Summary of Study ST000912

This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000631. The data can be accessed directly via it's Project DOI: 10.21228/M83T1G This work is supported by NIH grant, U2C- DK119886.

See: https://www.metabolomicsworkbench.org/about/howtocite.php

This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.

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Study IDST000912
Study TitleInsights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part III)
Study SummaryMyalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling illness characterized by six months or more of unexplained profound fatigue with post-exertional malaise, sleep abnormalities, cognitive dysfunction and autonomic disturbances. Focusing on the pathogenesis of central nervous system abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid (CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another fatiguing illness, and 19 healthy subjects with no neurological disease (ND). MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three untargeted metabolomic assays for primary metabolites, biogenic amines and complex lipids were performed with gas chromatography time-of-flight (GC-TOF) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS subjects with reduced levels in ME/CFS compared to both MS and ND subjects. Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher (cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with integration of both metabolomics and cytokine analyses (cross-validated AUC 0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of ME/CFS, and may enable new methods for diagnosis and insight into cognitive and autonomic disturbances in this syndrome.
Institute
University of California, Davis
DepartmentGenome and Biomedical Sciences Facility
LaboratoryWCMC Metabolomics Core
Last NameFiehn
First NameOliver
Address1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616
Emailofiehn@ucdavis.edu
Phone(530) 754-8258
Submit Date2017-12-11
Raw Data AvailableYes
Raw Data File Type(s)d
Analysis Type DetailLC-MS
Release Date2020-06-03
Release Version1
Oliver Fiehn Oliver Fiehn
https://dx.doi.org/10.21228/M83T1G
ftp://www.metabolomicsworkbench.org/Studies/ application/zip

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Factors:

Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)

