RefMet Compound Details

RefMet ID, RefMet name, exact mass and formula
RefMet ID	RM0135888
RefMet name	Glycine
Systematic name	2-aminoacetic acid
Synonyms	PubChem Synonyms
Exact mass	75.032029 (neutral)	Calculate m/z: (Choose adduct) [M+H]+ [M+H-H2O]+ [M.]+ [M+2H]2+ [M+3H]3+ [M+4H]4+ [M+K]+ [M+2K]2+ [M+2K-H]+ [M+Na]+ [M+2Na]2+ [M+2Na-H]+ [M+Li]+ [M+2Li]2+ [M+NH4]+ [M.CH3]+ [M+Ag]+ [M+H+CH3OH]+ [M+H+CH3CN]+ [M+H+2CH3CN]+ [M+Na+CH3CN]+ [M.NaFormate+H]+ [M.NH4Formate+H]+ [M.TMSi]+ [M.tBuDMSi]+ [M+H-Hexose]+ [M+H-EtnP]+ [M+H-SerP]+ [M-H]- [M-H-H2O]- [M-CH3]- [M-2H]2- [M-3H]3- [M-4H]4- [M+Cl]- [M+OAc]- [M+Na-2H]- [M+K-2H]- [M.Formate]- [M.NaFormate-H]- [M.NH4Formate-H]- [M.F]- [M-H-Ser]- [M.HF2]- M(neutral)    View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
Formula	C2H5NO2	View other entries in RefMet with this formula
Molecular descriptors
Molfile	37085 (Download molfile/View MW Metabolite Database details)
InChI	InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKey	DHMQDGOQFOQNFH-UHFFFAOYSA-N	View other enantiomers/diastereomers of this metabolite in RefMet
SMILES	C(C(=O)O)N Run Tanimoto similarity search (with similarity coefficient >=0.6)
Chemical/Biochemical Classification
Super Class	Organic acids
Main Class	Amino acids and peptides
Sub Class	Amino acids
Distribution of Glycine in NMDR studies
Species	Plot Species distribution
Sample source	Plot Sample source(tissue) distribution
Platform	Platform (MS/NMR) used for detection
Chromatography	Chromatography methods used for detection
Studies	NMDR Studies reporting Glycine
External Links
Pubchem CID	750
ChEBI ID	15428
KEGG ID	C00037
HMDB ID	HMDB0000123
Chemspider ID	730
MetaCyc ID	GLY
EPA CompTox	DTXCID90667
PhytoHub DB	PHUB002356
Spectral data for Glycine standards
BMRB ID(NMR)	View NMR spectra
NP-MRD ID(NMR)	View NMR spectra
MassBank(EU)	View MS spectra
Structural annotation level
Annotation level	1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Glycine

Rxn ID	KEGG Reaction	Enzyme
R00366	Glycine + H2O + Oxygen <=> Glyoxylate + Ammonia + Hydrogen peroxide	glycine:oxygen oxidoreductase (deaminating)
R00367	S-Adenosyl-L-methionine + Glycine <=> S-Adenosyl-L-homocysteine + Sarcosine	S-Adenosyl-L-methionine:glycine N-methyltransferase
R00371	Acetyl-CoA + Glycine <=> CoA + L-2-Amino-3-oxobutanoic acid	Acetyl-CoA:glycine C-acetyltransferase
R00372	Glycine + 2-Oxoglutarate <=> Glyoxylate + L-Glutamate	Glycine:2-oxoglutarate aminotransferase
R00565	L-Arginine + Glycine <=> L-Ornithine + Guanidinoacetate	L-Arginine:glycine amidinotransferase
R00588	L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine	L-Serine:glyoxylate aminotransferase
R00610	Sarcosine + H2O + Oxygen <=> Glycine + Formaldehyde + Hydrogen peroxide	sarcosine:oxygen oxidoreductase (demethylating)
R00611	Sarcosine + Electron-transferring flavoprotein + H2O <=> Glycine + Formaldehyde + Reduced electron-transferring flavoprotein	sarcosine:electron-transfer flavoprotein oxidoreductase (demethylating)
R00830	Succinyl-CoA + Glycine <=> 5-Aminolevulinate + CoA + CO2	succinyl-CoA:glycine C-succinyltransferase (decarboxylating)
R00945	5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine	5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
R01221	Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+	glycine synthase
R03425	Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2	glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
R03654	ATP + Glycine + tRNA(Gly) <=> AMP + Diphosphate + Glycyl-tRNA(Gly)	glycine:tRNA(Gly) ligase (AMP-forming)
R12967	Sarcosine + Tetrahydrofolate + Oxygen <=> Glycine + 5,10-Methylenetetrahydrofolate + Hydrogen peroxide	sarcosine, 5,6,7,8-tetrahydrofolate:O2 oxidoreductase (demethylating,5,10-methylenetetrahydrofolate-forming)
R13029	Sarcosine + 2 Oxidized ferredoxin + H2O <=> Glycine + Formaldehyde + 2 Reduced ferredoxin + 2 H+	sarcosine:ferredoxin oxidoreductase (demethylating)

Table of KEGG human pathways containing Glycine

Pathway ID	Human Pathway	# of reactions
hsa00260	Glycine, serine and threonine metabolism	11
hsa00630	Glyoxylate and dicarboxylate metabolism	3
hsa01100	Metabolic pathways	3
hsa01200	Carbon metabolism	3
hsa00480	Glutathione metabolism	2
hsa01230	Biosynthesis of amino acids	1
hsa00670	One carbon pool by folate	1
hsa00860	Porphyrin and chlorophyll metabolism	1
hsa00970	Aminoacyl-tRNA biosynthesis	1
hsa00120	Primary bile acid biosynthesis	1