RefMet Compound Details

RefMet ID, RefMet name, exact mass and formula
RefMet ID	RM0032433
RefMet name	Serine
Systematic name	(2S)-2-amino-3-hydroxypropanoic acid
Synonyms	PubChem Synonyms
Exact mass	105.042594 (neutral)	Calculate m/z: (Choose adduct) [M+H]+ [M+H-H2O]+ [M.]+ [M+2H]2+ [M+3H]3+ [M+4H]4+ [M+K]+ [M+2K]2+ [M+2K-H]+ [M+Na]+ [M+2Na]2+ [M+2Na-H]+ [M+Li]+ [M+2Li]2+ [M+NH4]+ [M.CH3]+ [M+Ag]+ [M+H+CH3OH]+ [M+H+CH3CN]+ [M+H+2CH3CN]+ [M+Na+CH3CN]+ [M.NaFormate+H]+ [M.NH4Formate+H]+ [M.TMSi]+ [M.tBuDMSi]+ [M+H-Hexose]+ [M+H-EtnP]+ [M+H-SerP]+ [M-H]- [M-H-H2O]- [M-CH3]- [M-2H]2- [M-3H]3- [M-4H]4- [M+Cl]- [M+OAc]- [M+Na-2H]- [M+K-2H]- [M.Formate]- [M.NaFormate-H]- [M.NH4Formate-H]- [M.F]- [M-H-Ser]- [M.HF2]- M(neutral)    View other RefMet entries with this exact (neutral) mass:   +/- 0.05 amu   +/- 0.1 amu   +/- 0.2 amu   +/- 0.5 amu
Formula	C3H7NO3	View other entries in RefMet with this formula
Molecular descriptors
Molfile	37123 (Download molfile/View MW Metabolite Database details)
InChI	InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKey	MTCFGRXMJLQNBG-REOHCLBHSA-N	View other enantiomers/diastereomers of this metabolite in RefMet
SMILES	C([C@@H](C(=O)O)N)O Run Tanimoto similarity search (with similarity coefficient >=0.6)
Chemical/Biochemical Classification
Super Class	Organic acids
Main Class	Amino acids and peptides
Sub Class	Amino acids
Distribution of Serine in NMDR studies
Species	Plot Species distribution
Sample source	Plot Sample source(tissue) distribution
Platform	Platform (MS/NMR) used for detection
Chromatography	Chromatography methods used for detection
Studies	NMDR Studies reporting Serine
External Links
Pubchem CID	5951
ChEBI ID	17822
KEGG ID	C00065
HMDB ID	HMDB0000187
Chemspider ID	5736
MetaCyc ID	SER
EPA CompTox	DTXCID20202802
Spectral data for Serine standards
BMRB ID(NMR)	View NMR spectra
NP-MRD ID(NMR)	View NMR spectra
MassBank(EU)	View MS spectra
Structural annotation level
Annotation level	1   (1:Known structure; 2:Known regiochemistry; 3:Partial structure; 4:Sum-composition)

Table of KEGG reactions in human pathways involving Serine

Rxn ID	KEGG Reaction	Enzyme
R00220	L-Serine <=> Pyruvate + Ammonia	L-serine ammonia-lyase
R00582	O-Phospho-L-serine + H2O <=> L-Serine + Orthophosphate	O-phospho-L-serine phosphohydrolase
R00585	L-Serine + Pyruvate <=> Hydroxypyruvate + L-Alanine	L-Serine:pyruvate aminotransferase
R00588	L-Serine + Glyoxylate <=> Hydroxypyruvate + Glycine	L-Serine:glyoxylate aminotransferase
R00589	L-Serine <=> D-Serine	serine racemase
R00590	L-Serine <=> Dehydroalanine + H2O	L-serine hydro-lyase
R00891	L-Serine + Hydrogen sulfide <=> L-Cysteine + H2O	L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)
R00945	5,10-Methylenetetrahydrofolate + Glycine + H2O <=> Tetrahydrofolate + L-Serine	5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
R01290	L-Serine + L-Homocysteine <=> L-Cystathionine + H2O	L-serine hydro-lyase (adding homocysteine
R03662	ATP + L-Serine + tRNA(Ser) <=> AMP + Diphosphate + L-Seryl-tRNA(Ser)	L-Serine:tRNA(Ser) ligase (AMP-forming)
R08218	ATP + L-Serine + tRNA(Sec) <=> AMP + Diphosphate + L-Seryl-tRNA(Sec)	L-serine:tRNASec ligase (AMP-forming)
R09099	L-Serine + 5,6,7,8-Tetrahydromethanopterin <=> 5,10-Methylenetetrahydromethanopterin + Glycine + H2O	5,10-methylenetetrahydromethanopterin:glycine hydroxymethyltransferase
R12342	ADP + L-Serine <=> AMP + O-Phospho-L-serine	ADP:L-serine 3-phosphotransferase
R12344	ATP + L-Serine <=> ADP + O-Phospho-L-serine	ATP:L-serine 3-phosphotransferase

Table of KEGG human pathways containing Serine

Pathway ID	Human Pathway	# of reactions
hsa00260	Glycine, serine and threonine metabolism	8
hsa01230	Biosynthesis of amino acids	4
hsa01200	Carbon metabolism	4
hsa01100	Metabolic pathways	3
hsa00630	Glyoxylate and dicarboxylate metabolism	2
hsa00970	Aminoacyl-tRNA biosynthesis	2
hsa00270	Cysteine and methionine metabolism	2
hsa00670	One carbon pool by folate	1
hsa00600	Sphingolipid metabolism	1