Summary of Study ST000912
This data is available at the NIH Common Fund's National Metabolomics Data Repository (NMDR) website, the Metabolomics Workbench, https://www.metabolomicsworkbench.org, where it has been assigned Project ID PR000631. The data can be accessed directly via it's Project DOI: 10.21228/M83T1G This work is supported by NIH grant, U2C- DK119886.
See: https://www.metabolomicsworkbench.org/about/howtocite.php
This study contains a large results data set and is not available in the mwTab file. It is only available for download via FTP as data file(s) here.
Study ID | ST000912 |
Study Title | Insights into the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) through metabolomic profiling of cerebrospinal fluid (part III) |
Study Summary | Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disabling illness characterized by six months or more of unexplained profound fatigue with post-exertional malaise, sleep abnormalities, cognitive dysfunction and autonomic disturbances. Focusing on the pathogenesis of central nervous system abnormalities in ME/CFS, we pursued metabolomics analysis of cerebrospinal fluid (CSF) in 32 ME/CFS cases, 40 subjects with multiple sclerosis (MS), another fatiguing illness, and 19 healthy subjects with no neurological disease (ND). MS/ND subjects were frequency matched for age and sex to ME/CFS subjects. Three untargeted metabolomic assays for primary metabolites, biogenic amines and complex lipids were performed with gas chromatography time-of-flight (GC-TOF) and liquid chromatography–tandem mass spectrometry (LC-MS/MS) yielding profiles for 525 known metabolites. Mannose was a cardinal biomarker in ME/CFS subjects with reduced levels in ME/CFS compared to both MS and ND subjects. Levels of acetylcarnitine were reduced in ME/CFS vs. MS subjects. The predictive power of metabolomic analysis for diagnosis of ME/CFS vs. ND was higher (cross-validated AUC 0.875; 95% CI: 0.726~0.949) than with cytokine analysis alone (cross-validated AUC 0.865; 95% CI: 0.673~0.952) and improved with integration of both metabolomics and cytokine analyses (cross-validated AUC 0.916; 95% CI: 0.791~0.969). Our findings confirm the biological basis of ME/CFS, and may enable new methods for diagnosis and insight into cognitive and autonomic disturbances in this syndrome. |
Institute | University of California, Davis |
Department | Genome and Biomedical Sciences Facility |
Laboratory | WCMC Metabolomics Core |
Last Name | Fiehn |
First Name | Oliver |
Address | 1315 Genome and Biomedical Sciences Facility, 451 Health Sciences Drive, Davis, CA 95616 |
ofiehn@ucdavis.edu | |
Phone | (530) 754-8258 |
Submit Date | 2017-12-11 |
Raw Data Available | Yes |
Raw Data File Type(s) | d |
Analysis Type Detail | LC-MS |
Release Date | 2020-06-03 |
Release Version | 1 |
Select appropriate tab below to view additional metadata details:
Factors:
Subject type: Human; Subject species: Homo sapiens (Factor headings shown in green)
mb_sample_id | local_sample_id | Diagnosis | Sex |
---|---|---|---|
SA053588 | Lipkin019_negCSH_DPCSF3671_034.d | MECFS | FEMALE |
SA053589 | Lipkin048_negCSH_DPCSF7598_086.d | MECFS | FEMALE |
SA053590 | Lipkin069_negCSH_DPCSF3712_009.d | MECFS | FEMALE |
SA053591 | Lipkin081_negCSH_DPCSF7638_068.d | MECFS | FEMALE |
SA053592 | Lipkin120_negCSH_DPCSF3152_084.d | MECFS | FEMALE |
SA053593 | Lipkin028_negCSH_DPCSF8065_085.d | MECFS | FEMALE |
SA053594 | Lipkin100_negCSH_DPCSF6448_016.d | MECFS | FEMALE |
SA053595 | Lipkin016_negCSH_DPCSF3752_069.d | MECFS | FEMALE |
SA053596 | Lipkin097_negCSH_DPCSF4353_065.d | MECFS | FEMALE |
SA053597 | Lipkin004_negCSH_DPCSF6529_083.d | MECFS | FEMALE |
SA053598 | Lipkin044_negCSH_DPCSF6143_067.d | MECFS | FEMALE |
SA053599 | Lipkin078_negCSH_DPCSF5981_073.d | MECFS | FEMALE |
SA053600 | Lipkin076_negCSH_DPCSF5502_070.d | MECFS | FEMALE |
SA053601 | Lipkin093_negCSH_DPCSF7263_094.d | MECFS | FEMALE |
SA053602 | Lipkin064_negCSH_DPCSF5421_088.d | MECFS | FEMALE |
SA053603 | Lipkin003_negCSH_DPCSF2216_007.d | MECFS | FEMALE |
SA053604 | Lipkin105_negCSH_DPCSF7944_046.d | MECFS | FEMALE |
SA053605 | Lipkin109_negCSH_DPCSF1870_082.d | MECFS | FEMALE |
SA053606 | Lipkin010_negCSH_DPCSF9145_018.d | MECFS | FEMALE |
SA053607 | Lipkin096_negCSH_DPCSF9226_039.d | MECFS | FEMALE |
SA053608 | Lipkin080_negCSH_DPCSF8371_014.d | MECFS | FEMALE |
SA053609 | Lipkin074_negCSH_DPCSF1495_036.d | MECFS | MALE |
SA053610 | Lipkin041_negCSH_DPCSF6765_032.d | MECFS | MALE |
SA053611 | Lipkin077_negCSH_DPCSF7476_001.d | MECFS | MALE |
SA053612 | Lipkin071_negCSH_DPCSF1576_044.d | MECFS | MALE |
SA053613 | Lipkin107_negCSH_DPCSF9012_005.d | MECFS | MALE |
SA053614 | Lipkin072_negCSH_DPCSF7863_071.d | MECFS | MALE |
SA053615 | Lipkin001_negCSH_DPCSF0426_003.d | MECFS | MALE |
SA053616 | Lipkin066_negCSH_DPCSF2603_048.d | MECFS | MALE |
SA053617 | Lipkin103_negCSH_DPCSF9826_042.d | MECFS | MALE |
SA053618 | Lipkin110_negCSH_DPCSF2938_066.d | MECFS | MALE |
SA053619 | Lipkin037_negCSH_DPCSF3285_072.d | MECFS | MALE |
SA053620 | Lipkin011_negCSH_DPCSF6890_090.d | MS | FEMALE |
SA053621 | Lipkin101_negCSH_DPCSF9292_037.d | MS | FEMALE |
SA053622 | Lipkin075_negCSH_DPCSF9627_092.d | MS | FEMALE |
SA053623 | Lipkin106_negCSH_DPCSF6902_103.d | MS | FEMALE |
SA053624 | Lipkin023_negCSH_DPCSF9506_013.d | MS | FEMALE |
SA053625 | Lipkin099_negCSH_DPCSF6688_062.d | MS | FEMALE |
SA053626 | Lipkin068_negCSH_DPCSF8824_081.d | MS | FEMALE |
SA053627 | Lipkin030_negCSH_DPCSF7877_079.d | MS | FEMALE |
SA053628 | Lipkin053_negCSH_DPCSF7970_102.d | MS | FEMALE |
SA053629 | Lipkin117_negCSH_DPCSF8397_025.d | MS | FEMALE |
SA053630 | Lipkin032_negCSH_DPCSF8478_008.d | MS | FEMALE |
