Summary of Study ST001507
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR001017. The data can be accessed directly via it's Project DOI: 10.21228/M87M4S This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
| Study ID | ST001507 |
| Study Title | Hepatic [U-13C]Lactate tracing and metabolomics in young and old WT and SIRT6 overexpressing mice |
| Study Summary | Our previous data had suggested that gluconeogenesis capacity from the precursors lactate and glycerol declines in old C57BL/6 mice. This decline was rescued by whole body SIRT6 overexpression. Since the liver is the main gluconeogenic organ, we performed here liver metabolomics in young (6 months) versus old (20-24 months) WT and SIRT6-transgenic mice. We used liver tissues of 6h morning-fasted mice, either in naïve state or 15 minutes after intraperitoneal injection of 1mg/kg [U-13C]Lactate. |
| Institute | Bar Ilan University |
| Department | The Mina & Everard Goodman Faculty of Life Sciences |
| Laboratory | Laboratory of Prof. Haim Cohen |
| Last Name | Cohen |
| First Name | Chaim |
| Address | Bar Ilan University, Ramat Gan, Israel, 5290002 |
| Haim.Cohen@biu.ac.il | |
| Phone | +97235318383 |
| Submit Date | 2020-10-06 |
| Num Groups | 8 |
| Total Subjects | 40 |
| Raw Data Available | Yes |
| Raw Data File Type(s) | raw(Thermo) |
| Analysis Type Detail | LC-MS |
| Release Date | 2021-03-11 |
| Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Mammal; Subject species: Mus musculus (Factor headings shown in green)
| mb_sample_id | local_sample_id | Age |
|---|---|---|
| SA126674 | 93_Old_Liver_25a | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126675 | 94_Old_Liver_25b | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126676 | 89_Old_Liver_23c | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126677 | 87_Old_Liver_23a | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126678 | 83_Old_Liver_21c | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126679 | 95_Old_Liver_25c | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126680 | 88_Old_Liver_23b | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126681 | 102_Old_Liver_28a | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126682 | 109_Old_Liver_30b | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126683 | 110_Old_Liver_30c | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126684 | 108_Old_Liver_30a | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126685 | 104_Old_Liver_28c | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126686 | 103_Old_Liver_28b | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126687 | 82_Old_Liver_21b | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126688 | 81_Old_Liver_21a | Old | Genotype:SIRT6-tg | Treatment:N/A |
| SA126689 | 121_Old_Liver_34b | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126690 | 122_Old_Liver_34c | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126691 | 131_Old_Liver_37c | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126692 | 130_Old_Liver_37b | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126693 | 112_Old_Liver_31b | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126694 | 129_Old_Liver_37a | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126695 | 125_Old_Liver_35c | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126696 | 135_Old_Liver_39a | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126697 | 111_Old_Liver_31a | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126698 | 113_Old_Liver_31c | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126699 | 123_Old_Liver_35a | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126700 | 124_Old_Liver_35b | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126701 | 136_Old_Liver_39b | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126702 | 137_Old_Liver_39c | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126703 | 120_Old_Liver_34a | Old | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126704 | 105_Old_Liver_29a | Old | Genotype:Wild-type | Treatment:N/A |
| SA126705 | 107_Old_Liver_29c | Old | Genotype:Wild-type | Treatment:N/A |
| SA126706 | 106_Old_Liver_29b | Old | Genotype:Wild-type | Treatment:N/A |
| SA126707 | 90_Old_Liver_24a | Old | Genotype:Wild-type | Treatment:N/A |
| SA126708 | 101_Old_Liver_27c | Old | Genotype:Wild-type | Treatment:N/A |
| SA126709 | 98_Old_Liver_26c | Old | Genotype:Wild-type | Treatment:N/A |
| SA126710 | 86_Old_Liver_22c | Old | Genotype:Wild-type | Treatment:N/A |
| SA126711 | 92_Old_Liver_24c | Old | Genotype:Wild-type | Treatment:N/A |
| SA126712 | 91_Old_Liver_24b | Old | Genotype:Wild-type | Treatment:N/A |
| SA126713 | 85_Old_Liver_22b | Old | Genotype:Wild-type | Treatment:N/A |
| SA126714 | 84_Old_Liver_22a | Old | Genotype:Wild-type | Treatment:N/A |
