RefMet Compound Details

MW structure50967 (View MW Metabolite Database details)
RefMet nameHomocysteine
Systematic name2-amino-4-sulfanylbutanoic acid
Canonical SMILESN[C@@H](CCS)C(O)=O
Exact mass135.0354View other entries in RefMet with this exact mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
FormulaC4H9NO2SView other entries in RefMet with this formula
InChIInChI=1S/C4H9NO2S/c5-3(1-2-8)4(6)7/h3,8H,1-2,5H2,(H,6,7)/t3-/m0/s1
InChIKeyFFFHZYDWPBMWHY-VKHMYHEASA-NView other enantiomers/diastereomers of this metabolite in RefMet
Super ClassOrganic acids
Main ClassAmino acids and peptides
Sub ClassAmino acids
Pubchem CID91552

Table of KEGG reactions in human pathways involving Homocysteine

Rxn IDKEGG ReactionEnzyme
R00192 S-Adenosyl-L-homocysteine + H2O <=> Adenosine + L-HomocysteineS-Adenosyl-L-homocysteine hydrolase
R01286 L-Cystathionine + H2O <=> L-Homocysteine + Ammonia + PyruvateL-cystathionine L-homocysteine-lyase (deaminating
R02821 Betaine + L-Homocysteine <=> N,N-Dimethylglycine + L-MethionineTrimethylaminoacetate:L-homosysteine S-methyltransferase
R01290 L-Serine + L-Homocysteine <=> L-Cystathionine + H2OL-serine hydro-lyase (adding homocysteine
R00946 5-Methyltetrahydrofolate + L-Homocysteine <=> Tetrahydrofolate + L-Methionine5-Methyltetrahydrofolate:L-homocysteine S-methyltransferase
R00650 S-Adenosyl-L-methionine + L-Homocysteine <=> S-Adenosyl-L-homocysteine + L-MethionineS-Adenosyl-L-methionine:L-homocysteine S-methyltransferase
R04405 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
R10305 O-Acetyl-L-serine + L-Homocysteine <=> L-Cystathionine + AcetateO3-acetyl-L-serine:L-homocysteine S-(2-amino-2-carboxyethyl)transferase

Table of KEGG human pathways containing Homocysteine

Pathway IDHuman Pathway# of reactions
hsa00270 Cysteine and methionine metabolism 6
hsa00260 Glycine, serine and threonine metabolism 2
hsa00670 One carbon pool by folate 1
hsa01230 Biosynthesis of amino acids 1
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