RefMet Compound Details

RefMet IDRM0018304
MW structure52634 (View MW Metabolite Database details)
RefMet nameSapropterin   Species distribution   Sample source distribution
Systematic name(6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one
SMILESC[C@@H]([C@@H]([C@H]1CNc2c(c(=O)[nH]c(N)n2)N1)O)O   Run Tanimoto similarity search (with similarity coefficient >=0.6)
Exact mass241.117489 (neutral)
Calculate m/z:   
View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
FormulaC9H15N5O3View other entries in RefMet with this formula
InChIInChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17)/t3-,4+,6-/m0/s1
InChIKeyFNKQXYHWGSIFBK-RPDRRWSUSA-NView other enantiomers/diastereomers of this metabolite in RefMet
Super ClassOrganoheterocyclic compounds
Main ClassPterins
Sub ClassBiopterins
Pubchem CID135398654
ChEBI ID59560
Annotation level1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Sapropterin

Rxn IDKEGG ReactionEnzyme
R01793 Dihydrobiopterin + NADH + H+ <=> Tetrahydrobiopterin + NAD+5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase
R01794 Dihydrobiopterin + NADPH + H+ <=> Tetrahydrobiopterin + NADP+5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase
R01813 Tetrahydrobiopterin + NADP+ <=> 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+tetrahydrobiopterin:NADP+ oxidoreductase
R07211 L-Phenylalanine + Tetrahydrobiopterin + Oxygen <=> L-Tyrosine + 4a-HydroxytetrahydrobiopterinL-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating)
R07212 L-Tyrosine + Tetrahydrobiopterin + Oxygen <=> 3,4-Dihydroxy-L-phenylalanine + 4a-HydroxytetrahydrobiopterinL-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase(3-hydroxylating)
R07213 L-Tryptophan + Tetrahydrobiopterin + Oxygen <=> 5-Hydroxy-L-tryptophan + 4a-HydroxytetrahydrobiopterinL-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)
R08208 Tetrahydrobiopterin + 2 NADP+ <=> 6-Pyruvoyltetrahydropterin + 2 NADPH + 2 H+tetrahydrobiopterin:NADP+ oxidoreductase (6-pyruvoyltetrahydropterin-forming)
R11764 Tetrahydrobiopterin + NADP+ <=> 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin + NADPH + H+tetrahydrobiopterin:NADP+ oxidoreductase [6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin-forming]
R11765 Tetrahydrobiopterin + NADP+ <=> 7,8-Dihydrobiopterin + NADPH + H+tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming)

Table of KEGG human pathways containing Sapropterin

Pathway IDHuman Pathway# of reactions
hsa00790 Folate biosynthesis 9
hsa01100 Metabolic pathways 2
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