| SA126715 | 99_Old_Liver_27a | Old | Genotype:Wild-type | Treatment:N/A |
| SA126716 | 97_Old_Liver_26b | Old | Genotype:Wild-type | Treatment:N/A |
| SA126717 | 96_Old_Liver_26a | Old | Genotype:Wild-type | Treatment:N/A |
| SA126718 | 100_Old_Liver_27b | Old | Genotype:Wild-type | Treatment:N/A |
| SA126719 | 117_Old_Liver_33a | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126720 | 132_Old_Liver_38a | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126721 | 128_Old_Liver_36c | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126722 | 114_Old_Liver_32a | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126723 | 133_Old_Liver_38b | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126724 | 134_Old_Liver_38c | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126725 | 140_Old_Liver_40c | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126726 | 139_Old_Liver_40b | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126727 | 138_Old_Liver_40a | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126728 | 126_Old_Liver_36a | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126729 | 127_Old_Liver_36b | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126730 | 119_Old_Liver_33c | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126731 | 116_Old_Liver_32c | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126732 | 115_Old_Liver_32b | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126733 | 118_Old_Liver_33b | Old | Genotype:Wild-type | Treatment:[U-13C]Lactate |
| SA126734 | 03_Young_Liver_1c | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126735 | 02_Young_Liver_1b | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126736 | 14_Young_Liver_4b | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126737 | 06_Young_Liver_2b | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126738 | 13_Young_Liver_4a | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126739 | 07_Young_Liver_2c | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126740 | 05_Young_Liver_2a | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126741 | 15_Young_Liver_4c | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126742 | 38_Young_Liver_10b | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126743 | 01_Young_Liver_1a | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126744 | 37_Young_Liver_10a | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126745 | 39_Young_Liver_10c | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126746 | 34_Young_Liver_9b | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126747 | 33_Young_Liver_9a | Young | Genotype:SIRT6-tg | Treatment:N/A |
| SA126748 | 62_Young_Liver_16b | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126749 | 63_Young_Liver_16c | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126750 | 66_Young_Liver_17b | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126751 | 61_Young_Liver_16a | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126752 | 65_Young_Liver_17a | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126753 | 54_Young_Liver_14b | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126754 | 53_Young_Liver_14a | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126755 | 67_Young_Liver_17c | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126756 | 55_Young_Liver_14c | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126757 | 57_Young_Liver_15a | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126758 | 59_Young_Liver_15c | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126759 | 58_Young_Liver_15b | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126760 | 69_Young_Liver_18a | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126761 | 71_Young_Liver_18c | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126762 | 70_Young_Liver_18b | Young | Genotype:SIRT6-tg | Treatment:[U-13C]Lactate |
| SA126763 | 17_Young_Liver_5a | Young | Genotype:Wild-type | Treatment:N/A |
| SA126764 | 31_Young_Liver_8c | Young | Genotype:Wild-type | Treatment:N/A |
| SA126765 | 18_Young_Liver_5b | Young | Genotype:Wild-type | Treatment:N/A |
| SA126766 | 11_Young_Liver_3c | Young | Genotype:Wild-type | Treatment:N/A |
| SA126767 | 21_Young_Liver_6a | Young | Genotype:Wild-type | Treatment:N/A |
| SA126768 | 30_Young_Liver_8b | Young | Genotype:Wild-type | Treatment:N/A |
| SA126769 | 19_Young_Liver_5c | Young | Genotype:Wild-type | Treatment:N/A |
| SA126770 | 27_Young_Liver_7c | Young | Genotype:Wild-type | Treatment:N/A |
| SA126771 | 09_Young_Liver_3a | Young | Genotype:Wild-type | Treatment:N/A |
| SA126772 | 25_Young_Liver_7a | Young | Genotype:Wild-type | Treatment:N/A |
| SA126773 | 23_Young_Liver_6c | Young | Genotype:Wild-type | Treatment:N/A |