SA053631 | Lipkin091_negCSH_DPCSF8692_015.d | MS | FEMALE |
SA053632 | Lipkin090_negCSH_DPCSF7410_043.d | MS | FEMALE |
SA053633 | Lipkin094_negCSH_DPCSF8183_080.d | MS | FEMALE |
SA053634 | Lipkin029_negCSH_DPCSF7318_087.d | MS | FEMALE |
SA053635 | Lipkin057_negCSH_DPCSF6088_055.d | MS | FEMALE |
SA053636 | Lipkin046_negCSH_DPCSF1896_029.d | MS | FEMALE |
SA053637 | Lipkin087_negCSH_DPCSF3686_093.d | MS | FEMALE |
SA053638 | Lipkin119_negCSH_DPCSF4165_101.d | MS | FEMALE |
SA053639 | Lipkin007_negCSH_DPCSF4592_121.d | MS | FEMALE |
SA053640 | Lipkin014_negCSH_DPCSF1815_122.d | MS | FEMALE |
SA053641 | Lipkin027_negCSH_DPCSF1041_058.d | MS | FEMALE |
SA053642 | Lipkin089_negCSH_DPCSF0614_035.d | MS | FEMALE |
SA053643 | Lipkin042_negCSH_DPCSF0747_027.d | MS | FEMALE |
SA053644 | Lipkin104_negCSH_DPCSF0868_089.d | MS | FEMALE |
SA053645 | Lipkin049_negCSH_DPCSF4633_104.d | MS | FEMALE |
SA053646 | Lipkin063_negCSH_DPCSF3137_060.d | MS | FEMALE |
SA053647 | Lipkin052_negCSH_DPCSF5274_054.d | MS | FEMALE |
SA053648 | Lipkin118_negCSH_DPCSF1174_023.d | MS | MALE |
SA053649 | Lipkin065_negCSH_DPCSF8732_075.d | MS | MALE |
SA053650 | Lipkin033_negCSH_DPCSF5395_077.d | MS | MALE |
SA053651 | Lipkin035_negCSH_DPCSF5447_011.d | MS | MALE |
SA053652 | Lipkin031_negCSH_DPCSF4927_074.d | MS | MALE |
SA053653 | Lipkin067_negCSH_DPCSF6728_056.d | MS | MALE |
SA053654 | Lipkin102_negCSH_DPCSF0909_078.d | MS | MALE |
SA053655 | Lipkin018_negCSH_DPCSF9719_033.d | MS | MALE |
SA053656 | Lipkin020_negCSH_DPCSF2029_041.d | MS | MALE |
SA053657 | Lipkin086_negCSH_DPCSF7329_006.d | MS | MALE |
SA053658 | Lipkin050_negCSH_DPCSF7664_076.d | MS | MALE |
SA053659 | Lipkin045_negCSH_DPCSF7023_091.d | MS | MALE |
SA053660 | Lipkin036_negCSH_DPCSF6128_115.d | ND | FEMALE |
SA053661 | Lipkin024_negCSH_DPCSF0106_108.d | ND | FEMALE |
SA053662 | Lipkin034_negCSH_DPCSF0828_031.d | ND | FEMALE |
SA053663 | Lipkin098_negCSH_DPCSF7115_106.d | ND | FEMALE |
SA053664 | Lipkin005_negCSH_DPCSF7756_002.d | ND | FEMALE |
SA053665 | Lipkin116_negCSH_DPCSF6769_051.d | ND | FEMALE |
SA053666 | Lipkin113_negCSH_DPCSF6555_107.d | ND | FEMALE |
SA053667 | Lipkin056_negCSH_DPCSF0146_105.d | ND | FEMALE |
SA053668 | Lipkin108_negCSH_DPCSF2710_064.d | ND | FEMALE |
SA053669 | Lipkin039_negCSH_DPCSF3310_047.d | ND | FEMALE |
SA053670 | Lipkin009_negCSH_DPCSF9332_017.d | ND | FEMALE |
SA053671 | Lipkin114_negCSH_DPCSF7797_045.d | ND | FEMALE |
SA053672 | Lipkin084_negCSH_DPCSF1281_053.d | ND | FEMALE |
SA053673 | Lipkin055_negCSH_DPCSF1215_019.d | ND | MALE |
SA053674 | Lipkin059_negCSH_DPCSF2924_118.d | ND | MALE |
SA053675 | Lipkin038_negCSH_DPCSF2750_120.d | ND | MALE |
SA053676 | Lipkin092_negCSH_DPCSF2110_119.d | ND | MALE |
SA053677 | Lipkin043_negCSH_DPCSF8865_117.d | ND | MALE |
SA053678 | Lipkin051_negCSH_DPCSF3605_116.d | ND | MALE |
Showing results 1 to 91 of 91 |