mb_sample_id local_sample_id Diagnosis
SA053588Lipkin019_negCSH_DPCSF3671_034.dMECFS | Sex:FEMALE
SA053589Lipkin048_negCSH_DPCSF7598_086.dMECFS | Sex:FEMALE
SA053590Lipkin069_negCSH_DPCSF3712_009.dMECFS | Sex:FEMALE
SA053591Lipkin081_negCSH_DPCSF7638_068.dMECFS | Sex:FEMALE
SA053592Lipkin120_negCSH_DPCSF3152_084.dMECFS | Sex:FEMALE
SA053593Lipkin028_negCSH_DPCSF8065_085.dMECFS | Sex:FEMALE
SA053594Lipkin100_negCSH_DPCSF6448_016.dMECFS | Sex:FEMALE
SA053595Lipkin016_negCSH_DPCSF3752_069.dMECFS | Sex:FEMALE
SA053596Lipkin097_negCSH_DPCSF4353_065.dMECFS | Sex:FEMALE
SA053597Lipkin004_negCSH_DPCSF6529_083.dMECFS | Sex:FEMALE
SA053598Lipkin044_negCSH_DPCSF6143_067.dMECFS | Sex:FEMALE
SA053599Lipkin078_negCSH_DPCSF5981_073.dMECFS | Sex:FEMALE
SA053600Lipkin076_negCSH_DPCSF5502_070.dMECFS | Sex:FEMALE
SA053601Lipkin093_negCSH_DPCSF7263_094.dMECFS | Sex:FEMALE
SA053602Lipkin064_negCSH_DPCSF5421_088.dMECFS | Sex:FEMALE
SA053603Lipkin003_negCSH_DPCSF2216_007.dMECFS | Sex:FEMALE
SA053604Lipkin105_negCSH_DPCSF7944_046.dMECFS | Sex:FEMALE
SA053605Lipkin109_negCSH_DPCSF1870_082.dMECFS | Sex:FEMALE
SA053606Lipkin010_negCSH_DPCSF9145_018.dMECFS | Sex:FEMALE
SA053607Lipkin096_negCSH_DPCSF9226_039.dMECFS | Sex:FEMALE
SA053608Lipkin080_negCSH_DPCSF8371_014.dMECFS | Sex:FEMALE
SA053609Lipkin074_negCSH_DPCSF1495_036.dMECFS | Sex:MALE
SA053610Lipkin041_negCSH_DPCSF6765_032.dMECFS | Sex:MALE
SA053611Lipkin077_negCSH_DPCSF7476_001.dMECFS | Sex:MALE
SA053612Lipkin071_negCSH_DPCSF1576_044.dMECFS | Sex:MALE
SA053613Lipkin107_negCSH_DPCSF9012_005.dMECFS | Sex:MALE
SA053614Lipkin072_negCSH_DPCSF7863_071.dMECFS | Sex:MALE
SA053615Lipkin001_negCSH_DPCSF0426_003.dMECFS | Sex:MALE
SA053616Lipkin066_negCSH_DPCSF2603_048.dMECFS | Sex:MALE
SA053617Lipkin103_negCSH_DPCSF9826_042.dMECFS | Sex:MALE
SA053618Lipkin110_negCSH_DPCSF2938_066.dMECFS | Sex:MALE
SA053619Lipkin037_negCSH_DPCSF3285_072.dMECFS | Sex:MALE
SA053620Lipkin011_negCSH_DPCSF6890_090.dMS | Sex:FEMALE
SA053621Lipkin101_negCSH_DPCSF9292_037.dMS | Sex:FEMALE
SA053622Lipkin075_negCSH_DPCSF9627_092.dMS | Sex:FEMALE
SA053623Lipkin106_negCSH_DPCSF6902_103.dMS | Sex:FEMALE
SA053624Lipkin023_negCSH_DPCSF9506_013.dMS | Sex:FEMALE
SA053625Lipkin099_negCSH_DPCSF6688_062.dMS | Sex:FEMALE
SA053626Lipkin068_negCSH_DPCSF8824_081.dMS | Sex:FEMALE
SA053627Lipkin030_negCSH_DPCSF7877_079.dMS | Sex:FEMALE
SA053628Lipkin053_negCSH_DPCSF7970_102.dMS | Sex:FEMALE
SA053629Lipkin117_negCSH_DPCSF8397_025.dMS | Sex:FEMALE
SA053630Lipkin032_negCSH_DPCSF8478_008.dMS | Sex:FEMALE
SA053631Lipkin091_negCSH_DPCSF8692_015.dMS | Sex:FEMALE
SA053632Lipkin090_negCSH_DPCSF7410_043.dMS | Sex:FEMALE
SA053633Lipkin094_negCSH_DPCSF8183_080.dMS | Sex:FEMALE
SA053634Lipkin029_negCSH_DPCSF7318_087.dMS | Sex:FEMALE
SA053635Lipkin057_negCSH_DPCSF6088_055.dMS | Sex:FEMALE
SA053636Lipkin046_negCSH_DPCSF1896_029.dMS | Sex:FEMALE
SA053637Lipkin087_negCSH_DPCSF3686_093.dMS | Sex:FEMALE
SA053638Lipkin119_negCSH_DPCSF4165_101.dMS | Sex:FEMALE
SA053639Lipkin007_negCSH_DPCSF4592_121.dMS | Sex:FEMALE
SA053640Lipkin014_negCSH_DPCSF1815_122.dMS | Sex:FEMALE
SA053641Lipkin027_negCSH_DPCSF1041_058.dMS | Sex:FEMALE
SA053642Lipkin089_negCSH_DPCSF0614_035.dMS | Sex:FEMALE
SA053643Lipkin042_negCSH_DPCSF0747_027.dMS | Sex:FEMALE
SA053644Lipkin104_negCSH_DPCSF0868_089.dMS | Sex:FEMALE
SA053645Lipkin049_negCSH_DPCSF4633_104.dMS | Sex:FEMALE
SA053646Lipkin063_negCSH_DPCSF3137_060.dMS | Sex:FEMALE
SA053647Lipkin052_negCSH_DPCSF5274_054.dMS | Sex:FEMALE
SA053648Lipkin118_negCSH_DPCSF1174_023.dMS | Sex:MALE
SA053649Lipkin065_negCSH_DPCSF8732_075.dMS | Sex:MALE
SA053650Lipkin033_negCSH_DPCSF5395_077.dMS | Sex:MALE
SA053651Lipkin035_negCSH_DPCSF5447_011.dMS | Sex:MALE
SA053652Lipkin031_negCSH_DPCSF4927_074.dMS | Sex:MALE
SA053653Lipkin067_negCSH_DPCSF6728_056.dMS | Sex:MALE
SA053654Lipkin102_negCSH_DPCSF0909_078.dMS | Sex:MALE
SA053655Lipkin018_negCSH_DPCSF9719_033.dMS | Sex:MALE
SA053656Lipkin020_negCSH_DPCSF2029_041.dMS | Sex:MALE
SA053657Lipkin086_negCSH_DPCSF7329_006.dMS | Sex:MALE
SA053658Lipkin050_negCSH_DPCSF7664_076.dMS | Sex:MALE
SA053659Lipkin045_negCSH_DPCSF7023_091.dMS | Sex:MALE
SA053660Lipkin036_negCSH_DPCSF6128_115.dND | Sex:FEMALE
SA053661Lipkin024_negCSH_DPCSF0106_108.dND | Sex:FEMALE
SA053662Lipkin034_negCSH_DPCSF0828_031.dND | Sex:FEMALE
SA053663Lipkin098_negCSH_DPCSF7115_106.dND | Sex:FEMALE
SA053664Lipkin005_negCSH_DPCSF7756_002.dND | Sex:FEMALE
SA053665Lipkin116_negCSH_DPCSF6769_051.dND | Sex:FEMALE
SA053666Lipkin113_negCSH_DPCSF6555_107.dND | Sex:FEMALE
SA053667Lipkin056_negCSH_DPCSF0146_105.dND | Sex:FEMALE
SA053668Lipkin108_negCSH_DPCSF2710_064.dND | Sex:FEMALE
SA053669Lipkin039_negCSH_DPCSF3310_047.dND | Sex:FEMALE
SA053670Lipkin009_negCSH_DPCSF9332_017.dND | Sex:FEMALE
SA053671Lipkin114_negCSH_DPCSF7797_045.dND | Sex:FEMALE
SA053672Lipkin084_negCSH_DPCSF1281_053.dND | Sex:FEMALE
SA053673Lipkin055_negCSH_DPCSF1215_019.dND | Sex:MALE
SA053674Lipkin059_negCSH_DPCSF2924_118.dND | Sex:MALE
SA053675Lipkin038_negCSH_DPCSF2750_120.dND | Sex:MALE
SA053676Lipkin092_negCSH_DPCSF2110_119.dND | Sex:MALE
SA053677Lipkin043_negCSH_DPCSF8865_117.dND | Sex:MALE
SA053678Lipkin051_negCSH_DPCSF3605_116.dND | Sex:MALE
Showing results 1 to 91 of 91
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