RefMet Compound Details

RefMet ID, RefMet name, exact mass and formula
RefMet IDRM0161726
RefMet nameMethionine
Systematic name(2S)-2-amino-4-(methylsulfanyl)butanoic acid
SynonymsPubChem Synonyms
Exact mass149.051051 (neutral)
Calculate m/z:   
View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
FormulaC5H11NO2SView other entries in RefMet with this formula
Molecular descriptors
Molfile37371 (Download molfile/View MW Metabolite Database details)
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-NView other enantiomers/diastereomers of this metabolite in RefMet
SMILESCSCC[C@@H](C(=O)O)N
Run Tanimoto similarity search (with similarity coefficient >=0.6)
Chemical/Biochemical Classification
Super ClassOrganic acids
Main ClassAmino acids and peptides
Sub ClassAmino acids
Distribution of Methionine in NMDR studies
SpeciesPlot Species distribution
Sample sourcePlot Sample source(tissue) distribution
PlatformPlatform (MS/NMR) used for detection
ChromatographyChromatography methods used for detection
StudiesNMDR Studies reporting Methionine
External Links
Pubchem CID6137
ChEBI ID16643
KEGG IDC00073
HMDB IDHMDB0000696
Chemspider ID5907
MetaCyc IDMET
EPA CompToxDTXCID50821
Spectral data for Methionine standards
BMRB ID(NMR)View NMR spectra
NP-MRD ID(NMR)View NMR spectra
MassBank(EU)View MS spectra
Structural annotation level
Annotation level1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Methionine

Rxn IDKEGG ReactionEnzyme
R00177 Orthophosphate + Diphosphate + S-Adenosyl-L-methionine <=> ATP + L-Methionine + H2OATP:L-methionine S-adenosyltransferase
R00648 L-Methionine + H2O + Oxygen <=> 4-Methylthio-2-oxobutanoic acid + Ammonia + Hydrogen peroxideL-Methionine:oxygen oxidoreductase (deaminating)
R00650 S-Adenosyl-L-methionine + L-Homocysteine <=> S-Adenosyl-L-homocysteine + L-MethionineS-Adenosyl-L-methionine:L-homocysteine S-methyltransferase
R00946 5-Methyltetrahydrofolate + L-Homocysteine <=> Tetrahydrofolate + L-Methionine5-Methyltetrahydrofolate:L-homocysteine S-methyltransferase
R02821 Betaine + L-Homocysteine <=> N,N-Dimethylglycine + L-MethionineTrimethylaminoacetate:L-homosysteine S-methyltransferase
R03659 ATP + L-Methionine + tRNA(Met) <=> AMP + Diphosphate + L-Methionyl-tRNAL-Methionine:tRNAMet ligase (AMP-forming)
R04405 5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine5-Methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
R07396 4-Methylthio-2-oxobutanoic acid + L-Glutamate <=> L-Methionine + 2-Oxoglutarate4-Methylthio-2-oxobutanoic acid + L-Glutamate <=> L-Methionine + 2-Oxoglutarate
R12055 L-Methionine + Indolepyruvate <=> 4-Methylthio-2-oxobutanoic acid + L-TryptophanL-methionine:indole-3-pyruvic acid aminotransferase

Table of KEGG human pathways containing Methionine

Pathway IDHuman Pathway# of reactions
hsa00270 Cysteine and methionine metabolism 6
hsa01100 Metabolic pathways 2
hsa01230 Biosynthesis of amino acids 2
hsa00260 Glycine, serine and threonine metabolism 1
hsa00670 One carbon pool by folate 1
hsa00970 Aminoacyl-tRNA biosynthesis 1
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