RefMet Compound Details
RefMet ID | RM0018304 | |
---|---|---|
MW structure | 52634 (View MW Metabolite Database details) | |
RefMet name | Sapropterin Species distribution Sample source distribution | |
Systematic name | (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one | |
SMILES | C[C@@H]([C@@H]([C@H]1CNc2c(c(=O)[nH]c(N)n2)N1)O)O Run Tanimoto similarity search (with similarity coefficient >=0.6) | |
Exact mass | 241.117489 (neutral) |
Table of KEGG reactions in human pathways involving Sapropterin
Rxn ID | KEGG Reaction | Enzyme |
---|---|---|
R01793 | Dihydrobiopterin + NADH + H+ <=> Tetrahydrobiopterin + NAD+ | 5,6,7,8-tetrahydrobiopterin:NAD+ oxidoreductase |
R01794 | Dihydrobiopterin + NADPH + H+ <=> Tetrahydrobiopterin + NADP+ | 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase |
R01813 | Tetrahydrobiopterin + NADP+ <=> 6-Lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+ | tetrahydrobiopterin:NADP+ oxidoreductase |
R07211 | L-Phenylalanine + Tetrahydrobiopterin + Oxygen <=> L-Tyrosine + 4a-Hydroxytetrahydrobiopterin | L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase(4-hydroxylating) |
R07212 | L-Tyrosine + Tetrahydrobiopterin + Oxygen <=> 3,4-Dihydroxy-L-phenylalanine + 4a-Hydroxytetrahydrobiopterin | L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase(3-hydroxylating) |
R07213 | L-Tryptophan + Tetrahydrobiopterin + Oxygen <=> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin | L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating) |
R08208 | Tetrahydrobiopterin + 2 NADP+ <=> 6-Pyruvoyltetrahydropterin + 2 NADPH + 2 H+ | tetrahydrobiopterin:NADP+ oxidoreductase (6-pyruvoyltetrahydropterin-forming) |
R11764 | Tetrahydrobiopterin + NADP+ <=> 6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin + NADPH + H+ | tetrahydrobiopterin:NADP+ oxidoreductase [6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin-forming] |
R11765 | Tetrahydrobiopterin + NADP+ <=> 7,8-Dihydrobiopterin + NADPH + H+ | tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming) |
Table of KEGG human pathways containing Sapropterin
Pathway ID | Human Pathway | # of reactions |
---|---|---|
hsa00790 | Folate biosynthesis | 9 |
hsa01100 | Metabolic pathways | 2 |