RefMet Compound Details

MW structure37135 (View MW Metabolite Database details)
RefMet nameOxoglutaric acid
Systematic name2-oxopentanedioic acid
SMILESOC(=O)CCC(=O)C(O)=O
Exact mass146.021525 (neutral)
Calculate m/z:   
View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
FormulaC5H6O5View other entries in RefMet with this formula
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-NView other enantiomers/diastereomers of this metabolite in RefMet
Super ClassOrganic acids
Main ClassTCA acids
Sub ClassTCA acids
Pubchem CID51
Annotation level1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)
Human quantitationView measurements in targeted assays on human samples

Table of KEGG reactions in human pathways involving Oxoglutaric acid

Rxn IDKEGG ReactionEnzyme
R08549 2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+2-Oxoglutarate dehydrogenase complex
R00268 Oxalosuccinate <=> 2-Oxoglutarate + CO2oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
R01197 2 Reduced ferredoxin + Succinyl-CoA + CO2 + 2 H+ <=> 2 Oxidized ferredoxin + 2-Oxoglutarate + CoA2-oxoglutarate:ferredoxin oxidoreductase (decarboxylating)
R00093 2 L-Glutamate + NAD+ <=> L-Glutamine + 2-Oxoglutarate + NADH + H+L-glutamate:NAD+ oxidoreductase (transaminating)
R03534 2-Hydroxyglutarate + FAD <=> 2-Oxoglutarate + FADH22-Hydroxyglutarate:(acceptor) 2-oxidoreductase
R00269 2-Oxoglutaramate + H2O <=> 2-Oxoglutarate + Ammonia2-oxoglutaramate amidohydrolase
R00114 2 L-Glutamate + NADP+ <=> L-Glutamine + 2-Oxoglutarate + NADPH + H+L-glutamate:NADP+ oxidoreductase (transaminating)
R00709 Isocitrate + NAD+ <=> 2-Oxoglutarate + CO2 + NADH + H+isocitrate:NAD+ oxidoreductase (decarboxylating)
R00267 Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+Isocitrate:NADP+ oxidoreductase (decarboxylating)
R00248 L-Glutamate + NADP+ + H2O <=> 2-Oxoglutarate + Ammonia + NADPH + H+L-glutamate:NADP+ oxidoreductase (deaminating)
R00243 L-Glutamate + NAD+ + H2O <=> 2-Oxoglutarate + Ammonia + NADH + H+L-glutamate:NAD+ oxidoreductase (deaminating)

Table of KEGG human pathways containing Oxoglutaric acid

Pathway IDHuman Pathway# of reactions
hsa00260 Glycine, serine and threonine metabolism 2
hsa01200 Carbon metabolism 2
hsa00020 Citrate cycle (TCA cycle) 2
hsa01210 2-Oxocarboxylic acid metabolism 1
hsa00480 Glutathione metabolism 1
hsa00250 Alanine, aspartate and glutamate metabolism 1
hsa00650 Butanoate metabolism 1
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