2K]2+ [M+2K-H]+ [M+Na]+ [M+2Na]2+ [M+2Na-H]+ [M+Li]+ [M+2Li]2+ [M+NH4]+ [M.CH3]+ [M+Ag]+ [M+H+CH3OH]+ [M+H+CH3CN]+ [M+H+2CH3CN]+ [M+Na+CH3CN]+ [M.NaFormate+H]+ [M.NH4Formate+H]+ [M.TMSi]+ [M.tBuDMSi]+ [M+H-Hexose]+ [M+H-EtnP]+ [M+H-SerP]+ [M-H]- [M-H-H2O]- [M-CH3]- [M-2H]2- [M-3H]3- [M-4H]4- [M+Cl]- [M+OAc]- [M+Na-2H]- [M+K-2H]- [M.Formate]- [M.NaFormate-H]- [M.NH4Formate-H]- [M.F]- [M-H-Ser]- [M.HF2]- M(neutral)    View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
Formula	C16H25N5O16P2	View other entries in RefMet with this formula
Molecular descriptors
Molfile	37631 (Download molfile/View MW Metabolite Database details)
InChI	InChI=1S/C16H25N5O16P2/c17-16-19-12-6(13(28)20-16)18-3-21(12)14-10(26)8(24)5(34-14)2-33-38(29,30)37-39(31,32)36-15-11(27)9(25)7(23 )4(1-22)35-15/h3-5,7-11,14-15,22-27H,1-2H2,(H,29,30)(H,31,32)(H3,17,19,20,28)/t4-,5-,7-,8-,9+,10-,11+,14-,15-/m1/s1
InChIKey	MVMSCBBUIHUTGJ-GDJBGNAASA-N	View other enantiomers/diastereomers of this metabolite in RefMet
SMILES	C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)OP(=O)(O)OP(=O)(O)OC[C@@H]1[C@H]([C@H]([C@H](n2cnc3c2nc(N)[nH]c3=O)O1)O)O)O)O)O)O Run Tanimoto similarity search (with similarity coefficient >=0.6)
Chemical/Biochemical Classification
Super Class	Nucleic acids
Main Class	Purines
Sub Class	Purine rNDP
Distribution of GDP-mannose in NMDR studies
Species	Plot Species distribution
Sample source	Plot Sample source(tissue) distribution
Platform	Platform (MS/NMR) used for detection
Chromatography	Chromatography methods used for detection
Studies	NMDR Studies reporting GDP-mannose
External Links
Pubchem CID	135398627
ChEBI ID	15820
KEGG ID	C00096
HMDB ID	HMDB0001163
Chemspider ID	17372
MetaCyc ID	GDP-MANNOSE
Spectral data for GDP-mannose standards
MassBank(EU)	View MS spectra
Structural annotation level
Annotation level	1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving GDP-mannose

Rxn ID	KEGG Reaction	Enzyme
R00883	GDP + D-Mannose 1-phosphate <=> Orthophosphate + GDP-mannose	GDP:D-mannose-1-phosphate guanylyltransferase
R00885	GTP + D-Mannose 1-phosphate <=> Diphosphate + GDP-mannose	GTP:alpha-D-mannose-1-phosphate guanylyltransferase
R00888	GDP-mannose <=> GDP-4-dehydro-6-deoxy-D-mannose + H2O	GDP-alpha-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-alpha-D-rhamnose-forming)

Table of KEGG human pathways containing GDP-mannose

Pathway ID	Human Pathway	# of reactions
hsa00051	Fructose and mannose metabolism	2
hsa00520	Amino sugar and nucleotide sugar metabolism	2
hsa00510	N-Glycan biosynthesis	1
hsa01100	Metabolic pathways	1